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Impact of microplastics and nanoplastics on liver health:Current understanding and future research directions

World Journal of Gastroenterology 2024年第9期30卷 1011-1017页

作者： Chun-Cheng Chiang Hsuan Yeh Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai Yen School of Medicine University of PittsburghPittsburghPA 15213United States Pittsburgh Liver Research Center University of PittsburghPittsburghPA 15213United States Division of Experimental Pathology Department of PathologyUniversity of PittsburghPittsburghPA 15213United States Division of Endocrinology Department of PediatricsUniversity of PittsburghPittsburghPA 15213United States Center of Excellence for The Oceans National Taiwan Ocean UniversityKeelung 20224Taiwan Institute of Marine Environment and Ecology National Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Materials Science and Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalTaoyuan 333TaiwanChina College of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

With continuous population and economic growth in the 21st century,plastic pollution is a major global ***,the health concern of microplastics/nanoplastics(MPs/NPs)decomposed from plastic wastes has drawn public attention only in the recent *** article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ,which is one of the primary routes that MPs/NPs enter human *** interrelated mechanisms including oxidative stress,hepatocyte energy re-distribution,cell death and autophagy,as well as immune responses and inflammation,were also *** addition,the disturbance of microbiome and gut-liver axis,and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease,steatohepatitis,liver fibrosis,and cirrhosis were briefly ***,we discussed potential directions in regard to this trending topic,highlighted current challenges in research,and proposed possible solutions.

关键词： Microplastics Nanoplastics Liver Reactive oxidative species Cell death Autophagy Innate immunity Metabolic dysfunction-associated fatty liver disease Gut-liver axis

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Add-on perceptual learning on refractive amblyopia in children

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1850-1856页

作者： Heng-Chiao Huang Wan-Hua Cho Po-Chiung Fang Pei-Wen Lin Yi-Hao Chen Hsiu-Mei Huang Department of Ophthalmology Chang Gung Memorial HospitalChiayi 613TaiwanChina Department of Ophthalmology Chi-Mei Medical CenterTainan 710TaiwanChina Department of Ophthalmology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung City 833TaiwanChina School of Medicine Chang Gung UniversityTaoyuan City 333TaiwanChina

AIM:To evaluate the visual outcomes of standard amblyopic treatment add-on training via perceptual learning in refractive amblyopic children and to identify the risk factors for treatment ***:Retrospective charts were reviewed in children with refractive amblyopia who received standard treatment and add-on Cambridge Visual Stimulator(CAM)*** add-on CAM group that was enrolled had worn full-corrected glasses for at least 2mo before training.A control group received only the standard *** success was defined as best-corrected visual acuity(BCVA)≥20/*** age,sex,initial BCVA,refractive errors,sessions and duration of training,and final BCVA were ***:A total of 209 children(129 children in add-on CAM group and 80 children in control group)were ***-six percent of unilateral and 87%of bilateral amblyopic children achieved treatment *** children with unilateral or bilateral moderate amblyopia,the duration to reach BCVA≥20/25 was significantly shorter in add-on CAM group than in control *** initial BCVA(P<0.001)and high astigmatism(P=0.007)were risk factors for treatment failure after add-on CAM ***,sex,and types of refractive error were not associated with treatment ***:Add-on CAM training is an effective strategy for visual improvement and can shorten the treatment course when the effect of standard treatment is limited in amblyopic children.

关键词： amblyopia amblyopic children add-on Cambridge Visual Stimulator training astigmatism

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Modeling the dendritic evolution and micro-segregation of cast alloy with cellular automaton

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Journal of University of Science and Technology Beijing 2004年第6期11卷 511-516页

作者： QiangLi DianzhongLi BainianQian InstituteofMetalResearch ChineseAcademyofSciencesShenyang110016China

In order to precisely describe the dendritic morphology and micro-segregationduring solidification process, a novel continuous model concerning the different physicalproperties in the solid phase, liquid phase and interface is developed. Coupling the heat and solutediffusion with the transition rales, the dendrite evolution is simulated by cellular automatonmethod. Then, the solidification microstructure evolution of a small ingot is simulated by usingthis method. The simulated results indicate that this model can simulate the dendrite growth, showthe second dendrite arm and tertiary dendrite arm, and reveal the micro-segregation in theinter-dendritic zones. Furthermore, the columnar-to-equiaxed transition (CET) is predicted.

