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A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy

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Nano-Micro Letters 2022年第2期14卷 24-44页

作者： Xiaoge Zhang Lili Cheng Yao Lu Junjie Tang Qijun Lv Xiaomei Chen You Chen Jie Liu School of biomedical Engineering Shenzhen Campus of Sun Yat-Sen UniversityNo.66Gongchang RoadGuangming DistrictShenzhenGuangdong 518107People’s Republic of China Department of General Surgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510006People’s Republic of China

The enzyme-mediated elevation of reactive oxygen species(ROS)at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer ***,we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti_(3)C_(2)nanosheets for combined tumor enzyme dynamic therapy(EDT),phototherapy and deoxygenation-activated ***,glucose oxidase(GOX)and chloroperoxidase(CPO)were chemically conjugated onto Ti_(3)C_(2)nanosheets,where the deoxygenation-activated drug tirapazamine(TPZ)was also loaded,and the Ti_(3)C_(2)-GOX-CPO/TPZ(TGCT)was embedded into nanosized cancer cell-derived membrane vesicles with high-expressed CD47(m_eTGCT).Due to biomimetic membrane camouflage and CD47 overexpression,m_eTGCT exhibited superior immune escape and homologous targeting capacities,which could effectively enhance the tumor preferential targeting and *** internalized into tumor cells,the cascade reaction of GOX and CPO could generate HClO for efficient ***,additional laser irradiation could accelerate the enzymic-catalytic reaction rate and increase the generation of singlet oxygen(~1O_(2)).Furthermore,local hypoxia environment with the oxygen depletion by EDT would activate deoxygenation-sensitive prodrug for additional ***,m_eTGCT exhibits amplified synergistic therapeutic effects of tumor phototherapy,EDT and chemotherapy for efficient tumor *** intelligent cascaded-enzyme nanoreactor provides a promising approach to achieve concurrent and significant antitumor therapy.

关键词： Cascaded-enzyme nanoreactor Deoxygenation-sensitive prodrugs Tumor enzyme dynamic therapy Phototherapy CD47

Compensation of Pressure Enthalpy Effects on Temperature Fields for Throttling of High-Pressure Real Gas

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Journal of Shanghai Jiaotong university(Science) 2017年第2期22卷 216-223页

作者：罗语溪梁九兴王宣银徐志鹏 School of Engineering Sun Yat-sen University State key laboratory of Fluid Power Transmission and Control Zhejiang University College of Metrology and Measurement Engineering China Jiliang University

For the pressure enthalpy of high pressure pneumatics, the computational fluid dynamics (CFD) simulation based on ideal gas assumption fails to obtain the real temperature information. Therefore, we propose a method to compensate the pressure enthalpy of throttling for CFD simulation based on ideal gas assumption. Firstly, the pressure enthalpy is calculated for the pressure range of 0.101 to 30 MPa and the temperature range of 190 to 298 K based on Soave-Redlich-Kwong (S-R-K) equation. Then, a polynomial fitting equation is applied to practical application in the above mentioned range. The basic idea of the compensation method is to convert the pressure enthalpy difference between inlet air and nodes into the compensation temperature. In the above temperature and pressure range, the compensated temperature is close to the real one, and the relative temperature drop error is below 10%. This error is mainly caused by the velocity difference of the orifice between the real and ideal gas models. Finally, this compensation method performs an icing analysis for practical high pressure slide pilot valve. © 2017, Shanghai Jiaotong University and Springer-Verlag Berlin Heidelberg.

关键词： real gas effect pressure enthalpy temperature field throttling computational fluid dynamics(CFD) Soave-Redlich-Kwong(S-R-K) equation

Microwave-assisted synthesis of colorimetric and fluorometric dual-functional hybrid carbon nanodots for Fe^(3+) detection and bioimaging

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Chinese Chemical Letters 2021年第10期32卷 3189-3194页

作者： Yupeng Shi Jingjing Liu Yong Zhang Jianfeng Bao Jingliang Cheng Changqing Yi key laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging(Henan Province) Department of MRIThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China guangdong provincial Engineering and technology Center of Advanced and Portable Medical Devices School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China

