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Gut liver brain axis in diseases:the implications for therapeutic interventions

Signal Transduction and Targeted Therapy 2024年第1期9卷 79-104页

作者： Mengyao Yan Shuli Man Benyue Sun Long Ma Lanping Guo Luqi Huang Wenyuan Gao State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&Technology300457 TianjinChina National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityWeijin Road300072 TianjinChina

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous *** the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment *** this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain *** therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain ***,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)*** gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related *** liver-brain axis contains epigenetic regulation and Aβmetabolism-related *** the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

关键词： metabolism therapeutic immunity

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Chemical composition,pharmacological activity and development strategies of Rubus chingii:A review

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Chinese Herbal Medicines 2024年第3期16卷 313-326页

作者： Xiangmei Xiong Zheng Liu Xiance Che Xuemin Zhang Xia Li Wenyuan Gao tianjin University of Traditional Chinese Medicine Tianjin 301600China tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyFaculty of MedicineTianjin UniversityTianjin 300110China Key Laboratory of Advanced Chinese Medicine Resources Research Enterprises Tianjin 300402China

Raspberries are used for both food and medicine,but it has not yet attracted widespread *** this paper,the chemical constituen of the original plant *** is one of the new“Zhe Bawei”medicinal materials selected in 2017.“Zhe Bawei”refers to eight kinds of genuine medicinal materials in Zhejiang *** chemical constituents,pharmacological effects,processing,and application of Rubus chingii Hu were reviewed to provide a reference for its further *** literature in recent years was collected in databases such as China Knowledge Network,Web of science,Elsevier,PubMed,and X-Mol,using“raspberry”,“Rubus chingii”,“traditional use”,“chemical composition”,“pharmacology”,*** keywords individually or in *** summary of pharmacological activities shows that the relationship between the pharmacological activities of raspberry is still not deep *** in-depth research should be carried out in this direction to explore the mechanism of action of its active ingredients and provide effective reference for the further development of the raspberry *** the future,with the participation of more researchers,it is expected to develop innovative drugs based on raspberry for the treatment of diseases.

关键词： applications chemical compositions processing pharmacological effects Rubus chingii Hu

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Lycorine derivative effectively inhibits the replication of coronaviruses both in vitro and in vivo

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hLife 2024年第2期2卷 75-87页

作者： Liang Shen Jianzhong Zhao Ying Xia Junjie Lu Jiali Sun Jian Tang Hui Xing Lijuan Yin Yang Yang Chunhua Wang Department of Clinical Laboratory Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceHubeiChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyGuangdongChina Department of Clinical Laboratory Xiangyang No.1 People’s HospitalHubei University of MedicineHubeiChina State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjinChina

The established and ongoing prevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and seasonal human coronaviruses(HCoV)like HCoV-OC43,HCoV-NL63,and HCoV-229E,pose a continuous threat to public ***,it is urgently needed to explore antiviral drugs with broad-spectrum anti-coronavirus *** previous studies have revealed that lycorine is a potent broad-spectrum anti-coronavirus drug,a natural alkaloid extracted from Amaryllidaceae with various pharmacological and microbiological ***,it is unsafe to directly use lycorine as a clinical antiviral drug due to the cytotoxicity and induction of cell *** this study,a series of lycorine derivatives were designed and *** of them,named Ly-8,was found to effectively inhibit the replication of different coronavirus strains in vitro,including ***,Ly-8 was also shown to effectively inhibit HCoVOC43 replication in the central nervous system,and provide effective protection against HCoV-OC43 infection in mice with low drug ***,Ly-8-resistant mutants were not observed during the 30 times sequential passages in cell ***,these findings suggest that Ly-8 may be a potential candidate drug for the future development of broad-spectrum anti-coronavirus drugs.

