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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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Uncertainties of nuclear level density estimated using Bayesian neural networks

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Chinese Physics C 2024年第8期48卷 185-189页

作者： Xinyu Wang Ying Cui Yuan Tian Kai Zhao Yingxun Zhang China institute of Atomic Energy Beijing 102413China China Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China

Nuclear level density(NLD)is a critical parameter for understanding nuclear reactions and the structure of atomic nuclei;however,accurate estimation of NLD is challenging owing to limitations inherent in both experimental measurements and theoretical *** paper presents a sophisticated approach using Bayesian neural networks(BNNs)to analyze NLD across a wide range of *** uniquely incorporates the assessment of model *** application of BNNs demonstrates remarkable success in accurately predicting NLD values when compared to recent experimental data,confirming the effectiveness of our *** reliability and predictive power of the BNN approach not only validates its current application but also encourages its integration into future analyses of nuclear reaction cross sections.

关键词： Bayesian neural network nuclear reaction nuclear level density

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Strong-field photoelectron holography in the subcycle limit

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Light(science & Applications) 2024年第6期13卷 1032-1040页

作者： Tsendsuren Khurelbaatar Jaewuk Heo ShaoGang Yu XuanYang Lai XiaoJun Liu Dong Eon Kim Center for Attosecond science and Technology Department of PhysicsPohang University of Science and TechnologyPohangGyeongbuk37673Korea Max Planck POSTECH/KOREA Research Initiative PohangGyeongbuk37673Korea State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences430071WuhanChina Wuhan institute of Quantum Technology 430206WuhanChina

Strong-field photoelectron holography is promising for the study of electron dynamics and structure in atoms and molecules,with superior spatiotemporal resolution compared to conventional electron and X-ray ***,the application of strong-field photoelectron holography has been hindered by inter-cycle interference from multicycle ***,we address this challenge by employing a near-single-cycle field to suppress the inter-cycle *** observed and separated two distinct holographic patterns for the first *** measurements allow us not only to identify the Gouy phase effect on electron wavepackets and holographic patterns but also to correctly extract the internuclear separation of the target molecule from the holographic *** work leads to a leap jump from theory to application in the field of strong-field photoelectron holography-based ultrafast imaging of molecular structures.

关键词： photoelectron holographic cycle

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MXene Enhanced 3D Needled Waste Denim Felt for High‑Performance Flexible Supercapacitors

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Nano-Micro Letters 2024年第2期16卷 383-394页

作者： Wei Fan Qi Wang Kai Rong Yang Shi Wanxi Peng Handong Li Zhanhu Guo Ben Bin Xu Hua Hou Hassan Algadi Shengbo Ge Key Laboratory of Functional Textile Material and Product of the Ministry of Education School of Textile Science and EngineeringInstitute of Flexible electronics and Intelligent TextileXi’an Polytechnic UniversityXi’an 710048People’s Republic of China Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China Henan Province International Collaboration Lab of Forest Resources Utilization School of ForestryHenan Agricultural UniversityZhengzhou 450002People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Electrical Engineering Faculty of EngineeringNajran University11001 NajranSaudi Arabia

MXene,a transition metal carbide/nitride,has been prominent as an ideal electrochemical active material for ***,the low MXene load limits its practical *** environmental concerns and sustainable development become more widely recognized,it is necessary to explore a greener and cleaner technology to recycle textile by-products such as *** present study proposes an effective 3D fabrication method that uses MXene to fabricate waste denim felt into ultralight and flexible supercapacitors through needling and *** 3D structure provided more sites for loading MXene onto Z-directional fiber bundles,resulting in more efficient ion exchange between the electrolyte and ***,the carbonization process removed the specific adverse groups in MXenes,further improving the specific capacitance,energy density,power density and electrical conductivity of *** electrodes achieve a maximum specific capacitance of 1748.5 mF cm-2 and demonstrate remarkable cycling stability maintaining more than 94%after 15,000 galvanostatic charge/discharge ***,the obtained supercapacitors present a maximum specific capacitance of 577.5 mF cm^(-2),energy density of 80.2μWh cm^(-2)and power density of 3 mW cm^(-2),*** resulting supercapacitors can be used to develop smart wearable power devices such as smartwatches,laying the foundation for a novel strategy of utilizing waste cotton in a high-quality manner.

