Human genes involved in hepatitis B virus infection

作     者：Zheng Zeng 

作者机构：Department of Infectious DiseasesPeking University First Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第24期

页      面：7696-7706页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by National Cancer Institute,National Institute of Health,USA,No.N01-CO-12400 National Nature Science Foundation of China,No.30671855 International Science&Technology Cooperation Program of China,No.2014DFR31200 

主　　题：Hepatitis B virus Hepatocellular carcinoma Epidemiology Clearance Persistance Genetic Polymorphism Outcome Natural history 

摘      要：Persistent hepatitis B virus(HBV)infection is a significant public health problem because it is a major cause of chronic liver disease,cirrhosis,and hepatocellular carcinoma(HCC).Roughly one-third of the world population has been infected with HBV and there are about350 million(5%-6%)persistent *** causes80%of all liver cancer cases and is the second most important carcinogen,after smoking *** is an approximate 90%risk of becoming a persistent carrier following perinatal infection in infants born to e antigen positive carrier mothers and a 30%risk in pre-school *** 5%-10%of adults become persistent carriers following *** individuals persistently infected with HBV,10%-30%will develop liver cirrhosis and *** highly variable outcomes in both clearance rates and disease outcomes in persistently infected individuals cannot be fully explained by differences in immunological,viral or environmental ***,differences in host genetic factors may affect the natural history of hepatitis B.