检索结果-南通市图书馆

Reconfigurable elastomeric graded-index optical elements controlled by light

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2018年第1期7卷 964-972页

作者： Angelo Angelini Federica Pirani Francesca Frascella Emiliano Descrovi Department of Applied Science and Technology(DISAT) Politecnico di TorinoC.so Duca degli Abruzzi 24Torino IT-10129Italy Center for Sustainable Future Technologies@PoliTo Istituto Italiano di TecnologiaC.so Trento 21Torino IT-10129Italy

In many optical applications,there is an increasing need for dynamically tunable optical elements that are able to shape the wavefront of light‘on demand’.In this work,an elastomeric easy-to-fabricate optical element whose transmission functions can be reversibly phase configured by visible light is *** light responsivity of proper azopolymers incorporated within an elastomeric matrix is exploited to induce a light-controlled graded refractive index(GRIN)distribution within the bulk *** induced refractive index distribution is continuous and conformal to the intensity profile of the illumination at moderate power.A 100mW doubled-frequency Nd:YAG Gaussian beam focused to a 650μm waist is shown to induce a maximum relative refractive index change of~0.4%in the elastomeric matrix,with an approximately parabolic *** restoring characteristics of the elastomeric matrix enable full recovery of the initial homogeneous refractive index distribution within a few seconds when the incident laser is switched *** an exemplary application,the configurable GRIN element is used in a microscope-based imaging system for light control of the effective focal length.

关键词： optical switched index

Amyloid fragments and their toxicity on neural cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2019年第2期6卷 121-127页

作者： Eva Bystrenova Zuzana Bednarikova Marianna Barbalinardo Cristiano Albonetti Francesco Valle Zuzana Gazova Institute of Nanostructured Materials I.S.M.N–C.N.R. via Gobetti101Bologna 40129Italy Department of Biophysics Institute of Experimental Physics SASWatsonova 47Kosice 04353Slovakia

The formation of amyloid fibrils from soluble proteins is a common form of self-assembly phenomenon that has fundamental connections with biological functions and human *** was converted from its soluble native state into highly organized amyloid *** treatment was used to break amyloid fibrils to fibrillar fragments–*** force microscopy and fluorescence microscopy was employed to characterize the morphology of the amyloid assemblies and neural cells–amyloid *** results demonstrate that prefibrillar intermediated and their mixture with proteins exhibit toxicity,although native proteins and fibrils appear to have no effect on number of *** findings confirm that innocuous hen lysozyme can be engineered to produce both cytotoxic fibrillar fragments and non-toxic mature amyloid *** work further strengthens the claim that amyloid conformation,and not the identity of the protein,is key to cellular toxicity and the underlying specific cell death mechanism.

关键词： amyloid fibrils protein aggregation neural cells atomic force microscopy fluorescence microscopy

Multimodal nonlinear microscopy: A powerful label-free method for supporting standard diagnostics on biological tissues

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2014年第5期7卷 1-16页

作者： Riccardo Cicchi Francesco Saverio Pavone National Institute of Optics National Research Council(INO-CNR)Largo E.Fermi6 50125 FlorenceItaly European Laboratory for Nonlinear Spectroscopy(LENS)University of Florence Sesto FiorentinoItaly Department of Physics University of Florence Sesto FiorentinoItaly International Center of Computational Neurophotonics(ICON)Florence Italy

The large use of nonlinear laser scanning microscopy in the past decade paved the way forpot ential clinical application of this imaging *** nonlinear microscopy techniquesoffer promising label-free solutions to improve diagnostic performances on *** particular,the combination of multiple nonlinear imaging techniques in the same microscope allows inte-grating_morphological with functional information in a morpho-functional *** provides a high-resolution label-free alternative to both histological and immunohis-tochemicai examination of tissues and is becoming increasingly popular among the ***,several technical improvements,including automatic scanning andimage analysis,are required before the technique represents a standard diagnostic *** thisreview paper,we highlight the capabilit ies of multimodal nonlinear microscopy for tissue inaging,by providing various examples on colon,arterial and skin *** comparison between images acquired using multimodal nonlinear microscopy and histology shows a good agreement bet ween the two *** results demonstrate that multimodal nonlinear microscopy is apowerful label-free alternative to standard histopathological methods and has the potential tofind a stable place in the clinical setting in the near future.

关键词： Non-linear microscopy tissue imaging.

ADVANCED OPTICAL TECHNIQUES TO EXPLORE BRAIN STRUCTURE AND FUNCTION

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2013年第1期6卷 1-15页

作者： L.SILVESTRI A.L.ALLEGRA MASCARO J.LOTTI L.SACCONI F.S.PAVONE European Laboratory for Nonlinear Spectroscopy(LENS)University of Florence Italy National Institute of Optics(INO-CNR) Sesto FiorentinoItaly Department of Physics University of FlorenceItaly International Center for Computational Neurophotonics-ICON Foundation FlorenceItaly

Understanding brain structure and function,and the complex relationships bet ween them,is one of the grand challenges of contemporary *** to their fexiblity,optical techniques could be the key to explore this complex *** this manuscript,we briefly review recent adv ancements in optical methods applied to three main issues:anatomy,plasticity and *** describe novel implement ations of light-sheet microscopy to resolve neuronal anat-omy in whole fixed brains with cellular *** to liv ing samples,we show how real-time dynamics of brain rewiring can be visualized through two-photon microscopy with the spatial resolution of single synaptic *** plasticity of the injured brain can also be dissected through cut ting edge optical methods that specifically ablate single neuronal ***,we report how nonlinear microscopy in combination with novel voltage sensitive dyes allow optical registrations of action potential across a population of neurons opening promising prospective in understanding brain *** knowledge acquired from these complementary optical methods may provide a deeper comprehension of the brain and of its unique features.

关键词： Brain optical microscopy light sheet microscopy two-photon microscopy