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Phylogenetic Analysis of the Dengue Virus strains Causing the 2019 Dengue Fever Outbreak in hainan,China

Virologica sinica 2021年第4期36卷 636-643页

作者： Jiang Du Liyuan Zhang Xiaoyuan Hu Ruoyan Peng Gaoyu Wang Yi Huang Wenqi Wang Kunliang Wu Qiang Wang Haoxiang su Fan Yang Yun Zhang Chuanning Tang Xiuji Cui Lina Niu Gang Lu Meifang Xiao Yongguo Du Feifei Yin Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical UniversityHaikou 571199China hainan Medical university-The university of Hong Kong Joint Laboratory of Tropical Infectious Diseases Hainan Medical UniversityHaikou 571199China Department of Pathogen Biology Hainan Medical UniversityHaikou 571199China Department of Infectious Disease The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216China Department of Clinical Laboratory Center for Laboratory MedicineHainan Women and Children's Medical CenterHaikou 570206China NHC Key Laboratory of systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Dengue virus is an arthropod-borne pathogen that is transmitted to humans primarily by Aedes ***,causing the acute infectious disease,dengue fever(DF).Until 2019,no dengue outbreak had been reported in hainan Province for over 20 ***,in early september of 2019,an increasing number of infected cases appeared and the DF outbreak lasted for over one month in Haikou City,hainan *** our study,we collected 97 plasma samples from DF patients at three hospitals,as well as 1585 mosquito larvae samples from puddles in different areas of *** were 49(50.5%)plasma samples found to be strongly positive and 9(9.3%)plasma samples were weakly positive against the Ns1 *** discovered DENV both in the patient's plasma samples and mosquito larvae samples,and isolated the virus from C6/36 cells inoculated with the acute phase serum of *** analysis revealed that the new strains were the most closely related to the epidemic strain in the southern regions of China,belonging to lineageⅣ,genotypeⅠ,*** to the seven closest strains from neighboring countries and provinces,a total of 18 amino acid mutations occurred in the coding sequences(CDs)of the new isolated strain,DENV1 *** data shows that dengue virus is re-emerged in hainan,and pose new threats for public *** regular molecular epidemiological surveillance is necessary for control and prevention of DENV transmission.

关键词： DENV-1 Aedes spp.mosquitos hainan Province Dengue fever patients Mosquito larvae

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Network pharmacology and verification experiment-based prediction of active components and potential targets of Alpiniae Oxyphyllae Fructus-saposhnikoviae Radix(Yizhiren-Fangfeng)for treatment of diabetic kidney disease

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Traditional Medicine research 2023年第5期8卷 11-20页

作者： Xian Wang Chang Liu Huan Jiang Bo-Cen Chen Xu Yang Man Xiao Yi-Qiang Xie Kai Li school of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China school of Basic Medicine and the Life sciences Hainan Medical UniversityHaikou 571199China

Background:In this study,we analyzed the potential active components,related crucial targets and possible signaling pathway mechanisms of Alpiniae Oxyphyllae Fructus and saposhnikoviae Radix(AOF-sR)herb pairs in the treatment of diabetic kidney disease(DKD)using network pharmacology and verification ***:The active compounds and potential targets of AOF-sR were derived from the Traditional Chinese Medicine systems Pharmacology Database and Analysis Platform,The Encyclopedia of Traditional Chinese Medicine,and PubChem databases,and the potential therapeutic targets of DKD were derived from the OMIM,Drugbank,and DisGeNET ***“compounds-diseases-targets”network was constructed using Cytoscape *** functionality in Cytoscape is being used to screen important targets for AOF-sR treatment of *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of important targets were performed using DAVID *** addition,according to the predicted results of network pharmacology,HK-2 cells were used to construct DKD model for verification ***-2 cells were divided into control group,high glucose(HG)group and AOF-sR(HG+AOF-sR)group to detect survival rate and expression of key proteins in NF-κB and PI3K/Akt signaling ***:A total of 38 compounds were selected from AOF-sR,of which 23 were Alpiniae Oxyphyllae Fructus and 15 were saposhnikoviae *** enrichment analysis of 82 important targets,88 signaling pathways were identified;some of these pathways,such as the NF-κB,PI3K-Akt,IL-17,and JAK/sTAT signaling pathways,regulate the pathological process of *** verification experiment,the HK-2 cells survival rate was higher in the HG+AOF-sR group than in the HG group(Pstern blotting results showed that the expression levels of NF-κB,p-PI3K,and p-Akt in HG+AOF-sR group were significantly lower than those in HG group(Psion:Overall,this study revealed the active co

