Cognitive impairment and its association with circulating biomarkers in patients with acute decompensated heart failure

作     者：Ying-Chang Tung Fu-Chih Hsiao Chia-Pin Lin Wen-Chuin Hsu Pao-Hsien Chu 

作者机构：Division of CardiologyDepartment of Internal MedicineTaipeiTaiwanChina Department of NeurologyChang Gung Memorial HospitalChang Gung University College of MedicineTaipeiTaiwanChina Dementia CenterChang Gung Memorial HospitalTaoyuanTaiwanChina Chang Gung Memorial HospitalChang Gung University College of MedicineTaipeiTaiwanChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2022年第19卷第3期

页      面：227-237页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by research grants from Linkou Chang Gung Memorial Hospital Taiwan China(CMRPG3F1633) 

主　　题：patients impairment compensated 

摘      要：BACKGROUND Cognitive impairment(CI)is common in patients with heart failure(HF),but the association between CI and biomarkers related to HF or cognitive decline in patients with HF remains *** This prospective observational study investigated the incidence of CI,subsequent cognitive changes,and the asso-ciation between CI and novel biomarkers in patients with left ventricular ejection fraction1621.1 pg/mL was significantly associated with CI(area under the curve=0.64;P=0.003).An increase in GDF-15 per 1000 units was associated with an increased risk of the primary endpoint(hazard ratio=1.42;95%confidence interval:1.17-1.73;P0.001).CONCLUSIONS In patients with HF with CI,cognitive function,depression,and quality of life measures improved at the 3-month and 1-year ***-15 predicted CI with moderate discrimination capacity and was associated with worse HF out-comes.