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Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder

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Signal Transduction and Targeted Therapy 2021年第3期6卷 897-908页

作者： Fatao Liu Yongsheng Li Dongjian Ying Shimei Qiu Yong He Maoian Li Yun Liu Yijian Zhang Qin Zhu Yunping Hu Liguo Liu Guoqiang Li Weihua Pan Wei Jin Jiasheng Mu Yang Cao Yingbin Liu Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineYangpu DistrictShanghai 200092China Shanghai key Laboratory of Biliary Tract Disease Yangpu DistrictShanghai 200092China State key Laboratory of Oncogenes and Related Genes ShanghaiChina Shanghai research Center of Biliary Tract Disease Yangpu DistrictShanghai 200092China Department of Biliary-Pancreatic Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Minimal Invasive Surgery Ningbo Medical Center Lihuili HospitalNingboZhejiang 315040China Department of hepatopancreatobiliary surgery Ganzhou hospital affiliated to Nanchang universityJiangxi 341000China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineYangpu DistrictShanghai 200092China Information and Big Data Center Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineYangpu DistrictShanghai 200092China Department of Surgery Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310009China Department of Gastric Surgery Cancer Hospital of the University of Chinese Academy of SciencesHangzhouZhejiang 310022China

Neuroendocrine carcinoma(NEC)of the gallbladder(GB-NEC)is a rare but extremely malignant subtype of gallbladder cancer(GBC).The genetic and molecular signatures of GB-NEC are poorly understood;thus,molecular targeting is currently *** present study,we applied whole-exome sequencing(WES)technology to detect gene mutations and predicted somatic singlenucleotide variants(SNVs)in 15 cases of GB-NEC and 22 cases of general *** 15 GB-NECs,the C>T mutation was predominantamong the 6 types of ***53 showed the highest mutation frequency(73%,11/15).Compared with neuroendocrine carcinomasof other organs,signifcantly mutated genes(SMGs)in GB-NECs were more similar to those in pulmonary large-cell euroendocrinecarcinomas(LCNECs),with drver roles for TP53 and *** the COSMIC database of cancer-related genes,211 genes were ***,RB1(4/15,27%)and NAB2(3/15,20%)mutations were found specifically in GB-NECs;in contrast,mutations in 29 genes,including ERB82 and ERBB3,were identified exclusively in *** in RB1 and NAB2 were significanty related to downregulation of the RB1 and NAB2 proteins,respectively,according to immunohistochemical(IHC)data(p values=0.0453 and0.0303).Clinically actionable genes indicated 23 mutated genes,including ALK,BRCA1,and *** addition,potential somaticSNVs predicted by ISowN and SomVarlUS constituted 6 primary coSMIC mutation signatures(1,3,30,6,7,and 13)in *** carrying somatic SNVs were enriched mainly in oncogenic signaling pathways involving the Notch,WNT,Hippo,and *** summary,we have systematically identified the mutation landscape of GB-NEC,and these findings may providemechanistic insights into the specifc pathogenesis of this deadly disease.

关键词： gallbladder carcinomas organs

Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI

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General Psychiatry 2020年第4期33卷 188-193页

作者： Yuzhu Mu Yumei Li Qi Zhang Zhongxiang Ding Mei Wang Xingguang Luo Xiaoyun Guo Maosheng Xu Department of Ultrasound the First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhouChina Department of Radiology Zhejiang Provincial People's HospitalHospital of Hangzhou Medical CollegeHangzhouChina Department of Radiology the First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhouChina Translational Medicine research Center Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouChina Department of Psychiatry Yale University School of MedicineNew HavenConnecticutUSA Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina

Background The prevalence of Alzheimer's disease(AD)comorbid with depression is ***,the mechanisms of AD with depression remain *** To investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging(rs-fMRI).Methods 154 patients with AD who met the inclusion criteria were recruited from the zhejiang Provincial People’s Hospital from October 2014 to October *** to whether the core symptoms of depression were present,patients were divided into two groups,22 patients with AD with depression(AD-D)and 52 patients with AD without depression(AD-nD).The amplitude of low frequency fluctuations(ALFF)was compared between two groups by performing independent-samples *** Compared with the AD-D group,increased ALFF values in the bilateral superior frontal gyrus,left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD *** brain activity in the AD-nD group in the bilateral superior frontal gyrus,left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D *** Resting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms.