Carbon nanodots(CDs) based fluorescent nanoprobes have recently drawn much attention in chemo-/bio-sensing and ***,it is still challenging to integrate the colorimetric and fluorometric dual readouts into a single ***,novel hybrid CDs(HCDs) are prepared by a simple microwave-assisted reaction of citric acid(CA),branched polyethyleneimine(BPEI) and potassium thiocyanate(KSCN).As-prepared HCDs show extraordinary properties,including excitation-dependent emission,satisfactory fluorescence quantum yield(46.8%),excellent biocompatibility and optical ***,the fluorescence intensity at 450 nm exhibits linear correlation over the Fe^(3+)concentration from 1 mmol/L to 150 mmol/L with a detection limit(LOD) of 52 nmol/***,the solution color changes from colorless to orange,and the absorbance at 460 nm increased linearly with Fe^(3+)concentration ranging from 0.02 mmol/L to 5 mmol/L(LOD:3.4 mmol/L).All the evidence illustrates that the HCDs can be conditioned for specific Fe^(3+)sensing with colorimetric and fluorometric dual readouts,which has also been verified with paper-based *** possible mechanism is attributed to the specific interactions between surface functional groups on the HCDs and Fe^(3+).Additionally,the HCDs are successfully applied in sensing Fe^(3+)in wastewater and living cells,demonstrating its potential applications in future environment monitoring and disease diagnosis.

关键词： Paper-based chip Carbon nanodots Colorimetric Fluorescence Fe^(3+)ions detection Dual-functional

Galactose-modified enzymatic synthesis of poly(amino-co-ester)micelles for co-delivery miR122 and sorafenib to inhibit hepatocellular carcinoma development

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Chinese Chemical Letters 2020年第5期31卷 1173-1177页

作者： Jianhua Xie Yao Lu Baiqing Yu Jun Wu Jie Liu School of biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China

Nanomaterials as drug carriers hold promise for the treatment of carcinomas,but integrating multiple functions into a single vector is *** this study,we aim to develop efficie nt materials as vectors for co-delivery of microRNA-122(miR-122)and sorafenib(SRF).We successfully synthesized amphiphilic galactose-modified PEGylated poly(ami no-co-ester)(Gal-PEG-PPMS)copolymers consisted of hydrophilic Gal-PEG5 k chain segments and hydrophobic poly(ω-pentadecalactone-co-N-methyldiethyleneamine-co-sebacic acid)chain segments,which self-assembled to form cationic micelles at pH *** results showed that the micelles could encapsulate SRF and bind miR122 simultaneously,increase cellular uptake ***,the micelles showed favorable transfection efficiency in enhancing miR122 expression level,the migration and invasion ability of hepatocellular carcinoma(HCC)cells we re significantly inhibited after being tra nsfected with miR122-loaded *** importantly,the co-delivery micelles decreased cell activities of HepG2 cells,which was more effective than miR122 or SRF loaded micelles ***,Gal-PEG-PPMS nanoparticles are promising multifunctional carriers for miR122 and SRF co-delivery system to treat HCC.

关键词： Micelles miR122 Sorafenib Hepatocellular carcinoma Co-delivery

A targeting black phosphorus nanoparticle based immune cells nanoregulator for photodynamic/photothermal and photo-immunotherapy

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Bioactive Materials 2021年第2期6卷 472-489页

作者： Xiaoge Zhang Junjie Tang Chao Li Yao Lu Lili Cheng Jie Liu School of biomedical Engineering Sun Yat-sen UniversityGuangzhouGuangdong 510006China