关键词： broad-spectrum antiviral drug lycorine derivative Ly-8

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Inefficiency of C3H/HeN Mice to Control Chlamydial Lung Infection Correlates with Downregulation of Neutrophil Activation during the Late Stage of Infection

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Cellular & Molecular Immunology 2009年第4期6卷 253-260页

作者： Xiaofei Tang Xiaokun Bu Naihong Zhang Xiaoxia Li Huanjun Huang Hong Bai Xi Yang Department of Immunology Tianjin Medical University Tianjin Key Laboratory of Cellular and Molecular Immunology Key Laboratory of Educational Ministry of China Tianjin China Laboratory fur Infection and Immunity Departments of Medical Microbiology and Immunology Faculty of Medicine University of Manitoba Winnipeg Manitoba Canada These authors contributed equally to this work Department of Immunology Tianjin Medical University 22 Qixiangtai Road Heping Distinct Tianjin 300070 China

We previously reported that massive infiltration of neutrophils in C3H/HeN （C3H） mice could not efficiently control Chlamydia muridarum （Cm） infection and might contribute to the high susceptibility of these mice to lung infection. To further define the nature of neutrophil responses in C3H mice during chlamydial infection, we examine the expression of adhesion molecules and CDllb related to neutrophils infiltration and activation, respectively, following intranasal Cm infection. The results showed that the expression of selectins （E-selectin, P-selectin and L-selectin）, and intercellular cell adhesion molecule-1 （ICAM-1） in the lung of C3H mice increased more significantly than in C57BL/6 （B6） mice, the more resistant strain. These results correlated well with the massive neutrophils infiltration in C3H mice. In contrast, CDllb expression on peripheral blood and lung neutrophils in C3H mice exhibited a significant reduction compared with B6 mice during the late phage of infection （day 14）. These findings suggest that the high-level expression of adhesion molecules in C3H mice may enhance neutrophils recruitment to the lung, but the decline of CDllb expression on neutrophils may attenuate neutrophil function. Therefore, CDllb down-regulation on neutrophils may contribute to the failure of C3H mice to control chlamydial lung infection.

关键词： Chlamydia trachomatis neutrophils selectins ICAM-1 CD11b

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Cloning and expression of special F protein from human liver

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World Journal of Gastroenterology 2007年第12期13卷 1799-1804页

作者： Shu-Ye Liu Xin-Da Yu Chun-Juan Song Wei Lu Jian-Dong Zhang Xin-Rong Shi Ying Duan Ju Zhang tianjin Third Central Hospital Tianjin Artificial Cell Laboratory Tianjin 300170 China Nankai University Biology Science Institute Tianjin 300071 China

AIM： To clone human liver special F protein and to express it in a prokaryotic system. METHODS： Total RNA was isolated from human liver tissue and first-strand cDNA was reverse transcribed using the PCR reverse primer. Following this, cDNA of the F protein was ligated into the clone vector pUCm-T. The segment of F protein＇s cDNA was subdoned into the expression vector pET-15b and transformed into E. coli BL21 （DE3） pLyss. Isopropy-β-D-thiogalactoside （IPTG） was then used to induce expression of the target protein. RESULTS： The cDNA clone of human liver special F protein （1134bp） was successfully produced, with the cDNA sequence being published in Gene-bank： DQ188836. We confirmed the expression of F protein by Western blot with a molecular weight of 43 kDa. The expressed protein accounted for 40% of the total protein extracted. CONCLUSION： F protein expresses cDNA clone in a prokaryotic system, which offers a relatively simple way of producing sufficient quantities of F protein and contributes to understanding the principal biological functions of this protein.

