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In situ neutron diffraction unravels deformation mechanisms of a strong and ductile Fe Cr Ni medium entropy alloy

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Journal of Materials Science & Technology 2022年第21期116卷 103-120页

作者： L.Tang F.Q.Jiang J.S.Wróbel B.Liu S.Kabra R.X.Duan J.H.Luan Z.B.Jiao M.M.Attallah D.Nguyen-Manh B.Cai School of Metallurgy and Materials University of BirminghamB152TTUnited Kingdom Institute of Metal research Chinese Academy of SciencesShenyang 110016China Faculty of Materials Science and Engineering Warsaw University of Technologyul.Wołoska 141Warsaw 02-507Poland State Key Laboratory for Powder Metallurgy Central South UniversityChangsha 410083China Rutherford Appleton Laboratory ISIS FacilityDidcot OX110QXUnited Kingdom Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina CCFE United Kingdom Atomic Energy AuthorityAbingdonOxfordshire OX143DBUnited Kingdom

We investigated the mechanical and microstructural responses of a high-strength equal-molar medium entropy FeCrNi alloy at 293 and 15 K by in situ neutron diffraction *** 293 K,the alloy had a very high yield strength of 651±12 MPa,with a total elongation of 48%±5%.At 15 K,the yield strength increased to 1092±22 MPa,but the total elongation dropped to 18%±1%.Via analyzing the neutron diffraction data,we determined the lattice strain evolution,single-crystal elastic constants,stacking fault probability,and estimated stacking fault energy of the alloy at both temperatures,which are the critical parameters to feed into and compare against our first-principles calculations and dislocation-based slip system *** density functional theory calculations show that the alloy tends to form shortrange order at room ***,atom probe tomography and atomic-resolution transmission electron microscopy did not clearly identify the short-range ***,at 293 K,experimental measured single-crystal elastic constants did not agree with those determined by first-principles calculations with short-range order but agreed well with the values from the calculation with the disordered configuration at 2000 *** suggests that the alloy is at a metastable state resulted from the fabrication *** view of the high yield strength of the alloy,we calculated the strengthening contribution to the yield strength from grain boundaries,dislocations,and lattice *** lattice distortion contribution was based on the Varenne-Luque-Curtine strengthening theory for multi-component alloys,which was found to be 316 MPa at 293 K and increased to 629 MPa at 15 K,making a significant contribution to the high yield *** plastic deformation,dislocation movement and multiplication were found to be the dominant hardening mechanism at both temperatures,whereas twinning and phase transformation were not *** is mainly due to the high stack

关键词： Medium entropy alloy Multi-component alloy Cryogenic temperature Neutron diffraction

Retinal ganglion cell neuroprotection by growth factors and exosomes:lessons from mesenchymal stem cells

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Neural Regeneration research 2018年第2期13卷 228-229页

作者： Ben Mead Stanislav Tomarev Section of retinal ganglion cell biology laboratory of retinal cell and molecular biologynational eye institutenational institutes of healthBethesdaMDUSA

Retinal ganglions cells （RGCs） are responsible for propagating electrochemical information from the eye to the brain along their axons which make up the optic nerve. The loss of RGCs is characteristic in several conditions such as glaucoma and trau- matic optic neuropathy and leads to visual loss and blindness. While no therapy exists to directly treat RGCs, the use of bone marrow-derived mesenchymal stem cells （BMSCs） has shown promise in eliciting significant RGC neuroprotection.

关键词： BMSCs Retinal ganglion cell neuroprotection by growth factors and exosomes lessons from mesenchymal stem cells PDGFR

Quantitative phase imaging through an ultra-thin lensless fiber endoscope

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Light(Science & Applications) 2022年第8期11卷 1843-1852页

