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high mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

high-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

Characterization of decellularized scaffold derived from porcine meniscus for tissue engineering applications

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Frontiers of Materials Science 2016年第2期10卷 101-112页

作者： Shuang GAO Zhiguo YUAN Tingfei XI Xiaojuan WEI Quanyi GUO Center for Biomaterial and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China Key Laboratory of PLA Institute of Orthopaedics Chinese PLA General Hospital Beijing 100853 China Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China

Menisci are fundamental fibrocartilaginous organs in knee joints. The injury in meniscus can impair normal knee function and predisposes patients to osteoarthritis. This study prepared decellularized meniscus scaffolds using a 1% （w/w） sodium dodecyl sulfate solution and sufficient rinsing steps. Complete cell removal was verified by hematoxylin and eosin staining and DNA content assay. Decellularized menisci had accordant tension properties to intact ones, but with declined compression properties. This occurred because the collagen fiber was not damaged but glycosami- noglycans was significantly lost during the decellularization process, which was confirmed by biochemical assay and histology staining. In vitro cytotoxicity assay demonstrated that decellularized meniscus scaffolds have no toxicity on L929 murine fibroblasts and porcine chondrocytes. Further experiment showed that porcine chondrocytes could adhere and proliferate on the scaffold surface, and some cells even could infiltrate into the scaffold. All results showed the potential of this decellularized meniscus to be the scaffolds in tissue engineering.

关键词： meniscus scaffold decellularization biomechanical cytotoxicity tissueengineering

Biomaterial Scaffolds with Biomimetic Fluidic Channels for Hepatocyte Culture

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Journal of Bionic Engineering 2013年第1期10卷 57-64页

作者： Xiao Li Jiankang He Yaxiong Liu Qian Zhao WanquanWu Dichen Li Zhongmin Jin State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an 710054 P. R. China

Biomaterial scaffolds play an important role in maintaining the viability and biological functions of highly metabolic hepatocytes in liver tissue engineering. One of the major challenges involves building a complex microchannel network inside three-dimensional （3D） scaffolds for efficient mass transportation. Here we presented a biomimetic strategy to generate a mi- crochannel network within porous biomaterial scaffolds by mimicking the vascular tree of rat liver. The typical parameters of the blood vessels were incorporated into the biomimetic design of the microchannel network such as branching angle and diameter. Silk fibroin-gelatin scaffolds with biomimetic vascular tree were fabricated by combining micromolding, freeze drying and 3D rolling techniques. The relationship between the micro-channeled design and flow pattern was revealed by a flow experiment, which indicated that the scaffolds with biomimetic vascular tree exhibited unique capability in improving mass transportation inside the 3D scaffold. The 3D scaffolds, preseeded with primary hepatocytes, were dynamically cultured in a bioreactor system. The results confirmed that the pre-designed biomimetic microchannel network facilitated the generation and expansion of hepatocytes.

关键词： liver tissue engineering scaffold biomimetic vascular tree dynamic culture hepatocyte

The Micro-structural Studies of Ni-BaTiO_3 Nanocomposite Films by TEM and EELS

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Journal of Wuhan University of technology(Materials Science) 2011年第5期26卷 897-901页

作者：陈士娟吴卫东 Institute of Atomic and Molecular Physics Sichuan University research Center of Laser Fusion China Academy of Engineering Physics

Epitaxial BaTiO3 films with embedded metallic Ni nanocrystal （Ni-BaTiO3） were successfully fabricated on SrTiO3 （001） single-crystalline substrate through the laser molecular beam epitaxial （L-MBE） *** resolution transmission electron microscopy （HRTEM） and electron energy loss spectrum （EELS） with Kramers-Kronig analysis methods were employed to characterize the microstructures,elementary distribution and the electron structure of these *** results suggested that the structure of BaTiO3 was tetragonal with lattice parameters of a=0.399 nm and c=0.403 *** dispersive X-Ray spectroscopy （EDX） confirmed metallic Ni nanocrystal embedded successfully in BaTiO3 epitaxial *** Ni-BaTiO3 composite films were compound of the epitaxial BaTiO3 （110） layers alternating with Ni NCs array （111） ***,the existence of the misfit dislocations induced by the embedding of Ni nanoparticles was also clearly demonstrated by the HRTEM *** Ni L2,3 edges of EELS revealed that Ni NCs in their metallic state were embedded uniformly in the BaTiO3 matrix.A chemical shift of about 7 eV regarding L3 edges in the Ni EELS was also *** optical band gap of BaTiO3 in these films was about 3.84 eV,higher than 3.55 eV for pure BaTiO3 films at room temperature.

关键词： Laser molecular beam epitaxial transmission electron microscopy electron energy loss spectrum Kramers-Kronig analysis

Patients with ST-segment elevation of myocardial infarction miss out on early reperfusion： when to undergo delayed revascularization

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Journal of Geriatric Cardiology 2017年第8期14卷 524-531页

作者： Wen ZHENG Cheuk-Man YU Jing LIU Wu-Xiang XIE Miao WANG Yu-Jiao ZHANG Jian SUN Shao-Ping NIE Dong ZHAO Department of Epidemiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases No.2 Anzhen Road Chaoyang District Beijing China Emergency Critical Care Center Beijing Anzhen Hospital Capital Medical University Beijing China Prince of Wales Hospital Institute of Vascular Medicine the Chinese University of Hong Kong Hong Kong China Department of Infectious Disease China-Japan Friendship Hospital Beijing China Department of Cardiology the First Hospital of Jilin University Changchun Jilin China

