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Intestinal Protozoan Infections in Patients with Diarrhea—Shanghai Municipality,Zhenjiang City,and Danyang City,china,2011–2015 and 2019–2021

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china CDC weekly 2022年第8期4卷 143-147页

作者： Yanyan Jiang Zhongying Yuan Hua Liu Jianhai Yin Yuan Qin Xiaofeng Jiang Jie Xu Jianping Cao Yujuan Shen National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)Key Laboratory of Parasite and Vector BiologyNational Health Commission of the People’s Republic of ChinaWorld Health Organization Collaborating Centre for Tropical DiseasesShanghaiChina School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina

Summary What is already known about this topic?Intestinal protozoa are common pathogens of diarrhea globally.However,the etiology of diarrhea due to intestinal protozoan infections in china is not known.What is added by this report?Based on active syndromic surveillance in Shanghai,Zhenjiang,and Danyang during 2011–2015 and 2019–2021,89(1.67%)patients were infected with intestinal protozoa(Cryptosporidium spp.,Giardia duodenalis,Enterocytozoon bieneusi,and Cyclospora cayetanensis),and positivity rates statistically differed by region and age.What are the implications for public health practice?This was the most comprehensive data collection in investigating parasitic diarrheal diseases in humans.Identification of these protozoa in diarrhea will provide new perspectives for detecting hidden etiological agents of diarrhea as early as possible.

关键词： globally ang detecting

A cotton mitogen-activated protein kinase (GhMPK6) is involved in ABA-induced CAT1 expression and H_2O_2 production

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Journal of Genetics and Genomics 2011年第11期38卷 557-565页

作者： Juan Luo Li-Li Zhao Si-Ying Gong Xiang Sun Peng Li Li-Xia Qin Ying Zhou Wen-Liang Xu Xue-Bao Li Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life Sciences Central China Normal University Wuhan 430079 China

The mitogen-activated protein kinase （MAPK） cascade is one of the a pivotal role in the regulation of stress and developmental signals in plants. major and evolutionally conserved signaling pathways and plays Here, we identified one gene, GhMPK6, encoding an MAPK protein in cotton. GFP fluorescence assay demonstrated that GhMAPK6 is a cytoplasm localized protein. Quantitative RT-PCR analysis revealed that mRNA accumulation of GhMPK6 was significantly promoted by abscisic acid （ABA）. Overexpression of GhMPK6 gene in the T-DNA insertion mutant atmkkl （SALK_015914） conferred a wild-type phenotype to the transgenic plants in response to ABA. Under ABA treatment, cotyledon greening/expansion in GhMPK6 transgenic lines and wild type was significantly inhibited, whereas the atmkkl mutant showed a relatively high cotyledon greening/expansion ratio. Furthermore, CAT1 expression and H2O2 levels in leaves of GhMPK6 transgenic lines and wild type were remarkably higher than those of atmkkl mutant with ABA treatment. Collectively, our results suggested that GhMPK6 may play an important role in ABA-induced CAT1 expression and H2O2 production.

关键词： Cotton （Gossypium hirsutum） Mitogen-activated protein kinase （MAPK） Hydrogen peroxide （H2O2） Abscisic acid （ABA） Hypersensitivity

Therapeutic Mechanism of Kai Xin San on Alzheimer's Disease Based on Network Pharmacology and Experimental Validation

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Chinese Journal of Integrative Medicine 2023年第5期29卷 413-423页

作者： WANG Kan YANG Rong CHEN Tuan-tuan QIN Mei-rong WANG Ping KONG Ming-wang The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Hepatology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhenGuangdong Province(518033)China Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao SARChina Key Laboratory of Cosmetics Monitoring and Evaluation State Drug AdministrationShenzhen Institute for Drug ControlShenzhenGuangdong Province(518057)China The School of Basic Medical Sciences Hubei University of Chinese MedicineWuhan(430065)China

