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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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A strategy to significantly improve the classification accuracy of LIBS data:application for the determination of heavy metals in Tegillarca granosa

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Plasma science and Technology 2021年第8期23卷 118-126页

作者： Yangli XU Liuwei MENG Xiaojing CHEN Xi CHEN Laijin SU Leiming YUAN Wen SHI Guangzao HUANG wenzhou Vocational College of science and Technology Wenzhou 325006People's Republic of China College of Electrical and Electronic Engineering Wenzhou UniversityWenzhou 325035People's Republic of China Research and Development Department Hangzhou Goodhere Biotechnology Co.LtdHangzhou 311100People's Republic of China College of Life and Environmental science Wenzhou UniversityWenzhou 325035People's Republic of China

Tegillarca granosa,as a popular seafood among consumers,is easily susceptible to pollution from heavy ***,it is essential to develop a rapid detection method for Tegillarca *** this issue,five categories of Tegillarca granosa samples consisting of a healthy group;Zn,Pb,and Cd polluted groups;and a mixed pollution group of all three metals were used to detect heavy metal pollution by combining laser-induced breakdown spectrometry(LIBS)and the newly proposed linear regression classification-sum of rank difference(LRC-SRD)*** the comparison models,least regression classification(LRC),support vector machine(SVM),and k-nearest neighbor(KNN)and linear discriminant analysis were also *** accuracy(0.93)was obtained by LRC-SRD model and which performs better than other *** demonstrated that LIBS coupled with LRC-SRD is an efficient framework for Tegillarca granosa heavy metal detection and provides an alternative to replace traditional methods.

关键词： Tegillarca granosa sum of ranking difference heavy metal linear regression classification

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SOME RATIONALITY CONDITIONS OF JOINT EFFICIENT MAPPING IN GROUP MULTI-OBJECTIVE PROGRAMMING

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Journal of Systems science & Complexity 2007年第4期20卷 585-591页

作者： Jing LI Yuda HU School of Mathematics and Information science Wenzhou University Wenzhou 325035 China Department of Mathematics Shanghai Jiaotong University Shanghai 200030 China.

The joint efficient ordering method is a fundamental method of ordering alternatives in group multi-objective programming problems. In this paper, the rational properties of the joint efficient mapping corresponding t... 详细信息

关键词： group multi-objective programming joint efficient mapping joint efficient ordering method rationality condition.

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Adaptive Barebones Salp Swarm Algorithm with Quasi-oppositional Learning for Medical Diagnosis Systems: A Comprehensive Analysis

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Journal of Bionic Engineering 2022年第1期19卷 240-256页

作者： Jianfu Xia Hongliang Zhang Rizeng Li Zhiyan Wang Zhennao Cai Zhiyang Gu Huiling Chen Zhifang Pan Department of General Surgery The Second Affiliated Hospital of Shanghai University(Wenzhou Central Hospital)Wenzhou325000ZhejiangPeople’s Republic of China Soochow University SuzhouJiangsuPeople’s Republic of China Department of Computer science and Artificial Intelligence Wenzhou UniversityWenzhou325035People’s Republic of China School of Artificial Intelligence Jilin International Studies UniversityChangchun130000People’s Republic of China wenzhou Polytechnic Wenzhou325035People’s Republic of China The First Affiliated Hospital of wenzhou Medical University Wenzhou325000People’s Republic of China

The Salp Swarm Algorithm(SSA)may have trouble in dropping into stagnation as a kind of swarm intelligence *** paper developed an adaptive barebones salp swarm algorithm with quasi-oppositional-based learning to compensate for the above weakness called *** the proposed QBSSA,an adaptive barebones strategy can help to reach both accurate convergence speed and high solution quality;quasi-oppositional-based learning can make the population away from traping into local optimal and expand the search *** estimate the performance of the presented method,a series of tests are ***,CEC 2017 benchmark test suit is used to test the ability to solve the high dimensional and multimodal problems;then,based on QBSSA,an improved Kernel Extreme Learning Machine(KELM)model,named QBSSA–KELM,is built to handle medical disease diagnosis *** the test results and discussions state clearly that the QBSSA is superior to and very competitive to all the compared algorithms on both convergence speed and solutions accuracy.

