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s.lvianolic acid C potently inhibits sARs-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

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signal Transduction and Targeted Therapy 2020年第1期5卷 640-642页

作者： Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang lin li shibo Jiang Wei Xu Gengfu Xiao shuwen liu Guangdong Provincial Key laboratory of New Drug screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouChina state Key laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina Key laboratory of Medical Molecular Virology(MOE/NHC/CAMs) School of Basic Medical SciencesFudan-Jinbo Joint Research CenterFudan UniversityShanghaiChina state Key laboratory of Organ Failure Research Guangdong Provincial Institute of NephrologySouthern Medical UniversityGuangzhouChina

Dear Editor,The pandemic of COVID-19 caused by sARs-CoV-2 infection has posed a serious threat to global public health and the *** to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been *** herein report that the hydrophilic compound s.lvianolic acid C(s.l-C)from Danshen,a traditional chinese medicine(TCM),potently inhibit sARs-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(s)protein.

关键词： infection drugs bundle

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traditional chinese medicine as monotherapy or combined with os.ltamivir in the treatment of H1N1 influenza:a systematic review and meta-analysis

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TMR Modern Herbal medicine 2022年第3期5卷 1-12页

作者： Chun-Ping Gu Dong-Wei Ye Xin Mao shu-Wen liu Clinical Pharmacy Center Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key laboratory of New Drug screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Objective This study aimed to assess the efficacy and safety of traditional chinese medicine,alone or in combination with os.ltamivir,in patients with H1N1 *** In the present study,we searched the Cochrane Central Register of Controlled Trials,PUBMED,EMBAsE,chinese Biomedical literature Database,China science and Technology Journal Database,China National Knowledge Infrastructure Database,and WanFang Data for studies published in or before February 8,*** were extracted and checked by two *** Manager 5.4 and sTATA statistical software 16.0 were used for the data *** We identified 22 individual studies reporting data from 2292 individuals with H1N1 *** with os.ltamivir,the fever clearance duration[MD=-3.99,95%CI(-6.89,-1.09)]and sore throat relief time[MD=-5.39,95%CI(-10.19,-0.59)]in the intervention group of traditional chinese medicine monotherapy or combined with os.ltamivir were *** was the primary component of *** subgroup analyses indicated that Maxingshigan shortened fever clearance time[MD=-3.23,95%CI(-5.60,-0.85)],and also had certain advantages in relieving sore throat[RR=-4.55,95%CI(-10.04,0.95)].However,as for the effective rate,fever duration,cough disappearance time,hospital length of stay,clinical symptoms time as well as viral shedding duration,there were no significant differences between the two ***,no serious adverse effects were reported in the included *** Although we couldn’t get a definitive conclusion due to the small sample sizes and high risk of bias in the included studies,most traditional chinese medicine showed similar effects to os.ltamivir in treating H1N1 *** were showed to have a statistically significant shorter time of fever clearance and sore throat remission when they were used alone or in combination with os.ltamivir and were well-tolerated treatment,such as Maxingshigan.

关键词： traditional chinese medicine maxingshigan os.ltamivir H1N1 influenza meta-analysis

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