Metabolic changes in an animal model of amyotrophic lateral sclerosis evaluated by[^(18)F]-FDG positron emission tomography

作     者：Bruno Lima Giacobbo Tomas Mediavilla Daniel JMarcellino Fahad Sultan Bruno Lima Giacobbo;Tomás Mediavilla;Daniel J.Marcellino;Fahad Sultan

作者机构：Department of Integrative Medical BiologyUmea UniversityUmeaSweden 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2021年第10卷第2期

页      面：272-274页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：BG was funded by a Kempestiftelserna grant to DM and FS.This study was also supported by the Department of Integrative Medical Biology UmeåUniversity(DM and FS)and from Umea University Medical Faculty(DM).Open Access funding provided by Umea University 

主　　题：metabolism amyotrophic sclerosis 

摘      要：Main text Energy metabolism has been proposed to be affected in amyotrophic lateral sclerosis(ALS),due to its relationship with SOD1^(G93A)-dependent mitochondrial loss-offunction[1,2].Although the metabolic state and the use of its dysfunction as an early diagnostic criterion have been evaluated in ALS patients by positron emission tomography(PET),preclinical research in animal models is *** this study,we imaged glucose metabolism using[^(18)F]-fluorodeoxyglucose(FDG)(NanoScan PET/CT,Mediso Medical Imaging Systems,Hungary)in both male and female mice expressing a mutated human SOD1 variant(hSOD1^(G93A))with ALS-like symptoms,and compared these animals to age-and sex-matched littermate controls(SOD1WT).