A Mother-to-Child Transmission Study in Nigeria:The Impact of Maternal HIV Infection and HAART on Plasma Immunoglobulins,Cytokine Profiles and Infant Outcome

作     者：Chinwe O.Ewenighi-Amankwah Charles Chinedum Onyenekwe Ogochukwu Udemba Patience Muogbo Lijun Rong Chinwe O.Ewenighi-Amankwah;Charles Chinedum Onyenekwe;Ogochukwu Udemba;Patience Muogbo;Lijun Rong

作者机构：Department of Medical Laboratory ScienceEbonyi State UniversityAbakaliki 480214Nigeria Department of Microbiology and ImmunologyCollege of MedicineUniversity of Illinois at ChicagoChicagoIL 60612USA Department of Medical Laboratory ScienceFaculty of Health Science and TechnologyNnamdi Azikiwe UniversityAwka 5025Nigeria Laboratory UnitMother of Christ Specialist HospitalOguiEnugu 400252Nigeria Monitoring and Evaluation UnitART DepartmentMother of Christ Specialist HospitalOguiEnugu 400252Nigeria 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2020年第35卷第4期

页      面：468-477页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by TETFUND Nigeria through Ebonyi State University(EBSU) Abakaliki 

主　　题：Human immunodeficiency virus(HIV) Prevention from mother-to-child transmission(PMTCT) Highly active antiretroviral therapy(HAART) Lymphocyte stimulation Mitogen Cytokine Immunoglobulins 

摘      要：Prevention of mother-to-child transmission(PMTCT)of HIV with highly active antiretroviral therapy(HARRT)allows the HIV^+pregnant mothers to have vaginal delivery and *** we investigated the maternal plasma immunoglobulin,cytokine secretion and the outcome of the exposed infants among the HIV^+HAART treated pregnan women in *** this study,different plasma immunoglobulins and cytokines were measured in the HIV^+HAART treated pregnant *** culture supernatants of B and T lymphocytes showed lower levels of IFN-γ,IL-10 and *** were lower IFN-γand IL-10 secretions at 1st trimester;however,IL-10 continued to be lower throughout 2nd and 3rd ***-αsecretion significantly decreased as pregnancy progressed to *** were high plasma IgG and low IgM in the HIV^+HAART treated pregnant *** IgG was high during 1st and 3rd *** one year of follow up,all the exposed children were seronegative for HIV-1 and *** delivery and breastfeeding among HIV^+HAART treated mothers have shown to be *** use of HAART by the infected mothers and the use of septrin and niverapin by the exposed infants prevented mother to-child transmission of HIV.