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Human genes involved in hepatitis B virus infection

World Journal of Gastroenterology 2014年第24期20卷 7696-7706页

作者： Zheng Zeng Department of Infectious Diseases Peking University First Hospital

Persistent hepatitis B virus(HBV)infection is a significant public health problem because it is a major cause of chronic liver disease,cirrhosis,and hepatocellular carcinoma(HCC).Roughly one-third of the world population has been infected with HBV and there are about350 million(5%-6%)persistent *** causes80%of all liver cancer cases and is the second most important carcinogen,after smoking *** is an approximate 90%risk of becoming a persistent carrier following perinatal infection in infants born to e antigen positive carrier mothers and a 30%risk in pre-school *** 5%-10%of adults become persistent carriers following *** individuals persistently infected with HBV,10%-30%will develop liver cirrhosis and *** highly variable outcomes in both clearance rates and disease outcomes in persistently infected individuals cannot be fully explained by differences in immunological,viral or environmental ***,differences in host genetic factors may affect the natural history of hepatitis B.

关键词： Hepatitis B virus Hepatocellular carcinoma Epidemiology Clearance Persistance Genetic Polymorphism Outcome Natural history

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Human immune repertoire in hepatitis B virus infection

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World Journal of Gastroenterology 2021年第25期27卷 3790-3801页

作者： Qiao Zhan Jing-Hang Xu Yan-Yan Yu Emily Lo KK Felicianna Hani El-Nezami Zheng Zeng Department of Infectious Diseases Peking University First HospitalBeijing 100034China School of Biological sciences University of Hong KongHong KongChina Institute of Public Health and Clinical Nutrition School of MedicineUniversity of Eastern FinlandKuopio FI-70211Finland

Hepatitis B virus(HBV)infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis,liver failure,and hepatocellular *** HBV antigen-induced adaptive immune response plays an important role in HBV *** repertoire sequencing(IRS)has been used to investigate the molecular mechanisms behind the immune system,find novel ways to treat HBV infection,and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV *** review summarizes the human immune repertoire analysis methodology,and the application of the IRS in the prediction of HBV infection progression,treatment,and vaccination.

关键词： Immune repertoire T-cell receptor B-cell receptor Hepatitis B virus Chronic viral infection High-throughput sequencing

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New Gene Variants Associated with the Risk of Chronic HBV Infection

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Virologica Sinica 2020年第4期35卷 378-387页

作者： Mengjie Fan Jing Wang Sa Wang Tengyan Li Hong Pan Hankui Liu Huifang Xu Daria V.Zhernakova Stephen J.O’Brien Zhenru Feng Le Chang Erhei Dai Jianhua Lu Hongli Xi Yanyan Yu Jianguo Zhang Binbin Wang Zheng Zeng Department of Infectious Diseases Peking University First HospitalBeijing 100034China Department of Medical Genetics and Development Biology School of Medical BasicCapital Medical UniversityBeijing 100069China Center for Genetics National Research Institute for Family PlanningBeijing 100081China BGI-Shenzhen Shenzhen 518083China BGI Genomics BGI-ShenzhenShenzhen 518083China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySt.PetersburgRussia 197101 Guy Harvey Oceanographic Center Halmos College of Natural Sciences and OceanographyNova Southeastern UniversityFt LauderdaleFL 33004USA Department of Laboratory Medicine Peking University First HospitalBeijing 100034China The Fifth Hospital of Shijiazhuang Shijiazhuang 050024China

Some patients with chronic hepatitis B virus(HBV)infection failed to clear HBV,even persistently continue to produce antibodies to *** we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of *** first stage involved genome wide exome sequencing of 101 cases(HBsAg plus anti-HBs positive)compared with 102 control patients(antiHBs positive,HBsAg negative).Over 80%of individual sequences displayed 209 sequence ***,uncertain bases[10%or low-quality base calls([50%)were filtered and compared to the human reference genome *** the second stage,579 chronic HBV infected cases and 439 HBV clearance controls were sequenced with selected genes from the first *** there were no significant associated gene variants in the first stage,two significant gene associations were discovered when the two stages were assessed in a combined *** association showed rs506121-“T”allele[within the dedicator of cytokinesis 8(DOCK8)gene]was higher in chronic HBV infection group than that in clearance group(P=0.002,OR=0.77,95%CI[0.65,0.91]).The second association involved rs2071676—A allele within the Carbonic anhydrase(CA9)gene that was significantly elevated in chronic HBV infection group compared to the clearance group(P=0.0003,OR=1.35,95%CI[1.15,1.58]).Upon replication these gene associations would suggest the influence of DOCK8 and CA9 as potential risk genetic factors in the persistence of HBV infection.

关键词： Whole exome sequencing HBV infection DOCK8 CA9 Variation

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