关键词： continuous model cellular automaton dendrite evolution micro-segregation columnar-to-equiaxed transition (CET)

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Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study

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World Journal of Gastrointestinal Surgery 2021年第5期13卷 476-492页

作者： Chao-Wei Lee Ming-Chin Yu Chih-Chi Wang Wei-Chen Lee Hsin-I Tsai Feng-Che Kuan Chun-Wei Chen Yi-Chung Hsieh Hsing-Yu Chen Division of General Surgery Department of SurgeryLinkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan College of Medicine Chang Gung UniversityGuishan 333TaoyuanTaiwan Graduate Institute of Clinical Medical Sciences Chang Gung UniversityGuishan 333TaoyuanTaiwan Department of Surgery New Taipei Municipal Tu-Cheng Hospital(Built and Operated by Chang Gung Medical Foundation)Tu-Cheng 236017New Taipei CityTaiwan Division of General Surgery Department of SurgeryKaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Division of General Surgery Department of SurgeryChiayi Chang Gung Memorial HospitalChiayi 613Taiwan Department of Anesthesiology Linkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan Department of Hematology and Oncology Chiayi Chang Gung Memorial HospitalChiayi 613Taiwan Department of Gastroenterology and Hepatology Linkou Chang Gung Memorial HospitalGuishan 333TaoyuanTaiwan Division of Chinese Internal Medicine Center for Traditional Chinese MedicineTaoyuan Chang Gung Memorial HospitalGuishan 33378TaoyuanTaiwan School of Traditional Chinese Medicine College of MedicineChang Gung UniversityGuishan 333TaoyuanTaiwan

BACKGROUND The treatment of hepatocellular carcinoma(HCC)≥10 cm remains a *** To consolidate the role of surgical resection for HCC larger than 10 *** Eligible HCC patients were identified from the chang gung Research Database,the largest multi-institution database,which collected medical records of all patients from chang gung memorial *** surgical outcome of HCC≥10 cm(L-HCC)was compared to that of HCCchang gung Research *** 3985 patients who received liver resection,3559(89.3%)had S-HCC,and 426 had *** L-HCC patients had a worse disease-free survival(0.27 for L-HCC vs 0.40 for S-HCC)and overall survival(0.18 for L-HCC vs 0.45 for S-HCC)than the S-HCC after liver resection(both P<0.001).However,the surgical and long-term outcome of resected L-HCC had improved dramatically in the recent *** adjusting for covariates,surgery could provide a better outcome for L-HCC than TACE(adjusted hazard ratio of all-cause mortality:0.46,95%confidence interval:0.38-0.56 for surgery).Subgroup analysis stratified by different stages showed similar trend of survival benefit among L-HCC patients receiving *** Our study demonstrated an improving surgical outcome for HCC larger than 10 *** selected conditions,surgery is better than TACE in terms of disease control and survival and should be *** to inferior survival,a subclassification within T1 stage should be *** studies are mandatory to confirm our findings.

关键词： Hepatocellular carcinoma 10 cm Liver resection Transarterial chemoembolization chang gung Research Database

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First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease

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World Journal of Gastroenterology 2017年第47期23卷 8395-8404页

作者： Chih-Ming Liang Ming-Te Kuo Pin-I Hsu Chao-Hung Kuo Wei-Chen Tai Shih-Cheng Yang Keng-Liang Wu Hsing-Ming Wang Chih-Chien Yao Cheng-En Tsai Yao-Kuang Wang Jiunn-Wei Wang Chih-Fang Huang Deng-Chyang Wu Seng-Kee Chuah 无 Division of Hepato-Gastroenterology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Gastroenterology Department of Internal MedicineKaohsiung Veterans General HospitalNational Yang-Ming University Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital and Kaohsiung Medical University Division of Family Physicians Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Acid-Related Disease Study Group