Objective There are still a high proportion of patients with ST-segment elevation myocardial infarction （STEMI） missing out early reperfusion even in the primary percutaneous coronary intervention （PCI） era. Most of them are stable latecomers, but the optimal time to undergo delayed PCI for stable ones remains controversial. Methods We investigated all STEMI patients who underwent delayed PCI （2-28 days after STEMI） during 2007-2010 in Beijing and excluded patients with hemodynamic instability. The primary outcome was maj or adverse cardiovascular events （MACEs）. Results This study finally enrolled 5,417 STEMI patients and assigned them into three groups according to individual delayed time （Early group, 55.9%; Medium group, 35.4%; Late group, 8.7%）. During 1-year follow-up, MACEs occurred in 319 patients. The incidence of MACEs were respectively 7.1%, 5.6% and 6.7% among three groups. The Medium group had less recurrent myocardial infarction plus cardiac death （hazard ratio, 0.525; 95% confidence interval, 0.294-0.938, P = 0.030） than Late group and less repeat revascularization （hazard ratio, 0.640; 95% confidence interval, 0.463-0.883, P = 0.007） than Early group in pairwise comparisons. We depicted the incidence of major adverse cardiovascular event （MACE） by delayed time as a quadratic curve and found the bottom appeared at day 14. Conclusions The delayed PCI time varied in the real-world practice, but undergoing operations on the second week after STEMI had greater survival benefit and less adverse events for whom without early reperfusion and hemodynamic instability.

关键词： Angioplasty Epidemiology Latecomer Myocardial infarction Stents

Preparation and Surface Properties of Silicon-Containing Waterborne Polyurethane Functionalized with Fluorine-Containing Acrylate and Micro-Nano Silica

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Journal of Wuhan University of technology(Materials Science) 2018年第1期33卷 233-241页

作者：蔡棋 HUANG Jiemin 翁睿 LIU Shichen School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 China

In order to prepare hydrophobic waterborne polyurethane coatings with better performances, the silicon-containing waterborne polyurethane（SiWPU） with functional chain extender hydroxyethyl acrylate（HEA） was prepared first, and then a series of silicon＆fluorine-containing polyurethane/acrylate（FSiPUA） emulsions were obtained with flourine containing acrylic monomer by seed emulsion polymerization, introducing micro-nano SiO2 into FSiPUA emulsion to make the final hybrid emulsion. The properties of Si WPU, FSiPUA and SiO2/FSiPUA were investigated by fourier transform infrared spectra（FTIR）, transmission electron microscope（TEM）, Scanning Electron Microscope（SEM） and some other analytical methods. The results revealed that FSiPUA emulsion particles possessed composite core-shell structure and FSiPUA films with suitable ratio performed better than Si WPU films in hardness, water resistance and solvent resistance. The SiO2/FSiPUA films with micro-nano dual roughness structure showed a water contact angle of 136° with good resistance to acid and alkali.

关键词： waterborne polyurethane acrylic SiO2 surface properties

Synthesis and Properties of Perfluorinated Alkyl Silicone Oil Modified Epoxy Resin

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Journal of Wuhan University of technology(Materials Science) 2014年第2期29卷 361-366页

作者：孙明慧 MA Ben 翁睿 School of Materials Science and Engineering Wuhan University of Technology

Perfluorinated alkyl silicone oil （PFASO） was successfully synthesized from N-ethyl-N- hydroxylethyl perfluorinated octane sulfonamide, succinie anhydride and amino silicone oil by esterification and amide reaction at moderate temperature in the presence of different catalysts. The chemical structure of the synthesized samples was characterized by Fourier transform infrared spectroscopy （FT-IR）, the relative molecular mass（MM） and molecular mass distribution（MMD） of PFASO were tested by gel filtration chromatography（GFC）. A commercial epoxy resin （DGEBA） was modified with PFASO, with the content of PFASO 1-5 phr. Thermo-gravimetric analysis （TGA）, impact tests, scanning electron microscope （SEM） and water contact angle test were applied to provide accurate results on the thermal stability, toughness and hydrophobicity of PFASO/epoxy complex. The experimental results reveal that epoxy resins can be successfully modified by adding a small amount of as-synthesized modifiers via simple direct mixing, and verify that the as-synthesized modifier can improve the toughness and hydrophobicity of epoxy resin without sacrificing its thermal properties.

关键词： perfluorinated alkyl silicone oil epoxy resin modification

The Fabrication of Bio-ceramsite for the Removal of Heavy Metals and Its Toxicity to Bacteria

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Journal of Wuhan University of technology(Materials Science) 2015年第3期30卷 649-654页

作者：石岩 SUN Ken 齐学斌 GAO Qing Farmland Irrigation research Institute Chinese Academy of Agricultural Sciences School of Environmental and Municipal Engineering North China University of Water Resources and Electric Power School of Water Resource & Environment China University of Geosciences

Bio-ceramsite technology is one of the most effective technologies in the pretreatment of drinking water. In this work, bio-ceramsite was fabricated by Citrobacterfreundii （C. freundii） immobilization on the ceramsite. The findings of the current study suggest that the bio-ceramites showed biosorption abilities for Cd（II） and Pb（II） and the removal efficiency for Pb（II） is lower than Cd（II）. The adsorption mechanism can be attributed to electrostatic attraction and covalent bond. The morphology of the cells changed after the adsorption of Cd（II） and Pb（II） due to the dissociation of the assembly of peptidoglycan and lipopolysaccharide. The fluorescence polarization has shown a significant decrease in membrane fluidity and an increase of permeability of cell membrane. The spectral profile of C. freundii suggests the alteration of carbonyl, amide and phosphonic groups on the cell membrane.

关键词： immobilization biosorption bio-ceramsite dissociation cell membrane