The bad and the good of mesenchymal stem cells in cancer: Boosters of tumor growth and vehicles for targeted delivery of anticancer agents

作     者：Umberto Galderisi Antonio Giordano Marco G Paggi 

作者机构：Sbarro Institute for Cancer Research and Molecular MedicineCenter for BiotechnologyTemple UniversityPhiladelphiaPA 19122United States Department of Experimental MedicineBiotechnology and Molecular Biology SectionSecond University of NaplesNaples 80138Italy Human Health FoundationTerni 05100Italy National Cancer Institute"Regina Elena"Rome 00144Italy 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2010年第2卷第1期

页      面：5-12页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grants from Associazione Italiana Ricerca sul Cancro(AIRC) to Paggi MG Ministero della Salute grants to Paggi MG from Sbarro Health Research Organization funds to Galderisi U and Giordano A 

主　　题：Mesenchymal stem cells Cancer Cell therapy Angiogenesis Niche Immunomodulation 

摘      要：In cancer biology,mesenchymal stem cells(MSCs)display aspects that can appear *** one hand,these cells possess several features which give them the ability to specifically target and then sustain cancer cells in their ability to survive the multifaceted host response against *** the other hand,due to this excellent aptitude to home-in on tumor tissues,regardless their location in the host’s body,MSCs are considered to be extremely selective vehicles to reach cancer cells ***,MSC sustainment of cancer cell growth is a hot research ***,these cells are known to sustain tumor angiogenesis and metastasis formation,to create a microenvironment favorable for cancer cell growth and to down-modulate the immune system capabilities in the host *** the other hand,since scientists became able to take advantage of their extremely selective capability to target cancer cells,MSCs are now also thought of in a different ***,MSCs are now considered a promising vehicle for local expression or delivery of even particularly toxic anticancer agents,ranging from Herpes Simplex Virus to locally-acting antineoplastic *** this basis,investigation is now focused on how to impair the pro-neoplastic features of MSCs on one hand whilst taking advantage of their specific tropism toward cancer cells,on the *** with the two faces of Janus,this review will concisely explore the research activity in these two apparently conflicting fields.