关键词： alterations Alzheimer patients

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D72树脂对镨(Ⅲ)的吸附性能(英文)

Chinese Journal of Chemical Engineering 2012年第5期20卷 823-830页

作者：熊春华朱京妃沈忱陈青 Department of Applied Chemistry Zhejiang Gongshang University

In this work, the feasibility of using a macroporous strong acid ion exchange resin (D72) as an adsorbent for praseodymium (Ⅲ) was examined. The adsorption behavior and mechanism were investigated with various chemical methods and IR spectrometry. The results showed that the loading of Pr (III) ions was strongly dependent on pH of the medium and the optimal adsorption condition is in HAc-NaAc medium with pH value of 3.0. Adsorption kinetics of Pr (III) ions onto D72 resin could be best described by pseudo-second-order model. The maximum adsorption capacity of D72 for Pr (Ⅲ) was evaluated to be 294 mg·g 1 for the Langmuir model at 298K. The apparent activation energy, E a , was 14.71 kJ·mol 1 . The calculated data of thermodynamic parameters, ΔSΘ value of 100 J·mol 1 ·K 1 and ΔHΘ value of 8.89 kJ·mol 1 , indicate the endothermic nature of the adsorption process, while a decrease of ΔGΘ with increasing temperature indicates the spontaneous nature of the adsorption process. Finally, Pr (Ⅲ) can be eluted by using 1.00 mol·L 1 HCl-0.50 mol·L 1 NaCl solution and the D72 resin can be regenerated and reused. Thomas model was successfully applied to experimental data to predict the breakthrough curves and to determine the characteristic parameters of the column useful for process design. The characterization before and after adsorption of Pr (Ⅲ) ions on D72 resin was conformed by IR.

关键词：离子交换树脂镨(Ⅲ) 吸附剂 Langmuir模型水溶液解吸 NaCl溶液二阶模型

Metabolite profiling and transcriptome analyses reveal novel regulatory mechanisms of melatonin biosynthesis in hickory

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Horticulture research 2021年第1期8卷 2637-2649页

作者： Wenchao Chen Jiaqi Zhang Shan Zheng Zhanqi Wang Chuanmei Xu Qixiang Zhang Jiasheng Wu Heqiang Lou State key Laboratory of Subtropical Silviculture Zhejiang A&F University311300 HangzhouZhejiangChina key Laboratory of Vector Biology and Pathogen Control of zhejiang Province College of Life SciencesHuzhou University313000 HuzhouChina

Studies have shown that melatonin regulates the expression of various elements in the biosynthesis and catabolism of plant *** contrast,the effects of these different plant hormones on the biosynthesis and metabolism of melatonin and their underlying molecular mechanisms are still *** this study,the melatonin biosynthesis pathway was proposed from constructed metabolomic and transcriptomic libraries from hickory(Carya cathayensis Sarg.)*** candidate pathway genes were further identified by phylogenetic analysis,amino-acid sequence alignment,and subcellular ***,most of the transcription factor-related genes coexpressed with melatonin pathway genes were hormone-responsive ***,dual-luciferase and yeast one‐hybrid assays revealed that CcEIN3(response to ethylene)and CcAZF2(response to abscisic acid)could activate melatonin biosynthesis pathway genes,a tryptophan decarboxylase coding gene(CcTDC1)and an N-acetylserotonin methyltransferase coding gene(CcASMT1),by directly binding to their promoters,*** results provide a molecular basis for the characterization of novel melatonin biosynthesis regulatory mechanisms and demonstrate for the first time that abscisic acid and ethylene can regulate melatonin biosynthesis.

