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Impact of intrarectal chromofungin treatment on dendritic cellsrelated markers in different immune compartments in colonic inflammatory conditions

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World Journal of Gastroenterology 2021年第47期27卷 8138-8155页

作者： Kunal Kapoor Nour Eissa Diane Tshikudi Charles N Bernstein Jean-Eric Ghia Department of Immunology University of ManitobaWinnipeg R3E0T5MBCanada Children's Hospital Research Institute of Manitoba University of ManitobaWinnipeg R3E0T5MBCanada Section of Gastroenterology Department of Internal MedicineRady Faculty of Health SciencesUniversity of ManitobaWinnipeg R3E0T5MBCanada University of Manitoba IBD Clinical and Research Centre University of ManitobaWinnipeg R3E0T5MBCanada

BACKGROUND Chromofungin(CHR:chromogranin-A 47-66)is a chromogranin-A derived peptide with anti-inflammatory and anti-microbial *** colitis(UC)is characterized by a colonic decrease of CHR and a dysregulation of dendritic CD11c+*** To investigate the association between CHR treatment and dendritic cells(DCs)-related markers in different immune compartments in *** A model of acute UC-like colitis using dextran sulphate sodium(DSS)was used in addition to biopsies collected from UC *** Intrarectal CHR treatment reduced the severity of DSS-induced colitis and was associated with a significant decrease in the expression of CD11c,CD40,CD80,CD86 and interleukin(IL)-12p40 in the inflamed colonic mucosa and CD11c,CD80,CD86 IL-6 and IL-12p40 within the mesenteric lymph nodes and the ***,CHR treatment decreased CD80 and CD86 expression markers of splenic CD11c+cells and decreased NF-κB expression in the colon and of splenic CD11c+*** vitro,CHR decreased CD40,CD80,CD86 IL-6 and IL-12p40 expression in naïve bone marrow-derived CD11c+DCs stimulated with *** studies demonstrated an impact of CHR on the NF-κB *** patients with active UC,CHR level was reduced and showed a negative linear relationship with CD11c and *** CHR has protective properties against intestinal inflammation via the regulation of DC-related markers and CD11c+*** could be a potential therapy of UC.

关键词： Chromofungin Chromogranin-A Colitis Cytokines Dendritic cells Gut hormones

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聚合物介导的红细胞免疫修饰：聚合物分子大小在血细胞抗原识别中的效果

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中国科学：生命科学 2011年第6期41卷 429-438页

作者：王敦成 KYLUIK Dana L. MURAD Kari L. TOYOFUKU Wendy M. SCOTT Mark D. canadianBloodServices VancouverBCV6T123Canada Centre for Blood Research and the Department of Pathology and Laboratory Medicine University of British ColumbiaVancouverBCV6T123Canada Department of Biology CollegeofSt.RoseAlbanyNY12208USA

降低血型抗原的异体免疫水平对于慢性输血病人有很重要的临床意义.利用甲氧基聚乙二醇修饰红细胞的策略,可以免疫修饰血型抗原以降低红细胞的异体免疫水平.本研究显示,抗体识别非ABO的水平随甲氧基聚乙二醇的分子大小和浓度的升高而显... 详细信息

降低血型抗原的异体免疫水平对于慢性输血病人有很重要的临床意义.利用甲氧基聚乙二醇修饰红细胞的策略,可以免疫修饰血型抗原以降低红细胞的异体免疫水平.本研究显示,抗体识别非ABO的水平随甲氧基聚乙二醇的分子大小和浓度的升高而显著下降,分子量大的多聚体的免疫保护作用比分子量小的显著.同时,动物实验表明,甲氧基聚乙二醇修饰的异种红细胞(羊红细胞)以及同种不同品系(C57Bl/6)或自体(Balb/c)红细胞的体内免疫原性均明显降低.与对照相比,小鼠接受甲氧基聚乙二醇修饰的绵羊血,发现抗绵羊红细胞的抗体产生降低了90%.与对照相比,两次输入甲氧基聚乙二醇修饰的绵羊血的小鼠,抗绵羊血抗体产生降低了80%.尤为重要的是,甲氧基聚乙二醇修饰的自体血细胞没有诱导新抗原的产生,也没有IgG或IgM应答.以上结果表明,聚合物对红细胞的免疫修饰可以安全有效地降低异体免疫的水平,具有潜在的输血医学临床应用价值.

关键词：甲氧基聚乙二醇红细胞血型抗原小鼠异体免疫

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Stand history is more important than climate in controlling red maple (Acer rubrum L.) growth at its northern distribution limit in western Quebec, Canada

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Journal of Plant Ecology 2015年第4期8卷 368-379页

作者： Yun Zhang Yves Bergeron Xiu-Hai Zhao Igor Drobyshev Institut de recherche sur les forêts Universitédu Québec en Abitibi-Témiscamingue(UQAT)445 boul.de l’UniversitéRouyn-NorandaQuébec J9X 5E4Canada Key Laboratory for Forest Resources&Ecosystem Processes of Beijing Beijing Forestry UniversityBeijing 100083P.R.China Swedish University of Agricultural Sciences Southern Swedish Forest Research CentrePO Box 49Alnarp SE-23053Sweden Present address:National Plateau Wetlands Research Center Southwest Forestry UniversityKunming 650224P.R.China.