关键词： network pharmacology traditional Chinese medicine Alpiniae Oxyphyllae Fructus saposhnikoviae Radix HK-2 cells diabetic kidney disease

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Applying Feature-Weighted Gradient Decent K-Nearest Neighbor to select Promising Projects for scientific Funding

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Computers, Materials & Continua 2020年第9期64卷 1741-1753页

作者： Chuqing Zhang Jiangyuan Yao Guangwu Hu Thomas schott school of Economics and Management North China Electric Power UniversityBeijing102206China school of Computer science&Cyberspace security Hainan UniversityHaikou570228China school of Computer science Shenzhen Institute of Information TechnologyShenzhen518172China The Faculty of Business and social science University of Southern DenmarkKoldingDK-6000Denmark

Due to its outstanding ability in processing large quantity and high-dimensional data,machine learning models have been used in many cases,such as pattern recognition,classification,spam filtering,data mining and *** an outstanding machine learning algorithm,K-Nearest Neighbor(KNN)has been widely used in different situations,yet in selecting qualified applicants for winning a funding is almost *** major problem lies in how to accurately determine the importance of *** this paper,we propose a Feature-weighted Gradient Decent K-Nearest Neighbor(FGDKNN)method to classify funding applicants in to two types:approved ones or not approved *** FGDKNN is based on a gradient decent learning algorithm to update *** updates the weight of labels by minimizing error ratio iteratively,so that the importance of attributes can be described *** investigate the performance of FGDKNN with Beijing *** results show that FGDKNN performs about 23%,20%,18%,15%better than KNN,sVM,DT and ANN,***,the FGDKNN has fast convergence time under different training scales,and has good performance under different settings.

关键词： FGDKNN project selection scientific funding machine learning

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strongly screened electron capture rates of chromium isotopes in presupernova evolution

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research in Astronomy and Astrophysics 2017年第10期17卷 91-96页

作者： Jing-Jing Liu Qiu-He Peng Liang-Huan Hao Xiao-Ping Kang Dong-Mei Liu College of Marine science and Technology Hainan Tropical Ocean University Department of Astronomy Nanjing University

Taking into account the effect of electron screening on electron energy and electron capture threshold energy, by using the method of shell-Model Monte Carlo and random phase approximation theory, we investigate the capture rates of chromium isotopes with strong electron screening according to the linear response theory screening model. strong screening rates can decrease by about 40.43% （e.g., for 6Cr at T9 = 3.44, Ye = 0.43）. Our conclusions may be helpful to researches on supernova explosions and related numerical simulation methods.

关键词： nuclear reactions -- electron capture -- supernovae

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New insights into the limit of the magnetic monopole flux and the heatingsource in white dwarfs

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Chinese Physics C 2023年第8期47卷 95-106页

作者：刘晶晶刘冬梅郝良焕 College of science Hainan Tropical Ocean UniversitySanya 572022China

