检索结果-南通市图书馆

World Journal of Clinical Cases 2024年第3期12卷 596-600页

作者： Shi-Ju Chen Da-Ya Zhang Yan-Ting Lv Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical University570216 HaikouHainan ProvinceChina Department of Gastroenterology Clinical Medical Center of Hainan ProvinceHaikou 570216Hainan ProvinceChina

BACKGROUND Guidewire slippage into the peritoneal cavity during clinical operations is extremely ***,this paper aims to report a successful case of guidewire removal using transgastric natural orifice transluminal endoscopic surgery(NOTES).The goal is to enhance physicians'understanding of the management plan for this unique scenario and provide a valuable reference for clinical *** SUMMARY A 64-year-old man presented with abdominal distension and was diagnosed with cirrhosis combined with massive *** proceed with treatment,the patient underwent ultrasound-guided peritoneal puncture and underwent catheterization and ***,a 0.035-inch guidewire slipped into the abdominal cavity during the *** a comprehensive evaluation and consultation by a multidisciplinary team,the guidewire was successfully removed using *** This case highlights the potential consideration of transgastric NOTES removal when encountering a foreign body,such as a guidewire,within the abdominal cavity.

关键词： Guidewire Abdominal cavity Natural orifice transluminal endoscopic surgery Cirrhosis Massive ascites Case report

Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第11期30卷 1572-1587页

作者： Shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Microbiota Medicine&Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina

BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical ***,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been *** To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to *** We conducted a prospective,open-label,single-center clinical *** CD patients underwent *** clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the *** Seven of the 11 patients(63.6%)showed an optimal clinical response three months *** microbiome diversity significantly increased after WMT,consistent with improved clinical *** of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as Faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia *** addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the ***,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after *** WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s ***-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.

关键词： Crohn’s disease Clinical trials Fecal microbiota transplant Metagenome Metatranscriptome Metabolome

Plasma induced grain boundaries to boost electrochemical reduction of CO_(2)to formate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第8期95卷 636-643,I0014页

作者： Guan Wang Shengtao Zhong Xiaoqian Xiong Jing Li Fangyuan Wang Li Huo Daoxiong Wu Xingqi Han Zhitong Wang Qi Chen Xinlong Tian Peilin Deng School of Marine Science and Engineering State Key Laboratory of Marine Resource Utilization in South China SeaHainan UniversityHaikou 570228HainanChina

Bismuth-based catalysts are highly promising for the electrochemical carbon dioxide reduction reaction(eCO_(2)RR)to formate ***,achieving high activity and selectivity towards formate and ensuring long-term stability remains *** work reports the oxygen plasma inducing strategy to construct the abundant grain boundaries of Bi/BiO_x on ultrathin two-dimensional Bi *** oxygen plasma-treated Bi nanosheet(OP-Bi)exhibits over 90%Faradaic efficiency(FE)for formate at a wide potential range from-0.5 to-1.1 V,and maintains a great stability catalytic performance without significant decay over 30 h in flow ***,membrane electrode assembly(MEA)device with OPBi as catalyst sustains the robust current density of 100 mA cm^(-2)over 50 h,maintaining a formate FE above 90%.In addition,rechargeable Zn-CO_(2)battery presents the peak power density of1.22 mW cm^(-2)with OP-Bi as bifunctional *** mechanism experiments demonstrate that the high-density grain boundaries of OP-Bi provide more exposed active sites,faster electron transfer capacity,and the stronger intrinsic activity of Bi *** situ spectroscopy and theo retical calculations further elucidate that the unsaturated Bi coordination atoms between the grain boundaries can effectively activate CO_(2)molecules through elongating the C-O bond,and reducing the formation energy barrier of the key intermediate(^(*)OCOH),thereby enhancing the catalytic performance of eCO_(2)RR to formate product.

关键词： CO_(2)electroreduction Bi nanosheet Grain boundary Unsaturation Bi atoms MEA device

In-situ Generation of Hydroxyl Layers in Coo@FeSe_(2) Catalyst for High Selectivity Seawater Electrolysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第1期42卷 48-54,I0004页

作者： Suyang Feng Peng Rao Xiao Wu Ke Li Anyuan Qi Yanhui Yu Jing Li Peilin Deng Yuliang Yuan Shaolei Wang Xinlong Tian Zhenye Kang State Key Laboratoryof Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchoolof Chemical Engineering andTechnologyHainan UniversityHaikouHainan 570228China Key Laboraory of Polyoxmetalate andReticular Material Chemtry of Ministy of Education School of Chmistry Northeast NormalUniversity ChangchunJilin 130024China National Energy Group Ledong Power Generation Co. Ltd.LedongHainan 572539China