Aims We examined growth of red maple(Acer rubrum l.)to evaluate environmental controls of its northern distributional limit in Eastern North america and its potential response to future climate *** We collected growth data from nine sites located along a 300-km transect(47-49°N),which included frontier population of red maple and covered three bioclimatic domains in western *** ana-lyzed three growth variables:growth rates during the first 30 years of maple lifespan,cumulative basal area increment(ba I)over the most recent decade(2000-2009)and annual growth rate over the whole tree lifespan ranging from 58 to 112 *** also examined growth sensitivity to climate by using response function *** Findingsthree different proxies of maple absolute growth(initial growth rate,ba I during 2000-09 and mean diameter growth rate)indicated a better growth with an increase in *** speculate that stand history effectively overrode the direct effects of colder climate on maple growth along the s-N *** of maple in the southern sites likely occurred in canopy gaps,whereas in the north it was contingent upon large disturbances such as stand-replacing fires,which apparently provided more favorable light environment for maple growth than canopy *** annual growth variability,which reflects effects of annual weather on growth and is largely independent from the absolute growth rate,was significantly affected by monthly climate,suggesting a positive effect of higher summer temperature in the northern part of the transect(48-49°N)and a negative effect of summer drought in the south(47-48°N).In the future,the natural and human disturbance regimes will be dominant controls of the actual biomass productivity of red maple at the northern limit of its present distribution *** effects of climate on maple growth would likely be less important in this context,and will likely entail negative effect of increased summer drought

关键词： biomass productivity climate change dendrochronology ecotone hardwoods species migration

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Applying reticular synthesis to the design of Cu-based MOFs with mechanically interlocked linkers

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Nano Research 2021年第2期14卷 417-422页

作者： Alexander J.Stirk Benjamin H.Wilson Christopher A.O’Keefe Hazem Amame Kelong Zhu Robert W.Schurko Stephen J.Loeb Department of Chemistry and Biochemistry University of WindsorWindsorOntarioN9B 3B4Canada Department of Chemistry The University of JordanAmman11942Jordan School of Chemistry Sun Yat-Sen UniversityGuangzhou 510275China Department of Chemistry and Biochemistry Florida State UniversityTallahasseeFlorida 32306-4390USA

The concept of“robust dynamics”describes the incorporation of mechanically interlocked molecules(MIMs)into metal-organic framework(MOF)materials such that large amplitude motions(e.g.,rotation or translation of a macrocycle)can occur inside the free volume pore of the *** aid in the preparation of such materials,reticular synthesis was used herein to design rigid molecular building blocks with predetermined ordered structures starting from the well-known MOF *** linkers were synthesized that have a T-shape,based on a triphenylene tetra-carboxylate strut,and their incorporation into Cu(II)-based MOFs was *** single-crystal structures of three new MOFs,UWCM-12(fof),β-UWCM-13(loz),UWCM-14(lil),with naked T-shaped linkers were determined;β-UWCM-13 is the first reported example of the loz topology.A fourth MOF,UWDM-14(lil)is analogous to UWCM-14(lil)but contains a[2]rotaxane ***-temperature,^(2)H solid-state NMR was used to probe the dynamics of a 24-membered macrocycle threaded onto the MOF skeleton.

关键词： reticular chemistry metal-organic frameworks mechanically interlocked molecules rotaxane

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Intracerebral haemorrhage: from clinical settings to animal models

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Stroke & Vascular Neurology 2020年第4期5卷 388-395页

作者： Qian Bai Zhaofu Sheng Yang Liu Ruiyi Zhang Voon Wee Yong Mengzhou Xue The Departments of Cerebrovascular Diseases Henan Medical Key Laboratory of Translational Cerebrovascular DiseasesThe Second Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Hotchkiss Brain Institute and Department of Clinical Neurosciences University of CalgaryCalgaryAlbertaCanada

Spontaneous intracerebral haemorrhage(ICH)is a devastating type of stroke with high mortality and morbidity and for which no effective treatments are available to *** experimental and clinical research have been performed to explore its mechanisms regard the subsequent inflammatory cascade and to seek the potential therapeutic *** aim of this review is to discuss insights from clinical settings that have led to the development of numerous animal models of *** of the current and future challenges for clinicians to understand ICH are also surveyed.

关键词： clinical mortality cerebral

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Persistent occult hepatitis B virus infection:Experimental findings and clinical implications

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World Journal of Gastroenterology 2007年第43期13卷 5682-5686页

作者： Patricia M Mulrooney-Cousins Tomasz I Michalak Molecular Virology and Hepatology Research Division of BioMedical Science Faculty of Medicine Health Sciences Centre Memorial University St. John's NL A1B 3V6 Canada

Hepatitis B virus (HBV) is a highly pathogenic virus that causes chronic liver diseases in millions of people globally. In addition to a symptomatic, serologically evident infection, occult persistent HBV carriage has been identified since nucleic acid amplification assays of enhanced sensitivity became introduced for detection of hepadnaviral genomes and their replicative intermediates. Current evidence indicates that occult HBV infection is a common and long-term consequence of resolution of acute hepatitis B. This form of residual infection is termed as secondary occult infection (SOI). The data from the woodchuck model of HBV infection indicate that exposure to small amounts of hepadnavirus can also cause primary occult infection (POI) where virus genome, but no serological makers of exposure to virus, are detectable, and the liver may not be involved. However, virus replicates at low levels in the lymphatic system in both these forms. We briefly summarize the current understanding of the nature and characteristics of occult hepadnaviral persistence as well as of its documented and expected pathological consequences.

