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A multicenter uroflowmetry study of healthy women in China

Chinese Medical Journal 2024年第10期137卷 1225-1227页

作者： Xiaodong Liu Lingfeng Meng Jiawen Wang Tianming Ma Benkang Shi Hai Huang Qingwei Wang Min Chen Limin Liao Hong Shen Zhongqing Wei Yuansong Xiao Tiejun Pan Jian Ren Peng Zhang Xiaojun Tian Yaoguang Zhang Department of Urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China Department of Urology Qilu HospitalShandong UniversityJinanShandong 250013China Department of Urology SUN YAT-SEN Memorial HospitalGuangzhouGuangdong 510235China Department of Urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450003China Department of Urology Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430030China Department of Urology China Rehabilitation Research CenterBeijing 100068China Department of Urology West China HospitalChengduSichuan 610041China Department of Urology The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China Department of Urology General Hospital of Southern Theatre CommandGuangzhouGuangdong 510010China Department of Urology General Hospital of Central Theatre CommandWuhanHubei 430071China Department of Urology China-Japan Friendship HospitalBeijing 100029China Department of Urology Beijing Chao-Yang HospitalBeijing 100027China Department of Urology Peking University Third HospitalBeijing 100191China

Uroflowmetry is an uroflow measurement technique used to record the voided volume(VV)and flow rate,which can help clinicians objectively evaluate lower urinary tract ***,few uroflowmetry studies have focused on the female population,[1]especially on the uroflow curve standard ***,we sought to establish dependable uroflow reference values and nomograms for Chinese women and to evaluate the relationship between uroflow patterns and demographic data.

关键词： function. flowmetry analysis.

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Multi-disciplinary surgery for simultaneous resection of multiple tumors in a patient with newly diagnosed metastatic pheochromocytoma/paraganglioma

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Cancer Pathogenesis and Therapy 2023年第4期1卷 290-294页

作者： Jibo Jing Lingfeng Meng Yaoguang Zhang Runhua Tang Haoran Wang Jiaxing Ning Xinhao Wang Department of Urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Metastatic pheochromocytoma/paraganglioma(MPP)is a rare endocrine tumor that originates from extra-adrenal chromaffin cells such as the paraganglia cells of sympathetic and parasympathetic *** usually causes multiple solid tumors and exhibits strong aggressiveness with poor prognosis,with a reported 5-year survival rate of less than 50%.Cases of brain and retroperitoneal metastases at the initial diagnosis have not yet been *** report a 41-year-old male patient initially diagnosed with MPP in the brain and retroperitoneum who underwent multi-disciplinary collaborative surgery and simultaneous removal of two tumors at our *** pathology revealed infiltrative growth of a skull base *** patient chose to receive the tyrosine kinase inhibitor sunitinib as a targeted treatment.A 3-month follow-up after surgery showed that the patient recovered well without signs of metastasis or *** present multi-disciplinary surgery under similar circumstances for enhanced treatment and postoperative *** patient demonstrates a favorable prognosis during postoperative follow-up,indicating that simultaneous multidisciplinary surgery may offer greater benefits for MPP patients.

关键词： Metastatic pheochromocytoma/paraganglioma Multi-disciplinary surgery Skull base tumor Retroperitoneal metastases

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Urethral pressure profilometry in artificial urinary sphincter implantation: A case report

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World Journal of Clinical Cases 2019年第23期7卷 4084-4090页

作者： Ling-Feng Meng Xiao-Dong Liu Miao Wang Wei Zhang Yao-Guang Zhang Department of Urology Beijing HospitalNational Center of Gerontology

BACKGROUND Artificial urethral sphincter(AUS)implantation is currently the gold standard for treating moderate and severe urinary ***,cuffs are chosen based on the surgeon’s experience,and adjusting cuff tightness is *** TDOC air-charged catheter has not been proven to be inferior to traditional *** report how intraoperative urethral pressure profilometry is performed using a T-DOC air-charged catheter with ambulatory urodynamic equipment,to guide cuff selection and *** SUMMARY A 67-year-old man presented to our hospital with complete urinary incontinence following transurethral prostatectomy,using five pads/d to maintain local ***,the maximum urethral pressure(MUP)and maximum urethral closure pressure(MUCP)were 52 cmH2O and 17 cmH2O,*** AUS was ***,in the inactivated state,the MUP and MUCP were 53 cmH2O and 50 cmH2O,respectively;in the activated state,they were 112 cmH2O and 109 cmH2O,*** pump was activated 6 wk ***-measurement of the urethral pressure on the same day showed that in the inactivated state,MUP and MUCP were 89 cmH2O and 51 cmH2O,respectively,and in the activated state,120 cmH2O and 92 cmH2O,*** month after device activation,telephonic follow-up revealed that pad use had decreased from five pads/d to one pad/d,which met the standard for social continence(0-1 pad per day).There were no *** The relationship between intraoperative urethral pressure and urinary continence post-surgery can provide data for standardizing AUS implantation and evaluating efficacy.

