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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUCIO HAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN CHURCHILL JAMES C.GATES JAMES HILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI JENS H.SCHMID ILARIA CRISTIANI PAVEL CHEBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES COSIMO LACAVA PERIKLIS PETROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

Interleukin 1βreceptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1

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Neural Regeneration Research 2025年第2期20卷 416-423页

作者： Roberto Piacentini Claudio Grassi Department of Neuroscience UniversitàCattolica del Sacro CuoreRomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s ***,the molecular mechanisms underlying this association are not completely *** the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central ***,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.

关键词： herpes simplex virus type 1 interleukin 1β microglia neuroinflammation synaptic dysfunction

The interplay of drug therapeutics and immune responses to SARS-CoV-2

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Cellular & Molecular Immunology 2024年第2期21卷 197-200页

作者： Valeria Fumagalli Matteo Iannacone Division of Immunology Transplantationand Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Experimental Imaging Centre IRCCS San Raffaele Scientific InstituteMilanItaly

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative *** vaccines form the frontline of defense,antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures,particularly for those unable or unwilling to be *** review delves into the potential influence of nirmatrelvir on enduring *** parallel,the potential of drug repurposing is explored,with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory *** importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.

关键词： SARS-CoV-2 Nirmatrelvir Bisphosphonates Adaptive immunity Drug repurposing

Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

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Bio-Design and Manufacturing 2024年第3期7卷 292-306页

作者： Giuliana Grasso Valentina Onesto Stefania Forciniti Eliana D’Amone Francesco Colella Lara Pierantoni Valeria Famà Giuseppe Gigli Rui L.Reis J.Miguel Oliveira Loretta L.del Mercato nstitute of Nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly Department of Mathematics and Physics“Ennio De Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal Department of Experimental Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing matrices are promising tools for the live monitoring of extracellular O_(2) consumption levels in long-term cell *** this study,ratiometric O_(2)-sensing membranes were prepared by electrospinning,an easy,low-cost,scalable,and robust method for fabricating ***(ε-caprolactone)and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was used as the O_(2)-sensing probe,and rhodamine B isothiocyanate,which was used as the reference *** functionalized scaffolds were morphologically characterized by scanning electron microscopy,and their physicochemical profiles were obtained by Fourier transform infrared spectroscopy,thermogravimetric analysis,and water contact angle *** sensing capabilities were investigated by confocal laser scanning microscopy,performing photobleaching,reversibility,and calibration curve studies toward different dissolved O_(2)(DO)*** sensing nanofibers showed a high response to changes in DO concentrations in the physiological-pathological range from 0.5%to 20%and good stability under ratiometric *** addition,the sensing systems were highly biocompatible for cell growth promoting adhesiveness and growth of three cancer cell lines,namely metastatic melanoma cell line SK-MEL2,breast cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus recreating a suitable biological environment in *** O_(2)-sensing biomaterials can potentially measure alterations in cell metabolism caused by changes in ambient O_(2)content during drug testing/validation and tissue regeneration processes.

关键词： Electrospinning Ruthenium(II)dichloride Oxygen sensors Ratiometric imaging Fluorescence

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二维范德华磁体的拓扑自旋结构的研究进展

Science Bulletin 2024年第11期69卷 1612-1616页

作者：许洪军刘艺舟 Giovanni Finocchio Kang LWang 于国强 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190China RIKEN Center for Emergent Matter Science(CEMS) Wako 351-0198Japan Department of Mathematical and Computer Sciences Physical Sciences and Earth SciencesUniversity of MessinaMessina 98166Italy Department of Electrical Engineering University of CaliforniaLos Angeles CA 90095USA

The importance of topological spin textures(TSTs), such as skyrmions, merons, hopfions, etc., is due to their static and dynamic properties [1]. They carry a topological number that characterizes the homotopy group Π_(n)(S^(2))(n ∈ Z) and classifies maps from S^(n) to S^(2)(e.g., the skyrmion winding number corresponds to Π_(2)(S^(2))).

关键词：自旋结构 topological homotopy

From individual elements to macroscopic materials: in search of new superconductors via machine learning

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npj Computational Materials 2023年第1期9卷 1640-1648页

作者： Claudio Pereti Kevin Bernot Thierry Guizouarn František Laufek Anna Vymazalová Luca Bindi Roberta Sessoli Duccio Fanelli Dipartimento di Fisica e Astronomia Universitàdi FirenzeINFN and CSDCVia Sansone 150019 Sesto FiorentinoFirenzeItaly Univ.Rennes Universitéde Rennes 1INSA RennesCNRSISCR(Institut des Sciences Chimiques de Rennes)UMR 6226F-35000 RennesFrance Institut Universitaire de France 1 rue DescartesParisFrance Czech Geological Survey Geologická615200 Praha 5Czech Republic Dipartimento di Science della Terra Universitàdi FirenzeVia G.La Pira450121 FirenzeItaly Dipartimento di Chimica U.Schiff-DICUS and INSTM Research Unit Universitàdi FirenzeVia della Lastruccia 3-13Sesto Fiorentino 50019 FirenzeItaly

An approach to supervised classification and regression of superconductive materials is proposed which builds on the DeepSet *** enables us to provide the chemical constituents of the examined compounds as an input to the algorithm,while avoiding artefacts that could originate from the chosen ordering in the *** performance of the method are successfully challenged for both classification(tag a given material as superconducting)and regression(quantifying the associated critical temperature).We then searched through the International Mineralogical Association list with the trained neural *** the obtained superconducting candidates,three materials were selected to undergo a thorough experimental *** has been indeed confirmed for the synthetic analogue of michenerite,PdBiTe,and observed for the first time in monchetundraite,Pd2NiTe2,at critical temperatures in good agreement with the theory *** latter is the first certified superconducting material to be identified by artificial intelligence methodologies.

