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A retrospective study of occlusal reconstruction in patients with old jaw fractures and dentition defects

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Chinese Journal of Traumatology 2024年第5期27卷 272-278页

作者： Ming-Chao Ding Bo-Ya Jing Jin Shi Liu Yang Xiang-Dong Liu Jing-Fu Wang Shuang Qu Jia-Wu Liang Zi-Hao Tang Jin-Long Zhao Lei Tian state key laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Clinical Research Center for OralDiseasesDepartment of Oral and MaxillofacialSchool of StomatologyThe Fourth Military Medical UniversityXi'an710032China Department of Maxillofacial Trauma and Orthognathic Surgery The Third Affiliated HospitalThe Air Force Military Medical UniversityXi'an710038China Department of stomatology 941th Hospital of People's Liberation Army Joint Logistic Support ForceXining810000China

Purpose:This study evaluated the methods and clinical effects of multidisciplinary collaborative treatment for occlusal reconstruction in patients with old jaw fractures and dentition ***:Patients with old jaw fractures and dentition defects who underwent occlusal reconstruction at the Third Affiliated Hospital of Air Force military Medical University from January 2018 to December 2022 were *** treatment was classified into 3 *** phase I,techniques such as orthognathic surgery,microsurgery,and distraction osteogenesis were employed to reconstruct the correct 3-dimensional(3D)jaw position *** phase II,bone augmentation and soft tissue management techniques were utilized to address insufficient alveolar bone mass and poor gingival soft tissue *** phase III,implant-supported overdentures or fixed dentures were used for occlusal reconstruction.A summary of treatment methods,clinical efficacy evaluation,comparative analysis of imageological examinations,and satisfaction questionnaire survey were utilized to evaluate the therapeutic efficacy in patients with traumatic old jaw fractures and dentition *** data are summarized using the arithmetic mean±standard deviation and compared using independent ***:In 15 patients with old jaw fractures and dentition defects(an average age of 32 years,ranging from 18 to 53 years),there were 7 cases of malocclusion of single maxillary fracture,6 of malocclusion of single mandible fracture,and 2 of malocclusion of both maxillary and mandible *** were 5 patients with single maxillary dentition defects,2 with single mandibular dentition defects,and 8 with both maxillary and mandibular dentition *** reconstruct the correct 3D jaw positional relationship,5 patients underwent Le Fort I osteotomy of the maxilla,3 underwent bilateral sagittal split ramus osteotomy of the mandible,4 underwent open reduction and internal fixation for old jaw fracture

关键词： Old jaw fractures Malocclusion Occlusal reconstruction Dental implant prosthesis

SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors

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Cellular & Molecular Immunology 2024年第3期21卷 213-226页

作者： Sixin Liang Rui Zheng Baile Zuo Jia Li Yiyi Wang Yujie Han Hao Dong Xiaojuan Zhao Yiting Zhang Pengju Wang Ruotong Meng Lintao Jia Angang Yang Bo Yan state key laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Biochemistry and Molecular BiologyFourth Military Medical UniversityXi’anShaanxi710032China School of Medicine Technology Xinxiang Medical UniversityXinxiangHenan453003China Department of Obstetrics and Gynecology Xijing Hospital of Fourth Military Medical UniversityXi’anShaanxi710032China College of Life Science Yan’an UniversityYan’anShaanxi716000China Department of Immunology Fourth Military Medical UniversityXi’anShaanxi710032China

Despite the tremendous progress of chimeric antigen receptor T(CAR-T)cell therapy in hematological malignancies,their application in solid tumors has been limited largely due to T-cell exhaustion in the tumor microenvironment(TME)and systemic toxicity caused by excessive cytokine *** a key regulator of the immunosuppressive TME,TGF-βpromotes cytokine synthesis via the NF-κB ***,we coexpressed SMAD7,a suppressor of TGF-βsignaling,with a HER2-targeted CAR in engineered T *** novel CAR-T cells displayed high cytolytic efficacy and were resistant to TGF-β-triggered exhaustion,which enabled sustained tumoricidal capacity after continuous antigen ***,SMAD7 substantially reduced the production of inflammatory cytokines by antigen-primed CAR-T ***,SMAD7 downregulated TGF-βreceptor I and abrogated the interplay between the TGF-βand NF-κB pathways in CAR-T *** a result,these CAR-T cells persistently inhibited tumor growth and promoted the survival of tumor-challenged mice regardless of the hostile tumor microenvironment caused by a high concentration of TGF-β.SMAD7 coexpression also enhanced CAR-T-cell infiltration and persistent activation in patient-derived tumor ***,our study demonstrated the feasibility of SMAD7 coexpression as a novel approach to improve the efficacy and safety of CAR-T-cell therapy for solid tumors.