关键词： Urethral pressure profilometry Urinary sphincter,Artificial Maximum urethral pressure Maximum urethral closure pressure Urinary incontinence Case report

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The sphingosine-1-phosphate/RhoA/Rho associated kinases/myosin light chain pathway in detrusor of female rats is down-regulated in response to ovariectomy

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Chinese Medical Journal 2020年第10期133卷 1203-1210页

作者： Wei Zhang Xiao-Dong Liu Jia-Wen Wang Ling-Feng Meng Yao-Guang Zhang Jian-Ye Wang Peking University Fifth School of Clinical Medicine Beijing 100730China Department of Urology Beijing HospitalNational Center of GerontologyBeijing 100730China.

Background:Dysuria is one of the main symptoms of genitourinary syndrome of menopause,which causes serious disruption to the normal life of peri-menopausal *** have shown that it is related to decrease of detrusor contractile function,but the exact mechanism is still poorly *** results have suggested that the sphingosine-1-phosphate(S1P)pathway can regulate detrusor contraction,and this pathway is affected by estrogen in various ***,how estrogen affects this pathway in the detrusor has not been *** this study,we detected changes of the S1P/RhoA/Rho associated kinases(ROCK)/myosin light chain(MLC)pathway in the detrusor of ovariectomized rats in order to explore the underlying mechanism of dysuria during ***::Thirty-six female Sprague-Dawley rats were randomly divided into SHAM(sham operation),OVX(ovariectomy),and E groups(ovariectomy+estrogen),with 12 rats in each *** obtained bladder detrusor tissues from each group and examined the mRNA and protein levels of the major components of the S1P/RhoA/ROCK/MLC pathway using quantitative real-time polymerase chain reaction and Western blotting,*** also quantified the content of S1P in the detrusor using an enzyme linked immunosorbent ***,we compared results between the groups with one-way analysis of ***::The components of the S1P pathway and the RhoA/ROCK/MLC pathway of the OVX group were significantly decreased,as compared with SHAM *** percent decreases of the components in the S1P pathway were as follows:sphingosine kinase 1(mRNA:39%,protein:45%)(both P0.05).The percent decreases of the components in the RhoA/ROCK/MLC pathway were a

关键词： Myosin light chains Ovariectomy Rats Rho-associated kinases Sphingosine-1-phosphate Urinary bladder

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Clinical outcomes of sacral neuromodulation in non-neurogenic,non-obstructive dysuria:A 5-year retrospective,multicentre study in China

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World Journal of Clinical Cases 2020年第12期8卷 2494-2501页

作者： Ling-Feng Meng Wei Zhang Jian-Ye Wang Yao-Guang Zhang Peng Zhang Li-Min Liao Jian-Wei Lv Qing Ling Zhong-Qing Wei Tie Zhong Zhi-Hui Xu Wei Wen Jia-Yi Li De-Yi Luo Department of Urology Beijing HospitalNational Center of GerontologyBeijing 100730China Department of Urology Beijing Chaoyang HospitalInstitute of UrologyCapital Medical UniversityBeijing 100000China Department of Urology China Rehabilitation Research CentreRehabilitation School of Capital Medical UniversityBeijing 100000China Department of Urology South CampusRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China Department of Urology Tongji HospitalHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina Department of Urology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Urology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina Department of Urology Zhejiang Provincial People’s HospitalHangzhou 310000Zhejiang ProvinceChina Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China Department of Urology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China Department of Urology West China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND Management of non-neurogenic,non-obstructive dysuria represents one of the most challenging dilemmas in urological *** main clinical symptom is the increase in residual *** dysfunction is the main cause of dysuria or urinary retention,mainly due to the decrease in bladder contraction(the decrease in contraction amplitude or duration)or the increase in outflow tract *** neuromodulation(SNM)has been used for>10 years to treat many kinds of lower urinary tract *** has become increasingly popular in China in recent ***,studies focusing on nonneurogenic,non-obstructive dysuria patients treated by SNM are highly *** To assess the outcome of two-stage SNM in non-neurogenic,non-obstructive *** Clinical data of 54 patients(26 men,28 women)with non-neurogenic,nonobstructive dysuria treated by SNM from January 2012 to December 2016 in ten medical centers in China were retrospectively *** patients received two or more conservative *** voiding diary,urgency score,and quality of life score before operation,after implantation of tined lead in stage I(test period),and during short-term follow-up(latest follow-up)after implantation of the implanted pulse generator in stage II were compared to observe symptom *** Among the 54 study patients,eight refused to implant an implanted pulse generator because of the unsatisfactory effect,and 46 chose to embed the implanted pulse generator at the end of stage *** conversion rate of stage I to stage II was 85.2%.The average follow-up time was 18.6 *** were significant differences between baseline(before stage I)and the test period(after stage I)in residual urine,voiding frequency,average voiding amount,maximum voiding amount,nocturia,urgency score,and quality of life *** residual urine and urgency score between the test period and the latest follow-up time(after stage II)were also significantly different

关键词： Dysuria Implanted pulse generator Non-neurogenic Non-obstructive Sacral neuromodulation

