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Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson's disease

Neural Regeneration research 2017年第5期12卷 747-748页

作者： Takashi Morishita Tooru Inoue Department of Neurosurgery Fukuoka University Faculty of Medicine Fukuoka Japan

Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric *** efforts to improve the clinical outcomes of the procedure have been prev... 详细信息

关键词： DBS Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson’s disease deep

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Myelin protein zero (P0)- and Wnt1-Cre marked muscle resident neural crest-derived mesenchymal progenitor cells give rise to heterotopic ossification in mouse models

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Genes & Diseases 2023年第3期10卷 731-734页

作者： Chengzhu Zhao Yoshiko Inada Kazuya Sekiguchi Kyosuke Hino Megumi Nishio Yasuhiro Yamada Shuichi Matsuda Junya Toguchida Makoto Ikeya Department of Clinical Application Center for iPS Cell Research and Application(CiRA)Kyoto UniversitySakyo-kuKyoto 606-8507Japan Laboratory of Skeletal Development and Regeneration Institute of Life SciencesChongqing Medical UniversityChongqing 400016China Department of Cell Growth and Differentiation Center for iPS Cell Research and Application(CiRA)Kyoto UniversitySakyo-kuKyoto 606-8507Japan Department of Orthopaedic Surgery Graduate School of MedicineKyoto UniversitySakyo-kuKyoto 606-8507Japan Regenerative&Cellular Medicine Kobe Center Sumitomo Pharma Co.Ltd.Konohana-kuOsaka 554-0022Japan Division of Stem Cell Pathology Center for Experimental Medicine and Systems BiologyInstitute of Medical ScienceUniversity of TokyoMinato-kuTokyo 108-8639Japan Department of Regeneration sciences and Engineering Institute for Frontier Life and Medical SciencesKyoto UniversitySakyo-kuKyoto 606-8507Japan

Heterotopic ossification(HO)describes bone formation at non-skeletal sites and results from traumatic injury,surgery,or genetic disease such as fibrodysplasia ossificans progressiva(FOP).1,2 Although it is known that BMP signaling regulates HO,knowledge about the developmental origin of the osteogenic progenitors responsible for the BMP-associated metamorphosis is comparably *** the use of transgenic mice and labelled neural crest-derived cell,3 we found myelin protein zero(P0,or MPZ)-and Wnt1-lineage cells give rise to BMP-7 induced adult ectopic cartilage and bone.

关键词： progenitor ossification neural

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Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury

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Cellular & Molecular Immunology 2021年第5期18卷 1249-1261页

作者： Ryota Sakai Minako Ito Kyoko Komai Mana Iizuka-Koga Kazuhiko Matsuo Takashi Nakayama Osamu Yoshie Koichi Amano Hiroshi Nishimasu Osamu Nureki Masato Kubo Akihiko Yoshimura Department of Microbiology and Immunology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Department of Rheumatology and Clinical Immunology Saitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan medical Institute of Bioregulation Kyushu University 3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of Chemotherapy Kindai University Faculty of PharmacyHigashi-Osaka577-8502Japan The Health and Kampo Institute SendaiMiyagi981-3205Japan Department of Biological science Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Animal Disease Models Research Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan

FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral immune *** addition,Tregs that reside or accumulate in nonlymphoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and *** an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease *** depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence *** Tregs that accumulated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,ST2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the *** understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient *** experiment demonstrates that ST2,Areg,and CCR4 in Tregs play important roles in the accumulation of GATA3^(+) Tregs in the kidney and in the amelioration of renal *** data suggest that GATA3 is important for the recruitment of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction.

关键词： Tissue Tregs autoantibody GATA3 kidney IL-33

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Resolution of inflammation and repair after ischemic brain injury

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Neuroimmunology and Neuroinflammation 2020年第3期7卷 264-276页

作者： Akihiko Yoshimura Minako Ito Department of Microbiology and Immunology Keio University School of MedicineTokyo 160-8582Japan Division of Allergy and Immunology Medical Institute of Bioregulation Kyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan

After ischemic stroke, proinflammatory molecules known as danger-associated molecular patterns (DAMPs) originating from damaged brain cells recruit and activate immune cells (neutrophils, macrophages, lymphocytes) further eliciting innate and adaptive immunity. During the acute phase from day 1 to day 3 of the stroke onset, macrophages play a major role in the progression of inflammation, promoting the destruction of brain tissue. During the recovery phase, from day 3~4 to day 7 after stroke onset, infiltrating macrophages switch to repairing macrophages, which clear the DAMPs and promote tissue repair by producing neurotrophic factors. Adaptive immunity during the late or chronic phase (> day 7) of stroke has not been well investigated. Recent studies have also indicated that antigen-specific T cells, especially regulatory T cells (Tregs), play major roles in neural repair. This review focuses mainly on the resolution of inflammation and tissue repair by macrophages and Tregs.

关键词： DAMPs tissue repair macrophages regulatory T cells amphiregulin IL-33

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