关键词： TGF-βpathway SMAD7 NF-κB pathway CAR-T-cell therapy Cytokine release syndrome(CRS)

Against all odds:The road to success in the development of human immune reconstitution mice

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Animal Models and Experimental Medicine 2024年第4期7卷 460-470页

作者： Yixiao Bin Jing Ren Haowei Zhang Tianjiao Zhang Peijuan Liu Zhiqian Xin Haijiao Yang Zhuan Feng Zhinan Chen Hai Zhang School of Basic Medical Sciences Shaanxi University of Chinese MedicineXianyangChina Department of Cell Biology National Translational Science Center for Molecular MedicineFourth Military Medical UniversityXi'anChina state key laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical UniversityXi'anChina Department of Occupational&Environmental Health and the Ministry of Education key Lab of Hazard Assessment and Control in Special Operational Environment School of Public HealthFourth Military Medical UniversityXi'anChina

The mouse genome has a high degree of homology with the human genome,and its physiological,biochemical,and developmental regulation mechanisms are similar to those of humans;therefore,mice are widely used as experimental ***,it is undeniable that interspecies differences between humans and mice can lead to experimental *** differences in the immune system have become an impor-tant factor limiting current immunological *** application of immunodefi-cient mice provides a possible solution to these *** transplanting human immune cells or tissues,such as peripheral blood mononuclear cells or hematopoietic stem cells,into immunodeficient mice,a human immune system can be reconstituted in the mouse body,and the engrafted immune cells can elicit human-specific immune *** have been actively exploring the development and differen-tiation conditions of host recipient animals and grafts in order to achieve better im-mune *** genetic engineering methods,immunodeficient mice can be further modified to provide a favorable developmental and differentiation microenvironment for the *** initially only being able to reconstruct single T lymphocyte lineages,it is now possible to reconstruct lymphoid and myeloid cells,providing important research tools for immunology-related *** this review,we compare the differences in immune systems of humans and mice,describe the devel-opment history of human immune reconstitution from the perspectives of immuno-deficient mice and grafts,and discuss the latest advances in enhancing the efficiency of human immune cell reconstitution,aiming to provide important references for im-munological related researches.

关键词： hematopoietic stem cell human immune reconstitution immune response immunodeficient mice peripheral blood mononuclear cell transplantation

Spontaneous healing of complicated crown-root fractures in children:Two case reports

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World Journal of Clinical Cases 2022年第18期10卷 6298-6306页

作者： Zi-Ling Zhou Lei Gao Shu-Kai Sun Hong-Shi Li Cai-Di Zhang Wen-Wen Kou Zheng Xu Li-An Wu Department of Pediatric Dentistry School of StomatologyFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Institute of stomatology The General Air Force Hospital of PLABeijing 110142China The Center for Pediatric Dentistry Department of Pediatric DentistryUniversity of WashingtonSeaatleWA 98115United States Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND Complicated crown-root fracture is considered a severe dental trauma and is unlikely to heal without ***,dentists have to remove the loose coronal fragment of the fractured tooth and treat the remaining part with multidisciplinary ***,we observed spontaneous healing of fracture in two pediatric cases with a history of complicated crown-root fractures over 4 years *** SUMMARY In case 1,a 12-year-old boy complained of pain at tooth 11 following an accidental fall 1 d *** examination showed a crack line on the crown of tooth *** beam computed tomography(CBCT)images of tooth 11 showed signs of hard tissue deposition between the fractured *** patient recalled that tooth 11 had struck the floor 1 year ago without seeking any other *** case 2,a 10-year-old girl fell down 1 d ago and wanted to have her teeth *** examination showed a fracture line on the crown of tooth *** images of tooth 21 also showed signs of hard tissue deposition between the fractured *** also had a history of dental trauma 1 year ago and her tooth 11 received dental treatment by another *** to her periapical radiograph at that time,tooth 21 was fractured 1 year ago and the fracture was overlooked by her *** of these two cases showed spontaneous healing of complicated crown-root *** over 4 years of follow-up,both fractured teeth showed no signs of *** These findings may provide new insights and perspectives on the management and treatment of crown-root fractures in children.

关键词： Dental trauma Complicated crown-root fracture Spontaneous healing Children Case report

Emerging role of tumor cell plasticity in modifying therapeutic response

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Signal Transduction and Targeted Therapy 2020年第1期5卷 549-584页

作者： Siyuan Qin Jingwen Jiang Yi Lu Edouard CNice Canhua Huang Jian Zhang Weifeng He state key laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for Biotherapy610041 ChengduPeople’s Republic of China School of Medicine Southern University of Science and Technology ShenzhenShenzhenGuangdong 518055People’s Republic of China Guangdong Provincial key laboratory of Cell Microenvironment and Disease Research ShenzhenGuangdongPeople’s Republic of China Department of Biochemistry and Molecular Biology Monash UniversityClaytonVICAustralia School of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine1166 Liutai Road611137 ChengduPeople’s Republic of China state key laboratory of Trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingPeople’s Republic of China Chongqing key laboratory for Disease Proteomics ChongqingPeople’s Republic of China

Resistance to cancer therapy is a major barrier to cancer *** views have proposed that acquisition of resistance may result from genetic ***,accumulating evidence implicates a key role of non-mutational resistance mechanisms underlying drug tolerance,the latter of which is the focus that will be discussed *** non-mutational processes are largely driven by tumor cell plasticity,which renders tumor cells insusceptible to the drug-targeted pathway,thereby facilitating the tumor cell survival and *** concept of tumor cell plasticity highlights the significance of re-activation of developmental programs that are closely correlated with epithelial–mesenchymal transition,acquisition properties of cancer stem cells,and transdifferentiation potential during drug *** observations in various cancers,this concept provides an opportunity for investigating the nature of anticancer drug *** the years,our understanding of the emerging role of phenotype switching in modifying therapeutic response has considerably *** expanded knowledge of tumor cell plasticity contributes to developing novel therapeutic strategies or combination therapy regimens using available anticancer drugs,which are likely to improve patient outcomes in clinical practice.

