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Computed tomography perfusion in evaluating the therapeutic effect of transarterial chemoembolization for hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第37期14卷 5738-5743页

作者： Guang Chen Da-Qing Ma Wen He Bao-Feng Zhang Li-Qin Zhao Department of Radiology Beijing FriendshipHospital Capital Medical University 95 YongAn Road XuanWu District Beijing 100050 China

AIM： To prospectively assess the changes in parameters of computed tomography （CT） perfusion pre- and post-transarterial chemoembolization （TACE） of hepatocellular carcinoma （HCC） in different treatment response groups, and to correlate the changes with various responses of HCC to TACE. METHODS： Thirty-nine HCC patients underwent CT perfusion examinations pre-（1 d before TACE） and post-treatment （4 wk after TACE）. The response evaluation criteria for solid tumors （RECIST） were referred to when treatment responses were distributed. Wilcoxon-signed ranks test was used to compare the differences in CT perfusion parameters pre- and post- TACE for different response groups. RESULTS： Only one case had treatment response to CR and the CT perfusion maps of post-treatment lesion displayed complete absence of signals. In the PR treatment response group, hepatic artery perfusion （HAP）, hepatic arterial fracture （HAF） and hepatic blood volume （HBV） of viable tumors post-TACE were reduced compared with pre-TACE （P = 0.001, 0.030 and 0.001, respectively）. In the SD group, all CT perfusion parameters were not significantly different pre- and post-TACE. In the PD group, HAP, HAl=, portal vein perfusion （PVP） and hepatic blood flow （HBF） of viable tumors post-TACE were significantly increased compared with pre-TACE （P = 0.005, 0.012, 0.035 and 0.005, respectively）. CONCLUSION： Changes in CT perfusion parameters of viable tumors are correlated with different responses of HCC to TACE. Therefore, CT perfusion imaging is a feasible technique for monitoring response of HCC to TACE.

关键词： Hepatocellular carcinoma Computed tomography Transarterial chemoembolization Digital subtraction arteriography Region of interest

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64-row multidetector computed tomography portal venography of gastric variceal collateral circulation

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World Journal of Gastroenterology 2010年第8期16卷 1003-1007页

作者： Zhao, Li-Qin He, Wen Li, Ming Liu, Peng Li, Peng Capital Med Univ Beijing Friendship Hosp Dept Radiol Beijing 100050 Peoples R China Capital Med Univ Beijing Friendship Hosp Dept Gastroenterol Beijing 100050 Peoples R China

AIM:To study characteristics of collateral circulation of gastric varices (GVs) with 64-row multidetector computer tomography portal venography (MDCTPV).METHODS:64-row MDCTPV with a slice thickness of 0.625 mm and a scanning field from 2 cm above the tracheal bifurcation to the lower edge of the kidney was performed in 86 patients with GVS diagnosed by endoscopy. The computed tomography protocol included unenhanced,arterial and portal vein phases. The MDCTPV was performed on an AW4.3 workstation. GVs were classified into three types according to Sarin's Classification. The afferent and efferent veins of each type of GV were ***:The afferent venous drainage originated mostly from the left gastric vein alone (LGV) (28/86,32.59%),or the LGV more than the posterior gastric vein/short gastric vein [LGV > posterior gastric vein/short gastric vein (PGV/SGV)] (22/86,25.58%),as seen by MDCTPV. The most common efferent venousdrainage was via the azygos vein to the superior vena cava (53/86,61.63%),or via the gastric/splenorenal shunt (37/86,43.02%) or inferior phrenic vein (8/86,9.30%) to the inferior vena cava. In patients with gastroesophageal varices type 1,the afferent venous drainage of GV mainly originated from the LGV or LGV > PGV/SGV (43/48,89.58%),and the efferent venous drainage was mainly via the azygos vein to the super vena cava (43/48,89.58%),as well as via the gastric/splenorenal shunt (8/48,16.67%) or inferior phrenic vein (3/48,6.25%) to the inferior vena cava. In patients with gastroesophageal varices type 2,the afferent venous drainage of the GV mostly came from the PGV/SGV more than the LGV (PGV/SGV > LGV) (8/16,50%),and the efferent venous drainage was via the azygos vein (10/16,62.50%) and gastric/splenorenal shunt (9/16,56.25%). In patients with isolated gastric varices,the main afferent venous drainage was via the PGV/SGV alone (16/22,72.73%),and the efferent venous drainage was mainly via the gastric/splenorenal shunt (20/22,90.91%),as we

关键词： Computed tomography Portal venography Gastric varices Portal hypertension Collateral circulation

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Characteristics of paraesophageal varices:A study with 64-row multidetector computed tomograghy portal venography