AIM To compare the one-week clinical effects of single doses of dexlansoprazole and esomeprazole on grades A and B erosive *** We enrolled 175 adult patients with gastroesophageal reflux disease(GERD). The patients were randomized in a 1:1 ratio into two sequence groups to define the order in which they received single doses of dexlansoprazole(n = 88) and esomeprazole(n = 87) for an intention-to-treat analysis. The primary endpoints were the complete symptom resolution(CSR) rates at days 1, 3, and 7 after drug *** Thirteen patients were lost to follow-up, resulting in 81 patients in each group for the per-protocol analysis. The CSRs for both groups were similar at days 1, 3 and 7. In the subgroup analysis, the female patients achieved higher CSRs in the dexlansoprazole group than in the esomeprazole group at day 3(38.3% vs 18.4%, P = 0.046). An increasing trend toward a higher CSR was observed in the dexlansoprazole group at day 7(55.3% vs 36.8%, P = 0.09). In the esomeprazole group, female sex was a negative predictive factor for CSR on post-administration day 1 [OR =-1.249 ± 0.543; 95%CI: 0.287(0.099-0.832), P = 0.022] and day 3 [OR =-1.254 ± 0.519; 95%CI: 0.285(0.103-0.789), P = 0.016]. Patients with spicy food eating habits achieved lower CSRs on day 1 [37.3% vs 21.4%, OR =-0.969 ± 0.438; 95%CI: 0.380(0.161-0.896), P = 0.027]. CONCLUSION The overall CSR for GERD patients was similar at days 1-7 for both the dexlansoprazole and esomeprazole groups, although a higher incidence of CSR was observed on day 3 in female patients who received a single dose of dexlansoprazole.

关键词： Dexlansoprazole Esomeprazole Oneweek response Complete symptom resolution rate Gastroesophageal reflux disease

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Analysis of peripapillary retinal nerve fiber layer and inner macular layers by spectral-domain optical coherence tomography for detection of early glaucoma

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1163-1172页

作者： Pei-Wen Lin Hsueh-Wen chang Jih-Pin Lin Ing-Chou Lai Department of Ophthalmology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Biological Sciences Sun Yat-Sen University

AIM： To analyze the diagnostic capabilities of peripapillary retinal nerve fiber layer（p RNFL） thickness and segmented inner macular layer（IML） thickness measured by spectraldomain optical coherence tomography for detection of early glaucoma. METHODS： Fifty-three patients with primary open angle glaucoma（POAG）, 60 patients with normal tension glaucoma（NTG） and 32 normal control subjects were enrolled. Thicknesses of p RNFL, total macular layers（TML）, and the IML, including macular RNFL（m RNFL） and macular ganglion cell layer（m GCL） were assessed. The areas under the receiver operating characteristic curves（AROC） were calculated to compare the diagnostic power of different parameters. RESULTS： There were no differences in the parameters of p RNFL, TML, and IML between POAG and NTG groups. The thicknesses of superior and inferior m GCL showed significant correlation with mean deviation of visual field（R2=0.071, P=0.004; R2=0.08, P=0.002）. The m GCL thickness significantly correlated with the p RNFL thickness in the superior and inferior quadrants（R2=0.156, P〈0.001; R2=0.407, P〈0.001）. The thickness of the inferior-outer sector of macula had greater AROCs than those in the inferior-inner sector of macula. The AROCs for superior（0.894） and inferior（0.879） p RNFL thicknesses were similar with the AROCs for superior（0.839） and inferior m GCL（0.864） thicknesses. Sensitivities at 80% specificity for global p RNFL, inferior-outer m GCL and inferior-outer m RNFL thicknesses were 0.938, 0.867, and 0.725, respectively. CONCLUSION： The diagnostic capability of the m GCL thickness is comparable to that of the p RNFL thickness in patients with early glaucoma. The inferior-outer sector of IML has a better diagnostic capability than the inferiorinner sector of IML for detection of early glaucoma.

