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Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer

World Journal of Gastroenterology 2017年第31期23卷 5787-5797页

作者： Yuan Xie Jian-Zhen Lin An-Qiang Wang Wei-Yu Xu Jun-Yu Long Yu-Feng Luo Jie Shi Zhi-Yong Liang Xin-Ting Sang Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

AIM To detect the expression of threonine and tyrosine kinase(TTK) in gallbladder cancer(GBC) specimens and analyze the associations between TTK expression and clinicopathological parameters and clinical *** A total of 68 patients with GBC who underwent surgical resection were enrolled in this study. The expression of TTK in GBC tissues was detected by immunohistochemistry. The assessment of TTKexpression was conducted using the H-scoring system. H-score was calculated by the multiplication of the overall staining intensity with the percentage of positive cells. The expression of TTK in the cytoplasm and nucleus was scored separately to achieve respective H-s c o r e v a l u e s. T h e c o r r e l a t i o n s b e t w e e n T T K expression and clinicopathological parameters and clinical prognosis were analyzed using Chi-square test, Kaplan-Meier method and Cox *** In both the nucleus and cytoplasm, the expression of TTK in tumor tissues was significantly lower than that in normal tissues(P < 0.001 and P = 0.026, respectively). Using the median H-score as the cutoff value, it was discovered that, GBC patients with higher levels of TTK expression in the nucleus, but not the cytoplasm, had favorable overall survival(P < 0.001), and it was still statistically meaningful in Cox regression analysis. Further investigation indicated that there were close negative correlations between TTK expression and tumor differentiation(P = 0.041), CA 19-9 levels(P = 0.016), T stage(P < 0.001), nodal involvement(P < 0.001), distant metastasis(P = 0.024) and TNM stage(P < 0.001). CONCLUSION The expression of TTK in GBC is lower than that in normal tissues. Higher levels of TTK expression in GBC are concomitant with longer overall survival. TTK is a favorable prognostic biomarker for patients with GBC.

关键词： Threonine and tyrosine kinase Biomarker Prognosis Gallbladder cancer

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Prognostic impact of the red cell distribution width in esophageal cancer patients: A systematic review and meta-analysis

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World Journal of Gastroenterology 2018年第19期24卷 2120-2129页

作者： Wei-Yu Xu Xiao-Bo Yang Wen-Qin Wang Yi Bai Jun-Yu Long Jian-Zhen Lin Jian-Ping Xiong Yong-Chang Zheng Xiao-Dong He Hai-Tao Zhao Xin-Ting Sang Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

AIM To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width(RDW) in esophageal cancer(EC). METHODS We searched the PubM ed, EMBASE, Web of science and Cochrane Library databases to identify clinical studies, followed by using STATA version 12.0 for statistical analysis. Studies that met the following criteria were considered eligible:(1) Studies including EC patients who underwent radical esophagectomy;(2) studies including patients with localized disease without distant metastasis;(3) studies including patients without preoperative neoadjuvant therapy;(4) studies including patients without previous antiinflammatory therapies and with available preoperative laboratory outcomes;(5) studies reporting association between the preoperative RDW and overall survival(OS)/disease-free survival(DFS)/cancer-specific survival(CSS); and(6) studies published in *** A total of six articles, published between 2015 and 2017, fulfilled the selection criteria in the end. Statistical analysis showed that RDW was not associated with the prognosis of EC patients, irrespective of OS/CSS [hazard ratio(HR) = 1.27, 95% confidence interval(CI): 0.97-1.57, P = 0.000] or DFS(HR = 1.42, 95%CI: 0.96-1.88, P = 0.000). Subgroup analysis indicated that elevated RDW was significantly associated with worse OS/CSS of EC patients when RDW > 13%(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000), when the patient number ≤ 400(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000) and when the study type was retrospective(HR = 1.42, 95%CI : 1.16-1.69, P = 0.000).CONCLUSION Contrary to our general understanding, this meta-analysis revealed that RDW cannot serve as an indicator of poor prognosis in patients with EC. However, it may still be a useful predictor of unfavorable prognosis using an appropriate cut-off value.