Seawater electrolysis holds great promise for hydrogen production in the future,while the development of anodic catalysts has been severely hampered by the side-reaction,chloride evolution *** this work,nano-flower-cluster structured Coo@FeSe_(2)/CF catalysts are synthesized via a scalable electrodeposition technique,and the performance is systematically *** oxygen evolution reaction(OER)overpotential of Co0@FeSe_(2)/CF is 267 mV at 100 ***^(-2),which is significantly lower than that of the IrO_(2) catalyst(435 mV).Additionally,the catalyst shows high selectivity for OER(97.9%)and almost no loss of activity after a durability test for 1100 *** impressive performance is attributed to the dense rod-like structure with abundant active centers after electrochemical activation and the in-situ generated CoOOH and FeOOH that improve the catalytic activity of the *** synergistic effect induced bythenon-uniform structureendows the catalyst with excellent stability.

关键词： Energy Transfer Seawat erelectrolysis Oxygen evolution reaction Electrodeposition method CoO@FeSe_(2)/CF catalyst Nano-flower-cluster structure Catalytic activity

Exploring the molecular mechanism of Suoquan pill in the treatment of diabetic kidney disease based on network pharmacology,molecular docking,in vitro experiment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine research 2024年第11期9卷 27-37页

作者： Zi-Jie Yan Yu Kang Shu-Man Liu Fang-Yu Wang Man Xiao Yi-Qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Graduate School Heilongjiang Academy of Traditional Chinese MedicineHarbin 150001China Department of Pharmacology College of PharmacyHainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:Diabetic kidney disease(DKD)is a microvascular complication of diabetes mellitus and is the main cause of end-stage renal *** pills(SQP)has a variety of pharmacological activities and multiple therapeutic effects,and it is used clinically as a basic formula for the treatment of ***:Public databases were used to identify SQP compounds and the potential targets of SQP and DKD.A drug-component-therapeutic target network was ***-protein interaction network analysis,Gene Ontology functional analysis,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were used to analyse the potential molecular mechanisms of SQP based on common targets of drugs and *** docking simulations were conducted to confirm the binding abity of the core compounds to key *** efficacy and predicted molecular mechanisms of SQP were validated using cell counting kit-8 assay,flow cytometry,and western blotting with HK-2 cells as a ***:Network pharmacology analysis showed that 26 compounds and 207 potential targets of SQP were involved in the treatment of DKD;boldine,denudatin B,pinocembrin,kaempferoid,and quercetin were considered core compounds,and epidermal growth factor receptor(EGFR)and proto-oncogene,non-receptor tyrosine kinase(SRC)were considered key *** Ontology enrichment analysis indicated that protein phosphorylation and negative regulation of apoptotic processes are important biological processes in the treatment of DKD by *** docking confirmed the excellent binding abilities of boldine,denudatin B,kaempferide,and quercetin to EGFR and *** results of in vitro experiments showed that treatment with an ethanolic extract of SQP significantly protected HK-2 cells from high glucose-induced cell *** addition,the SQP ethanol extract inhibited the phosphorylation of EGFR and SRC,suppressed the apoptosis rate,and regulated apoptosis-related proteins in HK-2 cells under hig

关键词： traditional Chinese medicine diabetic kidney disease Suoquan pill network analysis molecular docking

LbCas12a-nuclease-mediated tiling deletion for large-scale targeted editing of non-coding regions in rice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2024年第4期5卷 141-144页

作者： Guigen Ma Fang Yan Bin Ren Zhenwan Lu Hao Xu Fangxi Wu Shaofang Li Daowen Wang Xueping Zhou Huanbin Zhou State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Gene Editing Technologies(hainan) Ministry of Agricultural and Rural AffairsSanya 572024China Scientific Observing and Experimental Station of Crop Pests in Guilin Ministry of Agriculture and Rural AffairsGuilin 541399China Rice research Institute Fujian Academy of Agricultural SciencesFuzhou 350019China State Key Laboratory of Vegetable Biobreeding National Engineering Research Center for VegetablesBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China College of Agronomy State Key Laboratory of Wheat and Maize Crop Scienceand Center for Crop Genome EngineeringHenan Agricultural UniversityZhengzhou 450046China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China These authors contributed equally to this article

Dear Editor,This study reports a nuclease-mediated tiling deletion(NTD)method that uses LbCas12a nuclease with a tiling CRISPRderived RNA(crRNA)library to efficiently induce numerous nucleotide deletions in non-coding regulatory regions of endogenous rice *** method was applied to non-coding regions of the Green Revolution gene SD1,generating 6 mutants with quantitative variations in plant height,which were then used to investigate associations between genotype and *** is thus a promising tool for molecular rice breeding.