关键词： therapeutic plasticity thereby

A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants

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Bioactive Materials 2023年第9期27卷 488-504页

作者： Zhenbao Zhang Aobo Liu Jiadong Fan Menglin Wang Jiabao Dai Xiang Jin Huanze Deng Xuan Wang Yijie Liang Haixia Li Yantao Zhao Peng Wen Yanfeng Li Department of stomatology the Fourth Medical Center of PLA General HospitalBeijing100048China state key laboratory of Tribology in Advanced Equipment Beijing100084China Medical School of Chinese PLA Beijing100039China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Senior Department of Orthopedics the Fourth Medical Center of PLA General HospitalBeijing100048China Beijing Engineering Research Center of Orthopedics Implants Beijing100048China Institute of Process Engineering Chinese Academy of SciencesBeijing100190China

Zinc(Zn)alloy porous scaffolds produced by additive manufacturing own customizable structures and biodegradable functions,having a great application potential for repairing bone *** this work,a hydroxyapatite(HA)/polydopamine(PDA)composite coating was constructed on the surface of Zn-1Mg porous scaffolds fabricated by laser powder bed fusion,and was loaded with a bioactive factor BMP2 and an antibacterial drug *** microstructure,degradation behavior,biocompatibility,antibacterial performance and osteogenic activities were systematically *** with as-built Zn-1Mg scaffolds,the rapid increase of Zn2+,which resulted to the deteriorated cell viability and osteogenic differentiation,was inhibited due to the physical barrier of the composite *** vitro cellular and bacterial assay indicated that the loaded BMP2 and vancomycin considerably enhanced the cytocompatibility and antibacterial *** improved osteogenic and antibacterial functions were also observed according to in vivo implantation in the lateral femoral condyle of *** design,influence and mechanism of the composite coating were discussed *** was concluded that the additively manufactured Zn-1Mg porous scaffolds together with the composite coating could modulate biodegradable performance and contribute to effective promotion of bone recovery and antibacterial function.

关键词： Additive manufacturing Biodegradable metal Zn-Mg alloy Porous scaffold Composite coating Bone repair

Targeting PPARαin low ambient temperature exposure-induced cardiac dysfunction and remodeling

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military Medical Research 2022年第3期9卷 382-384页

作者： Xi-Yao Chen Yang Jiao Fu-Yang Zhang Department of Geriatrics Xijing HospitalAir Force Medical UniversityXi’an710032China Department of stomatology The 7th Medical Center of ChinesePLA General HospitalBeijing100700China Department of Cardiology Xijing HospitalAir Force Medical UniversityXi’an710032China

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α(PPARα)results in chronic low ambient temperature(LT)exposure-induced cardiac dysfunction and remodeling,emphasizing the therapeutic potential of PPARαactivation strategies(e.g.,fenofibrate treatment)in LT-associated cardiac injury.

关键词： Low ambient temperature Cardiac dysfunction Remodeling Peroxisome proliferator-activated receptor-α Fatty acid metabolism

Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate

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Journal of Geriatric Cardiology 2017年第11期14卷 696-702页

作者： Xi WANG Fan WANG Department of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein （HDL）. Findings from a growing number of studies further indicate that sphingosine-l-phosphate （S1P） mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protec- tion against atherosclerosis and ischemiaJreperfusion injury. In this review, we summarize the most recent literature investigating the effects of HDL-S 1 P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.

关键词： ApoM HDL-associated S1P Vascular function

Recent advances in nanotherapeutics for the treatment of burn wounds

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Burns & Trauma 2021年第1期9卷 220-239页

作者： Rong Huang Jun Hu Wei Qian Liang Chen Dinglin Zhang Department of Chemistry College of Basic MedicineThird Military Medical University(Army Medical University)Chongqing 400038China Department of Neurology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Burn Research Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of plastic surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China state key laboratory of Trauma Burn and Combined InjuryChongqing400038China

Moderate or severe burns are potentially devastating injuries that can even cause death,and many of them occur every *** prevention,anti-inflammation,pain management and administration of growth factors play key roles in the treatment of burn *** therapeutic strategies under development,such as nanotherapeutics,are promising prospects for burn wound ***,including metallic and polymeric nanoformulations,have been extensively developed to manage various types of *** human and animal studies have demonstrated that nanotherapeutics are biocompatible and effective in this ***,we provide comprehensive knowledge of and an update on the progress of various nanoformulations for the treatment of burn wounds.

关键词： Burn wounds Metal and metal oxide nanotherapeutics Polymeric nanotherapeutics Therapeutic mechanism Wound healing