Objective: To explore the specific pharmacological molecular mechanisms of Kai Xin San(KXS)on treating Alzheimer’s disease(AD) based on network pharmacology and experimental validation. Methods:The chemical compounds of KXS and their corresponding targets were screened using the Encyclopedia of Traditional Chinese Medicine(ETCM) database. AD-related target proteins were obtained from MalaCards database and DisGeNET databases. Key compounds and targets were identified from the compound-targetdisease network and protein-protein interaction(PPI) network analysis. Functional enrichment analysis predicted the potential key signaling pathways involved in the treatment of AD with KXS. The binding affinities between key ingredients and targets were further verified using molecular docking. Finally, the predicted key signaling pathway was validated experimentally. Positioning navigation and space search experiments were conducted to evaluate the cognitive improvement effect of KXS on AD rats. Western blot was used to further examine and investigate the expression of the key target proteins related to the predicted pathway. Results: In total, 38active compounds and 469 corresponding targets of KXS were screened, and 264 target proteins associated with AD were identified. The compound-target-disease and PPI networks identified key active ingredients and protein targets. Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis suggested a potential effect of KXS in the treatment of AD via the amyloid beta(Aβ)-glycogen synthase kinase-3 beta(GSK3β)-Tau pathway. Molecular docking revealed a high binding affinity between the key ingredients and targets. In vivo,KXS treatment significantly improved cognitive deficits in AD rats induced by Aβ1-42, decreased the levels of Aβ, p-GSK3β, p-Tau and cyclin-dependent kinase 5, and increased the expressions of protein phosphatase 1alpha(PP1A) and PP2A(P<0.05 or P<0.01). Conclusion: KXS exerted neuroprotective effects by regulating the Aβ-GSK3β-Tau signaling pathway, which provides

关键词： Kai Xin San Alzheimer's disease Tau protein network pharmacology molecular docking experimental validation Chinese medicine

Effect of copper slurry on polishing characteristics

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Journal of Semiconductors 2011年第11期32卷 172-176页

作者：胡轶刘玉岭刘效岩王立冉何彦刚 Institute of Microelectronics Hebei University of Technology

The composition of the polishing solution is optimized by investigating the impact of the WIWNU （the so-called within-wafer-non-uniformity WIWNU） and the removal rate （RR） on the polishing characteristics of copper, The oxidizer concentration is 1 Vol%; the abrasive concentration is 0.8 Vol%; the chelating agent of the solution is 2 Vol%. The working pressure is 1 kPa. The defect on the surface is degraded and the surface is clean after polishing. The removal rate is 289 nm/min and the WIWNU is 0,065. The surface roughness measured by AFM after CMP （chemical mechanical planarization） is 0.22 nm.

关键词： copper slurry chemical mechanical planarization WIWNU

Genome-wide transcriptional analysis of maize endosperm in response to ae wx double mutations

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Journal of Genetics and Genomics 2010年第11期37卷 749-762页

作者： Xiang Li Guang Hui Chen Wei Yang Zhang Xiansheng Zhang State Key Laboratory of Crop Biology College of Life Sciences Shandong Agricultural University Taian 271018 China

Starch biosynthesis is important during endosperm development. Much has been known for the regulation of gene expression involved in starch synthesis, less information is available on the genome-wide expression profiles as a consequence of impaired starch synthesis. In this study, we examined the transcriptional responses through microarray analysis in an ae wx double-mutant with loss-of-function starch branching enzyme IIb （SBEIIb） and granule-bound starch synthase I （GBSSI）. Through Gene Ontology enrichment analysis, we identified differentially expressed genes （DEGs） involved in chromatin organization and lipid transport. The DEGs also include alcohol dehydrogenase genes and pyruvate decarboxylase genes involved in sugar metabolism. In summary, the ae wx double mutations caused pleiotropic effects and transcriptional changes for a number of genes involved in metabolism, cellular response and organization. Therefore, a block in starch synthesis triggers transcriptional responses to favour the flux of excess carbohydrates into glycolysis, pentose phosphate pathway, and cell wall biosynthesis, but not toward the synthesis of alternative storage compounds.

关键词： transcriptional regulation starch biosynthesis carbohydrate metabolism

Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第2期12卷 143-148页

作者： Yang LU Shou-ying DU Xiao-lan CHEN Qing WU Xiao SONG Bing XU Yong-song ZHAI Department of Industrial Pharmacy School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China Department of Chinese Pharmacy Guiyang College of Traditional Chinese Medicine Guiyang 550002 China

Both geniposide (Ge) and natural borneol (NB) are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography (HPLC) after intranasal administration of Ge (4 mg/kg) alone and combined with different doses (0.08, 0.8, and 8 mg/kg) of NB. The intravenous administration was given as a reference (4 mg/kg of Ge and 8 mg/kg of NB). Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter (3-5 min vs. 40 min); the peak concentration became higher (1.32-4.25 μg/ml vs. 0.67 μg/ml); and, the relative bioavailability of Ge combined with NB was 90.3%-237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity.

