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Bioactive lipids in cancer stem cells

World Journal of Stem Cells 2019年第9期11卷 693-704页

作者： Romana-Rea Begicevic Frank Arfuso Marco Falasca Metabolic Signalling Group School of Pharmacy and Biomedical SciencesCurtin Health Innovation Research InstituteCurtin UniversityPerthWA 6102Australia Stem Cell and cancer Biology Laboratory School of Pharmacy and Biomedical SciencesCurtin Health Innovation Research InstituteCurtin UniversityPerthWA 6102Australia

Tumours are known to be a heterogeneous group of cells,which is why they are difficult to *** possible cause for this is the existence of slow-cycling cancer stem cells(CSCs)endowed with stem cell-like properties of self-renewal,which are responsible for resistance to chemotherapy and *** recent years,the role of lipid metabolism has garnered increasing attention in ***,the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs,have gained particular ***,despite accumulating evidence on the role of proteins in controlling lipid metabolism,very little is known about the specific role played by lipid products in *** review highlights recent findings on the role of lipid metabolism in CSCs,focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways.

关键词： cancer stem cells Lipid metabolism Bioactive lipids ABC transporters

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ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: what is the way forward?

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World Journal of Gastroenterology 2018年第29期24卷 3222-3238页

作者： Aleksandra Adamska Marco Falasca Metabolic Signalling Group School of Pharmacy and Biomedical Sciences Curtin Health Innovation Research Institute Curtin University

pancreatic ductal adenocarcinoma(PDAC) is one of the most aggressive diseases and is characterized by high chemoresistance, leading to the lack of effective therapeutic approaches and grim prognosis. Despite increasing understanding of the mechanisms of chemoresistance in cancer and the role of ATPbinding cassette(ABC) transporters in this resistance, the therapeutic potential of their pharmacological inhibition has not been successfully exploited yet. In spite of the discovery of potent pharmacological modulators of ABC transporters, the results obtained in clinical trials have been so far disappointing, with high toxicity levels impairing their successful administration to the patients. Critically, although ABC transporters have been mostly studied for their involvement in development of multidrug resistance(MDR), in recent years the contribution of ABC transporters to cancer initiation and progression has emerged as an important area of research, the understanding of which could significantly influence the development of more specific and efficient therapies. In this review, we explore the role of ABC transporters in the development and progression of malignancies, with focus on PDAC. Their established involvement in development of MDR will be also presented. Moreover, an emerging role for ABC transporters as prognostic tools for patients' survival will be discussed, demonstrating the therapeutic potential of ABC transporters in cancer therapy.

关键词： pancreatic ductal adenocarcinoma Multidrug resistance ATP-binding cassette transporters Targeted therapies pancreatic ductal adenocarcinoma prognosis Predictive markers

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Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer

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World Journal of Gastrointestinal Oncology 2017年第1期9卷 37-41页

作者： Omar Elaskalani Norbaini Binti Abdol Razak Marco Falasca Pat Metharom Platelet Research Laboratory Curtin Health Innovation and Research Institute Department of Health Sciences Curtin University School of Biomedical Sciences Curtin Health Innovation Research Institute Curtin University Metabolic Signalling Group School of Biomedical Sciences Curtin Health Innovation Research InstituteCurtin University

pancreatic cancer has one of the worst prognoses among all cancers due to the late manifestation of identifiable symptoms and high resistance to chemo- and radiation therapies. In recent years, a cancer development phase termed epithelial-mesenchymal transition(EMT) has gained increasing research focus. The process is implicated in tumour metastasis, and emerging evidence suggests EMT also contributes or induces chemoresistance in several cancers. Nevertheless, the applicability of therapeutic targeting of EMT faces many challenges. In this mini-review, we summarise the evidence supporting the role of EMT in pancreatic cancer progression, focusing particularly on its association with chemoresistance.

关键词： Epithelial-mesenchymal transition Drug resistance pancreatic cancer Chemotherapy

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