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Protection effect of Emodin pretreatment on intestinal I-RI damage of intestinal mucosa in ratsa

Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 749-753页

作者： Shu-Jie Zhao Shi-Ji Wang Hong-Xiang Li Li-Hua Dong Huai-Jiang He Zhong-Min Liu Yu-Shan Wang ICU First Hospital of Jilin University

Objective:To linvestigate the protective effect and mechanism of emodin pretreatment on intestinal mucosa of rats with intestinal ischemia-reperfusion ***:A total of 50SD rats were randomly divided into control group,model group,emodin groups of low,medium and high dose,with 10 in each ***-reperfusion injury(I-RI)mode was established by using noninvasive clamp on superior mesentericartery(SMA).Control group and model group were pretreated with 0.5%sodium carboxymethyl cellulose solution lavage 2 h before operation,emodin groups of low,medium and high dose were given emodin lavage with 20,40,60 mg/kg pretreatment,femoral venous blood before the lavage pretreatment(TO)and 1 h ischemia(Tl),and inferior vena venous blood after 1 h of reperfusion(T2)were extracted from each group of rats for detection of serun level of intestinal fatty acid binding protein(I-FABP),tumor necrosis factor(TNF-α),endotoxin,interleukin 6(IL-6),and die content of diamine oxidase(DAO);Mter model establishment,the rats were sacrificed,intestine homogenate was prepared by using blind intestinal tissue to detect intestinal tissue myeloperoxidase(MPO],malondialdehyde(MDA)and superoxide dismutase(SOD)*** upper small intestine tissue was retrieved,followed by fixation and conventional HE staining to observe intestinal tissue morphology under light ***:In emodin groups of low,medium and high dose at T1 and T2,I-FABP,TNF-α,***,-6 and DAO level were significandy lower than that of model group(P<0.05);in emodin group of low,medium and high dose,MPO and MDA content in intestinal tissue homogenate was significantly lower than that in model group(P<0.05),SOD level was significantly higher than that of model group(P<0.05).Intestinal damage of emodin low,medium and high dose groups were significandy lighter than model ***:Emodin pretreatment has certain protective effect on intestinal mucosa in ischemia reperfusion injury.

关键词： Emodin Ischemia-reperfusion injury Intestinal mucosa barrier Protection

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Effect of intestinal function-recovering decoction on treatment of multiple organ dysfunction syndrome in rats

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 889-892页

作者： Shu-Jie Zhao Dong Zhang Shi-Ji Wang Ying Chen Jin-Feng Han Yu-Shan Wang Intensive Care Unit First HospitalJilin University

Objective:To analyze the effect of intestinal function-recovering decoction on multiple organ dysfunction syndrome in rats,and to investigate a novel solution to multiple organ dysfunction ***:Multiple organ dysfunction syndrome was induced in 60 Sprague-Dawley rats by intestinal ischemia-reperfusion combined with cecal ligation and *** these rats were intragastrically administered physiological saline(group Ⅰ,n=20),ampicillin(group Ⅱ,n=20) or intestinal function-recovering decoction(group Ⅲ,n=20).After treatment, serum malondialdehyde and superoxide dismutase levels were compared among three groups. Simultaneously,bacterial culture of various organ tissues was performed and bacterial and endotoxin translocation were ***:Compared with group 1,serum malondialdehyde, alanine aminotransferase and aspartate aminotransferase levels were significantly decreased(all P0.05). The rate of bacterial translocation in the groups Ⅱ and Ⅲ was significantly lower than in the group Ⅰ(P0.05). Conclusions:Intestinal function-recovering decoction can significantly reduce endotoxin and bacterial translocation and stabilize enteral oxidative-antioxidative balance.

关键词： Multiple organ dysfunction syndrome Intestinal function-recovering decoction Malondialdehyde Superoxide dismutase

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Evaluation of clinical application of ESICM acute gastrointestinal injury grading system： a single-center observational study

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Chinese Medical Journal 2014年第10期127卷 1833-1836页

作者： Zhang Dong Li Nan Dong Lihua Fu Yao Liu Zhongmin Wang Yushan Intensive Care Unit First Hospital Jilin University Changchun Jilin 130021 China

Background In 2012,the working group on abdominal problems of the European Society of Intensive Care Medicine （ESICM） proposed a definition and also guidelines for the grading system and treatment of acute gastrointestinal injury （AGI）.Until now,clinical reports on this topic have not been available,and the practicality of using the AGI grading system requires further validation in the ***,we conducted this study to evaluate the feasibility of utilizing the current AGI grading system in a clinical environment,and to provide evidence for its usefulness in assessing the severity and prognosis of critically ill patients with gastrointestinal *** A total of 133 patients were examined for the presence or absence of AGI,their scores on the Acute Physiology and Chronic Health Evaluation （APACHE） Ⅱ and Lausanne Intestinal Failure Estimation （LIFE） test,and 28 days *** presence and severity of AGI was based on guidelines provided by the *** patients were assigned to a NOAGI group （n=50） or an AGI group （n=83）.The AGI group was then further divided into three subgroups,consisting ofAGI Ⅰ （risk group,n=38）,AGI Ⅱ （gastrointestinal dysfunction group,n=33） and AGI Ⅲ＋AGI Ⅳ （gastrointestinal failure group,n=12）.These subgroups were then compared for differences in AGI *** There were no statistically significant differences between the AGI group and the NO-AGI group in terms of age,gender,APACHE Ⅱ score or LIFE score （P ＞ 0.05）; however,the two groups showed a significant difference in their respective rates of 28 days mortality （32.5％ in the AGI group vs.8.0％ in the NO-AGI group （P ＜ 0.05））.Patients in the three AGI subgroups showed significant differences in their 28 d mortality rates,APACHE Ⅱ,and LIFE *** grading system showed strong positive correlations with APACHE Ⅱ and LIFE scores （P ＜ 0.05）.Conclusions The currentAGI grading system can be used to identify and evaluate gastrointestinal dysfunction in criticall

关键词： acute gastrointestinal injury multiple organ dysfunction syndrome gastrointestinal dysfunction prognosis

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