关键词： metabolism mechanisms melatonin

基于网络的整合心理干预对新冠肺炎患者抑郁焦虑症状的改善作用

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Journal of zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第5期21卷 400-404页

作者： Ning WEI Bo-chao HUANG Shao-jia LU Jian-bo HU Xiao-yi ZHOU Chan-chan HU Jing-kai CHEN Jin-wen HUANG Shu-guang LI Zheng WANG Dan-dan WANG Yi XU Shao-hua HU Department of Psychiatry the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China The key Laboratory of Mental Disorder's Management of zhejiang Province Hangzhou 310003China zhejiang Engineering Center for Mathematical Mental Health Hangzhou 310003China

目的:探讨基于网络的整合心理干预对新冠肺炎患者抑郁焦虑症状的有效性。创新点:针对大规模公共卫生事件的患者,首次采用基于网络的整合心理干预技术开展抑郁焦虑症状的治疗。这不仅能够让隔离患者更便捷地获得心理干预,而且减少了心理... 详细信息

目的:探讨基于网络的整合心理干预对新冠肺炎患者抑郁焦虑症状的有效性。创新点:针对大规模公共卫生事件的患者,首次采用基于网络的整合心理干预技术开展抑郁焦虑症状的治疗。这不仅能够让隔离患者更便捷地获得心理干预,而且减少了心理医生的感染暴露机会。方法:纳入26例伴有抑郁焦虑症状的新冠肺炎患者,随机分为干预组和对照组。干预组给予基于网络的整合心理干预,患者在医生指导下,通过智能手机聆听音频材料,并接受整合心理干预,包括放松训练、正念治疗、"安全地"技术和蝴蝶拥抱法;对照组则给予支持性心理治疗。通过HAMD-17与HAMA量表评估患者的抑郁焦虑水平。我们发现在1周末及2周末干预组患者HAMD-17与HAMA减分均明显优于对照组。结论:基于网络的整合心理干预可有效改善伴有抑郁焦虑症状的新冠肺炎患者的情绪症状,且对隔离患者来说更便捷,也减少了心理医生的感染暴露机会。

关键词：新冠肺炎基于网络的整合心理干预抑郁焦虑

Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2

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National Science Review 2021年第3期8卷 29-41页

作者： Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin CAS key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences State key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical Sciences Beijing Engineering research Center of Protein and Antibody Sinocelltech Ltd. Division of Animal Model research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC) School of Basic Medical Sciences Southwest Medical University Division of HIV/AIDS and Sex-Transmitted Virus Vaccines Institute for Biological Product Control NIFDC Beijing key Laboratory of Monoclonal Antibody research and development Sino Biological Inc. Cell Culture Engineering Center Chinese Academy of Medical Sciences &Peking Union Medical College Guangzhou Regenerative Medicine and Health Guangdong Laboratory

Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by *** these steps can cure *** we have identified and characterized a potent human monoclonal antibody,HB27,that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM ***,HB27 can also prevent SARS-CoV-2 membrane ***,a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse *** macaques showed no obvious adverse events when administrated with10 times the effective dose of ***-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 *** of the antibody also restrains any further conformational changes of the receptor binding domain,possibly interfering with progression from the prefusion to the postfusion *** results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19.

关键词： SARS-CoV-2 COVID-19 in vivo protection preclinical safety evaluation human neutralizing antibody immuno-therapy cryo-EM structure

Overhauling the assessment of agrochemical-driven interferences with microbial communities for improved global ecosystem integrity

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Environmental Science and Ecotechnology 2020年第4期4卷 12-17页

作者： Mengcen Wang Tomislav Cernava Ministry of Agriculture key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of Pesticide and Environmental ToxicologyZhejiang UniversityHangzhou310058China Institute of Environmental Biotechnology Graz University of TechnologyGraz8010Austria

Recent studies have shown that various agrochemicals can substantially affect microbial communities;especially those that are associated with cultivated *** certain circumstances,up to 50% of the naturally occurring microorganisms can be negatively affected by common agricultural practices such as seed coating with fungicide-based ***,the off-target effects of commonly applied agrochemicals are still understudied in terms of their interferences with microbial *** the same time,agrochemical inputs are steadily increasing due to the intensification of agriculture and the increasing pathogen pressure that is currently observed *** this article,we briefly reflect on the current knowledge related to pesticide interference with microbial communities and discuss negative implications for the plant holobiont as well as such that are spanning beyond local system *** effects of pesticide inputs that cause alterations in microbial functioning likely have unforeseen implications on geochemical cycles that should be addressed with a high priority in ongoing research.A holistic assessment of such implications will allow us to objectively select the most suitable means for food production under the scenario of a growing global population and aggravating climatic *** present three hypothetical solutions that might facilitate a more sustainable and less damaging application of pesticides in the future.