关键词： breeding. generating nuclease

Thrombopoietin ameliorates doxorubicin-induced toxicities in H9c2 myocardiocytes by inhibiting oxidative stress through the SIRT1/p38 MAPK signaling pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 410-416页

作者： Xu-Han Zuo Yu Huang Bo-Cen Chen Ming-Yue Zhu Cai-Cai Zhang Han-Yi Jiao Li-Fang Lu Man Xiao Han Wang Key Laboratory of Tropical Translational Medicine of Ministry of Education School of Basic Medicine and Life SciencesHainan Medical UniversityHaikouHainanChina Experiment and Teaching Center for Clinical Skills Hainan Medical UniversityHaikouHainanChina

Objective:To explore whether thrombopoietin can exert a protective effect against doxorubicin-induced cardiotoxicity by modulating the sirtuin 1(SIRT1)signaling ***:H9c2 cell viability was determined by CCK-8 and cardiomyocyte apoptosis was detected by TUNEL *** protein expressions of SIRT1 and p38 MAPK were measured by Western ***-qPCR was also used to determine SIRT1 mRNA *** addition,intracellular reactive oxygen species levels and antioxidant enzyme activities were ***:Thrombopoietin treatment reversed doxorubicin-induced decline in H9c2 cell *** also increased SIRT1 and decreased p-p38 MAPK protein *** addition,thrombopoietin significantly attenuated doxorubicin-induced apoptosis and oxidative stress,and enhanced antioxidant enzyme ***,silencing SIRT1 abrogated the protective effects of thrombopoietin,as evidenced by reduced cell viability and increased oxidative stress and reactive oxygen species ***:Thrombopoietin alleviates doxorubicin-induced cardiomyocyte injury by reducing oxidative stress and apoptosis via the SIRT1/p38 MAPK ***,its protective effects need to be further verified in animal tests.

关键词： Doxorubicin Thrombopoietin Oxidative stress Sirtuin 1 Cardiotoxicity

Projecting Wintertime Newly Formed Arctic Sea Ice through Weighting CMIP6 Model Performance and Independence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第8期41卷 1465-1482页

作者： Jiazhen ZHAO Shengping HE Ke FAN Huijun WANG Fei LI Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5007Norway School of Atmospheric Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Nansen Environmental and Remote Sensing Center and Bjerknes Centre for Climate research Bergen 5007Norway Nansen-Zhu International research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

Precipitous Arctic sea-ice decline and the corresponding increase in Arctic open-water areas in summer months give more space for sea-ice growth in the subsequent cold seasons. Compared to the decline of the entire Arctic multiyear sea ice,changes in newly formed sea ice indicate more thermodynamic and dynamic information on Arctic atmosphere–ocean–ice interaction and northern mid–high latitude atmospheric teleconnections. Here, we use a large multimodel ensemble from phase 6 of the Coupled Model Intercomparison Project(CMIP6) to investigate future changes in wintertime newly formed Arctic sea ice. The commonly used model-democracy approach that gives equal weight to each model essentially assumes that all models are independent and equally plausible, which contradicts with the fact that there are large interdependencies in the ensemble and discrepancies in models' performances in reproducing observations. Therefore, instead of using the arithmetic mean of well-performing models or all available models for projections like in previous studies, we employ a newly developed model weighting scheme that weights all models in the ensemble with consideration of their performance and independence to provide more reliable projections. Model democracy leads to evident bias and large intermodel spread in CMIP6 projections of newly formed Arctic sea ice. However, we show that both the bias and the intermodel spread can be effectively reduced by the weighting scheme. Projections from the weighted models indicate that wintertime newly formed Arctic sea ice is likely to increase dramatically until the middle of this century regardless of the emissions ***, it may decrease(or remain stable) if the Arctic warming crosses a threshold(or is extensively constrained).

