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The bad and the good of mesenchymal stem cells in cancer: Boosters of tumor growth and vehicles for targeted delivery of anticancer agents

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World Journal of Stem Cells 2010年第1期2卷 5-12页

作者： Umberto Galderisi Antonio Giordano Marco G paggi Sbarro Institute for Cancer Research and Molecular Medicine Center for BiotechnologyTemple UniversityPhiladelphiaPA 19122United States Department of Experimental Medicine Biotechnology and Molecular Biology SectionSecond University of NaplesNaples 80138Italy Human Health Foundation Terni 05100Italy National Cancer Institute"Regina Elena" Rome 00144Italy

In cancer biology,mesenchymal stem cells(MSCs)display aspects that can appear *** one hand,these cells possess several features which give them the ability to specifically target and then sustain cancer cells in their ability to survive the multifaceted host response against *** the other hand,due to this excellent aptitude to home-in on tumor tissues,regardless their location in the host’s body,MSCs are considered to be extremely selective vehicles to reach cancer cells ***,MSC sustainment of cancer cell growth is a hot research ***,these cells are known to sustain tumor angiogenesis and metastasis formation,to create a microenvironment favorable for cancer cell growth and to down-modulate the immune system capabilities in the host *** the other hand,since scientists became able to take advantage of their extremely selective capability to target cancer cells,MSCs are now also thought of in a different ***,MSCs are now considered a promising vehicle for local expression or delivery of even particularly toxic anticancer agents,ranging from Herpes Simplex Virus to locally-acting antineoplastic *** this basis,investigation is now focused on how to impair the pro-neoplastic features of MSCs on one hand whilst taking advantage of their specific tropism toward cancer cells,on the *** with the two faces of Janus,this review will concisely explore the research activity in these two apparently conflicting fields.

关键词： Mesenchymal stem cells Cancer Cell therapy Angiogenesis Niche Immunomodulation

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