Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI
作者机构：Department of Ultrasoundthe First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhouChina Department of RadiologyZhejiang Provincial People's HospitalHospital of Hangzhou Medical CollegeHangzhouChina Department of Radiologythe First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhouChina Translational Medicine Research CenterKey Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouChina Department of PsychiatryYale University School of MedicineNew HavenConnecticutUSA Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina
出 版 物：《General Psychiatry》 (综合精神医学（英文）)
年 卷 期：2020年第33卷第4期
页 面：188-193页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100203[医学-老年医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：This study was funded by Science and Technology Department of Zhejiang Province(2014C33126) Public Welfare Technology Research and Social Development Projects(2014-) This study is also funded by the National Natural Science Foundation of China(81201057) Shanghai Municipal Health Bureau Project(20124109) Chinese Medical Association,Psychiatry-Servier Youth Research Fund,Shanghai Mental Health Center international cooperation project(2013-) Shanghai Municipal Center for Mental Health Clinical Research Program.This study is funded by Key Research Project of Zhejiang TCM Science and Technology Plan of China(2018ZZ010)
主 题：alterations Alzheimer patients
摘 要：Background The prevalence of Alzheimer s disease(AD)comorbid with depression is ***,the mechanisms of AD with depression remain *** To investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging(rs-fMRI).Methods 154 patients with AD who met the inclusion criteria were recruited from the Zhejiang Provincial People’s Hospital from October 2014 to October *** to whether the core symptoms of depression were present,patients were divided into two groups,22 patients with AD with depression(AD-D)and 52 patients with AD without depression(AD-nD).The amplitude of low frequency fluctuations(ALFF)was compared between two groups by performing independent-samples *** Compared with the AD-D group,increased ALFF values in the bilateral superior frontal gyrus,left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD *** brain activity in the AD-nD group in the bilateral superior frontal gyrus,left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D *** Resting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms.
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