关键词： Red cell distribution width Prognostic impact Systematic review Meta-analysis

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Nomogram to predict overall survival after gallbladder cancer resection in China

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World Journal of Gastroenterology 2018年第45期24卷 5167-5178页

作者： Yi Bai Zhi-Song Liu Jian-Ping Xiong Wei-Yu Xu Jian-Zhen Lin Jun-Yu Long Fei Miao Han-Chun Huang Xue-Shuai Wan Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Statistics Tianjin University of Finance and Economics Pearl River College

AIM To integrate clinically significant variables related to prognosis after curative resection for gallbladder carcinoma(GBC) into a predictive *** One hundred and forty-two GBC patients who underwent curative intent surgical resection at Peking Union Medical College Hospital(PUMCH) were included. This retrospective case study was conducted at PUMCH of the Chinese Academy of Medical sciences and Peking Union Medical College(CAMS & PUMC) in China from January 1, 2003 to January 1, 2018. The continuous variable carbohydrate antigen 19-9(CA19-9) was converted into a categorical variable(cCA19-9) based on the normal reference range. Stages 0 to IIIA were merged into one category, while the remaining stages were grouped into another category. Pathological grade X(GX) was treated as a missing value. A multivariate Cox proportional hazards model was used to select variables to construct a nomogram. Discrimination and calibration of the nomogram were performed via the concordance index(C-index) and calibration plots. The performance of the nomogram was estimated using the calibration curve. Receiver operating characteristic(ROC) curve analysis and decision curve analysis(DCA) were performed to evaluate the predictive accuracy and net benefit of the nomogram, *** Of these 142 GBC patients, 55(38.7%) were male, and the median and mean age were 64 and 63.9 years, respectively. Forty-eight(33.8%) patients in this cohort were censored in the survival analysis. The median survival time was 20 months. A series of methods, including the likelihood ratio test and Akaike information criterion(AIC) as well as stepwise, forward, and backward analyses, were used to select the model, and all yielded identical results. Jaundice [hazard ratio(HR) = 2.9; 95% confidence interval(CI): 1.60-5.27], cCA19-9(HR = 3.2; 95%CI: 1.91-5.39), stage(HR = 1.89; 95%CI: 1.16-3.09), and resection(R)(HR = 2.82; 95%CI: 1.54-5.16) were selected as significant predictors and combi

关键词： Nomogram Survival Prognosis Gallbladder cancer Resection

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Precision medicine: In need of guidance and surveillance

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World Journal of Gastroenterology 2017年第28期23卷 5045-5050页

作者： Jian-Zhen Lin Jun-Yu Long An-Qiang Wang Ying Zheng Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical ScienceUniversity of Macao

Precision medicine,currently a hotspot in mainstream medicine,has been strongly promoted in recent years. With rapid technological development,such as next-generation sequencing,and fierce competition in molecular targeted drug exploitation,precision medicine represents an advance in science and technology; it also fulfills needs in public health care. The clinical translation and application of precision medicine-especially in the prevention and treatment of tumors-is far from satisfactory; however,the aims of precision medicine deserve approval. Thus,this medical approach is currently in its infancy; it has promising prospects,but it needs to overcome numbers of problems and deficiencies. It is expected that in addition to conventional symptoms and signs,precision medicine will define disease in terms of the underlying molecular characteristics and other environmental susceptibility factors. Those expectations should be realized by constructing a novel data network,integrating clinical data from individual patients and personal genomic background with existing research on the molecular makeup of diseases. In addition,multi-omics analysis and multi-discipline collaboration will become crucial elements in precision medicine. Precision medicine deserves strong support,and its development demands directed momentum. We propose three kinds of impetus(research,application and collaboration impetus) for such directed momentum toward promoting precision medicine and accelerating its clinical translation and application.

关键词： Precision medicine Clinical translation Development Targeted therapy Immunotherapy

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Freestanding polypyrrole nanotube/reduced graphene oxide hybrid film as flexible scaffold for dendrite-free lithium metal anodes

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Journal of Energy Chemistry 2021年第7期30卷 285-291页

作者： Gan Luo Xiaolin Hu Wei Liu Guanjie Lu Qiannan Zhao Jie Wen Jian Liang Guangsheng Huang Bin Jiang Chaohe Xu Fusheng Pan College of Materials science and Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina College of Aerospace Engineering Chongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

Lithium metal anode is the most potential anode material for the next generation high-energy rechargeable batteries owing to its highest specific capacity and lowest redox ***,the uneven deposition of Li during plating/stripping and the formation of uncontrolled Li dendrites,which might cause poor battery performance and serious safety problems,are demonstrating to be a huge challenge for its practical ***,we show that a flexible and free-standing film hybriding with polypyrrole(PPy) nanotubes and reduced graphene oxide(rGO) can significantly regulate the Li nucleation and deposition,and further prohibit the formation of Li dendrites,owing to the large specific surface area,rich of nitrogen functional groups and porous ***,the high Coulombic efficiency and stable Li plating/stripping cycling performance with 98% for 230 cycles at 0.5 mA cm^(-2) and more than 900 hours stable lifespan are *** Li dendrites form even at a Li deposition capacity as high as4.0 mA h cm^(-2).Besides,the designed PPy/rGO hybrid anode scaffold can also drive a superior battery performance in the lithium-metal full cell applications.