关键词： Pesticides Sustainable agriculture Microbiome Microbial ecology Agrochemicals

Photooxidation stability of phytosterols with different relative spatial positions in different particles

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Food Innovation and Advances 2023年第3期2卷 225-232页

作者： Jingjian Liu Dan Wang Ping Shao Simin Feng Department of Food Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina key Laboratory of Food Macromolecular Resources Processing Technology research(zhejiang University of Technology) China National Light IndustryHangzhou 310014China

The aim of this study was to investigate the effects of relative spatial position of stigmasterol on its photooxidation stability in different *** oxidation products(POPs)from phytosterol oxidation were successfully isolated and studied using solid phase extraction(SPE)technology in conjunction with *** photooxidation stability of stigmasterol in four particles was as follows:zein stabilized particles(ZPs)≈zein-pectin stabilized particles(ZPPs)>soy protein isolate(SPI)-pectin stabilized particles(SPPs)>SPI stabilized particles(SPs).7β-Hydroxy and 5β,6β-epoxy was the main POPs in the first and second oxidation stages,respectively,which reached 8,945±43μg/g and 6,010±289μg/g after 240 min UV light exposure treatment in *** stigmasterol was hydrophobically adsorbed on the surface of SPs,the network gel generated by pectin outside SPPs prevented photooxidation of *** stigmasterol was encapsulated in the interior of ZPs,the blocking effect of pectin in ZPPs became *** study provided a feasible development direction for the storage and quality control of phytosterols as dietary supplements.

关键词： stability photooxidation stabilized

二维铁电材料对单分子磁性调控的第一性原理研究

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Science Bulletin 2020年第15期65卷 1252-1259,M0003页

作者：王欣伟肖承诚杨超陈苗根杨声远胡军任召辉潘辉朱文光许祝安陆赟豪 State key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Departments of Materials and the Thomas Young Centre for Theory and Simulation of Materials Imperial College LondonLondon SW72AZUK Department of Physics China Jiliang University.Hangzhou 310018China research Laboratory for Quantum Materials Singapore University of Technology and DesignSingapore 487372Singapore School of Physical Science and Technology Soochow UniversitySuzhou 215006China Joint key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoMacao SARChina ICQD Hefei National Laboratory for Physical Science at the MicroscaleKey Laboratory of Strongly-Coupled Quantum Matter PhysicsChinese Academy of SciencesDepartment of Physicsand Synergetic Innovation Center of Quantum Information and Quantum PhysicsUniversity of Science and Technology of ChinaHefei 230026China zhejiang Province key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityHangzhou 310027China Collaborative Innovation Centre of Advanced Microstructures Nanjing UniversityNanjing 210093China

基于磁电效应,通过电场调控材料的磁性能有利于低能耗、高密度存储设备的应用和发展.以前的相关研究大多为通过压电效应或外加电场进行材料磁性的易失性调控,即材料的磁性改变无法在撤掉电场后维持.虽然可以产生自发极化且能在外电场作... 详细信息

基于磁电效应,通过电场调控材料的磁性能有利于低能耗、高密度存储设备的应用和发展.以前的相关研究大多为通过压电效应或外加电场进行材料磁性的易失性调控,即材料的磁性改变无法在撤掉电场后维持.虽然可以产生自发极化且能在外电场作用下改变极化方向的铁电材料为非易失调控提供了优异的平台,但随着材料尺度的减小,其自发极化逐渐减小甚至消失,很难在原子尺度实现电控磁性.二维铁电材料在实验上的成功制备,为实现原子尺度下的非易失调控提供了新的机遇.本文基于第一性原理提出了一种通过二维铁电基底调节分子磁性的方法.研究发现,不仅磁矩大小可以在零或非零之间转换,其易轴也可以在面内或面外之间反转,同时较大的磁各向异性能使其有望实现在室温以上的应用.该结果为二维铁电调控材料磁性的研究提供了新思路.

关键词：铁电材料高密度存储原子尺度自发极化极化方向磁电效应易失性压电效应