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Understanding neuroendocrine regulatory pathways of sexual behavior in teleosts

Aquaculture and Fisheries 2024年第3期9卷 447-454页

作者： Saokat Ahamed Toshinobu Tokumoto Department of Bioscience Graduate School of Science and TechnologyShizuoka UniversityOhya 836Suruga-kuShizuoka422-8529Japan

The main neuroendocrine pathways of induction of reproductive behavior in fish are elucidated.17α,20β-dihydroxy-4-pregnen-3-one (17,20β-DHP),an oocyte maturation-inducing hormone,was found to act as a pheromone to induce male reproductive behavior.17α,20β-DHP-sulfate (17,20β-DHP-S),a derivative of 17,20β-DHP,was also identified as a later-acting *** addition,prostaglandin F2 alpha (PGF2α),which is synthesized during female ovulation,has been shown to also act as a pheromone,inducing the final oviposition-inducing behavior to make fertilization *** appears that these molecular events are initiated by stimuli from the *** neuropeptides have been discovered that promote the initiation of reproductive ***,with the proliferation of genome editing technology,a detailed analysis of the molecules involved in these pathways is *** of gene knockout in zebrafish and medaka is actively *** the other hand,many research reports have shown that the induction pathways of male reproductive behavior are adversely affected by chemical *** of the adverse effects of chemical substances is not only useful as information to prevent their mixing from the viewpoint of protecting the natural environment and as a point of caution in fish farming,but also provides clues for elucidating the pathways of reproductive behavior *** elucidation of the pathways of reproductive behavior induction is also important from the point of view of breeding technology for fish farming and biodiversity *** this review,we summarize recent research on the pathways of male reproductive behavior induction in fish and the possibility of developing new aquaculture techniques depending on the results.

关键词： Fish male reproductive behavior Steroid hormone Pheromone 17,20β-DHP Prostaglandin Goldfish Zebrafish CRISPR/Cas9

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

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Roles and regulations of the ETS transcription factor ELF4/MEF

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Journal of Molecular Cell Biology 2017年第3期9卷 168-177页

作者： Mary Ann Suico Tsuyoshi Shuto Hirofumi Kai Department of Molecular Medicine Graduate School of Pharmaceutical Sciences Kumamoto University 5-10e-honmachi Kumamoto 862-0973 Japan

Most E26 transformation-specific （ETS） transcription factors are involved in the pathogenesis and progression of cancer. This is in part due to the roles of ETS transcription factors in basic biological processes such as growth, proliferation, and differentiation, and also because of their regulatory functions that have physiological relevance in tumorigenesis, immunity, and basal cellular homoeostasis. A member of the E74-1ike factor （ELF） subfamily of the ETS transcription factor family--myeloid elf-l-Uke factor （MEF）, designated as ELF4~has been shown to be critically involved in immune response and signalling, osteogenesis, adipo- genesis, cancer, and stem cell quiescence. ELF4 carries out these functions as a transcriptional activator or through interactions with its partner proteins. Mutations in ELF4 cause aberrant interactions and induce downstream processes that may lead to dis- eased cells. Knowing how ELF4 impinges on certain cellular processes and how it is regulated in the cells can lead to a better understanding of the physiological and pathological consequences of modulated ELF4 activity.

关键词： myeloid elf-1-like factor (MEF) ELF4 ETS transcription factors immune regulation cancer transcriptional regulation

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Single-site surface-enhanced Raman scattering beyond spectroscopy

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Frontiers of physics 2016年第2期11卷 19-30页

作者： Mai Takas Satoshi Yasuda Kei Murakoshi Department of Chemistry Faculty of Science Hokkaido University Sapporo Hokkaido 060-0810 Japan Graduate School of Engineering Muroran Institute of Technology Muroran 050-8585 Japan

Recent progress in the observation of surface-enhanced Raman scattering （SERS） is reviewed to examine the possibility of finding a novel route for the effective photoexcitation of materials. The importance of well-controlled SERS experiments on a single molecule at a single site is discussed based on the difference in the information obtained from ensemble SERS measurements using mul- tiple active sites with an uncontrolled number of molecules. A single-molecule SERS observation performed at a mechanically controllable breaking junction with a simultaneous conductivity mea- surement provides clear evidence of the drastic changes both in the intensity and in the Raman mode selectivity of the electromagnetic field generated by localized surface plasmon resonance. Careful con- trol of the field at a few-nanometer-wide gap of a metal nanodimer results in the modification of the selection rule of electronic excitation of an isolated single-walled carbon nanotube. The examples shown in this review suggest that a single-site SERS observation could be used as a novel tool to find, develop, and implement applications of plasmon-induced photoexcitation of materials.