关键词： retinal nerve fiber layer ganglion cell layer primary open angle glaucoma normal tension glaucoma optical coherence tomography

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Cognitive impairment and its association with circulating biomarkers in patients with acute decompensated heart failure

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Journal of Geriatric Cardiology 2022年第3期19卷 227-237页

作者： Ying-chang Tung Fu-Chih Hsiao Chia-Pin Lin Wen-Chuin Hsu Pao-Hsien Chu Division of Cardiology Department of Internal MedicineTaipeiTaiwanChina Department of Neurology Chang Gung Memorial HospitalChang Gung University College of MedicineTaipeiTaiwanChina Dementia Center Chang Gung Memorial HospitalTaoyuanTaiwanChina chang gung memorial hospital Chang Gung University College of MedicineTaipeiTaiwanChina

BACKGROUND Cognitive impairment(CI)is common in patients with heart failure(HF),but the association between CI and biomarkers related to HF or cognitive decline in patients with HF remains *** This prospective observational study investigated the incidence of CI,subsequent cognitive changes,and the asso-ciation between CI and novel biomarkers in patients with left ventricular ejection fractionhospitalized for acute decompensated *** were evaluated for CI,depressive symptoms,and quality of life with the Mini-Mental State Examin-ation(MMSE)and the Mini-Cog,Beck Depression Inventory(BDI)-II,and Kansas City Cardiomyopathy Questionnaire(KCCQ),*** primary endpoint was a composite of all-cause mortality or hospitalization for HF at one *** Among the 145 patients enrolled in this study,54 had CI(37.2%)at *** mean MMSE increased signific-antly at the 3-month and 1-year follow-up,accompanied by decreased BDI-II and increased KCCQ *** improvement in the MMSE scores mainly occurred in patients with *** the biomarkers assayed,only growth/differentiation factor(GDF)-15>1621.1 pg/mL was significantly associated with CI(area under the curve=0.64;P=0.003).An increase in GDF-15 per 1000 units was associated with an increased risk of the primary endpoint(hazard ratio=1.42;95%confidence interval:1.17-1.73;P<0.001).CONCLUSIONS In patients with HF with CI,cognitive function,depression,and quality of life measures improved at the 3-month and 1-year ***-15 predicted CI with moderate discrimination capacity and was associated with worse HF out-comes.

关键词： patients impairment compensated

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A three-level authenticated conference key establishment protocol for UMTS networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第5期12卷 371-378页

作者： Chung-Fu LU Tzong-Chen WU Chien-Lung HSU Department of Information Management National Taiwan University of Science and Technology Department of Computer and Communication Engineering Taipei College of Maritime Technology Department of Information Management Chang Gung University

A conference key establishment protocol allows a group of conferees to agree on a secret key shared among them for secure group *** paper proposes a three-level conference key establishment protocol based on the Universal Mobile Telecommunications System (UMTS) framework to establish a group-level key,home location register (HLR) level keys,and visitor location register (VLR) level keys simultaneously for a group of *** group-level key is used to secure the communications for all conferees,the HLR-level key is for those within the same HLR domain,and the VLR-level key is for those within the same VLR *** group-level key can be used for securing inter-domain group-oriented applications such as commercial remote conferencing *** HLRand VLR-level keys can be used for securing intra-domain subgroup applications (e.g.,location-based or context-aware services) and dynamic key *** our proposed protocol exploits existing UMTS security functions and the exclusive-or operation,it is compatible with UMTS *** means that it is fast and easy to implement on the existing UMTS ***,the proposed protocol has low computational complexities and can provide cost effectiveness,load-amortization,scalability,user authentication,key establishment,key confirmation,key updating,and lawful interception.

