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Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance

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journal of Sport and Health Science 2023年第2期12卷 194-201页

作者： Wouter M.A.Franssen Charly Keytsman Nastasia Marinus Kenneth Verboven Bert O.Eijnde Lisa van Ryckeghem Paul Dendale Renate Zeevaert Guy Massa Dominique Hansen Rehabilitation Research Centre(REVAL) Faculty of Rehabilitation SciencesHasselt UniversityHasselt 3500Belgium Biomedical Research Institute(BIOMED) Faculty of Medicine and Life SciencesHasselt UniversityHasselt 3500Belgium ADLON Sports Medical Center Hasselt 3500Belgium Heart Centre Hasselt Jessa HospitalHasselt 3500Belgium Department of Pediatric Endocrinology and Diabetology Jessa HospitalHasselt 3500Belgium

Background:Adults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing,which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular *** is unknown whether cardiac chronotropic incompetence(CI)during maximal exercise is already present in obese adolescents and,if so,how that relates to cardiometabolic ***:Sixty-nine obese adolescents(body mass index standard deviation score=2.23±0.32,age=14.1±1.2 years;mean±SD)and 29lean adolescents(body mass index standard deviation score=-0.16±0.84,age=14.0±1.5 years)performed a maximal cardiopulmonary exercise testing from which indicators for peak performance were *** resting heart rate and peak heart rate were used to calculate the maximal chronotropic response ***(lipid profile,glycemic control,inflammation,and leptin)was studied in fasted blood samples and during an oral glucose tolerance test within obese *** analyses were applied to examine associations between the presence of CI and blood or exercise capacity parameters,respectively,within obese ***:CI was prevalent in 32 out of 69 obese adolescents(46%)and 3 out of 29 lean adolescents(10%).C-reactive protein was significantly higher in obese adolescents with CI compared to obese adolescents without CI(p=0.012).Furthermore,peak oxygen uptake and peak cycling power output were significantly reduced(p<0.05)in obese adolescents with CI *** adolescents without *** chronotropic index was independently related to blood total cholesterol(standardized coefficientβ=-0.332;p=0.012)and C-reactive protein concentration(standardized coefficientβ=-0.269;p=0.039).Conclusion:CI is more common in the current cohort of obese adolescents,and is related to systemic inflammation and exercise intolerance.

关键词： Adolescents Cardiometabolic health Exercise tolerance Heart rate Obesity

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Turnkey algorithmic approach for the evaluation of gastroesophageal reflux disease after bariatric surgery

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Gastroenterology Report 2023年第1期11卷 123-130页

作者： Omar M.Ghanem Rabih Ghazi Farah Abdul Razzak Fateh Bazerbachi Karthik Ravi Leena Khaitan Shanu N.Kothari Barham K.Abu Dayyeh Department of Surgery Mayo ClinicRochesterMNUSA Department of Medicine Mayo ClinicRochesterMNUSA CentraCare Interventional Endoscopy ProgramSt Cloud HospitalSt CloudMNUSA Department of Surgery CaseWestern Reserve UniversityClevelandOHUSA Department of Surgery Prisma HealthGreenvilleSCUSA

Bariatric surgeries are often complicated by de-novo gastroesophageal reflux disease(GERD)or worsening of pre-existing *** growing rates of obesity and bariatric surgeries worldwide are paralleled by an increase in the number of patients requiring post-surgical GERD ***,there is currently no standardized approach for the assessment of GERD in these *** this review,we delineate the relationship between GERD and the most common bariatric surgeries:sleeve gastrectomy(SG)and Roux-en-Y gastric bypass(RYGB),with a focus on pathophysiology,objective assessment,and underlying anatomical and motility *** suggest a stepwise algorithm to help diagnose GERD after SG and RYGB,determine the underlying cause,and guide the management and treatment.

关键词： RYGB sleeve gastrectomy bariatric surgery gastroesophageal reflux disease GERD

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Current progress in innovative engineerec antibodies

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Protein & Cell 2018年第1期9卷 86-120页