作者： Jiawei Sun Jiachen Wu Song Wu Ruchi Goswami Salvatore Girardo Liangcai Cao Jochen Guck Nektarios Koukourakis Juergen W.Czarske Laboratory of Measurement and Sensor System Technique(MST) TU DresdenHelmholtzstrasse 1801069DresdenGermany Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenDresdenGermany State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentsTsinghua University100084BeijingChina Institute for Integrative Nanosciences IFW DresdenHelmholtzstraße 2001069DresdenGermany Max Planck Institute for the Science of Light&Max-Planck-Zentrum für Physik und Medizin 91058ErlangenGermany Cluster of Excellence Physics of Life TU DresdenDresdenGermany Institute of Applied Physics TU DresdenDresdenGermany

Quantitative phase imaging(QPI)is a label-free technique providing both morphology and quantitative biophysical information in ***,applying such a powerful technique to in vivo pathological diagnosis remains ***-core fiber bundles(MCFs)enable ultra-thin probes for in vivo imaging,but current MCF imaging techniques are limited to amplitude imaging *** demonstrate a computational lensless microendoscope that uses an ultra-thin bare MCF to perform quantitative phase imaging with microscale lateral resolution and nanoscale axial sensitivity of the optical path *** incident complex light field at the measurement side is precisely reconstructed from the far-field speckle pattern at the detection side,enabling digital refocusing in a multi-layer sample without any mechanical *** accuracy of the quantitative phase reconstruction is validated by imaging the phase target and hydrogel beads through the *** the proposed imaging modality,three-dimensional imaging of human cancer cells is achieved through the ultra-thin fiber endoscope,promising widespread clinical applications.

关键词： fiber phase thin

Towards a tailored indoor horticulture:a functional genomics guided phenotypic approach

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Horticulture research 2018年第1期5卷 128-137页

作者： Claudius Marondedze Xinyun Liu Shihui Huang Cynthia Wong Xuan Zhou Xutong Pan Huiting An Nuo Xu Xuechen Tian Aloysius Wong Laboratoire de Physiologie Cellulaire et Végétale UniversitéGrenoble AlpesCEA/DRF/BIGINRA UMR1417CNRS UMR516838054Grenoble Cedex 9France Department of Biology Wenzhou-Kean University88 Daxue RoadOuhaiWenzhouZhejiang Province325060China Department of Cell and Systems Biology University of Toronto25 Willcocks StreetTorontoONM5S 3B2Canada

As indoor horticulture gathers momentum,electric(also termed artificial)lighting systems with the ability to generate specific and tunable wavelengths have been developed and *** the effects of light quality on plant growth and development have been studied,authoritative and reliable sets of light formulae tailored for the cultivation of economically important plants and plant traits are lacking as light qualities employed across laboratories are *** is due,at least in part,to the lack of molecular data for plants examined under electric lights in indoor *** has hampered progress in the field of indoor horticulture,in particular,the transition from small-scale indoor farming to commercial plant ***,we review the effects of light quality on model and crop plants studied from a physiological,physical and biochemical perspective,and explain how functional genomics can be employed in tandem to generate a wealth of molecular data specific for plants cultivated under indoor *** also review the current state of lighting technologies in indoor horticulture specifically discussing how recent narrow-bandwidth lighting technologies can be tailored to cultivate economically valuable plant species and *** gained from a complementary phenotypic and functional genomics approach can be harvested not only for economical gains but also for sustainable food *** believe that this review serves as a platform that guides future light-related plant research.