关键词： Universal Mobile Telecommunications System (UMTS) Three-level Conference key establishment Secure group communication Authentication

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Timing of endoscopic retrograde cholangiopancreatography in the treatment of acute cholangitis of different severity

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World Journal of Gastroenterology 2022年第38期28卷 5602-5613页

作者： Yao-Chi Huang Chi-Huan Wu Mu Hsien Lee Sheng Fu Wang Yung-Kuan Tsou Cheng-Hui Lin Kai-Feng Sung Nai-Jen Liu Department of Medicine College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalTaoyuan 333Taiwan

BACKGROUND The optimal timing of endoscopic retrograde cholangiopancreatography(ERCP)in acute cholangitis(AC) is uncertain,especially in patients with AC of varying *** To report whether the timing of ERCP is associated with outcomes in AC patients with different *** According to the 2018 Tokyo guidelines,683 patients who met the definite diagnostic criteria for AC were retrospectively *** results were first compared between patients receiving ERCP ≤ 24 h and>24 h and then between patients receiving ERCP ≤ 48 h and>48 *** analyses were performed in patients with grade Ⅰ,Ⅱ or Ⅲ *** primary outcome was 30-d *** outcomes were intensive care unit(ICU) admission rate,length of hospital stay(LOHS) and 30-d readmission *** Taking 24 h as the critical value,compared with ERCP>24 h,malignant biliary obstruction as a cause of AC was significantly less common in the ERCP ≤ 24 h group(5.2% vs 11.5%).The proportion of cardiovascular dysfunction(11.2% vs 2.6%),respiratory dysfunction(14.2% vs 5.3%),and ICU admission(11.2% vs 4%)in the ERCP ≤ 24 h group was significantly higher,while the LOHS was significantly shorter(median,6 d vs 7 d).Stratified by the severity of AC,higher ICU admission was only observed in grade Ⅲ AC and shorter LOHS was only observed in grade Ⅰ and Ⅱ *** were no significant differences in 30-d mortality between groups,either in the overall population or in patients with grade Ⅰ,Ⅱ or Ⅲ *** 48 h as the critical value,compared with ERCP>48 h,the proportion of choledocholithiasis as the cause of AC was significantly higher in the ERCP ≤ 48 h group(81.5% vs 68.3%).The ERCP ≤ 48 h group had significantly lower 30-d mortality(0 vs 1.9%) and shorter LOHS(6 d vs 8 d).Stratified by AC severity,lower 30-d mortality(0 vs 6.1%) and higher ICU admission rates(22.2% vs 10.2%) were only observed in grade Ⅲ AC,and shorter LOHS was only observed in grade I and Ⅱ *** the multivariate analysis,cardi

关键词： Acute cholangitis Endoscopic retrograde cholangiopancreatography severity Timing Thirtyday mortality Length of hospital stay

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Application of dental stem cells in three-dimensional tissue regeneration

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World Journal of Stem Cells 2021年第11期13卷 1610-1624页

作者： Hui-Yi Hsiao Chung-Yi Nien Hsiang-Hsi Hong Ming-Huei Cheng Tzung-Hai Yen Center for Tissue Engineering Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Life Sciences National Central UniversityZhongliTaoyuan 320Taiwan Department of Periodontics Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Division of Reconstructive Microsurgery Department of Plastic and Reconstructive SurgeryChang Gung Memorial HospitalLinkou BranchCollege of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 333Taiwan

Dental stem cells can differentiate into different types of *** pulp stem cells,stem cells from human exfoliated deciduous teeth,periodontal ligament stem cells,stem cells from apical papilla,and dental follicle progenitor cells are five different types of dental stem cells that have been identified during different stages of tooth *** availability of dental stem cells from discarded or removed teeth makes them promising candidates for tissue *** recent years,three-dimensional(3D)tissue scaffolds have been used to reconstruct and restore different anatomical *** rapid advances in 3D tissue engineering,dental stem cells have been used in the regeneration of 3D engineered *** review presents an overview of different types of dental stem cells used in 3D tissue regeneration,which are currently the most common type of stem cells used to treat human tissue conditions.

关键词： Dental stem cells Dental pulp stem cells Stem cells from human exfoliated deciduous teeth Periodontal ligament stem cells Stem cells from apical papilla Dental follicle progenitor cells Three-dimensional tissue regeneration

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