Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer

作     者：Omar Elaskalani Norbaini Binti Abdol Razak Marco Falasca Pat Metharom 

作者机构：Platelet Research Laboratory Curtin Health Innovation and Research Institute Department of Health Sciences Curtin University School of Biomedical SciencesCurtin Health Innovation Research Institute Curtin University Metabolic Signalling GroupSchool of Biomedical Sciences Curtin Health Innovation Research InstituteCurtin University 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2017年第9卷第1期

页      面：37-41页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Avner Pancreatic Cancer Foundation 

主　　题：Epithelial-mesenchymal transition Drug resistance Pancreatic cancer Chemotherapy 

摘      要：Pancreatic cancer has one of the worst prognoses among all cancers due to the late manifestation of identifiable symptoms and high resistance to chemo- and radiation therapies. In recent years, a cancer development phase termed epithelial-mesenchymal transition(EMT) has gained increasing research focus. The process is implicated in tumour metastasis, and emerging evidence suggests EMT also contributes or induces chemoresistance in several cancers. Nevertheless, the applicability of therapeutic targeting of EMT faces many challenges. In this mini-review, we summarise the evidence supporting the role of EMT in pancreatic cancer progression, focusing particularly on its association with chemoresistance.