关键词： Geniposide 自然龙脑 Intranasal 管理静脉内的管理 Pharmacokinetics

Evaluation of planarization performance for a novel alkaline copper slurry under a low abrasive concentration

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Journal of Semiconductors 2014年第11期35卷 173-178页

作者：蒋勐婷刘玉岭袁浩博陈国栋刘伟娟 Institute of Microelectronics Hebei University of Technology

A novel alkaline copper slurry that possesses a relatively high planarization performance is investigated under a low abrasive concentration. Based on the action mechanism of CMP, the feasibility of using one type of slurry in copper bulk elimination process and residual copper elimination process, with different process parameters, was analyzed. In addition, we investigated the regular change of abrasive concentration effect on cop- per and tantalum removal rate and within wafer non-uniformity （WIWNU） in CMP process. When the abrasive concentration is 3 wt%, in bulk elimination process, the copper removal rate achieves 6125 ~/min, while WIWNU is 3.5%, simultaneously. In residual copper elimination process, the copper removal rate is approximately 2700 A/min, while WIWNU is 2.8%. Nevertheless, the tantalum removal rate is 0 A./min, which indicates that barrier layer isn＇t elinainated in residual copper elimination process. The planarization experimental results show that an excellent planarization performance is obtained with a relatively high copper removal rate in bulk elimination process. Meanwhile, atier residual copper elimination process, the dishing value increased inconspicuously, in a control- lable range, and the wafer surface roughness is only 0.326 nm （sq 〈 1 nm） alter polishing. By comparison, the planarization performance and surface quality of alkaline slurry show almost no major differences with two kinds of commercial acid slurries after polishing. All experimental results are conducive to research and improvement of alkaline slurry in the future.

关键词： alkaline slurry abrasive concentration planarization performance acid slurry

A 5 GHz CMOS frequency synthesizer with novel phase-switching prescaler and high-Q LC-VCO

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Journal of Semiconductors 2011年第8期32卷 98-103页

作者：曹圣国杨玉庆谈熙闫娜闵昊 State Key Laboratory of ASIC & System Fudan University

A phase-locked loop（PLL） frequency synthesizer with a novel phase-switching prescaler and a high-Q LC voltage controlled oscillator（VCO） is presented.The phase-switching prescaler with a novel modulus control mechanism is much more robust on process variations.The Q factor of the inductor,I-MOS capacitors and varactors in the VCO are optimized.The proposed frequency synthesizer was fabricated by SMIC 0.13μm 1P8M MMRF CMOS technology with a chip area of 1150×2500μm^2.When locking at 5 GHz,the current consumption is 15 mA from a supply voltage of 1.2 V and the measured phase noise at a 1 MHz offset is -122.45 dBc/Hz.

关键词： PLL frequency synthesizer differential voltage controlled oscillator phase-switching prescaler CMOS

A low-power high-swing voltage-mode transmitter

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Journal of Semiconductors 2012年第4期33卷 89-94页

作者：陈帅李昊石小兵杨丽琼杨宗仁钟石强黄令仪 Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China Graduate University of the Chinese Academy of Sciences Beijing 100049China Loongson Technologies Corporation Limited Beijing 100190China

A low-power voltage-mode-logic （VML） transmitter fabricated in TSMC 28 nm CMOS technology is presented. The VML driver outputs a high-swing signal and consumes less power than a current-mode-logic （CML） driver. To further reduce power, the driver is divided into two voltage domains by level shifters. Moreover, the proposed driver topology can achieve mutually decoupled impedance self-calibration and equalization control. The measurement result shows that the transmitter merely dissipates 23 roW/channel while exhibiting an 880 mV differential eye height at 4.488 Gb/s.

关键词： voltage-mode transmitter low power impedance self-calibration equalization mutually decoupled