关键词： F protein Liver Gene-cloning, Protein expression Prokaryotic system

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Study on Enzymatic Hydrolysis of Gadus morrhua Skin Collagen and Molecular Weight Distribution of Hydrolysates

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Agricultural sciences in China 2009年第6期8卷 723-729页

作者： HUO Jian-xin ZHAO Zheng Jinzhong University Jinzhong 030600 P.R. China College of Food Engineering ＆ Biotechnology Tianjin University of Science ＆ Technology Tianjin 300457 P.R.China

Process parameters on enzymatic hydrolysis and molecular weight （MW） distribution of collagen hydrolysates from Gadus morrhua skin were investigated. The optimal process parameters were obtained by the single-factor and orthogonal experiments. The molecular weight distribution of hydrolysates was determined using both Sephadex G25 partition and high speed liquid chromatography electricity spray mass spectrum （HPLC-ESI-MS）. Collagen hydrolysates were first gained by an alkaline protease ＂alcalase＂ for 3 h at temperature （50~C）, pH （10.0）, substrate concentration （75 g L-~）, and E/S （3%）. The molecular weight distribution of collagen hydrolysates ranged from 300 to 1 500 Da, and most of peptides were under 1 200 Da. Sephadex G25 partition and HPLC-ESI-MS should be successfully employed to determine the molecular weight distribution of collagen hydrolysates.

关键词： collagen hydrolysates Gadus morrhua molecular weight distribution alkaline protease

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Studies on the overexpression of the soybean GmNHX1 in Lotus corniculatus: The reduced Na^+ level is the basis of the increased salt tolerance

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Chinese science Bulletin 2006年第11期51卷 1306-1315页

作者： SUN Yanxiang WANG Dan BAI Yanling WANG Ningning WANG Yong College of Life sciences Nankai University Tianjin 300071 China tianjin Research Center of Agricultural Biotechnology Tianjin 300183 China Department of Biology Teachers College of Langfang Langfang 065000 China

The full length cDNA coding for a novel vacuolar Na+/H+ antiporter (GmNHX1) was cloned from soybean and determined to consist of 2591 bp with a 5′-untranslated region of 464 bp, an open reading frame (ORF) of 1641 bp, and a 3′-untrans- lated region of 486 bp. The deduced protein se- quence contains 546 aa with the typical characters of the vacuolar Na+/H+ antiporters, and shares high similarity with that of AtNHX1, OsNHX1 and AgNHX1. The soybean genome showed a single copy of the GmNHX1 gene. Northern blot analysis demonstrated that the expression of the GmNHX1 was tissue-spe- cific, increased by ABA treatment, NaCl, KCl, LiCl and dehydration stress, and lower in leaves but higher in roots and hypocotyls of salt-tolerant than salt-sensitive cultivars. The GmNHX1 was overex- pressed under the control of a tandem cauliflower mosaic virus (CaMV) 35S promoter in the model le- guminous plant Lotus corniculatus L. and conferred salt-tolerance of the transgenic plants. Measure- ments of Na+ and K+ contents in both roots and shoots demonstrated that the plantlets of GmNHX1- overexpressing lines had lower Na+ and K+ content, and higher K+/Na+ ratio than the controlled lines that were transformed with the empty vector, which indi- cates that the salt-tolerance conferred by GmNHX1 is closely related with decreased accumulation of Na+ in the transgenic plants.

关键词：大豆 GmNHX1 莲耐盐性盐胁迫

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Conformation Analysis and Thermodynamics of Binding Behavior of DABCO to p/p type Dimeric Porphyrin Hosts

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Chinese Chemical Letters 2000年第11期11卷 981-984页

作者： Qi Zhi REN Zhi Ang ZHU Jin Wang HUANG Liang Nian JI Yong Ti CHEN Nankai University Department of ChemistryTianjin 300071 Zhongshan University School of Chemistry and Chemical EngineeringGuangzhou 510275

The binding conformations of bidentate ligand DABCO(1,4-diazobicyclo [2,2,2]octane) to a series of p'p type zinc porphyrin dimers covalently linked with flexible alkoxy chain - O(CH2)(n)O- (n=2-10) are described by H-1 NMR and UV-vis spectroscopy. DABCO can bind inside the cavities of porphyrin dimers and form a ternary sandwich complex as the alkoxy chain length is long enough. The thermodynamic parameters which control the binding behavior are investigated.

