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Translational Neurodegeneration 2023年第1期12卷 791-800页

作者： Vaibhav Sharma Fredrik Nikolajeff Saroj Kumar Department of Health Education and TechnologyLulea University of TechnologyLuleaSweden Department of Biophysics All India Institute of Medical SciencesNew DelhiIndia

Neurodegenerative diseases are a set of progressive and currently incurable diseases that are primarily caused by neuron *** diseases often lead to cognitive impairment and *** is now well recognized that molecular events precede the onset of clinical symptoms by *** the past decade,intensive research attempts have been aimed at the early diagnosis of these ***,exosomes have been shown to play a pivotal role in the occurrence and progression of many diseases including cancer and neurodegenerative ***,because exosomes can cross the blood-brain barrier,they may serve as a diagnostic tool for neural *** this review,we detail the mechanisms and current challenges of these diseases,briefly review the role of exosomes in the progression of neurodegenerative diseases,and propose a novel strategy based on salivary neuronal exosomes and nanoparticle tracking analysis that could be employed for screening the early onset of neurodegenerative diseases.

关键词： Exosomes Parkinson’s disease Alzheimer’s disease Neurodegenerative disease Diagnosis Prognosis Extracellular vesicles Nanoparticle tracking analysis

Metabolic changes in an animal model of amyotrophic lateral sclerosis evaluated by[^(18)F]-FDG positron emission tomography

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Translational Neurodegeneration 2021年第2期10卷 272-274页

作者： Bruno Lima Giacobbo Tomas Mediavilla Daniel JMarcellino Fahad Sultan Department of Integrative Medical Biology Umea UniversityUmeaSweden

Main text Energy metabolism has been proposed to be affected in amyotrophic lateral sclerosis(ALS),due to its relationship with SOD1^(G93A)-dependent mitochondrial loss-offunction[1,2].Although the metabolic state and the use of its dysfunction as an early diagnostic criterion have been evaluated in ALS patients by positron emission tomography(PET),preclinical research in animal models is *** this study,we imaged glucose metabolism using[^(18)F]-fluorodeoxyglucose(FDG)(NanoScan PET/CT,Mediso Medical Imaging Systems,Hungary)in both male and female mice expressing a mutated human SOD1 variant(hSOD1^(G93A))with ALS-like symptoms,and compared these animals to age-and sex-matched littermate controls(SOD1WT).

关键词： metabolism amyotrophic sclerosis

影响肝癌肝移植预后的高危因素分析及诊治经验

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中华医学杂志 2006年第18期86卷 1232-1235页

作者：贺轶锋樊嘉周俭吴志全邱双健黄晓武余耀孙健肖永胜杨国欢宋康王征汤钊猷王玉琦复旦大学肝癌研究所上海复旦大学附属中山医院200032

目的分析影响肝癌肝移植预后的临床病理因素,总结临床诊治经验。方法对198例肝癌肝移植患者临床病理特征进行生存率、无瘤生存率的比较(单因素分析),并通过Cox多因素分析得到有独立意义的预后指标。结果198例肝癌肝移植患者0.5年、1年、... 详细信息

目的分析影响肝癌肝移植预后的临床病理因素,总结临床诊治经验。方法对198例肝癌肝移植患者临床病理特征进行生存率、无瘤生存率的比较(单因素分析),并通过Cox多因素分析得到有独立意义的预后指标。结果198例肝癌肝移植患者0.5年、1年、2年生存率为89%、78%、65%,无瘤生存率为85%、73%、67%。单因素分析提示肿瘤大小、肿瘤侵犯血管程度、病理Edmondson分级、TNM分期、术前甲胎蛋白(AFP)影响患者无瘤生存率,并且前四个因素与患者生存率相关。Cox多因素分析示肿瘤侵犯血管是影响患者生存和肿瘤复发的独立因素。结论肿瘤侵犯血管是影响肝癌肝移植患者预后的重要因素,术前如何筛选出已有微小转移灶的患者以及如何在移植后预防肿瘤复发是肝癌肝移植发展的重要方向。

关键词：肝移植肝细胞癌预后因素复发生存

Suppressing the liquid product crossover in electrochemical CO_(2)reduction

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SmartMat 2021年第1期2卷 12-16页

作者： Ning Wang Rui Kai Miao Geonhui Lee Alberto Vomiero David Sinton Alexander H.Ip Hongyan Liang Edward H.Sargent School of Materials Science and Engineering Tianjin UniversityTianjinChina Department of Electrical and Computer Engineering University of TorontoTorontoOntarioCanada Department of Mechanical and Industrial Engineering University of TorontoTorontoOntarioCanada Department of Engineering Sciences and Mathematics Division of Materials ScienceLuleåUniversity of TechnologyLuleåSweden Department of Molecular Sciences and Nanosystems Ca’Foscari University of VeniceVeniceItaly

Coupling electrochemical CO_(2)reduction(CO_(2)R)with a renewable energy source to create high‐value fuels and chemicals is a promising strategy in moving toward a sustainable global energy ***_(2)R liquid products,such as formate,acetate,ethanol,and propanol,offer high volumetric energy density and are more easily stored and transported than their gaseous ***,a significant amount(~30%)of liquid products from electrochemical CO_(2)R in a flow cell reactor cross the ion exchange membrane,leading to the substantial loss of system‐level Faradaic *** severe crossover of the liquid product has—until now—received limited ***,we review promising methods to suppress liquid product crossover,including the use of bipolar membranes,solid‐state electrolytes,and cation‐exchange membranes‐based acidic CO_(2)R *** then outline the re-maining challenges and future prospects for the production of concentrated liquid products from CO_(2).

关键词： bipolar membranes CO_(2)reduction liquid product crossover solid‐state electrolytes

A framework to develop and test a model-free motion control system for a forestry crane

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Biomimetic Intelligence & Robotics 2023年第4期3卷 75-87页

作者： Pedro La Hera Omar Mendoza-Trejo Hakan Lideskog Daniel Ortíz Morales Swedish University of Agricultural Sciences Department of Forest Biomaterials and TechnologyUmea90183Sweden Lulea University of Technology Department of Engineering Sciences and MathematicsLulea 97187Sweden CRANAB AB Vindeln 92232Sweden

This article has the objective of presenting our method to develop and test a motion control system for a heavy-duty hydraulically actuated manipulator,which is part of a newly developed prototype featuring a fully-autonomous unmanned forestry *** control algorithm is based on functional analysis and differential algebra,under the concepts of a new type of approach known as model-free intelligent PID control(iPID).As it can be unsafe to test this form of control directly on real hardware,our main contribution is to introduce a framework for developing and testing control *** framework incorporates a desktop-size mockup crane equipped with comparable hardware as the real one,which we design and manufactured using *** downscaled mechatronic system allows to safely test the implementation of control software in real-time hardware directly on our desks,prior to the actual testing on the real *** results demonstrate that this development framework is useful to safely test control software for heavy-duty systems,and it helped us present the first experiments with the world’s first unmanned forestry machine capable of performing fully autonomous forestry tasks.

关键词： Model-free control Hydraulic manipulator Forestry crane control Intelligent PID control Forestry automation Controller implementation