Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer

作     者：Yuan Xie Jian-Zhen Lin An-Qiang Wang Wei-Yu Xu Jun-Yu Long Yu-Feng Luo Jie Shi Zhi-Yong Liang Xin-Ting Sang Hai-Tao Zhao 

作者机构：Department of Liver SurgeryPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of PathologyPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第31期

页      面：5787-5797页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by International Science and Technology Cooperation Projects,No.2015DFA30650 and No.2016YFE0107100 The Capital Special Research Project for Clinical Application,No.Z151100004015170 Capital Special Research Project for Health Development,No.2014-2-4012 Beijing Nature Science Foundation for Young Scholars,No.7164293 

主　　题：Threonine and tyrosine kinase Biomarker Prognosis Gallbladder cancer 

摘      要：AIM To detect the expression of threonine and tyrosine kinase(TTK) in gallbladder cancer(GBC) specimens and analyze the associations between TTK expression and clinicopathological parameters and clinical *** A total of 68 patients with GBC who underwent surgical resection were enrolled in this study. The expression of TTK in GBC tissues was detected by immunohistochemistry. The assessment of TTKexpression was conducted using the H-scoring system. H-score was calculated by the multiplication of the overall staining intensity with the percentage of positive cells. The expression of TTK in the cytoplasm and nucleus was scored separately to achieve respective H-s c o r e v a l u e s. T h e c o r r e l a t i o n s b e t w e e n T T K expression and clinicopathological parameters and clinical prognosis were analyzed using Chi-square test, Kaplan-Meier method and Cox *** In both the nucleus and cytoplasm, the expression of TTK in tumor tissues was significantly lower than that in normal tissues(P 0.001 and P = 0.026, respectively). Using the median H-score as the cutoff value, it was discovered that, GBC patients with higher levels of TTK expression in the nucleus, but not the cytoplasm, had favorable overall survival(P 0.001), and it was still statistically meaningful in Cox regression analysis. Further investigation indicated that there were close negative correlations between TTK expression and tumor differentiation(P = 0.041), CA 19-9 levels(P = 0.016), T stage(P 0.001), nodal involvement(P 0.001), distant metastasis(P = 0.024) and TNM stage(P 0.001). CONCLUSION The expression of TTK in GBC is lower than that in normal tissues. Higher levels of TTK expression in GBC are concomitant with longer overall survival. TTK is a favorable prognostic biomarker for patients with GBC.