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Differences in dietary habits of people with vs without irritable bowel syndrome and their association with symptom and psychological status:A pilot study

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World Journal of Clinical Cases 2021年第11期9卷 2487-2502页

作者： Qiao Meng Geng Qin Shu-Kun Yao Guo-Hui Fan Fen Dong Chang Tan Graduate School Peking University China-Japan Friendship School of Clinical MedicineBeijing 100029China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Institute of Clinical Medical Sciences China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Previous studies have demonstrated that dietary factors are involved in irritable bowel syndrome(IBS),but the role of diet was evaluated mostly based on food frequency *** food categories,quantity per time,and intake frequency are different between IBS patients and non-IBS individuals has not been clearly *** To explore differences in dietary habits of people with vs without IBS and their correlation with symptom and psychological *** A total of 220 questionnaires were administered in a community population and the Rome IV criteria was applied to diagnose *** dietary questionnaire used in this study was multidimensional from food categories,quantity per time,and intake frequency,in contrast to“yes or no”classification used in previous *** including IBS symptom severity scale(IBS-SSS),IBS quality of life,visceral sensitivity index,hospital anxiety and depression score(HADS),and gastrointestinal symptom rating scale were used to assess the *** sum test was used to compare the quantity per time and intake frequency between IBS patients and non-IBS *** correlation between psychological factors and diet was evaluated by Spearman correlation *** regression analysis was used to assess the possible dietary risk factors for *** In total,203 valid questionnaires were collected(response rate 92.3%).Twentyfive participants met the Rome IV criteria for IBS,including 15(60.0%)women and 10(40.0%)*** with the non-IBS group,the quantity per time and intake frequency of soybean and its products,spicy food,and dry-fried nuts were statistically significant in IBS participants(P<0.05).They were positively associated with IBS-SSS and HADS anxiety and depression scores(P<0.05).Besides,seafood,soft drinks,vegetables,and fruits differed only in quantity per *** intake frequencies of egg,barbecue,and coarse grain were statistically significant in IBS patient

关键词： Irritable bowel syndrome Dietary habits Quantity per time Intake frequency Symptom severity Psychosocial status

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Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrheapredominant irritable bowel syndrome

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World Journal of Gastroenterology 2019年第2期25卷 269-281页

作者： Yu zhang Geng Qin De-Rong Liu Yan Wang Shu-Kun Yao Graduate School Peking Union Medical College and Chinese Academy of Medical Sciences Department of Gastroenterology China-Japan Friendship Hospital beijing Key Laboratory for Immune-Mediated Inflammatory Diseases Institute of Clinical Medical Sciences China-Japan Friendship Hospital

BACKGROUND Visceral hypersensitivity is considered to play a vital role in the pathogenesis of irritable bowel syndrome(IBS). Neurotrophins have drawn much attention in IBS recently. Brain-derived neurotrophic factor(BDNF) was found to mediate visceral hypersensitivity via facilitating sensory nerve growth in pre-clinical studies. We hypothesized that BDNF might play a role in the pathogenesis of diarrhea-predominant IBS(IBS-D).AIM To investigate BDNF levels in IBS-D patients and its role in IBS-D *** Thirty-one IBS-D patients meeting the Rome IV diagnostic criteria and 20 ageand sex-matched healthy controls were recruited. Clinical and psychological assessments were first conducted using standardized questionnaires. Visceral sensitivity to rectal distension was tested using a high-resolution manometry system. Colonoscopic examination was performed and four mucosal pinch biopsies were taken from the rectosigmoid junction. Mucosal BDNF expression and nerve fiber density were analyzed using immunohistochemistry. Mucosal BDNF mRNA levels were quantified by quantitative real-time polymerase chain reaction. Correlations between these parameters were *** The patients had a higher anxiety score [median(interquartile range), 6.0(2.0-10.0) vs 3.0(1.0-4.0), P = 0.003] and visceral sensitivity index score [54.0(44.0-61.0)vs 21.0(17.3-30.0), P < 0.001] than controls. The defecating sensation threshold[60.0(44.0-80.0) vs 80.0(61.0-100.0), P = 0.009], maximum tolerable threshold[103.0(90.0-128.0) vs 182.0(142.5-209.3), P < 0.001] and rectoanal inhibitory reflex threshold [30.0(20.0-30.0) vs 30.0(30.0-47.5), P = 0.032] were significantly lower in IBS-D patients. Intestinal mucosal BDNF protein [3.46 E-2(3.06 E-2-4.44 E-2) vs3.07 E-2(2.91 E-2-3.48 E-2), P = 0.031] and mRNA [1.57(1.31-2.61) vs 1.09(0.74-1.42), P = 0.001] expression and nerve fiber density [4.12 E-2(3.07 E-2-7.46 E-2) vs1.98 E-2(1.21 E-2-4.25 E-2), P = 0.002] were significantly elevat