关键词： surface-enhanced Raman scattering localized surface plasmon resonance metalnanostructure single-molecule observation single-walled carbon nanotube selection rule ofelectronic excitation

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United theory of biological evolution:Disaster-forced evolution through Supernova,radioactive ash fall-outs,genome instability,and mass extinctions

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Geoscience Frontiers 2015年第1期6卷 103-119页

作者： Toshikazu Ebisuzaki Shigenori Maruyama RIKEN 2-1Hirosawa Earth-Life Science Institute Tokyo Institute of Technology

We present the disaster-forced biological evolution model as a general framework that includes Darwinian ＂phylogenic gradualism＂, Eldredge-Gould＇s ＂punctuated equilibrium＂, mass extinctions, and allopatric, parapatric, and sympatric speciation. It describes how reproductive isolation of organisms is established through global disasters due to supernova encounters and local disasters due to radioactive volcanic ash fall-outs by continental alkaline volcanism. Our new evolution model uniquely highlights three major factors of disaster-forced speciation： enhanced mutation rate by higher natural radiation level, smaller population size, and shrunken habitat size （i.e., isolation among the individual pop- ulations）. We developed a mathematical model describing speciation of a half-isolated group from a parental group, taking into account the population size （Ne）, immigration rate （m）, and mutation rate （μ）. The model gives a quantitative estimate of the speciation, which is consistent with the observations of speciation speed. For example, the speciation takes at least 105 generations, if mutation rate is less than 10 3 per generation per individual. This result is consistent with the previous studies, in which μ is assumed to be 10 3-10-5. On the other hand, the speciation is much faster （less than l0S generations） for the case that μ is as large as 0.1 in parapatric conditions （m 〈 μ）. Even a sympatric （m ~ 1 ） speciatiou can occur within 103 generations, if mutation rate is very high （μ- 1 mutation per individual per generation）, and if Ne 〈 20-30. Such a high mutation rate is possible during global disasters due to supernova encounters and local disasters due to radioactive ash fall-outs. They raise natural radiation level by a factor of 100-1000. Such rapid speciation events can also contribute to macro-evolution during mass extinction events, such as observed during the Cambrian explosion of biodiversity. A similar rapid speciation （though in a much smaller scale）

关键词： Speciation Supernova encounter Continental alkaline volcanism Cichlid Great African ape Cambrian explosion

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Effective Isolation of Retrotransposons and Repetitive DNA Families from the Wheat Genome

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Journal of Integrative Plant Biology 2010年第7期52卷 679-691页

作者： Motonori Tomita Munenori Asao Aya Kuraki Molecular Genetics Laboratory Faculty of AgricultureTottori University

New classes of repetitive DNA elements were effectively identified by isolating small fragments of the elements from the wheat genome. A wheat A genome library was constructed from Triticum monococcum by degenerate cleavage with EcoO1091, the recognition sites of which consisted of 5＇-PuGGNCCPy-3＇ multi-sequences. Three novel repetitive sequences pTm6, pTm69 and pTm58 derived from the A genome were screened and tested for high copy number using a blotting approach, pTm6 showed identity with integrase domains of the barley Tyl-Copia-retrotransposon BARE-1 and pTm58 showed similarity to the barley Ty3-gypsy-like retrotransposon Romani. pTm69, however, constituted a tandem array with useful genomic specificities, but did not share any identity with known repetitive elements. This study also sought to isolate wheat D-genome-specific repetitive elements regardless of the level of methylation, by genomic subtraction. Total genomic DNA of Aegilops tauschii was cleaved into short fragments with a methylation-insensitive 4 bp cutter, Mbol, and then common DNA sequences between Ae. tauschii and Triticum turgidum were subtracted by annealing with excess T. turgidum genomic DNA. The D genome repetitive sequence pAt1 was isolated and used to identify an additional novel repetitive sequence family from wheat bacterial artificial chromosomes with a size range of 1 395-1 850 bp. The methods successfully led pathfinding of two unique repetitive families.

