Prognostic significance of hemoglobin,albumin,lymphocyte,platelet in gastrointestinal stromal tumors:A propensity matched retrospective cohort study

作     者：Zhou Zhao Xiao-Nan Yin Jian Wang Xin Chen Zhao-Lun Cai Bo Zhang 

作者机构：Department of Gastrointestinal SurgerySichuan University West China HospitalChengdu 610041Sichuan ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第27期

页      面：3476-3487页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China,No.81572931 The 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYJC18034 

主　　题：Gastrointestinal stromal tumors Nutrition assessment Immuno-inflammatory-based prognostic scores Prognosis Propensity score 

摘      要：BACKGROUND The combined index of hemoglobin,albumin,lymphocyte,and platelet(HALP)can reflect systemic inflammation and nutritional status simultaneously,with some evidence revealing its prognostic value for some ***,the effect of HALP on recurrence-free survival(RFS)in patients with gastrointestinal stromal tumors(GISTs)has not been *** To investigate the prognostic value of HALP in GIST *** Data from 591 untreated patients who underwent R0 resection for primary and localized GISTs at West China Hospital between December 2008 and December 2016 were *** data,preoperative albumin,blood routine information,postoperative treatment,and recurrence status were *** eliminate baseline inequivalence,the propensity scores matching(PSM)method was ***,the relationship between RFS and preoperative HALP was *** The optimal cutoff value for HALP was determined to be 31.5 by X-tile *** was significantly associated with tumor site,tumor size,mitosis,Ki67,National Institutes of Health(NIH)risk category,and adjuvant therapy(all P0.001).Before PSM,GIST patients with an increased HALP had a significantly poor RFS(P0.001),and low HALP was an independent risk factor for poor RFS[hazard ratio(HR):0.506,95%confidence interval(95%CI):0.291-0.879,P=0.016].In NIH high-risk GIST patients,GIST patients with low HALP had a worse RFS than patients with high HALP(P0.05).After PSM,458 GIST patients were identified;those with an increased HALP still had significantly poor RFS after PSM(P0.001)and low HALP was still an independent risk factor for poor RFS(HR:0.558,95%CI:0.319-0.976,P=0.041).CONCLUSION HALP was significantly correlated with postoperative pathology and postoperative ***,HALP showed a strong ability to predict RFS in GIST patients who underwent radical resection.