关键词： Salp swarm algorithm Bare bones Quasi-oppositional based learning Function optimizations Kernel extreme learning machine

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Salt/current-triggered stabilization of β-cyclodextrins encapsulated host-guest low-molecular-weight gels

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Chinese Chemical Letters 2020年第2期31卷 369-372页

作者： Huan Xu Chaoyu Zhou Chuanjiang Jian Sunhai Yang Miaochang Liu Xiaobo Huang Wenxia Gao Huayue Wu College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325027China

Host-guest supramolecular gels were developed via the self-assembly of inclusion complexes(ICs) ofβ-cyclodextrins/phenylboronic acid gelator(PBA).Salts and current were involved in the self-assembly to stabilize the host-guest *** stability of the gels was greatly improved after salts were *** stable time of gels was extended from 2.5 h to 120 h with the addition of NH_4 NO_3 at the concentration of 2.5×10^(-2) g/*** morphology of the gel was affected by the concentrations of NH_4NO_*** images revealed that the gels were three-dimensional nanofibrous networks,the sizes of fibers decreased with decreasing NH_4NO_3 concentrations,which affected the stability of gels,further proved by the rheological properties of *** stable gels were obtained with current stimulation,the stable time of the gel was increased from 2.5 h to 55 h with current by adding NaBF_*** current also exhibited significant influence on the aggregation as the voltage varied(0-500 mV) with a constant concentration of *** result showed the self-assembly process of host-guest gel could be well controlled via the addition of salts and current to desired morphology and stability.

关键词： Supramolecular gel Inclusion complex Host-guest interaction Salt Current Stability

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A Highly Sensitive and Selective Fluorescence Chemosensor for Cu^2＋ and Zn^2＋ Based on Solvent Effect

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Chinese Journal of Chemistry 2013年第2期31卷 195-199页

作者： Xiaobo Huang Qian Miao Lu Wang Jieming Jiao Xianjing He Yixiang Cheng College of Chemistry and Materials Engineering Wenzhou University Wenzhou Zkejiang 325035 China Key Lab of Mesoscopic Chemistry of MOE School of Chemistry and Chemical Engineering Nanjing University Nanjing Jiangsu 210093 China

A novel fluorescence chemosensor 1 based on （R）-binaphthyl-salen can exhibit highly sensitive and selective recognition responses toward Cu^2＋ by ＂turn-off＂ fluorescence quench type in THF/H20, and Zn^2＋ by ＂turn-on＂ fluorescence enhancement type in CHC13/CH3CN, respectively, suggesting that solvents can dramatically affect the responsive properties of salen-based chemosensor. In addition, Cu^2＋ can lead to the most pronounced changes of CD spectra without the influence of solvents, which indicates this kind chemosensor can also be used as a sole Cu^2＋ probe based on CD spectra.

关键词： binaphthyl-salen fluorescence chemosensor solvent effect circular dichroism transition metal ion sensing

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Highly sensitive and selective electrochemical immunosensors by substrate-enhanced electroless deposition of metal nanoparticles onto three-dimensional graphene@Ni foams

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science Bulletin 2019年第17期64卷 1272-1279页

作者： Changrong Zhao Xiaoli Li Shixia An Dongliang Zheng Shuaili Pei Xiao Zheng Yu Liu Qingqing Yao Mei Yang Liming Dai Institute of Advanced Materials for Nano-Bio Applications School of Ophthalmology ■ Optometry Wenzhou Medical University Wenzhou 325027 China Department of Macromolecule science and Engineering Case Western Reserve University Cleveland OH 44106 USA

In this study, we have for the first time preformed the facile substrate-enhanced electroless deposition(SEED) of metal nanoparticles onto monolithic graphene@Ni foams for construction of disposable three-dimensional(3 D) electrochemical immunosensors. Specifically, we firstly used the SEED method to deposit gold nanoparticles(AuNPs) onto the graphene@Ni foam for immobilization of antibody(Ab1). This is followed by a second step SEED deposition to produce silver nanoparticles(AgNPs) for electrochemical stripping detection. Using a-fetoprotein antigen(AFP) as a module analyte, the newly-developed sensor showed a wide linear response, ranging from 5.0 pg/mL to 5.0 ng/mL and a low detection limit down to 2.3 pg/mL. The newly-developed 3 D-immunosensor is sensitive, reliable,and easy to be fabricated, showing great potential for clinic applications.

