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Stress granules: friend or foe in neurodegenerative disorders?

Neural Regeneration Research 2024年第2期19卷 403-404页

作者： Shanshan Xu Nico P.Dantuma Department of Cell and Molecular Biology(CMB) Karolinska InstitutetSolnavägen 9S-17165 StockholmSweden

neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral sclerosis,despite the diversity in clinical symptoms,share a striking feature at the cellular level:the accumulation of insoluble aggregates of misfolded proteins that are sequestered in intraneuronal inclusion *** mutations in disease-associated proteins that render them aggregation-prone,the decline of protein homeostasis(***)with aging is also believed to be a contributing factor to the accumulation of protein aggregates.

关键词： degenerative homeostasis clinical

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Engineering Solutions for Representative Models of the Gastrointestinal Human-Microbe Interface

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Engineering 2017年第1期3卷 60-65页

作者： Marc Mac Giolla Eain Joanna Baginska Kacy Greenhalgh Joelle V. Fritz Frederic Zenhausen Paul Wilmes Luxembourg Centre for Systems Biomedidne University of Luxembourg Esch-sur-Alzette L 4362 Luxembourg Center for Applied Nanobioscience and Medicine University of Arizona Tucson AZ 85721 USA

Host-microbe interactions at the gastrointestinal interface have emerged as a key component in the governance of human health and disease. Advances in micro-physiological systems are providing researchers with unprecedented access and insights into this complex relationship. These systems combine the benefits of microengineering, microfluidics, and cell culture in a bid to recreate the environmental con- ditions prevalent in the human gut. Here we present the human-microbial cross talk （HuMiX） platform, one such system that leverages this multidisciplinary approach to provide a representative in vitro model of the human gastrointestinal interface. HuMiX presents a novel and robust means to study the molecular interactions at the host-microbe interface. We summarize our proof-of-concept results obtained using the platform and highlight its potential to greatly enhance our understanding of host-microbe interactions with a potential to greatly impact the pharmaceutical, food, nutrition, and healthcare industries in the future. A number of key questions and challenges facing these technologies are also discussed.

关键词： Microbiome Microfluidics Organ-on-a-chip HuMiX

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