关键词： artificial Deep neural

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes

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Genes & Diseases 2023年第4期10卷 1187-1189页

作者： Giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi Katia De Marco Valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo Nicoletta Resta b Vittoria Disciglio Cristiano Simone Medical Genetics National Institute of Gastroenterology“S.de Bellis”Research HospitalCastellana GrotteBari 70013Italy Medical Genetics Department of Precision and Regenerative Medicine and Jonic Area(DiMePRe-J)University of Bari Aldo MoroBari 70124Italy

Familial adenomatous polyposis(FAP)and MUTYH-associ-ated polyposis(MAP)are colon cancer predisposition *** is an autosomal dominant inherited condition caused by germline mutations in the adenomatous polyposis coli(AP... 详细信息

关键词： polyposis adenomatous colon

Curl Constraint-Preserving Reconstruction and the Guidance it Gives for Mimetic Scheme Design

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Communications on Applied Mathematics and Computation 2023年第1期5卷 235-294页

作者： Dinshaw S.Balsara Roger Käppeli Walter Boscheri Michael Dumbser Physics and ACMS Departments University of Notre DameNotre DameINUSA Seminar for Applied Mathematics(SAM) Department of MathematicsETH ZürichCH-8092 ZurichSwitzerland Department of Mathematics and Computer Science University of FerraraFerraraItaly Laboratory of Applied Mathematics Department of CivilEnvironmental and Mechanical EngineeringUniversity of TrentoTrentoItaly

Several important PDE systems,like magnetohydrodynamics and computational electrodynamics,are known to support involutions where the divergence of a vector field evolves in divergence-free or divergence constraint-preserving ***,new classes of PDE systems have emerged for hyperelasticity,compressible multiphase flows,so-called firstorder reductions of the Einstein field equations,or a novel first-order hyperbolic reformulation of Schrödinger’s equation,to name a few,where the involution in the PDE supports curl-free or curl constraint-preserving evolution of a vector *** study the problem of curl constraint-preserving reconstruction as it pertains to the design of mimetic finite volume(FV)WENO-like schemes for PDEs that support a curl-preserving involution.(Some insights into discontinuous Galerkin(DG)schemes are also drawn,though that is not the prime focus of this paper.)This is done for two-and three-dimensional structured mesh problems where we deliver closed form expressions for the *** importance of multidimensional Riemann solvers in facilitating the design of such schemes is also *** two dimensions,a von Neumann analysis of structure-preserving WENOlike schemes that mimetically satisfy the curl constraints,is also *** shows the tremendous value of higher order WENO-like schemes in minimizing dissipation and dispersion for this class of *** results are also presented to show that the edge-centered curl-preserving(ECCP)schemes meet their design *** paper is the first paper that invents non-linearly hybridized curl-preserving reconstruction and integrates it with higher order Godunov *** its very design,this paper is,therefore,intended to be forward-looking and to set the stage for future work on curl involution-constrained PDEs.

关键词： PDEs Numerical schemes Mimetic

分子和异质化的双核Ir-Cp^*水氧化催化剂含EDTA或EDTMP作为桥接和锚定配体

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Science Bulletin 2020年第19期65卷 1614-1625,M0003页

作者： Chiara Domestici Leonardo Tensi Francesco Zaccaria Nade Kissimina Massimiliano Valentini Roberto D'Amato Ferdinando Costantino Cristiano Zuccaccia Alceo Macchioni Department of Chemistry Biology and BiotechnologyUniversity of Perugia and CIRCCPerugia 06123Italy école Supérieure d'Ingénieurs de Rennes University of Rennes 1Rennes 35042France Department of Chemistry Sultan Qaboos UniversityMuscat 123Oman

开发高效的水氧化催化剂对于推动以生产可再生燃料为目标的可持续还原过程具有重要意义.本文报道了两个新型双核铱配合物(Ir-H4-EDTMP和Ir-EDTA)的合成和广泛表征,其中N,N,N',N'-乙二胺四乙酸(EDTA)及其类似物N,N,N',N'-乙二胺四(亚甲... 详细信息

开发高效的水氧化催化剂对于推动以生产可再生燃料为目标的可持续还原过程具有重要意义.本文报道了两个新型双核铱配合物(Ir-H4-EDTMP和Ir-EDTA)的合成和广泛表征,其中N,N,N',N'-乙二胺四乙酸(EDTA)及其类似物N,N,N',N'-乙二胺四(亚甲基膦酸)(EDTMP)充当两个片段Ir-Cp^*的κ^3-O,N,O-桥接配体.文章还展示了如何利用它们的羧酸盐和膦酸酯团的锚点在TiO2上异质化这些复合物.由此获得的混合材料(Ir-H4-EDTMP@TiO2和Ir-EDTA@TiO2)代表双核异质水氧化催化剂的罕见例子.由NaIO4引导的水氧化中测试了分子和异质化的催化剂,显示出高效率和活性.特别是,在效率、TOF和可回收性方面,杂化材料的性能明显优于单核配合物的类似材料.

关键词： Renewable fuels Water oxidation Homogeneous catalysis Heterogenized catalysts Organometallic chemistry Dinuclear complexes