Based on the magnetic monopole(MM)catalytic nuclear decay(Rubakov-Callan(RC)effect),we propose five new models to discuss the limit of the MM flux and the heating energy resources of white dwarfs(WDs)based on observations of 13 red giant branch(RGB)*** find that the number of MMs captured can reach a maximum value of 9.1223×10^(24)when m=10^(17)GeV,nB=5.99×10^(31)cm^(-3),Φ=7.59×10^(-26)cm^(-2)s^(-1)sr^(-1).The good agreement of our calculated luminosities for WDs with observation provides support for our model based on the RC effect by *** obtain a new limit of the MM flux of ξ=Φ(σ_(m)^(v)T)_(-28)≤9.0935×10^(-13)cm^(-2)s^(-1)sr^(-1),and≤4.9950×10^(-13)cm^(-2)s^(-1)sr^(-1)at nB=5.99×1031cm-3 when m=1015GeV,β=9.4868×10^(-3),and m=1017Gev,β=10^(-3),*** results show that the RC effect could cause heating that prevents white dwarfs from cooling down into a stellar *** results will also provide a new idea for further research on the upper limit of MM flow(note:nB,σ_(m),m,φ,ξ,are the baryon number density,reaction cross section,mass,MM flux,and the new limit of the MM flux,respectively,andβ=v_(T/C)is the ratio of the speed of MMs to that of light).

关键词： white dwarfs evolution nuclear reactions

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Registration system reform and initial public offering ownership preference:Evidence from China

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China Journal of Accounting research 2024年第1期17卷 74-95页

作者： Xihao Wu Di Zhang Zhongxin Wu International Business school Hainan UniversityChina

Whether registration system reform(RsR)can curb administrative intervention and create a fair market environment has long been a concern in *** explore this issue from the perspective of the initial public offering(IPO)preference based on the entropy balancing method,and findings are as ***,an IPO ownership preference exists under approval *** is,state-owned enterprises(sOEs)are more likely than private enterprises to obtain IPO ***,RsR significantly changes this preference,especially for non-politically connected private ***,the post-IPO market performance of sOEs is inferior to that of private enterprises under approval system,thus excluding the view that approval is prioritized for sOEs because of superior ***,compared with sOEs,private enterprises are more likely to switch the issuance system from approval system to registration system;this change makes it easier for them to obtain IPO approval,indicating that private enterprise owners perceive the registration channel to be ***,the effect of RsR on IPO ownership preference mainly occurs in companies in three major urban agglomerations in China—the Pearl River Delta,the Yangtze River Delta,and the Beijing–Tian jin–Hebei region—and in technology-intensive ***,our findings reveal that RsR cultivates a fairer IPO approval process.

关键词： Registration system reform Administrative intervention Approval system IPO ownership preference

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ProbD: Faulty Path Detection Based on Probability in software-Defined Networking

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Intelligent Automation & soft Computing 2023年第5期36卷 1783-1796页

作者： Jiangyuan Yao Jiawen Wang shuhua Weng Minrui Wang Deshun Li Yahui Li Xingcan Cao school of Computer science and Technology Hainan UniversityHaikou570228China school of software Beijing Jiaotong UniversityBeijing10004China university of British Columbia VancouverV5K1K5Canada

With the increasing number of switches in software-Deﬁned Network-ing(sDN),there are more and more faults rising in the data ***,due to the existence of link redundancy and multi-path forwarding mechanisms,these problems cannot be detected in *** current faulty path detection mechan-isms have problems such as the large scale of detection and low efﬁciency,which is difﬁcult to meet the requirements of efﬁcient faulty path detection in large-scale *** this issue,we propose an efﬁcient network path fault testing model ProbD based on probability *** model achieves a high prob-ability of detecting arbitrary path fault in the form of small-scale random *** a certain path fault rate,ProbD obtains the curve of sample size and probability of detecting arbitrary path fault by randomly sampling network paths several *** a small number of experiments,the ProbD model can cor-rectly estimate the path fault rate of the network and calculate the total number of paths that need to be detected according to the different probability of detecting arbitrary path fault and the path fault rate of the ***ﬁnal experimental results show that,compared with the full path coverage test,the ProbD model based on probability detection can achieve efﬁcient network testing with less ***,the larger the network scale is,the more overhead will be saved.

