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Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution

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Asian Pacific Journal of tropical Medicine 2020年第10期13卷 464-466页

作者： Keswadee Lapphra Rati Diwitaya Sansnee Senawong Maneeprang thovarabha Parnwas Pinnobphun Alan Maleesatharn Nantaka Kongstan Benjawan Khumcha Wanatpreeya Phongsamart Orasri Wittawatmongkol Supattra Rungmaitree Kulkanya Chokephaibulkit Department of Pediatrics Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Department of Immunology Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand biomed Diagnostics(thailand)Co LtD BangkokThailand

Objective:to evaluate the performance of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune ***:A cross-sectional study was conducted in HIV-infected patients aged 5-18 years receiving antiretroviral treatment with CD4 t-lymphocytes>25%or>500 cells/mm3 for at least 6 *** ERON-tb Gold,***,and tuberculin skin test were performed in each ***:A total of 50 patients were enrolled with median age of 13.7 years,CD4 counts of 753(IQR:587-989)cells/*** 27 patients with tuberculosis(16)or tuberculosis exposure(11),8(29.6%)were positive to at least one test,2(7.4%)were positive QuantiFERON-tb Gold,3(11.1%)positive ***,and 7(25.9%)had tuberculin skin test≥5 *** 23 patients without history of tuberculosis or exposure,all had negative interferon gamma release assays,while 2(8.7%)had positive tuberculin skin ***:All tests had low sensitivity despite immune reconstitution.

关键词： Children HIV tb Interferon gamma release assays tuberculin skin test

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Performance and correlation of QuantiFERON-tb Gold, *** and tuberculin skin test in young children with or exposed to tuberculosis

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Asian Pacific Journal of tropical Medicine 2020年第9期13卷 423-425页

作者： Keswadee Lapphra Paninun Srinuchasart Sansnee Senawong Utane Rungpanich Pinklow Umrod Alan Maleesatharn Nantaka Kongstan Watcharee Lermankul Kulkanya Chokephaibulkit Department of Pediatrics Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Department of Immunology Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

Objective:to evaluate the performance of interferon gamma release assays and tuberculin skin test in Bacillus Calmette-Guerin vaccinated young ***:A cross-sectional study was conducted in healthy children younger than 5 years who were recently diagnosed with tuberculosis or had recent exposure to active ***-tb Gold,*** and tuberculin skin test were performed in each ***:Of the 60 children,median age 3.3 years,17 had tuberculosis and 43 had recent tuberculosis ***,15(25.0%)children had tuberculin skin test reaction≥10 mm;8(13.3%)were positive by QuantiFERON-tb Gold In-tube test,and 12(20.0%)by ***(31.7%)children had at least one positive *** was a moderate agreement between interferon gamma release assays and tuberculin skin ***:the positive rates of interferon gamma release assays and tuberculin skin test were low in young children who were infected with tuberculosis,supporting the management strategy of not testing children younger than 5 years.

关键词： tuberculin skin test QuantiFERON-tb Gold In-tube test t-spot.tb Young children

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