关键词： Lithium metal anode Polypyrrole nanotube Coulombic efficiency Lithium dendrites Uniform lithium deposition

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Efficacy and safety of lenvatinib for patients with advanced hepatocellular carcinoma: A retrospective, real-world study conducted in China

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World Journal of Gastroenterology 2020年第30期26卷 4465-4478页

作者： Dong-Xu Wang Xu Yang Jian-Zhen Lin Yi Bai Jun-Yu Long Xiao-Bo Yang Samuel Seery Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Humanities Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Lenvatinib has become an indispensable part of treatment regimens for patients with advanced hepatocellular carcinoma(aHCC).Several recent real-world studies appear to have confirmed this;however,there are etiological *** necessitates further real-world studies of lenvatinib across diverse populations,such as in *** To investigate the efficacy and safety of lenvatinib in a Chinese HCC patient population under real-world *** This is a retrospective and multiregional study involving patients with aHCC receiving lenvatinib *** was assessed using the Response Evaluation Criteria in Solid Tumors version *** characteristics and adverse events(AEs)were recorded throughout the entire *** In total,54 HCC patients treated with lenvatinib monotherapy were included for final *** objective response rate was 22%(n=12)with a progressionfree survival(PFS)of 168 d;however,AEs occurred in 92.8%of *** analysis showed that the Barcelona Clinic Liver Cancer stage[hazard ratio(HR)0.465;95%CI:0.23-0.93;P=0.031],portal vein tumor thrombus(HR 0.38;95%CI:0.15-0.94;P=0.037)and Child-Pugh classifications(HR 0.468;95%CI:and specificity(83.3%)of decreasing serum biomarkers including alphafetoprotein were calculated in order to predict tumor size *** sequencing also provided insights into potential gene mutation signatures related to the effect of *** Our findings confirm previous evidence from the phase III REFLECT *** majority of patients in this Chinese sample were suffering from concomitant hepatitis B virus-related ***,further analysis suggested that baseline characteristics,changes in serum biomarkers and gene sequencing may hold the key for predicting lenvatinib *** large-scale prospective studies that incorporate more basic medical science measures should be conducted.

关键词： Lenvatinib Real-world study Hepatocellular carcinoma Efficacy Safety Treatment

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High-Power and Ultralong-Life Aqueous Zinc-Ion Hybrid Capacitors Based on Pseudocapacitive Charge Storage

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Nano-Micro Letters 2019年第4期11卷 650-658页

作者： Liubing Dong Wang Yang Wu Yang Chengyin Wang Yang Li Chengjun Xu Shuwei Wan Fengrong He Feiyu Kang Guoxiu Wang Centre for Clean Energy technology Faculty of ScienceUniversity of Technology SydneySydneyNSW 2007Australia School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002People’s Republic of China School of Photovoltaic and Renewable Energy Engineering University of New South WalesSydneyNSW 2052Australia Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055People’s Republic of China HEC Group Pty Ltd CanterburyVIC 3216Australia

Rechargeable aqueous zinc-ion hybrid capacitors and zincion batteries are promising safe energy storage *** this study,amorphous RuO2·H2O for the first time was employed to achieve fast and ultralong-life Zn2+storage based on a pseudocapacitive storage *** the RuO2·H2O||Zn zinc-ion hybrid capacitors with Zn(CF3SO3)2 aqueous electrolyte,the RuO2·H2O cathode can reversibly store Zn2+in a voltage window of 0.4-1.6 V(***/Zn2+),delivering a high discharge capacity of 122 mAh g?*** particular,the zinc-ion hybrid capacitors can be rapidly charged/discharged within 36 s with a very high power density of 16.74 kW kg?1 and a high energy density of 82 Wh kg?***,the zinc-ion hybrid capacitors demonstrate an ultralong cycle life(over 10,000 charge/discharge cycles).The kinetic analysis elucidates that the ultrafast Zn2+storage in the RuO2·H2O cathode originates from redox pseudocapacitive *** work could greatly facilitate the development of high-power and safe electrochemical energy storage.

关键词： Zinc-ion hybrid capacitor Hydrous ruthenium oxide Ultralong life Redox pseudocapacitance High power

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Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 414-424页

作者： Jianzhen Lin Xu Yang Junyu Long Songhui Zhao Jinzhu Mao Dongxu Wang Yi Bai Jin Bian Lei Zhang Xiaobo Yang Anqiang Wang Fucun Xie Weiwei Shi Huayu Yang Jie Pan Ke Hu Mei Guan Lin Zhao Li Huo Yilei Mao Xinting Sang Kai Wang Haitao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)Beijing 100730China OrigiMed Shanghai 200135China Department of Gastrointestinal Surgery Peking University Cancer Hospital&InstituteBeijing 100142China Department of Radiology Peking Union Medical College HospitalBeijing 100730China Center of Radiotherapy Peking Union Medical College HospitalBeijing 100730China Department of Medical Oncology Peking Union Medical College HospitalBeijing 100730China Department of Nuclear Medicine Peking Union Medical College HospitalBeijing 100730China