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基于生物信息学分析法探讨BIRC5(Survivin)在肾透明细胞癌中的表达及其与预后的关系

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现代泌尿外科杂志 2020年第11期25卷 1019-1024页

作者：孟令峰田子健刘晓东王淼龙兴博张耀光张军北京医院泌尿外科国家老年医学中心中国医学科学院老年医学研究院北京100730 山东省夏津县人民医院泌尿外科山东德州253200

目的探讨BIRC5在肾透明细胞癌肿瘤组织中的表达水平及其与临床预后之间的关系。方法首先使用Oncomine以及癌症基因组图谱数据库预测BIRC5 mRNA在肾透明细胞癌中的表达情况,并探索其表达量与生存的关系。采用生存分析和比例风险回归模型... 详细信息

目的探讨BIRC5在肾透明细胞癌肿瘤组织中的表达水平及其与临床预后之间的关系。方法首先使用Oncomine以及癌症基因组图谱数据库预测BIRC5 mRNA在肾透明细胞癌中的表达情况,并探索其表达量与生存的关系。采用生存分析和比例风险回归模型评估BIRC5表达与肾透明细胞癌患者预后的相关性,并通过基因集变异分析以及基因集富集分析探讨BIRC5所富集的相关通路。此外,探究了BIRC5在肾透明细胞癌中共表达基因的情况。结果肾透明细胞癌组织中BIRC5 mRNA的表达水平明显高于正常组织(P<0.001)。生存分析显示,BIRC5高表达患者的生存时间显著减少(P<0.001)。此外,还发现BIRC5差异表达水平与病理分级、临床TNM分期以及性别相关(P均<0.01)。单因素、多因素比例风险回归模型表明BIRC5表达是肾透明细胞癌患者生存时间的独立预后因素(P均<0.05)。结论BIRC5在肾透明细胞癌中高表达,是影响预后的重要因素。BIRC5可能是肾透明细胞癌潜在的预后生物学标志物及治疗靶标。

关键词： BIRC5 生物信息学分析肾透明细胞癌预后

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女性原发性尿道癌4例报告并文献复习

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现代泌尿外科杂志 2019年第10期24卷 821-824,832页

作者：孟令峰张威刘晓东许森王淼张耀光北京医院泌尿外科国家老家医学中心

目的分析女性原发性尿道癌的流行病学特征、临床表现、诊治措施及预后等,并分享单中心经验。方法回顾性分析自2016年11月至2018年3月就诊于我院的4例原发性尿道癌患者的临床资料,进行了随访,了解其复发、转移及生存情况,并结合文献进行... 详细信息

目的分析女性原发性尿道癌的流行病学特征、临床表现、诊治措施及预后等,并分享单中心经验。方法回顾性分析自2016年11月至2018年3月就诊于我院的4例原发性尿道癌患者的临床资料,进行了随访,了解其复发、转移及生存情况,并结合文献进行讨论。结果4例患者均为女性,年龄53~72岁,平均64.5岁;其中2例因尿道口肿物就诊,1例因尿道无痛性出血就诊,1例因阴道分泌物增多就诊。4例患者均病理诊断为原发性尿道癌(3例腺癌,1例大细胞神经内分泌癌)并接受手术治疗,1例患者接受术后辅助化疗。患者随访8~28个月,2例患者带瘤生存,2例患者无瘤生存。结论女性原发性尿道癌临床表现无明显特异性,确诊需依靠病理,且预后较差。治疗以手术切除为主,对于远端尿道肿瘤,推荐在保证切缘阴性的情况下行尿道肿物及肿物内侧尿道切除重建术;而对于近端尿道肿瘤,则推荐行根治性切除术,同时根据情况可适当扩大切除范围以保证达到根治效果。

关键词：女性原发性尿道癌治疗预后

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年龄对骶神经调控术治疗难治性下尿路功能障碍临床疗效的影响

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现代泌尿外科杂志 2020年第12期25卷 1138-1140页

作者：孟令峰刘晓东张威许森王淼张耀光北京医院泌尿外科国家老年医学中心北京100730

高龄被认为是引发下尿路症状的一大因素,行为干预或药物治疗在老年难治性下尿路功能障碍患者中较难取得满意效果。骶神经调控术(SNM)用于治疗老年难治性下尿路功能障碍患者已有十余年历史,若想获得满意疗效,选择合适的患者至关重要,此... 详细信息

高龄被认为是引发下尿路症状的一大因素,行为干预或药物治疗在老年难治性下尿路功能障碍患者中较难取得满意效果。骶神经调控术(SNM)用于治疗老年难治性下尿路功能障碍患者已有十余年历史,若想获得满意疗效,选择合适的患者至关重要,此外还须考虑患者是否具有准确使用设备的能力。不同研究对SNM的临床效果以及年龄对疗效影响的结论不一,但总体而言其并发症发生较少。而面对中国人口老龄化的现状,进一步探究老年患者接受SNM治疗的获益与风险显得尤为重要。

关键词：年龄骶神经调控术难治性下尿路功能障碍

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