关键词： traits culture lighting

Breast Cancer Risk Genes-Association Analysis in More than 113,000 Women

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四川生理科学杂志 2021年第1期43卷 7-7页

作者： Leila Dorling The authors' affiliations are as follows: the Centre for Cancer Genetic Epidemiology Departments of Public Health and Primary Care (L.D. S. Carvalho J.A. K.A.P. Q.W. M.K.B. J.D. B.D. N. Mavaddat K. Michailidou A.C.A. P.D.P.P. D.F.E.) and Oncology (C.L. P.A.H. C. Baynes D.M.C. L.F. V.R. M. Shah P.D.P.P. A.M.D. D.F.E.) University of Cambridge Cambridge the Centre for Genomic and Experimental Medicine MRC Institute of Genetics and Molecular Medicine (A. Campbell D.J.P.) and the Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology (D.J.P.) University of Edinburgh the Cancer Research UK Edinburgh Centre (D.A.C. J.F.) and the Usher Institute of Population Health Sciences and Informatics University of Edinburgh Medical School (A. Campbell J.F.) Edinburgh the Divisions of Informatics Imaging and Data Sciences (E.F.H.) Cancer Sciences (A. Howell) Population Health Health Services Research and Primary Care (A. Lophatananon K. Muir) and Evolution and Genomic Sciences School of Biological Sciences (W.G.N. E.M.V. D.G.E.) University of Manchester the NIHR Manchester Biomedical Research Unit (E.F.H.) and the Nightingale Breast Screening Centre Wythenshawe Hospital (E.F.H. H.I.) Academic Health Science Centre and North West Genomics Laboratory Hub and the Manchester Centre for Genomic Medicine St. Mary's Hospital Manchester University NHS Foundation Trust (W.G.N. E.M.V. D.G.E.) Manchester the School of Cancer and Pharmaceutical Sciences Comprehensive Cancer Centre Guy's Campus King's College London London (E.J.S.) the Institute of Cancer and Genomic Sciences University of Birmingham Birmingham (I.T.) and the Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre University of Oxford Oxford (I.T.) - all in the United Kingdom the Human Genotyping-CEGEN Unit Human Cancer Genetic Program (A.G.-N. M.R.A. N.Á. B.H. R.N.-T.) and the Human Genetics Group (V.F. A.O. J.B.) Spanish National Cancer Research

Background:Genetic testing for breast cancer susceptibility is widely used,but for many genes,evidence of an association with breast cancer is weak,underlying risk estimates are imprecise,and reliable subtype-specific risk estimates are ***:We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 *** separate analyses for protein-truncating variants and rare missense variants in these genes,we estimated odds ratios for breast cancer overall and tumor *** evaluated missense-variant associations according to domain and classification of pathogenicity.

关键词： cancer Breast Cancer

A Survey of Lower Limb Rehabilitation Systems and Algorithms Based on Functional Electrical Stimulation

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Computers, Materials & Continua 2020年第1期62卷 281-292页

作者： Mingxu Sun Xueyan Wu Qi Liu Centre for Health Sciences research University of SalfordThe CrescentSalfordM54WTUK Jiangsu Collaborative innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science&TechnologyNanjing210044China School of Computing Edinburgh Napier University10 Colinton RoadEdinburgh EH105DTUK

Functional electrical stimulation is a method of repairing a dysfunctional limb in a stroke patient by using low-intensity electrical ***,it is widely used in smart medical treatment for limb rehabilitation in stroke *** this paper,the development of FES systems is sorted out and analyzed in a time ***,the progress of functional electrical stimulation in the field of rehabilitation is reviewed in details in two aspects,i.e.,system development and algorithm *** the system aspect,the development of the first FES control and stimulation system,the core of the lower limb-based neuroprosthesis system and the system based on brain-computer interface are *** algorithm optimization for control strategy is introduced in the *** stimulation to prolong the function time of the lower limbs and a method to improve the robustness of knee joint modeling using neural *** applications in each of these aspects have been investigated and analyzed.

关键词： Functional electrical stimulation lower limb systems algorithms rehabilitation

Microgrids-as-a-Service for Rural Electrification in Sub-Saharan Africa

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Computers, Materials & Continua 2020年第6期63卷 1249-1261页

作者： Qi Liu Kondwani Michael Kamoto Xiaodong Liu School of Computer and Software Nanjing University of Information Science&TechnologyNanjing210044China Jiangsu Collaborative innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science&TechnologyNanjing210044China School of Computing Edinburgh Napier UniversityEdinburghEH105DTUK