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World Journal of Gastroenterology 2008年第34期14卷 5331-5335页

作者： Li-Qin Zhao Wen He Guang Chen Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

AIM:To identify the characteristics of morphology, loca- tion and collateral circulation involved in paraesophageal varices (para-EV) of portal hypertension patients with 64-row multidetector computed tomograghy (MDCT). METHODS: Fifty-two of 501 patients with portal hypertensive cirrhosis accompanied with esophageal varices were selected for 64-row MDCT examination af- ter the observation of para-EV. The CT protocol includ- ed unenhanced, arterial and portal phases with a slice thickness of 0.625 mm and a scanning field of 2 cm above the bifurcation to the lower edge of kidney. The CT portal venography (CTPV) was reformatted on AW4.3 workstation. The characteristics of origina- tion, location, morphology and collateral circulation in para-EV were observed. RESULTS: Among the 52 cases of para-EV, 50 showed the originations from the posterior branch of left gastric vein, while the others from the anterior branch. Fifty cases demonstrated their locations close to the esoph- ageal-gastric junction, and the other two cases were extended to the inferior bifurcation of the trachea. The circuitous pattern was observed in 16 cases, while reticulated pattern was seen in 36 cases. Collateral circulation identifi ed 4 cases of single periesophageal varices (peri-EV) communication, 3 cases of single hemiazygous vein, one case of single inferior vena cava, 41 cases of mixed type (collateral communica-tions of at least 2 of above mentioned types) and 3 cases of undetermined communications. Among all the cases, 43 patients showed the communications between para-EV and peri-EV, while hemiazygous vein (43 cases) and inferior vena cava (5 cases) were also involved. CONCLUSION: Sixty-four-row multidetector computed tomograghy portal venography could display the loca- tion, morphology, origin, and collateral types of para- EV, which provides important and referable information for clinical management and disease prognosis.

关键词： Computer tomograghy Portal venography, Paraesophageal varices Hepatic cirrhosis Portal hypertension

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Liver and spleen volume variations in patients with hepatic fibrosis

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World Journal of Gastroenterology 2009年第26期15卷 3298-3302页

作者： Peng Liu Peng LI Wen He Li-Qin Zhao Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

AIM： To study the liver and spleen volume variations in hepatic fibrosis patients at different histopathological stages. METHODS： Multidetector computed tomography （MDCT） scan was performed in 85 hepatic fibrosis patients. Liver volume （LV） and spleen volume （SV） were measured. Fifteen healthy individuals served as a control group （SO）. The patients were divided into stage 1 （S1） group （n = 34）, stage 2 （S2） group （n = 25）, stage 3 （S3） group （n = 16）, and stage 4 （S4） group （n = 10） according to their histopathological stage of liver fibrosis. RESULTS： The LV and standard LV （SLV） had a tendency to increase with the severity of fibrosis, but no statistical difference was observed in the 5 groups （LV： F = 0.245, P = 0.912; SLV： F = 1.902, P = 0.116）. The SV was gradually increased with the severity of fibrosis, and a statistically significant difference in SV was observed among the 5 groups （P 〈 0.01）. The LV/SV ratio and SLV/SV ratio were gradually decreased with the aggravation of hepatic fibrosis, and statistically significant differences in both LV/SV and SLV/SV were found among the 5 groups （P 〈 0.01）.CONCLUSION： The absence of obvious LV reduction in patients with chronic liver disease may be a morphological index of patients without liver cirrhosis. The SV is related to the severity of fibrosis, and the spleen of patients with advanced fibrosis is enlarged evidently. The LV/SV ratio and SLV/SV ratio are of a significant clinical value in the diagnosis of advanced liver fibrosis.

关键词： Hepatic fibrosis Volume measurement Liver volume Standard liver volume Spleen volume Liver volume/spleen volume ratio Standard liver volume/spleen volume ratio

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Hyperbaric oxygen treatment induces dynamic ATPase activity changes in the rat brain following transient global cerebral ischemia-reperfusion

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Neural Regeneration Research 2008年第9期3卷 1018-1021页

作者： Shiming Xu Hongjuan Wang Tongnan Gu Xiuyan Zhou Rui Chen Department of Biochemistry Yanjing Medical College Capital Medical University Beijing 101300 China Department of Biochemistry and Molecular Biology Capital Medical University Beijing 100069 China