关键词： zinc porphyrin dimer DABCO thermodynamic parameters binding conformation

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Facile Fabrication of Fe3O4@TiO2@C Yolk–Shell Spheres as Anode Material for Lithium Ion Batteries

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Transactions of tianjin University 2020年第1期26卷 3-12页

作者： Wenming Liao Zhongqiang Shan Jianhua Tian School of Chemical Engineering and technology Tianjin UniversityTianjin 300072China School of Chemistry and Chemical Engineering Jinggangshan UniversityJiangxi 343009China

Transition metal oxides have been actively exploited for application in lithium ion batteries due to their facile synthesis,high specific capacity,and *** this paper,Fe3O4@TiO2@C yolk-shell(Y-S)spheres,used as anode material for lithium ion batteries,were successfully fabricated by Stober *** patterns reveal that Fe3O4@TiO2@C Y-S spheres possess a good *** the diffraction peaks’intensity of Fe3O4 crystals in the composites is much weaker than that of bare Fe3O4 spheres,indicating that the outer anatase TiO2@C layer can cover up the diffraction peaks of inner Fe3O4 *** yolk-shell structure of Fe3O4@TiO2@C spheres is further characterized by TEM,HAADFSTEM,and EDS *** yolk-shell structure is good for improving the cycling stability of the inner Fe3O4 spheres during lithium ions insertion-extraction *** tested at 200 mA/g,the Fe3O4@TiO2@C Y-S spheres can provide a stable discharge capacity of 450 mAh/g over 100 cycles,which is much better than that of bare Fe3O4 spheres and TiO2@C ***,cyclic voltammetry curves show that the composites have a good cycling stability compared to bare Fe3O4 spheres.

关键词： Fe3O4@TiO2@C yolk-shell spheres Cycle performance Lithium ion batteries Anode material

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Preparation and Characterization of Sulfated Cellulose Nanocrystalline and its Composite Membrane for Removal of Tetracycline Hydrochloride in Water

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Energy & Environmental Materials 2020年第2期3卷 209-215页

作者： Jie Liu Duo Liu Shisheng Liu Zhihong Li Xiaohui Wei Song Lin Minjie Guo College of Chemical Engineering and Materials science Tianjin University of Science&TechnologyTianjin 300457China Institute of Medical Support Academy of Military SciencesTianjin 300161China

The removal of antibiotic pollutants remaining in the environmental media has been a big challenge ***,we report a facile and green approach to fabricate an eco-friendly composite membrane without addition of any toxic polymers or chemical cross-linking agents to effectively remove the tetracycline hydrochloride in ***,the sulfated cellulose nanocrystalline(CNC) was obtained via hydrolysis of sulfuric acid by using microcrystalline cellulose(MCC) as raw material under ultrasonic *** as-prepared CNC has a nanowhisker dimension with 200.2 ± 110.2 nm in length,15.7 ± 9.3 nm in width,and 7.2 ± 3.1 nm in *** obtained CNC is cellulose type I as determined by X-ray diffraction(XRD),while its crystallinity index(Crl) can reach 82.3%.Then,the composite membrane derived from the obtained CNC and commercial mixed cellulose ester(MCE)membrane was facilely prepared through vacuum dewatering process,which is applied to remove tetracycline hydrochloride(Th) in *** results showed that the removal efficiency of Th through the neat MCE was only28 ± 4%,while it could be improved to 58 ± 5% and 89 11%,respectively,by filtering through composite membranes with different contents of CNC *** effect is derived from the combine factors based on both steric hindrance(sieving) and electrostatic interaction(Donnan) effect of the composite *** development of related CNC materials and composite fabrication processes is in favor of cost-effective and "green"polymer composites for the remediation of increasing antibiotic pollution and the purification of contaminated water nowadays.

关键词： adsorption removal cellulose nanocrystalline composite membrane tetracycline hydrochloride

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