Traditional Chinese medicine as monotherapy or combined with oseltamivir in the treatment of H1N1 influenza:a systematic review and meta-analysis
作者机构：Clinical Pharmacy CenterNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China
出 版 物：《TMR Modern Herbal Medicine》 (TMR现代中药)
年 卷 期：2022年第5卷第3期
页 面：1-12页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：This work was supported by the National Administration of Traditional Chinese Medicine Project(2019XZZX-LG04) Chinese Academy of Traditional Chinese Medicine Project(ZZ13-035-02)to S.L
主 题：traditional Chinese medicine maxingshigan oseltamivir H1N1 influenza meta-analysis
摘 要：Objective This study aimed to assess the efficacy and safety of traditional Chinese medicine,alone or in combination with oseltamivir,in patients with H1N1 *** In the present study,we searched the Cochrane Central Register of Controlled Trials,PUBMED,EMBASE,Chinese Biomedical Literature Database,China Science and Technology Journal Database,China National Knowledge Infrastructure Database,and WanFang Data for studies published in or before February 8,*** were extracted and checked by two *** Manager 5.4 and STATA statistical software 16.0 were used for the data *** We identified 22 individual studies reporting data from 2292 individuals with H1N1 *** with oseltamivir,the fever clearance duration[MD=-3.99,95%CI(-6.89,-1.09)]and sore throat relief time[MD=-5.39,95%CI(-10.19,-0.59)]in the intervention group of traditional Chinese medicine monotherapy or combined with oseltamivir were *** was the primary component of *** subgroup analyses indicated that Maxingshigan shortened fever clearance time[MD=-3.23,95%CI(-5.60,-0.85)],and also had certain advantages in relieving sore throat[RR=-4.55,95%CI(-10.04,0.95)].However,as for the effective rate,fever duration,cough disappearance time,hospital length of stay,clinical symptoms time as well as viral shedding duration,there were no significant differences between the two ***,no serious adverse effects were reported in the included *** Although we couldn’t get a definitive conclusion due to the small sample sizes and high risk of bias in the included studies,most traditional Chinese medicine showed similar effects to oseltamivir in treating H1N1 *** were showed to have a statistically significant shorter time of fever clearance and sore throat remission when they were used alone or in combination with oseltamivir and were well-tolerated treatment,such as Maxingshigan.
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