BACKGROUND： Energy depletion, induced by ischemia or hypoxia, is one of the first events in neuronal injury. OBJECTIVE： To investigate the dynamic changes of Na^＋-K^＋-ATPase and Ca^2＋-ATPase activity in the rat brain following transient global cerebral ischemia-reperfusion （IR）, as well as the effects of hyperbaric oxygen （HBO） treatment. DESIGN, TIME AND SETTING： A randomized and controlled animal study was performed in the Department of Biochemistry and Molecular Biology, Capital Medical University between February and December 2006. MATERIALS： Clean-grade, female, Sprague Dawley rats were provided by the Animal Research Department of Capital Medical University （License number： SYXK11-00-0047）. Na^＋-K^＋-ATPase and Ca^2＋-ATPase kits were provided by Nanjing Jiancheng Bioengineering Institute （Nanjing, China）. A hyperbaric oxygen chamber （DWC150-300） was supplied by Shanghai 701 Medical Oxygen Chamber Factory （Shanghai, China）. METHODS： Sixty-three rats were randomly divided into nine groups： sham operated group （sham-O） as control, groups of IR, and groups treated with hyperbaric oxygen （HBO） after IR. Animal from the IR and HBO groups were sacrificed after four different survival intervals of 6, 24, 48 and 96 hours, respectively. Each group consisted of seven rats. The rats of HBO groups were placed into the hyperbaric chamber. The HBO chamber was flushed with pure oxygen for 5 minutes, followed by a gradual rise in pressure over 5 minutes and stabilization at 0.2 MPa. Then, pure oxygen was supplied for 45 minutes in stabilized pressure, followed by gradually reduced pressure over 15 minutes. The rats of the 6-h HBO group were placed into the HBO chamber following reperfusion for 3 hours on the first day, which was repeated on three consecutive days, always at the same time. Rats in the sham-O group and IR group remained under normal atmospheric pressure. MAIN OUTCOME MEASURES： The Na^＋-K^＋-ATPase and Ca^2＋-ATPase activity in rat brain homogenate was detected by t

关键词： ATPase cerebral ischemia-reperfusion hyperbaric oxygen Sprague Dawley rats

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Effects of catalyst precursors on carbon nanowires by using ethanol catalytic combustion technique

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中国有色金属学会会刊：英文版 2006年第B1期16卷 385-387页

作者：程进邹小平李飞张红丹任鹏飞 Research Center for Sensor technology Beijing Information Technology InstituteBeijing 100101China beijing Key Laboratory for Sensor Beijing 100101China

Iron nitrate, nickel nitrate and cobalt nitrate were used as catalyst precursors to study their effects on carbon nanowires synthesized by ethanol catalytic combustion (ECC) process. The as-grown carbon nanowires were characterized by means of scanning electron microscopy, transmission electron microscopy and Raman spectroscopy. The results show that relatively uniform nanowires will be formed when the catalyst precursor is iron nitrate; while helical structure or disordered structure will be formed when the catalyst precursor is nickel nitrate or cobalt nitrate.

关键词：碳纳米线制备催化剂前驱物乙醇催化燃烧技术

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Electrical measurement on individual multi-walled carbon nanotubes

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中国有色金属学会会刊：英文版 2006年第B2期16卷 772-775页

作者：邹小平 H.ABE T.SHIMIZU A.ANDO H.OKUMOTO 朱申敏周豪慎 Research Center for Sensor technology beijing Information technology Institute Beijing 100101China beijing Key Laboratory for Sensor Beijing 100101 China Nanotechnology Research Institute National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 HigashiTsukubaIbalaki 305-8562Japan Energy Electronics Research Institute National Institute of Advanced Industrial Science and Technology (AIST)1-1-1 UmezonoTsukubaIbalaki 305-8568Japan Energy Electronics Research InstituteNational Institute of Advanced Industrial science and technology (AIST) 1-1-1 UmezonoTsukubaIbalaki 305-8568Japan Nanotechnology Research InstituteNational Institute of Advanced Industrial science and technology (AIST) 1-1-1 HigashiTsukubaIbalaki 305-8562Japan Nano-electronics Research Institute National Institute of Advanced Industrial science and technology (AIST) 1-1-1 Umezono Tsukuba Ibalaki 305-8568 Japan Nanotechnology Research Center Research Institute for Electronic ScienceHokkaido UniversitySapporo 001-0021Japan Energy Electronics Research InstituteNational Institute of Advanced Industrial science and technology (AIST) 1-1-1 UmezonoTsukubaIbalaki 305-8568Japan Energy Electronics Research Institute National Institute of Advanced Industrial science and technology (AIST) 1-1-1 Umezono Tsukuba Ibalaki 305-8568Japan

The characterization of electrical property of multi-walled carbon nanotubes (MWCNTs) on a nanometer scale is essential for their potential application in nano-electronic devices. The MWCNTs were synthesized on Fe2O3/SiO2/Si substrate and Pt plate substrate by simple thermal chemical vapor deposition (STCVD) technique and the electrical measurements of individual MWCNT grown on silicon substrate and Pt plate substrate were performed by home-made 'nano-manipulator', respectively. According to current-voltage curves obtained in the experiments the current density that the MWCNTs can carry is calculated to be about 107 A/cm2, which is much larger than that of normal metals.

