Quantitative phase imaging through an ultra-thin lensless fiber endoscope

作     者：Jiawei Sun Jiachen Wu Song Wu Ruchi Goswami Salvatore Girardo Liangcai Cao Jochen Guck Nektarios Koukourakis Juergen W.Czarske Jiawei Sun;Jiachen Wu;Song Wu;Ruchi Goswami;Salvatore Girardo;Liangcai Cao;Jochen Guck;Nektarios Koukourakis;Juergen W.Czarske

作者机构：Laboratory of Measurement and Sensor System Technique(MST)TU DresdenHelmholtzstrasse 1801069DresdenGermany Competence Center for Biomedical Computational Laser Systems(BIOLAS)TU DresdenDresdenGermany State Key Laboratory of Precision Measurement Technology and InstrumentsDepartment of Precision InstrumentsTsinghua University100084BeijingChina Institute for Integrative NanosciencesIFW DresdenHelmholtzstraße 2001069DresdenGermany Max Planck Institute for the Science of Light&Max-Planck-Zentrum für Physik und Medizin91058ErlangenGermany Cluster of Excellence Physics of LifeTU DresdenDresdenGermany Institute of Applied PhysicsTU DresdenDresdenGermany 

出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)

年 卷 期：2022年第11卷第8期

页      面：1843-1852页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：Deutsche Forschungsgemeinschaft(DFG)grant CZ55/40-1 Tsinghua Scholarship for Overseas Graduate Studies grant 2020023 European Union’s Horizon 2020 research and innovation programs No.953121(project FLAMIN-GO) Open Access funding enabled and organized by Projekt DEAL 

主　　题：fiber phase thin 

摘      要：Quantitative phase imaging(QPI)is a label-free technique providing both morphology and quantitative biophysical information in ***,applying such a powerful technique to in vivo pathological diagnosis remains ***-core fiber bundles(MCFs)enable ultra-thin probes for in vivo imaging,but current MCF imaging techniques are limited to amplitude imaging *** demonstrate a computational lensless microendoscope that uses an ultra-thin bare MCF to perform quantitative phase imaging with microscale lateral resolution and nanoscale axial sensitivity of the optical path *** incident complex light field at the measurement side is precisely reconstructed from the far-field speckle pattern at the detection side,enabling digital refocusing in a multi-layer sample without any mechanical *** accuracy of the quantitative phase reconstruction is validated by imaging the phase target and hydrogel beads through the *** the proposed imaging modality,three-dimensional imaging of human cancer cells is achieved through the ultra-thin fiber endoscope,promising widespread clinical applications.