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Applications of RNA interference highthroughput screening technology in cancer biology and virology
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Protein & Cell 2014年 第11期5卷 805-815页
作者: Shan Gao Chen Yang Shan Jiang Xiao-Ning Xu Xin Lu You-Wen He Annie Cheung Hui Wang Department of Oncology John Radcliffe Hospital Weatherall Institute of Molecular Medicine University of Oxford Oxford OX3 9DS UK Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794 USA Department of Immunology Duke University Durham NC 27708 USA Department of Immunology Chelsea & Westminster Hospital Imperial College of London 369 Fulham Road London SW10 9NH UK Nuffield Department of Clinical Medicine Ludwig Institute for Cancer Research Oxford Branch University of Oxford Old Road Campus Research Building Oxford OX3 7DQ UK Department of Pathology Queen Mary Hospital University of Hong Kong Pokfulam Road Hong Kong China Natural Environment Research Council Centre for Ecology & Hydrology Benson Lane Wallingford Oxfordshire OX10 8BB UK Department of Zoology University of Oxford South Parks Road Oxford OX1 3PS UK
RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi highthroughput screening (HTS) has opened an exciting frontier... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Nucleotide bias of DCL and AGO in plant anti-virus gene silencing
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Protein & Cell 2010年 第9期1卷 847-858页
作者: Thien Ho Liang Wang Linfeng Huang Zhigang Li Denise W.Pallett Tamas Dalmay Kazusato Ohshima John A.Walsh Hui Wang nerc/Centre for Ecology and Hydrology(CEH)Wallingford Maclean BuildingBenson LaneWallingfordOxfordshire OX108BBUK Department of Biochemistry University of OxfordSouth Parks RoadOxford OX13QUUK Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100029China School of Biological Sciences University of East AngliaNorwich NR47TJUK Laboratory of Plant Virology Faculty of AgricultureSaga University1-banchiHonjo-machiSaga 840-8502Japan Plant-Virus Interactions Group Warwick HRIWarwick UniversityWellesbourneWarwick CV359EFUK Current address:AF Building University of Dundee at SCRIInvergowrieDundee DD25DAUK Current address:Immune Disease Institute 200 Longwood AvenueBoston MA 02115USA
Plant Dicer-like(DCL)and Argonaute(AGO)are the key enzymes involved in anti-virus post-transcriptional gene silencing(AV-PTGS).Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTG... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论