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A Mother-to-Child Transmission Study in Nigeria:The Impact of Maternal HIV Infection and HAART on Plasma Immunoglobulins,Cytokine Profiles and Infant Outcome

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Virologica Sinica 2020年第4期35卷 468-477页

作者： Chinwe O.Ewenighi-Amankwah Charles Chinedum Onyenekwe Ogochukwu Udemba Patience Muogbo Lijun Rong Department of Medical Laboratory Science Ebonyi State UniversityAbakaliki 480214Nigeria Department of Microbiology and Immunology College of MedicineUniversity of Illinois at ChicagoChicagoIL 60612USA Department of Medical Laboratory Science Faculty of Health Science and TechnologyNnamdi Azikiwe UniversityAwka 5025Nigeria Laboratory Unit Mother of Christ Specialist HospitalOguiEnugu 400252Nigeria Monitoring and Evaluation Unit ART DepartmentMother of Christ Specialist HospitalOguiEnugu 400252Nigeria

Prevention of mother-to-child transmission(PMTCT)of HIV with highly active antiretroviral therapy(HARRT)allows the HIV^+pregnant mothers to have vaginal delivery and *** we investigated the maternal plasma immunoglobulin,cytokine secretion and the outcome of the exposed infants among the HIV^+HAART treated pregnan women in *** this study,different plasma immunoglobulins and cytokines were measured in the HIV^+HAART treated pregnant *** culture supernatants of B and T lymphocytes showed lower levels of IFN-γ,IL-10 and *** were lower IFN-γand IL-10 secretions at 1st trimester;however,IL-10 continued to be lower throughout 2nd and 3rd ***-αsecretion significantly decreased as pregnancy progressed to *** were high plasma IgG and low IgM in the HIV^+HAART treated pregnant *** IgG was high during 1st and 3rd *** one year of follow up,all the exposed children were seronegative for HIV-1 and *** delivery and breastfeeding among HIV^+HAART treated mothers have shown to be *** use of HAART by the infected mothers and the use of septrin and niverapin by the exposed infants prevented mother to-child transmission of HIV.

关键词： Human immunodeficiency virus(HIV) Prevention from mother-to-child transmission(PMTCT) Highly active antiretroviral therapy(HAART) Lymphocyte stimulation Mitogen Cytokine Immunoglobulins

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In vivo antiplasmodial activity of Bombax buonopozense root bark aqueous extract in mice infected by Plasmodium berghei

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Journal of Traditional Chinese Medicine 2017年第4期37卷 431-435页

作者： Akuodor Godwin Christian Ezeonu Chinonyelum Thecla Essien Augustine Dick Asika Ebere Chile Chilaka Kingsley Chimsorom Nwachukwu Daniel Ckukwu Nwobodo Ndubuisi Nwobodo Department of Pharmacology and Therapeutics Faculty of Medicine Ebonyi State UniversityAbakaliki P.M.B. 053 Nigeria Department of Paediatrics Faculty of Medicine Ebonyi State University Abakaliki RM.B.053 Nigeria Department of Pharmacology College of Medical Sciences University of Calabar Calabar P.M.B. 1115 Nigeria Department of Pharmacology and Therapeutics College of Health Sciences Nnamdi Azikiwe University Awka P.M.B. 5025 Nigeria Department of Physiology College of Medicine University of Nigeria Enugu P.M.B. 1011 Nigeria

OBJECTIVE: To evaluate the in vivo antiplasmodial activity and the oral acute toxicity of the Bombax buonopozense root bark aqueous ***: The in vivo antiplasmodial activity of the root bark aqueous extract of Bombax buonopozense against early and established rodent malaria infections in chloroquine sensitive Plasmodium berghei strain in mice was investigated, and oral acute toxicity of the aqueous root bark extract of Bombax buonopozense was also evaluated in ***: The findings of this study revealed significant(P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract(50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The aqueous extract was found no toxicity in mice and the oral LD50 was determined to be greater than 5000 mg/***: Bombax buonopozense root bark aqueous extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents.

关键词：寄生虫感染水提取物疟原虫根皮木棉体内小鼠急性毒性

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