关键词： Irritable bowel syndrome Diarrhea Brain-derived neurotrophic factor Visceral hypersensitivity Nerve growth

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Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis

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World Journal of Gastroenterology 2021年第24期27卷 3609-3629页

作者： zhen-Huan Yang Fang Liu Xiao-Ran zhu Fei-Ya Suo zi-jun Jia Shu-Kun Yao Graduate School Beijing University of Chinese MedicineBeijing 100029China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Gut microbiota and its metabolites may be involved in the pathogenesis of inflammatory bowel *** clinical studies have recently shown that patients with ulcerative colitis(UC)have altered profiles of fecal bile acids(BAs).It was observed that BA receptors Takeda G-protein-coupled receptor 5(TGR5)and vitamin D receptor(VDR)participate in intestinal inflammatory responses by regulating NF-ĸB *** hypothesized that altered profiles of fecal BAs might be correlated with gut microbiota and inflammatory responses in patients with *** To investigate the changes in fecal BAs and analyze the relationship of BAs with gut microbiota and inflammation in patients with *** The present study used 16S rDNA sequencing technology to detect the differences in the intestinal flora between UC patients and healthy controls(HCs).Fecal BAs were measured by targeted metabolomics *** TGR5 and VDR expression was analyzed using immunohistochemistry,and serum inflammatory cytokine levels were detected by *** Thirty-two UC patients and twenty-three HCs were enrolled in this *** was found that the diversity of gut microbiota in UC patients was reduced compared with that in ***,Clostridium IV,Butyricicoccus,Clostridium XlVa,Faecalibacterium,and Roseburia were significantly decreased in patients with UC(P=3.75E-05,P=8.28E-07,P=0.0002,P=0.003,P=0.0003,and P=0.0004,respectively).Proteobacteria,Escherichia,Enterococcus,Klebsiella,and Streptococcus were significantly enriched in the UC group(P=2.99E-09,P=3.63E-05,P=8.59E-05,P=0.003,and P=0.016,respectively).The concentrations of fecal secondary BAs,such as lithocholic acid,deoxycholic acid,glycodeoxycholic acid,glycolithocholic acid,and taurolithocholate,in UC patients were significantly lower than those in HCs(P=8.1E-08,P=1.2E-07,P=3.5E-04,P=1.9E-03,and P=1.8E-02,respectively)and were positively correlated with Butyricicoccus,Roseburia,Clostridium IV,Faecalibacterium,and

关键词： Ulcerative colitis Gut microbiota Bile acids Takeda G-protein-coupled receptor 5 Vitamin D receptor

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Serotonin transporter and cholecystokinin in diarrhea-predominant irritable bowel syndrome: Associations with abdominal pain, visceral hypersensitivity and psychological performance

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World Journal of Clinical Cases 2020年第9期8卷 1632-1641页