作者： William R. Strohl BiStro Biotech Consulting Bridgewater NJ 08807 USA

As of May 1, 2017, 74 antibody-based molecules have been approved by a regulatory authority in a major market. Additionally, there are 70 and 575 antibody- based molecules in phase III and phase 1/11 clinical trials, respectively. These total 719 antibody-based clinical stage molecules include 493 naked IgGs, 87 antibody- drug conjugates, 61 bispecific antibodies, 37 total Fc fusion proteins, 17 radioimmunoglobulins, 13 antibody fragments, and 11 immunocytokines. New uses for these antibodies are being discovered each year. For oncol- ogy, many of the exciting new approaches involve anti- body modulation of T-cells. There are over 80 antibodies in clinical trials targeting T cell checkpoints, 26 T-cell- redirected bispecific antibodies, and 145 chimeric anti- gen receptor （CAR） cell-based candidates （all currently in phase I or II clinical trials）, totaling more than 250 T cell interacting clinical stage antibody-based candi- dates. Finally, significant progress has been made recently on routes of delivery, including delivery of proteins across the blood-brain barrier, oral delivery to the gut, delivery to the cellular cytosol, and gene- and viral-based delivery of antibodies. Thus, there are cur- rently at least 864 antibody-based clinical stage mole- cules or cells, with incredible diversity in how they are constructed and what activities they impart. These are followed by a next wave of novel molecules, approa- ches, and new methods and routes of delivery, demon- strating that the field of antibody-based biologics is very innovative and diverse in its approaches to fulfill their promise to treat unmet medical needs.

关键词： antibody clinical candidates engineered antibodies chimeric antigen receptors

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用静电模壁润滑—温压复合工艺增高粉末冶金零件生坯与烧结件性能

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粉末冶金技术 2006年第3期24卷 227-232页

作者： P.Lemieux Y.Thomas P.E.Mongeon S.Pelletier S.St-Laurent 郭瑞金韩凤麟（译） Industrial Materials Institute National Research Council 75 de MortagneBouchervilleQuebecCanada J4B 6Y4 Quebec Metal Powders Limited 1655 Marie VictorinSorel-TracyQuebec J3R 4R4 不详

对于生产静态与动态力学性能高的粉末冶金零件,在合理价格下,使零件材料达到高密度,有一定效益。采用温压—模壁润滑复合工艺是增高粉末冶金零件材料密度的一条很受人关注的途径。在试验室条件下进行的一些研究证实了这条工艺路线的潜... 详细信息

对于生产静态与动态力学性能高的粉末冶金零件,在合理价格下,使零件材料达到高密度,有一定效益。采用温压—模壁润滑复合工艺是增高粉末冶金零件材料密度的一条很受人关注的途径。在试验室条件下进行的一些研究证实了这条工艺路线的潜力。在工业生产条件下,对于这种复合工艺的实际效益需要进一步探索。为确定这种复合工艺使材料达到较高密度,从而达到较高的力学性能方面能达到何种程度,在工业生产用机械式压机上进行了试验研究。这篇论文对这种复合工艺和常规的冷压与温压工艺,以及冷压—模壁润滑复合工艺的效益进行了比较与评估。

关键词：温压静电模壁润滑粉末冶金零件

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UCPC的并联补偿单元设计

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电力系统自动化 2000年第12期24卷 25-28,64页

作者：王志泳刘文华詹长江清华大学电机系北京100084

并联补偿单元是用户电力统一调节器 ( UCPC)的基本单元 ,由于并联补偿单元和串联补偿单元在拓扑上具有良好的对称性 ,因此 ,并联补偿单元的研究对 UCPC的研制具有相当的普遍意义。文中给出了基于三电平变流器的并联补偿单元的主电路以... 详细信息

并联补偿单元是用户电力统一调节器 ( UCPC)的基本单元 ,由于并联补偿单元和串联补偿单元在拓扑上具有良好的对称性 ,因此 ,并联补偿单元的研究对 UCPC的研制具有相当的普遍意义。文中给出了基于三电平变流器的并联补偿单元的主电路以及驱动与保护系统的设计 ,成功解决了主电路中器件耐压问题 ,并降低了输出电压电流中的谐波含量 ;同时还给出了基于双 DSP的先进的全数字控制系统的设计 ,快速 DSP的使用是实现基于重复控制和无差拍控制的上层算法和基于电压空间矢量的脉冲发生器的重要保证 ;在控制策略上 ,由于在无差拍控制的基础上采用了重复控制的原理 ,变流器可以同时完成谐波、无功与不对称的补偿。实验结果证明了设计的正确性 ,也表明UCPC并联单元的研制取得了阶段性成功。

关键词：电能质量并联补偿单元 DSP UCPC 电力系统

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Interim Results of a Phase 1-2a Trial of ***2.S Covid-19 Vaccine