关键词： Probability detection faulty path detection software-deﬁned networking

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OsNAC5 orchestrates OsABI5 to fine-tune cold tolerance in rice

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Journal of Integrative Plant Biology 2024年第4期66卷 660-682页

作者： Ruiqing Li Yue song Xueqiang Wang Chenfan Zheng Bo Liu Huali Zhang Jian Ke Xuejing Wu Liquan Wu Ruifang Yang Meng Jiang College of Agronomy Anhui Agricultural UniversityHefei 230036China hainan Institute Yazhou Bay Sci-Tech CityZhejiang UniversitySanya 572025China National Key Laboratory of Rice Biology Advanced Seed InstituteZhejiang UniversityHangzhou 311225China state Key Laboratory of Rice Biology and Chinese National Center for Rice Improvement China National Rice Research InstituteHangzhou 311401China Key Laboratory of Germplasm Innovation and Genetic Improvement of Grain and Oil Crops(Co-Construction by Ministry and Province) Ministry of Agriculture and Rural AffairsCrop Breeding and Cultivation Research InstituteShanghai Academy of Agricultural SciencesShanghai 201106China

Due to its tropical origins,rice(Oryza sativa)is susceptible to cold stress,which poses severe threats to ***5,a NAC-type transcription factor,participates in the cold stress response of rice,but the detailed mechanisms remain poorly ***,we demonstrate that OsNAC5 positively regulates cold tolerance at germination and in seedlings by directly activating the expression of ABsCIsIC ACID INsENsITIVE 5(OsABI5).Haplotype analysis indicated that single nucleotide polymorphisms in a NAC-binding site in the OsABI5 promoter are strongly associated with cold ***5 also enhanced OsABI5 stability,thus regulating the expression of cold-responsive(COR)genes,enabling fine-tuned control of OsABI5 action for rapid,precise plant responses to cold *** affinity purification sequencing coupled with transcriptome deep sequencing identified several OsABI5 target genes involved in COR expression,including DEHYDRATION-REsPONsIVE ELEMENT BINDING FACTOR 1A(OsDREB1A),OsMYB20,and PEROXIDAsE 70(OsPRX70).In vivo and in vitro analyses suggested that OsABI5 positively regulates COR gene transcription,with marked COR upregulation in OsNAC5-overexpressing lines and downregulation in osnac5 and/or osabi5 knockout *** study extends our understanding of cold tolerance regulation via OsNAC5 through the OsABI5-CORs transcription module,which may be used to ameliorate cold tolerance in rice via advanced breeding.

关键词： ABA signaling ABI5 cold tolerance DREB NAC5 rice

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Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

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Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong Xiangyu Kong Tingting Jiang Muyuan Ma shaojiang Zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China hainan Clinical Medical research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases research of hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

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Application of Zero-Watermarking for Medical Image in Intelligent sensor Network security

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Computer Modeling in Engineering & sciences 2023年第7期136卷 293-321页

作者： shixin Tu Yuanyuan Jia Jinglong Du Baoru Han Medical Data science Academy College of Medical InformaticsChongqing Medical UniversityChongqing400016China

The field of healthcare is considered to be the most promising application of intelligent sensor ***,the security and privacy protection ofmedical images collected by intelligent sensor networks is a hot problem that has attracted more and more ***,digital watermarking provides an effective method to solve this *** order to improve the robustness of the medical image watermarking scheme,in this paper,we propose a novel zero-watermarking algorithm with the integer wavelet transform(IWT),schur decomposition and image block ***,we first use IWT to extract low-frequency information and divide them into non-overlapping blocks,then we decompose the sub-blocks by schur *** that,the feature matrix is constructed according to the relationship between the image block energy and the whole image *** the same time,we encrypt watermarking with the logistic chaotic position ***,the zero-watermarking is obtained by XOR operation with the encrypted *** indexes of peak signal-to-noise ratio,normalization coefficient(NC)and the bit error rate(BER)are used to evaluate the robustness of the *** to the experimental results,most of the NC values are around 0.9 under various attacks,while the BER values are very close to *** experimental results show that the proposed algorithm is more robust than the existing zero-watermarking methods,which indicates it is more suitable for medical image privacy and security protection.

关键词： Intelligent sensor network medical image zero-watermarking integer wavelet transform schur decomposition

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