作者： Geng Qin Yu zhang Shu-Kun Yao Graduate School Peking Union Medical College and Chinese Academyof Medical SciencesBeijing 100730China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Visceral hypersensitivity and psychological performance are the main pathophysiological mechanisms of irritable bowel syndrome(IBS).Previous studies have found that cholecystokinin(CCK)can enhance colon movement and that serotonin transporter(SERT)is a transmembrane transport protein with high affinity for 5-hydroxytryptamine,which can rapidly reuptake 5-hydroxytryptamine and then regulate its action time and *** speculate that SERT and CCK might play a role in the pathogenesis of diarrheapredominant IBS(IBS-D)by affecting visceral sensitivity and the brain-gut *** To determine SERT and CCK levels in IBS-D patients diagnosed using Rome IV criteria and to analyze their associations with abdominal pain,visceral hypersensitivity and psychological *** This study collected data from 40 patients with IBS-D at the China-Japan Friendship Hospital from September 2017 to April 2018 and 18 healthy *** severity of abdominal pain,visceral sensitivity and psychological performance were evaluated in IBS-D patients and healthy controls,the levels of SERT and CCK in plasma and colonic mucosa were evaluated,and the correlations between them were *** There were significant differences in the initial sensation threshold(31.00±8.41 mL vs 52.22±8.09 mL,P<0.001),defecating sensation threshold(51.75±13.57 mL vs 89.44±8.73 mL,P<0.001)and maximum tolerable threshold(97.25±23.64 mL vs 171.11±20.83 mL,P<0.001)between the two ***-D patients had more severe anxiety(7.78±2.62 vs 2.89±1.02,P<0.001)and depressive(6.38±2.43 vs 2.06±0.73,P<0.001)symptoms than healthy *** differences were also found in mucosal CCK(2.29±0.30 vs 1.66±0.17,P<0.001)and SERT(1.90±0.51 vs 3.03±0.23,P<0.001)between the two *** was a significant positive correlation between pain scores and mucosal CCK(r=0.96,0.93,0.94,P<0.001).Significant negative correlations between anxiety(r=-0.98;P<0.001),depression(r=-0.99;P<0.001),pain evalua

关键词： Irritable bowel syndrome Abdominal pain Visceral hypersensitivity Psychological performance Serotonin transporter Cholecystokinin

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Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2020年第45期26卷 7153-7172页

作者： Wei Wei Hui-Fen Wang Yu zhang Yan-Li zhang Bing-Yu Niu Shu-Kun Yao Graduate School Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Bile acids(BAs)have attracted attention in the research of irritable bowel syndrome with predominant diarrhea(IBS-D)due to their ability to modulate bowel function and their tight connection with the gut *** composition of the fecal BA pool in IBS-D patients is reportedly different from that in healthy *** hypothesized that BAs may participate in the pathogenesis of IBS-D and the altered BA profile may be correlated with the gut *** To investigate the role of BAs in the pathogenesis of IBS-D and the correlation between fecal BAs and gut *** Fifty-five IBS-D patients diagnosed according to the Rome Ⅳ criteria and twentyeight age-,sex-,and body mass index-matched healthy controls(HCs)were enrolled in this study at the gastroenterology department of China-Japan Friendship ***,clinical manifestations were assessed with standardized questionnaires,and visceral sensitivity was evaluated via the rectal distension test using a high-resolution manometry *** primary BAs including cholic acid(CA)and chenodeoxycholic acid(CDCA),secondary BAs including deoxycholic acid(DCA),lithocholic acid(LCA),and ursodeoxycholic acid(UDCA)as well as the corresponding tauro-and glyco-BAs were examined by ultraperformance liquid chromatography coupled to tandem mass *** gut microbiota was analyzed using 16S rRNA gene *** between fecal BAs with clinical features and gut microbiota were *** Fecal CA(IBS-D:3037.66[282.82,6917.47]nmol/g,HC:20.19[5.03,1304.28]nmol/g;P<0.001)and CDCA(IBS-D:1721.86[352.80,2613.83]nmol/g,HC:57.16[13.76,1639.92]nmol/g;P<0.001)were significantly increased,while LCA(IBSD:1621.65[58.99,2396.49]nmol/g,HC:2339.24[1737.09,2782.40];P=0.002)and UDCA(IBS-D:8.92[2.33,23.93]nmol/g,HC:17.21[8.76,33.48]nmol/g;P=0.025)were significantly decreased in IBS-D patients compared to *** frequency was positively associated with CA(r=0.294,P=0.030)and CDCA(r=

关键词： Bile acids Irritable bowel syndrome Diarrhea Visceral hypersensitivity Microbiota Dysbiosis

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