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四川生理科学杂志 2021年第1期43卷 31-31页

作者： jerald Sadoff From janssen Vaccines and Prevention Leiden the Netherlands (J. Sadoff M.L.G. G. Shukarev A.M.G. J. Stoop S.T. E.C. G. Scheper J. Hendriks M.D. J.V.H. H.S.) janssen Research and Development Beerse (D.H. C.T. F.S.) Janssen Clinical Pharmacology Unit Merksem (W.V.D.) the Center for Vaccinology Ghent University Gent (I.L.-R.) SGS Life Sciences (P.-J.B.) and the Center for the Evaluation of Vaccination University of Antwerp (P.V.D.) Antwerp and the Center for Clinical Pharmacology University Hospitals Leuven Leuven (J. de Hoon) — all in Belgium Optimal Research Melbourne FL (M.K.) the Alliance for Multispecialty Research Knoxville TN (W.S.) the Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Boston (K.E.S. D.H.B.) and the Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle (S.C.D.R. K.W.C. M.J.M.).

Background:Efficacious vaccines are urgently needed to contain the ongoing coronavirus disease 2019(Covid-19)pandemic of infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).A candidate vaccine,***2.S,is a recombinant,replication-incompetent adenovirus serotype 26(Ad26)vector encoding a full-length and stabilized SARS-CoV-2 spike protein.

关键词： vaccine acute respiratory

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Measurement of chemosensory function

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World journal of Otorhinolaryngology-Head and Neck Surgery 2018年第1期4卷 11-28页

作者： Richard L. Doty Smell & Taste Center University of PennsylvaniaPhiladelphiaPA 19104USA Department of Otorhinolaryngology-Head and Neck Surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Although hundreds of thousands of patients seek medical help annually for disor-ders of taste and smell, relatively few medical practitioners quantitatively test their patients' chemosensory function, taking their complaints at face value. This is clearly not the approach paid to patients complaining of visual, hearing, or balance problems. Accurate chemosensory testing is essential to establish the nature, degree, and veracity of a patient's complaint, as well as to aid in counseling and in monitoring the effectiveness of treatment strategies and de-cisions. In many cases, patients perseverate on chemosensory loss that objective assessment demonstrates has resolved. In other cases, patients are malingering. Olfactory testing is crit-ical for not only establishing the validity and degree of the chemosensory dysfunction, but for helping patients place their dysfunction into perspective relative to the function of their peer group. It is well established, for example, that olfactory dysfunction is the rule, rather than the exception, in members of the older population. Moreover, it is now apparent that such dysfunction can be an early sign of neurodegenerative diseases such as Alzheimer's and Parkin-son's. Importantly, older anosmics are three times more likely to die over the course of an ensuring five-year period than their normosmic peers, a situation that may be averted in some cases by appropriate nutritional and safety counseling. This review provides the clinician, as well as the academic and industrial researcher, with an overview of the available means for accurately assessing smell and taste function, including up-to-date information and normative data for advances in this field.

关键词： Smell Taste Psychophysics Age Identification Detection Threshold Olfaction Anosmia Ageusia Hyposmia Hypogeusia

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Impact of antibiotics on smell dysfunction

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World journal of Otorhinolaryngology-Head and Neck Surgery 2018年第1期4卷 33-38页

作者： jing-jie Wang jonathan Chen Richard L. Doty Institute of Medicine Chung Shan Medical UniversityTaichungTaiwanChina Department of Otolaryngology Taichung Veterans General HospitalTaichungTaiwanChina Smell and Taste Center Department of Otorhinolaryngology - Head and Neck SurgeryPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

Objective: Viral or bacterial respiratory infections can cause long-lasting olfactory dysfunction. Antibiotic therapy is indicated in severe cases; however, it is unclear whether antibiotic use produces a positive, negative, or null effect on olfactory function. This retro-spective study sought to determine whether antibiotic use has an influence on odor identifica-tion and detection threshold test scores of patients with smell dysfunction secondary to upper respiratory infections (URIs), lower respiratory infections (LRIs), or rhinosinusitis. Methods: Data from a total of 288 patients presenting to the University of Pennsylvania Smell and Taste Center were evaluated. Results: Patients with a URI etiology who had taken bactericidal antibiotics had lower detec-tion thresholds than did patients who had not taken antibiotics (P < 0.023; analysis of covari-ance with age and time since infection onset as covariates). Moreover, thresholds were lower for bactericidal antibiotic users than for bacteriostatic antibiotic users with either URI (P = 0.023) or rhinosinusitis (P = 0.028) etiologies. No meaningful influences of antibiotics on the odor identification test scores were evident. Conclusions: These findings, which need to be confirmed in prospective double-blind studies, suggest that bactericidal antibiotic therapy may be beneficial in mitigating, at least to some degree, chronic decrements in smell sensitivity due to URIs and rhinosinusitis.

