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Prognostic significance of hemoglobin,albumin,lymphocyte,platelet in gastrointestinal stromal tumors:A propensity matched retrospective cohort study

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World Journal of Gastroenterology 2022年第27期28卷 3476-3487页

作者： Zhou Zhao Xiao-Nan Yin Jian Wang Xin Chen Zhao-Lun Cai Bo Zhang Department of Gastrointestinal Surgery Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND The combined index of hemoglobin,albumin,lymphocyte,and platelet(HALP)can reflect systemic inflammation and nutritional status simultaneously,with some evidence revealing its prognostic value for some ***,the effect of HALP on recurrence-free survival(RFS)in patients with gastrointestinal stromal tumors(GISTs)has not been *** To investigate the prognostic value of HALP in GIST *** Data from 591 untreated patients who underwent R0 resection for primary and localized GISTs at West china Hospital between December 2008 and December 2016 were *** data,preoperative albumin,blood routine information,postoperative treatment,and recurrence status were *** eliminate baseline inequivalence,the propensity scores matching(PSM)method was ***,the relationship between RFS and preoperative HALP was *** The optimal cutoff value for HALP was determined to be 31.5 by X-tile *** was significantly associated with tumor site,tumor size,mitosis,Ki67,national Institutes of Health(NIH)risk category,and adjuvant therapy(all P<0.001).Before PSM,GIST patients with an increased HALP had a significantly poor RFS(P<0.001),and low HALP was an independent risk factor for poor RFS[hazard ratio(HR):0.506,95%confidence interval(95%CI):0.291-0.879,P=0.016].In NIH high-risk GIST patients,GIST patients with low HALP had a worse RFS than patients with high HALP(P<0.05).After PSM,458 GIST patients were identified;those with an increased HALP still had significantly poor RFS after PSM(P<0.001)and low HALP was still an independent risk factor for poor RFS(HR:0.558,95%CI:0.319-0.976,P=0.041).CONCLUSION HALP was significantly correlated with postoperative pathology and postoperative ***,HALP showed a strong ability to predict RFS in GIST patients who underwent radical resection.

关键词： Gastrointestinal stromal tumors Nutrition assessment Immuno-inflammatory-based prognostic scores Prognosis Propensity score

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Gastrointestinal stromal tumor metastasis at the site of a totally implantable venous access port insertion:A rare case report

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World Journal of Clinical Cases 2020年第20期8卷 5007-5012页

作者： Xiao-Nan Yin Yuan Yin Jiang Wang Chao-Yong Shen Xin Chen Zhou Zhao Zhao-Lun Cai Bo Zhang Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The totally implantable venous access port(TIVAP)is an important device in patients for injecting blood products,parenteral nutrition or antineoplastic *** spread at the site of the insertion of a TIVAP is extremely *** SUMMARY We report the case of 33-year-old male with advanced gastrointestinal stromal tumor(GIST)who underwent radical tumor resection after neoadjuvant imatinib ***,a solitary GIST metastasis at the site of a TIVAP insertion developed during adjuvant imatinib *** analysis showed secondary mutation in KIT exon 13(V564 A),which is resistant to imatinib *** our knowledge,this is the first case report of a patient with advanced GIST developing GIST metastasis at the site of a TIVAP *** This case highlights that when a patient with advanced,high metastatic GIST requires TIVAP insertion,we should realize that there is a risk of developing tumor metastasis at the site of a TIVAP insertion.

关键词： Tumor metastasis Gastrointestinal stromal tumor Totally implantable venous access port Targeted therapy Mutational analysis Computed tomography Case report

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