Photo-immunotherapy is a novel therapeutic approach against malignant tumors with minimal ***,a targeting multifunctional black phosphorus(BP)nanoparticle,modified by PEGylated hyaluronic acid(HA),was designed for photothermal/photodynamic/*** vitro and in vivo assays indicated that HA-BP nanoparticles possess excellent biocompatibility,stability,and sufficient therapeutic efficacy in the combined therapy of photothermal therapy(PTT)and photodynamic therapy(PDT)for cancer ***,the results of in vitro showed that HA-BP down-regulated the expression of CD206(M2 macrophage marker)by 42.3%and up-regulated the ratio of CD86(M1 macrophage marker)by 59.6%,indicating that HABP nanoparticles have functions in remodeling tumor associated macrophages(TAMs)phenotype(from protumor M2 TAMs to anti-tumor M1 macrophages).Fluorescence(FL)and photoacoustic(PA)multimodal imaging confirmed the selective accumulation of HA-BP in tumor site via both CD44^+mediated active targeting and passive EPR *** vitro and in vivo studies suggested that the combined therapy of PDT,PTT and immunotherapy using HA-BP could not only significantly inhibit original tumor but also induce immunogenic cell death(ICD)and release Damage-associated molecular patterns(DAMPs),which could induce maturation of dendritic cells(DCs)and activate effector cells that robustly evoke the antitumor immune responses for cancer *** study expands the biomedical application of BP nanoparticles and displays the potential of modified BP as a multifunctional therapeutic platform for the future cancer therapy.

关键词： Black phosphorus Tumor associated macrophages Photothermal therapy Photodynamic therapy Immunotherapy

Multiple stimuli-responsive nanosystem for potent,ROS-amplifying,chemo-sonodynamic antitumor therapy

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Bioactive Materials 2022年第9期7卷 355-371页

作者： JunJie Tang Xiaoge Zhang Lili Cheng Yadong Liu You Chen Zhaozhong Jiang Jie Liu School of biomedical Engineering Sun Yat-sen UniversityGuangzhouGuangdong510006China Faculty of Arts and Sciences Department of Biomedical EngineeringIntegrated Science and Technology CenterYale University600 West Campus DriveWest HavenCT06516United States

Although sonodynamic therapy(SDT)is a promising non-invasive tumor treatment strategy due to its safety,tissue penetration depth and low cost,the hypoxic tumor microenvironment limits its therapeutic ***,we have designed and developed an oxygen-independent,ROS-amplifying chemo-sonodynamic antitumor therapy based on novel pH/GSH/ROS triple-responsive PEG-PPMDT *** formulated artemether(ART)/Fe_(3)O_(4)-loaded PEG-PPMDT NPs can rapidly release drug under the synergistic effect of acidic endoplasmic pH and high intracellular GSH/ROS levels to inhibit cancer cell ***,the ROS level in the NPs-treated tumor cells is magnified by ART via interactions with both Fe^(2+)ions formed in situ at acidic pH and external ultrasound irradiation,which is not affected by hypoxia tumor ***,the enriched intracellular ROS level can cause direct necrosis of ROS-stressed tumor cells and further accelerate the drug release from the ROS-responsive PEG-PPMDT NPs,achieving an incredible antitumor ***,upon the chemo-sonodynamic therapy by ART/Fe_(3)O_(4)-loaded PEG-PPMDT NPs,all xenotransplants of human hepatocellular carcinoma(HepG2)in nude mice shrank significantly,and 40% of the tumors were completely ***,the Fe3O4 encapsulated in the NPs is an efficient MRI contrast agent and can be used to guide the therapeutic ***,biosafety analyses show that the PEG-PPMDT NPs possess minimal toxicity to main ***,our combined chemo-sonodynamic therapeutic method is promising for potent antitumor treatment by controlled release of drug and facile exogenous generation of abundant ROS at target tumor sites.

关键词： Nanoparticle pH/GSH/ROS triple-Responsive MRI imaging Chemodynamic therapy Sonodynamic therapy

Altered Cortical Information Interaction During Respiratory Events in Children with Obstructive Sleep Apnea-Hypopnea Syndrome

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Neuroscience Bulletin 2024年第10期40卷 1458-1470页

作者： Jin Chen Minmin Lin Naikai Shi Jingxian Shen Xuchu Weng Feng Pang Jiuxing Liang key laboratory of Brain Cognition and Education ScienceMinistry of EducationChinaInstitute for Brain Research and RehabilitationGuangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou 510631China School of General Education Guangzhou Huali CollegeGuangzhou 511325China Department of Sleep Medicine The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Otorhinolaryngology Head and Neck SurgeryThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China TUM-Neuroimaging Center Technical University of Munich81675 MunichGermany guangdong provincial key laboratory of Sensor technology and biomedical Instrument Sun Yat-Sen UniversityGuangzhou 510006China biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China