关键词： MXene 3D needled waste denim felt Supercapacitors Carbonization

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Gp78 regulates PMP22 and causes ER stress and autophagy in EV71-VP1-overexpressing mouse Schwann cells

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BIOCELL 2024年第4期48卷 653-664页

作者： DANPING ZHU GUANGMING LIU KUAN FENG SUYUN LI DANDAN HU SIDA YANG PEIQING LI Pediatric Emergency Department Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Department of Child Health Care Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Pediatric Neurology Department Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina

Background:During Enterovirus type 71(EV71)infection,the structural viral protein 1(VP1)activates endoplasmic reticulum(ER)stress associated with peripheral myelin protein 22(PMP22)accumulation and induces ***,the speciﬁc mechanism behind this process remains ***:In this research,we used the VP1-overexpressing mouse Schwann cells(SCs)models co-transfected with a PMP22 silencing or Autocrine motility factor receptor(AMFR/gp78)overexpressing vector to explore the regulation of gp78 on PMP22 and its relationship with autophagy and ***:The activity of gp78 could be inﬂuenced by EV71-VP1,leading to a decrease in the ubiquitination and degradation of PMP22,resulting in PMP22 accumulation in *** VP1-overexpressing mouse SCs,all three ER stress sensors,including pancreatic endoplasmic reticulum kinase(PERK),activating transcription factor 6(ATF6)and inositol-requiring enzyme 1(IRE1)and the related downstream signals(C/EBP-homologous protein(CHOP)and Caspase 12)were activated,as well as the ER-resident chaperone Glucose-regulated protein 78(GRP78).In addition,VP1 upregulated the autophagy marker Microtubule-associated protein 1 light chain 3 beta(LC3B),while PMP22 silencing or gp78 overexpression reversed the ***,PMP22 silencing or gp78 overexpression increased proliferation of EV71-VP1-transfected mouse ***:Gp78 could regulate PMP22 accumulation through ubiquitination degradation and cause ER stress and autophagy in EV71-VP1-overexpressing mouse ***,the gp78/PMP22/ER stress axis might emerge as a promising therapeutic target for myelin and neuronal damage induced by EV71 infection.

关键词： Enterovirus type 71 AMFR/gp78 PMP22 Autophagy Schwann cells

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A polynomial resultant approach to algebraic constructions of extremal graphs

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science China Mathematics 2024年

作者： Tao Zhang Zixiang Xu Gennian Ge institute of Mathematics and Interdisciplinary sciences Xidian University School of Mathematical sciences Capital Normal University

The Turan problem asks for the largest number of edges ex（n, H） in an n-vertex graph not containing a fixed forbidden subgraph H, which is one of the most important problems in extremal graph theory. However,the order of magnitude of ex（n, H） for bipartite graphs is known only in a handful of cases. In particular,giving explicit constructions of extremal graphs is very challenging in this field. In this paper, we develop a polynomial resultant approach to the algebraic construction of explicit extremal graphs, which can efficiently decide whether a specified structure exists. A key insight in our approach is the multipolynomial resultant, which is a fundamental tool of computational algebraic geometry. Our main results include the matched lower bounds on the Turan number of 1-subdivision of K3,t1and the linear Turan number of the Berge theta hypergraphΘ3B,t2, where t1= 25 and t2= 217. Moreover, the constant t1 improves the random algebraic construction of Bukh and Conlon（2018） and makes the known estimation better on the smallest value of t1 concerning a problem posed by Conlon et al.（2021） by reducing the value from a magnitude of 1056 to the number 25, while the constant t2improves a result of He and Tait（2019）.

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Hollow Multishelled Structure Reviving Lithium Metal Anode for High-energy-density Batteries

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Chemical Research in Chinese Universities 2024年第3期40卷 428-436页

作者： WANG Haoyu WEI Peng WANG Jiangyan WANG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeIjing 100190P.R.China University of Chinese Academy of sciences Beijing 100049P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190P.R.China

Due to its highest theoretical capacity and its lowest redox potential,lithium(Li)metal has been considered as the ultimate anode choice for high-energy-density rechargeable ***,its commercialization is severely hindered by its poor cyclic stability and safety *** material structure design concepts have been raised to address these failure models,wherein,hollow structure has shown great power in solving the ***,a hollow multishelled structure(HoMs)featured with two or more shells has been proved to be more efficient to improve Li metal anode than their single-shelled ***,this up-to-date review summarizes the recent progress of the application of HoMs in Li metal anode,including their adoption as Li metal host,artificial solid electrolyte interphase film,electrolyte additive,solid state electrolyte,*** offers unique advantages,such as suppressing Li dendrite growth,stabilizing electrode-electrolyte interface,and improving overall battery *** research directions are outlined,emphasizing the need for multifunctional integrated smart HoMS design and large-scale fabrication of HoMS through low-cost accurate method to further advance the commercialization of Li metal batteries.