关键词： Electrochemical immunosensor Substrate-enhanced electroless deposition Graphene Ni foam Metal nanoparticles a-Fetoprotein antigen

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Mutation in a non-force-bearing region of protein L influences force-dependent unfolding behavior

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Chinese Physics B 2024年第7期33卷 624-629页

作者：蒋环杰王艳伟陈家媛胡丹潘海郭子龙陈虎 Department of Physics Wenzhou UniversityWenzhou 325035China Center of Biomedical Physics Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China

Single-molecule magnetic tweezers(MTs) have revealed multiple transition barriers along the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we utilized MTs to measure the force-dependent folding and unfolding rates of both protein L(PLWT) and its Y47W mutant(PLY47W) where the mutation point is not at the force-bearing β-strands. The measurements were conducted within a force range of 3–120 pN. Notably, the unfolding rates of both PLWT and PWY47W exhibit distinct force sensitivities below 50 pN and above 60 pN, implying a two-barrier free energy landscape. Both PLWT and PLY47W share the same force-dependent folding rate and the same transition barriers,but the unfolding rate of PLY47W is faster than that of PLWT. Our finding demonstrates that the residue outside of the force-bearing region will also affect the force-induced unfolding dynamics.

关键词： protein folding magnetic tweezers protein L

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Reversible grafting of antibiotics onto contact lens mediated by labile chemical bonds for smart prevention and treatment of corneal bacterial infections

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Journal of Materials science & Technology 2021年第2期61卷 169-175页

作者： Bailiang Wang Jiahong Zeng Yishun Guo Lin Liang Yingyingjin Siyuan Qian Renjie Miao Liang Hu Fan Lu School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou325027China

Eye trauma, decreased immunity, and contact lens wear often cause serious bacterial infections and irreversible corneal damage. To realize the responsive release of antibiotics such as gentamicin sulfate(GS), a novel antibacterial contact lens was constructed through self-assembly of antibiotics loaded ADAGS/PEI(polyethyleneimine) multilayer films on the surface. Both in vitro and in vivo antibacterial tests demonstrated high efficient and fast antibacterial property based on the smart responsive to bacterial infections and reversible drug loading and release.

关键词： Contact lens Corneal infections Dynamic chemical bonds Schiff base reaction Multilayer films

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Food emulsifier glycerin monostearate aggravates phthalates'testicular toxicity by disrupting tight junctions'barrier function in rats

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Food Quality and Safety 2021年第2期5卷 179-187页

作者： Lingzi Xia Min Yang Miao He Mingzhe Jiang Chang Qin Zhijun Wei Haitao Gao Department of Preventive Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina

Objectives:This study aimed to investigate the effect of the widely used food emulsifier glycerin monostearate(GM)on testicular toxicity caused by the mixture of three commonly used phthalate esters(MPEs)in rats,and further to explore the underlying *** and Methods:Thirty male Sprague-Dawley rats were randomly divided into three *** were orally treated with 160 mg/kg/d MPEs in the MPEs group;coinstantaneously treated with 160 mg/kg/d MPEs and 200 mg/kg/d GM in the MPEs+GM group;and treated with the excipient in the control *** intervention lasted for 5 *** weight,epididymis weight,testicular histopathology,and serum testosterone were detected for testicular toxicity *** testicular ultrastructure,the tight junction proteins zonula occluden(ZO)-1,and claudin were measured for the mechanism ***:The body weight,epididymis,serum testosterone level,and anogenital distance in the MPEs+GM group were significantly decreased compared with control group(P<0.05);Testicular histopathological observation showed that shed spermatids were observed in the MPEs+GM *** observation of testicular cells showed that the cristae number was decreased in some mitochondria in the MPEs group,whereas the cristae were fused and disappeared in most mitochondria in the MPEs+GM *** tight junctions were broken in the MPEs+GM group;meanwhile,the expression of ZO-1 and claudin were altered in the MPEs+GM group(P<0.01).Conclusions:The results from this study indicated that GM aggravated MPEs'testicular toxicity,which might relate to the injured mitochondria and damaged tight junctions in testicular tissue.

关键词： Glycerin monostearate butyl benzyl phthalate dibutyl phthalate di(2-ethylhexyl)phthalate male reproductive toxicity tight junction

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