Background:A therapeutic strategy involving combined treatment with lenvatinib plus pembrolizumab(LEP)has demonstrated a relatively high antitumor response in several solid tumors;however,the efficacy and safety of LEP in patients with refractory bile tract carcinoma(BTC)remains ***:This is a single-arm study for a preliminary assessment of the efficacy and tolerability of LEP in patients who experienced progression from prior systemic ***-treatment tumor tissues were collected to retrospectively evaluate the expression status of ***:Thirty-two patients received second-line and above treatment with ***,the objective response rate(ORR)was 25%,the disease control rate(DCR)was 78.1%,and the clinical benefit rate(CBR)was 40.5%.The median progression-free survival(PFS)was 4.9 months(95%CI:4.7–5.2 months),and the median overall survival(OS)was 11.0 months(95%CI:9.6–12.3 months).For tolerability,no grade 5 serious adverse events(AEs)were *** patients had any-grade AEs,and 59.3%of the patients experienced grade 3 AEs,while only 1 patient experienced a grade 4 AE of stomach *** was the most common AE,followed by hypertension and elevated aminotransferase *** analysis for PDL1 expression revealed that PDL1 positive tumor cells were associated with improved clinical benefits and survival ***:LEP is a promising alternative as a non-first-line therapeutic regimen for patients with refractory ***,well-designed prospective clinical trials with a control arm are still needed to obtain more evidences to confirm the efficacy and safety of this particular regimen as well as the role of PDL1 expression.

关键词： Pembrolizumab lenvatinib bile tract cancer PD1 PDL1

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Novel cellular therapies for hepatobiliary malignancies

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Hepatobiliary & Pancreatic Diseases international 2022年第5期21卷 450-454页

作者： Jing-Nan Xue Yan-Yu Wang Yun-Chao Wang Nan Zhang Long-Hao Zhang Zheng-Hui Lu Li-Jin Zhao Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Hepatobiliary and Pancreatic Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi 563000China Hepatobiliary and Pancreatic Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China

Background:The mortalities of hepatobiliary malignancies are *** the failure of conventional chemotherapy and unsatisfactory outcome of molecular targeted drugs,immune-based therapy has become a new focus of research in hepatobiliary cancers *** sources:We performed a Pub Med search with relevant articles published up to May 2022 and the following keywords:cellular immunotherapy,hepatobiliary cancer,antigen receptor T cell therapy,and receptor-engineered T *** of clinical trials was obtained from https://***/.Results:Cell therapies for hepatobiliary malignancies are at early stage of *** current review showed that cellular therapies are safe and feasible in *** findings provide an important platform for future lager scale clinical trials on immunotherapy in patients with hepatobiliary ***:With the continuous advances of cellular immunotherapy,the combination of cellular immunotherapy with surgery,chemotherapy and radiotherapy will be new therapeutic strategies for patients with hepatobiliary cancer.

关键词： Cellular therapy Chimeric antigen receptor T cell therapy Receptor-engineered T cell Hepatobiliary malignancy

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Development of solid-state electrolytes for sodium-ion battery–A short review

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Nano Materials science 2019年第2期1卷 91-100页

作者： Yumei Wang Shufeng Song Chaohe Xu Ning Hu Janina Molenda Li Lu Department of Mechanical Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117575 College of Aerospace Engineering Chongqing University Chongqing 400044 PR China AGH University of science and technology Faculty of Energy and Fuels al Mickiewicza 30 30-059 Krakow Poland National University of Singapore (Suzhou) Research Institute Suzhou PR China

All-solid-state sodium-ion battery is regarded as the next generation battery to replace the current commercial lithium-ion battery, with the advantages of abundant sodium resources, low price and high-level safety. As one critical component in sodium-ion battery, solid-state electrolyte should possess superior operational safety and design simplicity, yet reasonable high room-temperature ionic conductivity. This paper gives a comprehensive review on the recent progress in solid-state electrolyte materials for sodium-ion battery, including inorganic ceramic/glass-ceramic, organic polymer and ceramic-polymer composite electrolytes, and also provides a comparison of the ionic conductivity in various solid-state electrolyte materials. The development of solid-state electrolytes suggests a bright future direction: all solid-state sodium-ion battery could be fully used to power all electric road vehicles, portable electronic devices and large-scale grid support.

关键词： Sodium ion battery Ionic conductivity Inorganic solid electrolyte Solid polymer electrolyte Ceramic-polymer composite electrolyte

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