关键词： DNA Effective Isolation of Retrotransposons and Repetitive DNA Families from the Wheat Genome AABB

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The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability

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Protein & Cell 2011年第9期2卷 755-763页

作者： Kentaro Ito Akinori Takahashi Masahiro Morita Toru Suzuki Tadashi Yamamoto Division of Oncology Department of Cancer BiologyInstitute of Medical ScienceUniversity of TokyoTokyo 108-8639Japan Cell Signal Unit Okinawa Institute of Science and Technology1919-1Okinawa 904-0412Japan

The human CCR4-NOT deadenylase complex consists of at least nine enzymatic and non-enzymatic *** evidence suggests that the non-enzymatic subunits are involved in the regulation of mRNA deadenylation,although their precise roles remain to be *** this study,we addressed the function of the CNOT1 subunit by depleting its expression in HeLa *** cytometric analysis revealed that the sub G1 fraction was increased in CNOT1-depleted ***,the same level of the sub G1 fraction was seen when cells were treated with a mixture of siRNAs targeted against all enzymatic subunits,suggesting that CNOT1 depletion induces apoptosis by destroying the CCR4-NOT-associated deadenylase *** analysis revealed that CNOT1 depletion leads to a reduction in the amount of other CCR4-NOT ***,the specific activity of the CNOT6L immunoprecipitates-associated deadenylase from CNOT1-depleted cells was less than that from control *** formation of P-bodies,where mRNA decay is reported to take place,was largely suppressed in CNOT1-depleted ***,CNOT1 has an important role in exhibiting enzymatic activity of the CCR4-NOT complex,and thus is critical in control of mRNA deadenylation and mRNA *** further showed that CNOT1 depletion enhanced CHOP mRNA levels and activated caspase-4,which is associated with endoplasmic reticulum ER stress-induced *** together,CNOT1 depletion structurally and functionally deteriorates the CCR4-NOTcomplex and induces stabilization of mRNAs,which results in the increment of translation causing ER stress-mediated *** conclude that CNOT1 contributes to cell viability by securing the activity of the CCR4-NOT deadenylase.

关键词： deadenylation CCR4-NOT small interfering RNA P-bodies apoptosis

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Baryon-Baryon interactions from lattice QCD

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Chinese Physics C 2010年第9期34卷 1236-1240页

作者： S.Aoki Graduate School of Pure and Applied Sciences University of Tsukuba

We report on new attempt to investigate baryon-baryon interactions in lattice *** the Bethe-Salpeter （BS） wave function,we have successfully extracted the nucleon-nucleon （NN） potentials in quenched QCD simulations,which reproduce qualitative features of modern NN *** method has been extended to obtain the tensor potential as well as the central potential and also applied to the hyperonnucleon （YN） interactions,in both quenched and full QCD.

关键词： nucelon-nucelon potential Bethe-Salpeter wave function lattice QCD hyperon-nucleon interactions tensor potential

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Cortical transcriptome analysis after spinal cord injury reveals the regenerative mechanism of central nervous system in CRMP2 knock-in mice

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Neural Regeneration Research 2021年第7期16卷 1258-1265页

作者： Ayaka Sugeno Wenhui Piao Miki Yamazaki Kiyofumi Takahashi Koji Arikawa Hiroko Matsunaga Masahito Hosokawa Daisuke Tominaga Yoshio Goshima Haruko Takeyama Toshio Ohshima Laboratory for Molecular Brain Science Department of Life Science and Medical BioscienceGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Biomolecular Engineering Laboratory Department of Life Science and Medical BioscienceGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Computational Bio Big-Data Open Innovation Laboratory(CBBD-OIL) National Institute of Advanced Industrial Science and Technology(AIST)TokyoJapan Research Organization for Nano and Life Innovation Waseda UniversityTokyoJapan Institute for Advanced Research of Biosystem Dynamics Waseda Research Institute for Science and EngineeringGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Cellular and Molecular Biotechnology Research Institute National Institute of Advanced Industrial Science and Technology(AIST)TsukubaJapan Department of Molecular Pharmacology and Neurobiology Graduate School of MedicineYokohama City UniversityYokohamaJapan