关键词： wintertime newly formed Arctic sea ice model democracy model weighting scheme model performance model independence

In vivo evaluation of guide-free Cas9-induced safety risks in a pig model

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第8期9卷 3493-3506页

作者： Weikai Ge Shixue Gou Xiaozhu Zhao Qin Jin Zhenpeng Zhuang Yu Zhao Yanhui Liang Zhen Ouyang Xiaoyi Liul Fangbing Chen Hui Shi Haizhao Yan Han Wu Liangxue Lai Kepin Wang China-New Zealand Joint Laboratory on Biomedicine and Health CAS Key Laboratory of Regenerative BiologyGuangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineJoint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Sanya institute of Swine resource Hainan Provincial Research Center of Laboratory AnimalsSanya 572000China Guangdong Provincial Key Laboratory of Large Animal models for Biomedicine Wuyi UniversityJiangmen 529020China Guangzhou National Laboratory Guangzhou 510005China SUniversity of Chinese Academy of Sciences 100049 BeijingChina research Unit of Generation of Large Animal Disease Models Chinese Academy of Medical Sciences(2019RU015)Guangzhou 510530China

The CRISPR/Cas9 system has shown great potential for treating human genetic diseases through gene ***,there are concerns about the safety of this system,specifically related to the use of guide-free *** studies have shown that guidefree Cas9 can induce genomic instability in ***,the in vivo safety risks associated with guide-free Cas9 have not been evaluated,which is necessary for the development of gene therapy in clinical *** this study,we used doxycycline-inducible Cas9-expressing pigs to evaluate the safety risks of guide-free Cas9 in *** findings demonstrated that expression of guide-free Cas9 could induce genomic damages and transcriptome changes in *** severity of the genomic damages and transcriptome changes were correlate with the expression levels of Cas9 ***,prolonged expression of Cas9 in pigs led to abnormal phenotypes,including a significant decrease in body weight,which may be attributable to genomic damage-induced nutritional absorption and metabolic ***,we observed an increase in whole-genome and tumor driver gene mutations in pigs with long-term Cas9 expression,raising the risk of tumor *** in vivo evaluation of guide-free Cas9 in pigs highlights the necessity of considering and monitoring the detrimental effects of Cas9 alone as genome editing via the CRISPR/Cas9 system is implemented in clinical gene *** research emphasizes the importance of further study and implementation of safety measures to ensure the successful and safe application of the CRiSPR/Cas9 system in clinical practice.

关键词： CRISPR/Cas9 vivo alone

Load-bearing characteristics and energy evolution of fractured rock masses after granite and sandstone grouting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2024年第8期31卷 2810-2825页

作者： WU Xu-kun ZHAO Guang-ming MENG Xiang-rui LIU Chong-yan LIU Zhi-xi HUANG Shun-jie ZHANG Qi-hang Key Laboratory of Safe and Effective Coal Mining Ministry of EducationAnhui University of Science and TechnologyHuainan 232001China National Key Laboratory of Safe Mining of Deep Coal and Environmental Protection Anhui University of Science and TechnologyHuainan 232001China Joint National-Local Engineering research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China

Experiments on grouting-reinforced rock mass specimens with different particle sizes and features were carried out in this study to examine the effects of grouting reinforcement on the load-bearing characteristics of fractured rock *** strength and deformation features of grouting-reinforced rock mass were analyzed under different loading manners;the energy evolution mechanism of grouting-reinforced rock mass specimens with different particle sizes and features was investigated;the energy dissipation ratio and post-peak stress decreasing rate were employed to evaluate the bearing stability of grouting-reinforced rock *** results show that the strength and ductility of granite-reinforced rock mass(GRM)under biaxial loading are higher than that of sandstone-reinforced rock mass(SRM)under uniaxial ***,the energy evolution characteristics of grouting-reinforced rock mass under uniaxial and biaxial loading mainly could be divided into early,middle,and late *** the early stage,total,elastic,and dissipation energies were quite small with flatter curves;in the middle stage,elastic energy increased rapidly,whereas dissipation energy increased slowly;in the late stage,dissipation energy increased *** energy dissipation ratio was used to represent the pre-peak plastic *** uniaxial loading,this ratio increased as the particle size increased and the pre-peak plastic deformation of grouting-reinforced rock mass became larger;under biaxial loading,it dropped as the particle size increased,and the pre-peak plastic deformation of grouting-reinforced rock mass became *** post-peak stress decline rate A_(v) was used to assess the post-peak bearing performance of grouting-reinforced rock *** uniaxial loading,parameter A_(v) exhibited reduction as the particle size kept increasing,and the ability of post-peak of grouting-reinforced rock mass to allow deformation development was greater,and the bearing capacity was greater;

关键词： grouting-reinforced rock mass particle size energy dissipation ratio post-peak stress decreasing rate load-bearing characteristics