关键词：多壁碳纳米管电学测量简易热化学汽相沉积合成

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Preparation of carbon nanotubes by ethanol catalytic combustion technique using nickel salt as catalyst precursor

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中国有色金属学会会刊：英文版 2006年第B1期16卷 381-384页

作者：李飞邹小平程进张红丹任鹏飞 Research Center for Sensor technology Beijing Information Technology InstituteBeijing 100101China beijing Key Laboratory for Sensor Beijing 100101China

A simple growth technique of carbon nanotubes (CNTs) by combustion of ethanol was developed. In the experiment, copper plate was employed as substrate, nickel nitrate (Ni(NO3)2) and nickel chloride (NiCl2) as catalyst precursor, and ethanol as carbon source. The cleaned copper substrate was dipped into catalyst precursor solution for mounting catalyst precursor particles. The dip-coated substrate was then placed into ethanol flame for about 10 min after drying. The black wool-like production grown on copper plate was obtained. This route is called an ethanol catalytic combustion(ECC) process. The black powders were characterized by means of scanning electron microscopy(SEM), transmission electron microscopy(TEM), energy dispersive X-ray spectrometer(EDS) and Raman spectroscopy. The results show that the techique is much simpler and more economical to meet the future broader applications.

关键词：碳纳米管制备催化剂前驱物乙醇催化燃烧技术硝酸镍

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Selective growth of carbon nanotube on silicon substrates

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中国有色金属学会会刊：英文版 2006年第B1期16卷 377-380页

作者：邹小平 H.ABE T.SHIMIZU A.ANDO H.TOKUMOTO 朱申敏周豪慎 Research Center for Sensor technology Beijing Information Technology InstituteBeijing 100101China beijing Key Laboratory for Sensor Beijing 100101China Nanotechnology Research Institute National Institute of Advanced Industrial Science and Technology1-1-1 HigashiTsukubaIbalaki 305-8562Japan Energy Electronics Research Institute National Institute of Advanced Industrial Science and Technology1-1-1 UmezonoTsukubaIbalaki 305-8568Japan Nano-electronics Research Institute National Institute of Advanced Industrial Science and Technology1-1-1 UmezonoTsukubaIbalaki 305-8568Japan Nanotechnology Research Center Research Institute for Electronic ScienceHokkaido UniversitySapporo 001-0021Japan

The carbon nanotube (CNT) growth of iron oxide-deposited trench-patterns and the locally-ordered CNT arrays on silicon substrate were achieved by simple thermal chemical vapor deposition(STCVD) of ethanol vapor. The CNTs were uniformly synthesized with good selectivity on trench-patterned silicon substrates. This fabrication process is compatible with currently used semiconductor-processing technologies, and the carbon-nanotube fabrication process can be widely applied for the development of electronic devices using carbon-nanotube field emitters as cold cathodes and can revolutionize the area of field-emitting electronic devices. The site-selective growth of CNT from an iron oxide nanoparticle catalyst patterned were also achieved by drying-mediated self-assembly technique. The present method offers a simple and cost-effective method to grow carbon nanotubes with self-assembled patterns.

关键词： carbon nanotubes silicon substrate STCVD trench-patterned locally-ordered pattern

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Synthesis of Y-junction carbon nanofibres by ethanol catalytic combustion technique

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中国有色金属学会会刊：英文版 2006年第B1期16卷 431-434页

Y-shaped structure was synthesized by ethanol catalytic combustion(ECC) technique on the copper plate substrate, without directly seeding catalyst into the flame. The as-grown Y-junction carbon nanofibres were investigated by transmission electron microscopy (TEM). The very common laboratory ethanol burner was used for synthesizing carbon nanofibres. Two kinds of the catalyst precursor, which are iron nitrate (Fe(NO3)3) and nickel nitrate (Ni(NO3)2), were respectively employed to assist the formation of Y-junction carbon nanofibres. TEM analysis confirm the formation of Y-junction in the coiled and noncoiled carbon nanofibres. The type of the catalyst is found to be crucial to grow different Y-junction carbon nanofibres. Different Y-shaped structure may possess different mechanical and electronic properties. These three-terminal nanofibres provide the nanoelectronics community with a novel material for the development of molecular-scale electronic devices.

关键词： Y-结碳纳米纤维乙醇催化燃烧技术合成 Fe(NO3)3 Ni(NO3)2

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