The majority of the population on the African continent is unable to access basic electricity services,this despite the abundance of renewable energy sources(RESs).The inability to adequately tap into these RESs has led to the continued dependence on non-renewable energy sources such as coal for electricity generation,and kerosene for cooking and lighting,the resulting use of which is poor health *** use of Microgrids(MGs)is being extensively researched as a feasible means of tackling the challenge of electrification,especially in rural and remote *** times have seen an increasing number of research works focusing on Sub-Saharan Africa(SSA),which is one of the regions with the lowest electrification rates in the *** provide the most suitable means to integrate RESs into the electricity generation process,paving the way towards clean energy for the African *** paper presents a review of recent literature on the usage of MG technology for rural electrification,with a specific focus on the applicability of MGs in the SSA *** paper additionally presents the challenges and opportunities to *** findings indicate that SSA has already begun the transition towards clean energy via implementation of RES-based ***,two resonating challenges in the literature are adequate support via policy,and proper planning of project *** two major barriers are needed to be overcome in order to fully utilize MGs for rural electrification in *** key methodology derived from this study is that any effort towards rural electrification requires a sufficient amount of investigation,incorporating both the technological and socio-economic aspects into a suitable design for the target location.

关键词： Microgrid rural electrification Sub-Saharan Africa

A Survey of Error Analysis and Calibration Methods for MEMS Triaxial Accelerometers

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Computers, Materials & Continua 2020年第7期64卷 389-399页

作者： Bo Xiao Yinghang Jiang Qi Liu Xiaodong Liu Mingxu Sun Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Centre of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing210044China School of Computer&Software Nanjing University of Information Science&TechnologyNanjingChina School of Computing Edinburgh Napier UniversityEdinburghUK Centre for Health Sciences research University of SalfordSalfordM54WTUK Shandong Beiming Medical Technology Ltd. Jinan250101China

MEMS accelerometers are widely used in various fields due to their small size and low cost,and have good application ***,the low accuracy limits its range of *** ensure data accuracy and safety we need to calibrate MEMS *** authors have improved accelerometer accuracy by calculating calibration parameters,and a large number of published calibration methods have been *** this context,this paper introduces these techniques and methods,analyzes and summarizes the main error models and calibration procedures,and provides useful ***,the content of the accelerometer calibration method needs to be overcome.

关键词： MEMS accelerometer calibration error analysis accelerometer calibration

Field-resolved high-order sub-cycle nonlinearities in a terahertz semiconductor laser

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Light(Science & Applications) 2021年第12期10卷 2531-2540页

作者： J.Riepl J.Raab P.Abajyan H.Nong J.R.Freeman L.H.Li E.H.Linfield A.G.Davies A.Wacker T.Albes C.Jirauschek C.Lange S.S.Dhillon R.Huber Department of Physics University of RegensburgRegensburgGermany Laboratoire de Physique de l’Ecole Normale Supérieure ENSUniversitéPSLCNRSSorbonne UniversitéUniversitéde ParisParisFrance School of Electronic and Electrical Engineering University of LeedsWoodhouse LaneLeedsUK Mathematical Physics and NanoLund Lund UniversityLundSweden Department of Electrical and Computer Engineering Technical University of MunichMunichGermany Department of Physics TU Dortmund UniversityDortmundGermany

The exploitation of ultrafast electron dynamics in quantum cascade lasers(QCLs)holds enormous potential for intense,compact mode-locked terahertz(THz)sources,squeezed THz light,frequency mixers,and comb-based metrology *** the important sub-cycle dynamics have been notoriously difficult to access in operational THz ***,we employ high-field THz pulses to perform the first ultrafast two-dimensional spectroscopy of a free-running THz *** incoherent and coherent nonlinearities up to eight-wave mixing are detected below and above the laser *** data not only reveal extremely short gain recovery times of 2 ps at the laser threshold,they also reflect the nonlinear polarization dynamics of the QCL laser transition for the first time,where we quantify the corresponding dephasing times between 0.9 and 1.5 ps with increasing bias currents.A density-matrix approach reproducing the emergence of all nonlinearities and their ultrafast evolution,simultaneously,allows us to map the coherently induced trajectory of the Bloch *** observed high-order multi-wave mixing nonlinearities benefit from resonant enhancement in the absence of absorption losses and bear potential for a number of future applications,ranging from efficient intracavity frequency conversion,mode proliferation to passive mode locking.

关键词： polarization mixer cycle