Obstructive sleep apnea-hypopnea syndrome(OSAHS)significantly impairs children's growth and *** study aims to elucidate the pathophysiological mechanisms underlying OSAHS in children,with a particular focus on the alterations in cortical information interaction during respiratory *** analyzed sleep electroencephalography before,during,and after events,utilizing Symbolic Transfer Entropy(STE)for brain network construction and information flow *** results showed a significant increase in STE after events in specific frequency bands during N2 and rapid eye movement(REM)stages,along with increased STE during N3 stage ***,a noteworthy rise in the information flow imbalance within and between hemispheres was found after events,displaying unique patterns in central sleep apnea and ***,some of these alterations were correlated with symptom *** findings highlight significant changes in brain region coordination and communication during respiratory events,offering novel insights into OSAHS pathophysiology in children.

关键词： Obstructive sleep apnea-hypopnea syndrome Children Respiratory events Electroencephalogram Effective connectivity-Symbolic transfer entropy

Manganese-doped mesoporous polydopamine nanoagent for T1-T2 magnetic resonance imaging and tumor therapy

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Nano Research 2023年第2期16卷 2991-3003页

作者： Xiuqi Hou Xi Yang Yanwen Xu Jiayin Lin Fang Zhang Xiaohui Duan Sitong Liu Jie Liu Jun Shen Xintao Shuai Zhong Cao School of biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Translational Medicine Institute Shenzhen Second People’s Hospitalthe First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen 518035China Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and ***,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodrug incorporating the nitric oxide(NO)prodrug BNN6 and immune agonist R848 was *** nanodrug responded to the H^(+)and glutathione being enriched in tumor microenvironment to release R848 and Mn^(2+).The abundant Mn^(2+)produced through a Fenton-like reaction enabled a highly sensitive T1-T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug,based on which an MRI-guided laser irradiation was achieved to trigger the NO gas ***,R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 ***,a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer,which manifested the great promise of this multifunctional nanoplatform in cancer treatment.

关键词： mesoporous polydopamine magnetic resonance imaging T1-T2 dual-mode NO gas therapy immunotherapy

Soft Electronics for Health Monitoring Assisted by Machine Learning

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Nano-Micro Letters 2023年第5期15卷 83-168页

作者： Yancong Qiao Jinan Luo Tianrui Cui Haidong Liu Hao Tang Yingfen Zeng Chang Liu Yuanfang Li Jinming Jian Jingzhi Wu He Tian Yi Yang Tian-Ling Ren Jianhua Zhou School of biomedical Engineering Shenzhen Campus of Sun Yat-sen UniversityNo.66Gongchang RoadGuangming DistrictShenzhen 518107People’s Republic of China School of Integrated Circuits and Beijing National Research Center for Information Science and technology(BNRist) Tsinghua UniversityBeijing 100084People’s Republic of China key laboratory of sensing technology and biomedical instruments of guangdong Province School of Biomedical EngineeringSun Yat-sen UniversityGuangzhou 510275People’s Republic of China

Due to the development of the novel materials,the past two decades have witnessed the rapid advances of soft *** soft electronics have huge potential in the physical sign monitoring and health *** of the important advantages of soft electronics is forming good interface with skin,which can increase the user scale and improve the signal ***,it is easy to build the specific dataset,which is important to improve the performance of machine learning *** the same time,with the assistance of machine learning algorithm,the soft electronics have become more and more intelligent to realize real-time analysis and *** soft electronics and machining learning algorithms complement each other very *** is indubitable that the soft electronics will bring us to a healthier and more intelligent world in the near ***,in this review,we will give a careful introduction about the new soft material,physiological signal detected by soft devices,and the soft devices assisted by machine learning *** soft materials will be discussed such as two-dimensional material,carbon nanotube,nanowire,nanomesh,and ***,soft sensors will be discussed according to the physiological signal types(pulse,respiration,human motion,intraocular pressure,phonation,etc.).After that,the soft electronics assisted by various algorithms will be reviewed,including some classical algorithms and powerful neural network ***,the soft device assisted by neural network will be introduced ***,the outlook,challenge,and conclusion of soft system powered by machine learning algorithm will be discussed.

关键词： Soft electronics Machine learning algorithm Physiological signal monitoring Soft materials