关键词： Antibiotics Rhinosinusitis Viruses Bacteria Olfaction

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动态多频数字锁相算法及其应用

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电子与信息学报 2009年第8期31卷 2006-2010页

作者：谢琼李建平高晓光贾建中国科学院电子学研究所传感技术国家重点实验室北京100190

该文提出一种动态多频锁相算法。与传统锁相方法相比,该算法不需要选择参考信号的类型,在继承了传统锁相方法高信噪比优点的基础上,能够锁出由一个基频和多个倍频分量合成的复合信号的幅值,从而获得更多的有用信息。同时,采用动态调整... 详细信息

该文提出一种动态多频锁相算法。与传统锁相方法相比,该算法不需要选择参考信号的类型,在继承了传统锁相方法高信噪比优点的基础上,能够锁出由一个基频和多个倍频分量合成的复合信号的幅值,从而获得更多的有用信息。同时,采用动态调整参考信号频率的方法,有效地解决了实际信号频率漂移引起的幅值求取误差问题。应用于NDIR红外气体浓度检测的结果表明,该算法可以增大检测量程,并提高系统检测灵敏度。

关键词：数字锁相频率漂移红外气体检测

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中国急性心肌梗死患者教育程度与预后的关联分析

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英国医学杂志中文版 2019年第4期22卷 243-243页

作者： Xiqian Huo Rohan Khera Lihua Zhang jeph Herrin Xueke Bai Qianying Wang Yuan Lu Khurram Nasir Shuang Hu jing Li Xi Li Xin Zheng Frederick A Masoudi john A Spertus Harlan M Krumholz Lixin jiang National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Division of Cardiology University of Texas Southwestern Medical Center at Dallas Dallas Texas USA. Section of Cardiovascular Medicine Department of Internal Medicine Yale University School of Medicine New Haven Connecticut USA. Center for Outcomes Research and Evaluation Yale-New Heaven Hospital New Heaven Connecticut USA. Division of Cardiology University of Colorado Anschutz Medical Campus Aurora Connecticut USA. Health Outcomes Research Saint Luke's Mid America Heart Institude/University of Missouri-Kansas City Kansas City Missouri USA. Department of Health Policy and Management Yale Univeristy School of Public Health New Heaven Connecticut USA.

目的中国是人口多样化、教育程度差异很大的国家,然而教育程度与我国急性心肌梗死(AMI)患者预后的相关性仍不清楚。本研究旨在探索AMI患者的教育程度与预后的相关性,以期进一步指导未来健康医疗干预的方向。方法研究基于China PEACE前瞻... 详细信息

目的中国是人口多样化、教育程度差异很大的国家,然而教育程度与我国急性心肌梗死(AMI)患者预后的相关性仍不清楚。本研究旨在探索AMI患者的教育程度与预后的相关性,以期进一步指导未来健康医疗干预的方向。方法研究基于China PEACE前瞻性AMI研究的数据,共纳入来自中国53家医院的3 369名连续入选的AMI患者,并根据其接受教育的程度分为高(高中、大学及研究生)、中(初中学位)、低(小学及小学以下)3个不同水平。采用生存模型分析不同教育程度与AMI后1年严重心血管病不良事件(MACE)发生率和全因病死率的关系,并校正了人口统计学和心血管危险因素等差异的影响。结果研究人群的中位年龄为61(52~69)岁,23.2%为女性,33.3%为高学历水平,32.4%为中等学历水平,34.3%为低学历水平。与高中、大学或研究生学历相比,小学或小学以下学历患者的1年MACE发生率更高(危害比2.41, 95%可信区间1.72~3.37),全因病死率也显著增高(危害比3.09, 95%可信区间1.69~5.65)。在校正人口统计学及共病因素后,教育程度与1年全因病死率的关联减弱(危害比1.41, 95%可信区间0.74~2.69, P=0.30),但教育程度与AMI后1年MACE的关联仍有统计学意义,且学历低的患者的不良事件发生风险是学历高者的近1.7倍(调整危害比1.68, 95%可信区间1.18~2.41, P=0.004)。结论在中国AMI住院患者人群中,教育程度较低的患者在AMI发病1年内发生不良心血管事件和全因死亡的风险更高。将来对AMI患者的健康干预应根据其教育程度的不同,有针对性地完善出院后的宣教和护理,以期改善患者预后。临床试验注册号NCT01624909。

关键词：急性心肌梗死患者教育预后中国人口统计学学历水平心血管危险因素不良心血管事件

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