关键词： Hollow multishelled structure Lithium metal anode Solid electrolyte interphase Coulombic efficiency Cyclic stability

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Polarization control of above-threshold ionization spectrum in elliptically polarized two-color laser fields

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Chinese Physics B 2024年第4期33卷 136-144页

作者：金发成杨慧慧宋晓红李飞杜玲玲薛红杰魏丽敏白悦刘浩翔王兵兵杨玮枫 Faculty of science Xi'an Aeronautical InstituteXi'an 710077China School of Physics and Optoelectronic Engineering Hainan UniversityHaikou 570288China Center for Theoretical Physics Hainan UniversityHaikou 570288China Laboratory of Optical Physics Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China College of science Shantou UniversityShantou 515063China University of Chinese Academy of sciences Beijing 100049China

We study the above-threshold ionization(ATI)process of atoms exposed to fundamental and high-frequency lasers with arbitrary ellipticity by applying the frequency-domain *** is found that the angular-resolved ATI spectrum is sensitive to ellipticities of two lasers and emitted angles of the *** for the photon energy of the highfrequency laser more than atomic ionization potential,the width of plateau tends to a constant with increasing ellipticity of fundamental field,the dip structure disappears with increasing ellipticity of the high-frequency *** the help of the quantum channel analysis,it is shown that the angular distribution depends mainly on the ellipticity of high-frequency field in the case that its frequency is ***,one can see that the maximal and minimal energies in quantum numerical results are in good agreement with the classical *** investigation may provide theoretical support for experimental research on polarization control of ionization in elliptically polarized two-color laser fields.

关键词： above-threshold ionization two-color laser polarization control

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The Spectral Characterization of Blue Spinel and Other Blue Gemstones with the Alexandrite Effect

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宝石和宝石学杂志（中英文） 2024年第4期26卷 69-76页

作者： Jiling Zhou Chengsi Wang Xishan Zhao Yunqi Yang Andy Hsitien Shen Gemmological institute China University of GeosciencesWuhan 430074China Hubei Gems and Jewelry Engineering Technology Research Center Wuhan 430074China Shenzhen Research institute of China University of Geosciences Shenzhen 518000China Guangzhou CUG Gems and Jewelry Testing Co. Ltd.Guangzhou 510000China

In gemmology,the term“Alexandrite effect”is used to describe colour change phenomenon when a gemstone is observed under different light sources,usually between daylight and incandescent *** definition of the Alexandrite effect is constantly being broadened with new discovery of gem *** traditional definition of the Alexandrite effect attributing the colour change phenomenon to the presence of two maximum transmission regions and a maximum absorption region in the absorption *** this study,7 blue spinels and 5 blue gemstones(including tanzanite,kyanite,fluorite,and 2 sapphires)showing the Alexandrite effect were *** goal is to explain the cause of blue-to-violet Alexandrite effect and the spectral features causing such colour *** the UV-Vis spectra,all samples showed a maximum absorption peak in the range of 534-610 nm,within the green region to orange *** traditional explanation of green to red Alexandrite effect required a transmission window in the red region;however,some of our samples did not show this transmission window and the blue-to-violet Alexandrite effect was still ***,it is incomplete to explain the mechanism of the Alexandrite effect according to their characteristic absorption spectra,a systematic study based on modern colour science and colour perception in human vision is required to elucidate the blue-to-violet Alexandrite effect.

关键词： blue spinel Alexandrite effect absorption spectrum

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RNA viromes of Dermacentor nuttalli ticks reveal a novel uukuvirus in Qinghai Province,China

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Virologica Sinica 2024年第4期39卷 537-545页

作者： Yaohui Fang Jun Wang Jianqing Sun Zhengyuan Su Shengyao Chen Jian Xiao Jun Ni Zhihong Hu Yubang He Shu Shen Fei Deng Key Laboratory of Special Pathogens and Biosafety and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of sciences Beijing 101408China Qinghai Lake National Nature Reserve Administration Xining 810000China Hubei Jiangxia Laboratory Wuhan 430200China Xinjiang Key Laboratory of Vector-borne Infectious Diseases Urumqi830002China

Ticks are a major parasite on the Qınghai-Tibet Plateau,western China,and represent an economic burden to agriculture and animal *** research on tick-borne pathogens that threaten humans and animals,the viromes of dominant tick species in this area remain *** this study,we collected Dermacentor nuttalli ticks near Qınghai Lake and identified 13 viruses belonging to at least six families through metagenomic *** viruses were of high abundance in pools,including Xınjiang tick-associated virus 1(XJTAV1),and three novel viruses:Qınghai Lake virus 1,Qınghai Lake virus 2(QHLV1,and QHLV2,unclassified),and Qınghai Lake virus 3(QHLV3,genus Uukuvirus of family Phenuiviridae in order Bunyavirales),which lacks the M *** minimum infection rates of the four viruses in the tick groups were 8.2%,49.5%,6.2%,and 24.7%,respectively,suggesting the prevalence of these viruses in *** ticks.A putative M segment of QHLV3 was identified from the next-generation sequencing data and further characterized for its signal peptide cleavage site,N-glycosylation,and transmembrane ***,we probed the L,M,and S segments of other viruses from sequencing data of other tick pools by using the putative M segment sequence of *** revealing the viromes of *** ticks,this study enhances our understanding of tick-borne viral communities in highland *** putative M segment identified in a novel uukuvirus suggests that previously identified uukuviruses without M segments should have had the same genome organization as typical *** findings will facilitate virus discovery and our understanding of the phylogeny of tick-borne uukuviruses.

关键词： Dermacentor nuttalli Qınghai Province Virome Uukuvirus M segment

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