检索结果-南通市图书馆

Evaluating autism in a Chinese population:the Clinical Autism Diagnostic Scale

World Journal of Pediatrics 2014年第2期10卷 160-163页

作者： Grace Hao Thomas L Layton Xiao-Bing Zou Dong-Yun Li Department of Allied Professions North Carolina Central University710 Cecil StreetDurhamNC 27707USA T and T Communication Services Inc.100 Meredith DriveSuite 100DurhamNC 27713USA Children Development and Behavior Center Third Affi liated Hospital to Sun Yet-sen UniversityNo 600 Tianhe RoadGuangzhou 510630China

Background:The purpose of this study was to report on the psychometric measures and discriminatory function of a new diagnostic test for autism spectrum disorders,the Clinical Autism Diagnostic Scale(CADS).Methods:The CADS was used to test 216 children in the study,including 86 with low-functioning autism specturm disorders(ASD),16 children with highfunctioning ASD,16 with pervasive developmental disorder,not otherwise specified,7 with Asperger syndrome,65 with typical development,11 children with language impairments and 15 with intellectual *** ranged from 38-73 *** for the groups were compared across seven ***:The results indicated the instrument was reliable,valid,and successfully differentiated the different groups of children with and without *** ASD groups were found to display difficulties in the domains of sensory behaviors and stereotyped *** play and social domains were found to measure similar underlying concepts of behaviors,while the receptive language and expressive language domains were also found to measure similar underlying-language *** group of children diagnosed as having low-functioning autism performed less well on all tested domains in the instrument than did the other three groups of children with ASD,and these other three groups each also presented unique patterns of behaviors and differed on individual ***:CADS is a reliable and valid *** successfully differentiates the abilities of children with ASD at different levels of functioning.

关键词： autism spectrum disorders diagnosis rating scale

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antioxidant and antiarthritic potential of berberine: In vitro and in vivo studies

引用

Chinese Herbal Medicines 2023年第4期15卷 549-555页

作者： Shweta Jain Shalini Tripathi Pushpendra Kumar Tripathi Sir Madanlal Institute of Pharmacy Etawah 206130India Rameshwaram Institute of Technology and Management Dr.A.P.J.Abdul Kalam Technical UniversityLucknow 226001India Institute of Pharmaceutical Sciences University of LucknowLucknow 226001India

Objective: To extract and isolate berberine from Berberis aristata(Berberidaceae). Isolated berberine was characterised using spectroscopy and its antioxidant and antiarthritic activity was ***: The berberine was isolated from B. aristata using microwave-assisted extraction(MAE) and characterised by a spectroscopic technique. The isolated berberine was evaluated for its antioxidant activity in DPPH, nitric oxide, and superoxide scavenging assays, while antiarthritic activity was evaluated in the complete freund’s adjuvant(CFA)-induced arthritis rat ***: The antioxidant activity of berberine revealed potent antioxidant activity in DPPH, nitric oxide,and superoxide scavenging assays. The in vivo antiarthritic activity of berberine in the CFA-induced arthritis rat model showed a significant reduction in paw diameter, arthritic score, and an increase in body weight. Furthermore, a concentration-dependent ameliorating action of berberine on haematological parameters was noticed. Proinfammatory biomarkers, including IL-6, IL-10, and TGF-b in serum were reported, and histopathology examination revealed that berberine decreased pannus formation, synovial hyperplasia, and bone erosion. Radiographic investigation showed soft tissue infammation, bone resorption and erosion, joint gap reduction, and substantial connective tissue expansion after treatment with ***: The ameliorating action on haematological parameters and proinfammatory biomarkers of berberine makes them a suitable remedy for the treatment of arthritis.

关键词： antioxidant antiarthritic activity berberine Berberis aristata DC microwave assistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Robust Transcriptional Activation in Plants Using Multiplexed CRISPR-Act2.0 and mTALE-Act Systems

引用

Molecular Plant 2018年第2期11卷 245-256页

作者： Levi G. Lowder Jianping Zhou Yingxiao Zhang Aimee Malzahn Zhaohui Zhong Tzung-Fu Hsieh Daniel F. Voytas Yong Zhang Yiping Qi Department of Biology East Carolina University Greenville NC 27858 USA Department of Biotechnology School of Life Science and Technology Center for informational Biology University of Electronic Science and Technology of ChinaChengdu 610054 China Department of Plant Science and Landscape Architecture University of Maryland College Park MD 20742 USA Department of Plant and Microbial Biology and Plants for Human Health Institute North Carolina State University North Carolina Research Campus KannapolisNC 28O81 USA Department of Genetics Ceil Biology and Development Center for Genome Engineering University of Minnesota Minneapolis MN 55455 USA Institute for Bioscience and Biotechnology Research University of Maryland Rockville MD 20850 USA

User-friendly tools for robust transcriptional activation of endogenous genes are highly demanded in plants. We previously showed that a dCas9-VP64 system consisting of the deactivated CRISPR- associated protein 9 （dCasg） fused with four tandem repeats of the transcriptional activator VP16 0/1=64） could be used for transcriptional activation of endogenous genes in plants. In this study, we developed a second generation of vector systems for enhanced transcriptional activation in plants. We tested multiple strategies for dCasg-based transcriptional activation, and found that simultaneous recruitment of VP64 by dCas9 and a modified guide RNA scaffold gRNA2.0 （designated CRISPR-Act2.0） yielded stronger transcrip- tional activation than the dCas9-VP64 system. Moreover, we developed a multiplex transcription activator- likeeffector activation （mTALE-Act） system for simultaneous activation of up to four genes in plants. Our results suggest that mTALE-Act is even more effective than CRISPR-Act2.0 in most cases tested. In addition, we explored tissue-specific gene activation using positive feedback loops. Interestingly, our study revealed that certain endogenous genes are more amenable than others to transcriptional activation, and tightly regulated genes may cause target gene silencing when perturbed by activation probes. Hence, these new tools could be used to investigate gene regulatory networks and their control mechanisms. Assembly of multiplex CRISPR-Act2.0 and mTALE-Act systems are both based on streamlined and PCR-independent Golden Gate and Gateway cloning strategies, which will facilitate transcriptional activation applications in both dicots and monocots.

关键词： CRISPR gRNA2.0 MS2-VP64 TALE-VP64 multiplex transcriptional activation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

资产价格泡沫的形成与治理

引用

体制改革 2004年第8期 22-29页

作者：黄孝武

本文是关于资产价格泡沫的理论综述。介绍了新近关于资产价格泡沫的若干理论，包括其定义、其与整体经济关系、其生成机制及其治理建议等。

关键词：资产价格泡沫行为金融学套利

来源：人大复印报刊资料评论

在线全文

人大复印报刊资料

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：