Recent studies have shown that mutation at Ser522 causes inhibition of collapsin response mediator protein 2(CRMP2) phosphorylation and induces axon elongation and partial recovery of the lost sensorimotor function after spinal cord injury(SCI).We aimed to reveal the intracellular mechanism in axotomized neurons in the CRMP2 knock-in(CRMP2KI) mouse model by performing transcriptome analysis in mouse sensorimotor cortex using micro-dissection punching *** to that, we analyzed the structural pathophysiology in axotomized or neighboring neurons after SCI and found that somatic atrophy and dendritic spine reduction in sensorimotor cortex were suppressed in CRMP2KI *** analysis of the transcriptome has aided in the identification of four hemoglobin genes Hba-a1, Hba-a2, Hbb-bs, and Hbb-bt that are significantly upregulated in wild-type mice with concomitant upregulation of genes involved in the oxidative phosphorylation and ribosomal pathways after ***, we observed substantial upregulation in channel activity genes and downregulation of genes regulating vesicles, synaptic function, glial cell differentiation in CRMP2KI ***, the transcriptome profile of CRMP2KI mice has been discussed wherein energy metabolism and neuronal pathways were found to be differentially *** results showed that CRMP2KI mice displayed improved SCI pathophysiology not only via microtubule stabilization in neurons, but also possibly via the whole metabolic system in the central nervous system, response changes in glial cells, and *** together, we reveal new insights on SCI pathophysiology and the regenerative mechanism of central nervous system by the inhibition of CRMP2 phosphorylation at *** these experiments were performed in accordance with the guidelines of the Institutional Animal Care and Use Committee at Waseda University, Japan(2017-A027 approved on March 21, 2017;2018-A003 approved on March 25, 2018;2019-A026 approved on March

关键词： CNS regeneration cortex CRMP2 hemoglobin metabolic pathway spinal cord injury spine transcriptome

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An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa

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World Journal of Gastroenterology 2014年第14期20卷 3927-3937页

作者： Hiroyuki Yamamoto Yoshiyuki Watanabe Tadateru Maehata Ryo Morita Yoshihito Yoshida Ritsuko Oikawa Shinya Ishigooka Shun-ichiro Ozawa Yasumasa Matsuo Kosuke Hosoya Masaki Yamashita Hiroaki Taniguchi Katsuhiko Nosho Hiromu Suzuki Hiroshi Yasuda Yasuhisa Shinomura Fumio Itoh Division of Gastroenterology and Hepatology Department of Internal MedicineSt. Marianna University School of Medicine Division of Cancer Cell Research Institute of Medical ScienceUniversity of Tokyo Department of Gastroenterology Rheumatology and Clinical ImmunologySapporo Medical University School of Medicine Department of Molecular Biology Sapporo Medical University School of Medicine

Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death *** is an increasing understanding of the roles that genetic and epigenetic alterations play in *** studies using nextgeneration sequencing(NGS)have revealed a number of potential cancer-driving genes in ***-exome sequencing of GC has identified recurrent somatic mutations in the chromatin remodeling gene ARID1A and alterations in the cell adhesion gene FAT4,a member of the cadherin gene *** in chromatin remodeling genes(ARID1A,MLL3 and MLL)have been found in 47%of ***-genome sequencing and whole-transcriptome sequencing analyses have also discovered novel alterations in *** studies of cancer epigenetics have revealed widespread alterations in genes involved in the epigenetic machinery,such as DNA methylation,histone modifications,nucleosome positioning,noncoding RNAs and *** advances in molecular research on GC have resulted in the introduction of new diagnostic and therapeutic strategies into clinical *** antihuman epidermal growth receptor 2(HER2)antibody trastuzumab has led to an era of personalized therapy in *** addition,ramucirumab,a monoclonal antibody targeting vascular endothelial growth factor receptor(VEGFR)-2,is the first biological treatment that showed survival benefits as a single-agent therapy in patients with advanced GC who progressed after firstline *** NGS to systematically identify gene alterations in GC is a promising approach with remarkable potential for investigating the pathogenesis of GC and identifying novel therapeutic targets,as well as useful *** this review,we will summarize the recent advances in the understanding of the molecular pathogenesis of GC,focusing on the potential use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets.

关键词： Next-generation sequencing Microsatellite instability MicroRNA Epigenetic field defect Gastric washes Insulin-like growth factor 1 receptor

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