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Bioengineered skin organoids:from development to applications

Military Medical Research 2024年第3期11卷 449-466页

作者： Zi-Xuan Hong Shun-Tian Zhu Hao Li Jing-Zhi Luo Yu Yang Yang An Xi Wang Kai Wang Department of Physiology and Pathophysiology School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China Department of Hepatopancreatobiliary Surgery the Third Affiliated Hospital of Soochow UniversityChangzhou 213000JiangsuChina Department of Plastic Surgery Peking University Third HospitalBeijing 100191China Clinical Stem Cell Research Center Peking University Third HospitalBeijing 100191China State Key Laboratory of cardiovascular Disease Fuwai HospitalBeijing 100037China Beijing Key Laboratory of Metabolic Disorder Related cardiovascular Disease Capital Medical UniversityBeijing 100050China

Signifcant advancements have been made in recent years in the development of highly sophisticated skin *** as three-dimensional(3D)models that mimic human skin,these organoids have evolved into complex structures and are increasingly recognized as efective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional(2D)systems and ethical *** inherent plasticity of skin organoids allows for their construction into physiological and pathological models,enabling the study of skin development and dynamic *** review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with ***,it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques,such as 3D printing and microfuidic *** review also summarizes and discusses the diverse applications of skin organoids in developmental biology,disease modelling,regenerative medicine,and personalized medicine,while considering their prospects and limitations.

关键词： Skin organoid Organoid generation Skin appendage Tissue engineering Disease modelling Regenerative medicine

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Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in china:a nation-wide study

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Science china(Life Sciences) 2022年第9期65卷 1855-1865页

作者： Jianping Li Nan Zhang Ziyi Zhou Xiao Huang Weiyi Fang Hongbing Yan Jiyan Chen Weimin Wang Dingcheng Xiang Xi Su Bo Yu Yan Wang Yawei Xu Lefeng Wang Chunjie Li Kai Huang Xiaobin Wang Yong Huo Junbo Ge Department of Cardiology Peking University First HospitalBeijing 100044China Key Laboratory of Precision Nutrition and Food Quality Ministry of EducationDepartment of Nutrition and HealthCollege of Food Sciences and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Institute of Biomedicine Anhui Medical UniversityHefei 230032China Department of cardiovascular Medicine Second Affiliated Hospital of Nanchang UniversityNanchang 330008China Department of Cardiology Huadong Hospital Affiliated to Fudan UniversityShanghai 200050China Department of Cardiology Fuwai Hospital Chinese Academy of Medical SciencesShenzhen 518057China Department of Cardiology Guangdong Provincial People’s HospitalGuangzhou 510080China Department of Cardiology Peking University People’s HospitalBeijing 100044China Department of Cardiology General Hospital of Southern Theatre CommandGuangzhou 510010China Department of Cardiology Wuhan ASIA Heart HospitalWuhan 430010China Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Cardiology Xiamen Cardiovascular Hospital Xiamen UniversityXiamen 361004China Department of Cardiology Shanghai Tenth People’s HospitalShanghai 200072China Department of Cardiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100069China Department of Emergency Tianjin Chest HospitalTianjin 300074China Department of Cardiology Union Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Population Family and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore 21218USA Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China

Lockdown and re-opening may become cyclical due to the recurrent waves of the COVID-19 *** studies have examined temporal trends and determinants of in-hospital mortality among patients with ST-segment elevation myocardial infarction(STEMI),a life-threatening condition that requires emergency medical *** nation-wide data before,during and after the Wuhan lockdown,we aimed to depict temporal patterns and major determinants of STEMI in-hospital mortality in china across five time periods of the COVID-19 *** analyzed the data of 283,661 STEMI patients who were admitted to 4,487 chest-pain-centers across china,from January 1,2019 to May 31,*** with the period before the lockdown,STEMI in-hospital mortality increased by 25%(OR 1.25,95%CI 1.16–1.34)during Early Lockdown,by 12%(OR 1.12,95%CI 1.03–1.22)during Later Lockdown,by 35%(OR 1.35,95%CI 1.21–1.50)during Early Lift,and returned to pre-COVID risk(OR 1.04,95%CI 0.95–1.14)during Later *** each time-period,we observed a clear mortality gradient by timing and types of revascularization *** conclusion,the COVID-19 epidemic had a significant adverse impact on STEMI in-hospital mortality,with bimodal peaks during early lockdown and early lift periods and clear mortality gradients by timing and types of revascularization procedure,independent of the time periods.

关键词： COVID-19 STEMI mortality lockdown re-opening

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