关键词： Hepatitis B viWoodchuck hepatitis virus Hepadnaviruses Hepadnaviral hepatitis Occult viral persistence Hepadnavirus lymphotropism Primary occult infection Secondary occult infection Virus reactivation

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Physical origins of ruled surfaces on the reduced density matrices geometry

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Science China(Physics,Mechanics & Astronomy) 2017年第2期60卷 1-8页

作者： Ji-Yao Chen Zhengfeng Ji Zheng-Xin Liu Xiaofei Qi Nengkun Yu Bei Zeng Duanlu Zhou State Key Laboratory of Low Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 China Perimeter Institute for Theoretical Physics Waterloo N2L 2Y5 Canada Centre for Quantum Computation ＆ Intelligent Systems School of Software Faculty of Engineering and Information Technology University of Technology Sydney Sydney 2007 Australia State Key Laboratory of Computer Science Institute of Software Chinese Academy of Sciences Beijing 100190 China Department of Physics Renmin University of China Beijing 100872 China Department of Mathematics Shanxi University Taiyuan 030000 China Institute for Quantum Computing University of Waterloo Waterloo N2L 3G1 Canada Department of Mathematics ＆ Statistics University of Guelph Guelph N1G 2W1 Canada Institute of Physics Chinese Academy of Sciences Beijing 100190 China

The reduced density matrices （RDMs） of many-body quantum states form a convex set. The boundary of low dimensional projections of this convex set may exhibit nontrivial geometry such as ruled surfaces. In this paper, we study the physical origins of these ruled surfaces for bosonic systems. The emergence of ruled surfaces was recently proposed as signatures of symmetry- breaking phase. We show that, apart from being signatures of symmetry-brealdng, ruled surfaces can also be the consequence of gapless quantum systems by demonstrating an explicit example in terms of a two-mode Ising model. Our analysis was largely simplified by the quantum de Finetti＇s theorem--in the limit of large system size, these RDMs are the convex set of all the symmetric separable states. To distinguish ruled surfaces originated from gapless systems from those caused by symmetry- breaking, we propose to use the finite size scaling method for the corresponding geometry. This method is then applied to the two-mode XY model, successfully identifying a ruled surface as the consequence of gapless systems.

关键词： ruled surfaces reduced density matrices bosonic system geometry

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Hypercholesterolemia,low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9

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The Journal of Biomedical Research 2015年第5期29卷 356-361页

作者： Hong-mei Gu Da-wei Zhang Departments of Pediatrics and Biochemistry Group on the Molecular and Cell Biology of LipidsUniversity of Alberta

Atherosclerotic cardiovascular disease is the main cause of mortality and morbidity in the world. Plasma levels of low density lipoprotein cholesterol （LDL-C） are positively correlated with the risk of atherosclerosis. High plasma LDL concentrations in patients with hypercholesterolemia lead to build-up of LDL in the inner walls of the arteries, which becomes oxidized and promotes the formation of foam cells, consequently initiating atherosclerosis. Plasma LDL is mainly cleared through the LDL receptor （LDLR） pathway. Mutations in the LDLR cause familiar hyperch- olesterolemia and increase the risk of premature coronary heart disease. The expression of LDLR is regulated at the transcriptional level via the sterol regulatory element binding protein 2 （SREBP-2） and at the posttranslational levels mainly through proprotein convertase subtilisin/kexin-type 9 （PCSK9） and inducible degrader of the LDLR （IDOL）. In this review, we summarize the latest advances in the studies of PCSK9.

关键词： hypercholesterolemia low density lipoprotein receptor statin atherosclerosis proprotein convertasesubtilisin/kexin -type 9

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Platelets in hemostasis and thrombosis:Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis

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The Journal of Biomedical Research 2015年第6期29卷 437-444页

作者： Yan Hou Naadiya Carrim Yiming Wang Reid C.Gallant Alexandra Marshall Heyu Ni Department of Laboratory Medicine Keenan Research Centre for Biomedical ScienceLi Ka Shing Knowledge InstituteSt.Michael's Hospital and Toronto Platelet Immunobiology Group Jilin Provincial Center for Disease Control and Prevention Department of Laboratory Medicine and Pathobiology University of Toronto canadian Blood Services Department of Medicine and Department of Physiology University of Toronto

Platelets are small anucleate cells generated from megakaryocytes in the bone marrow. Although platelet genera- tion, maturation, and clearance are still not fully understood, significant progress has been made in the last 1-2 dec- ades. In blood circulation, platelets can quickly adhere and aggregate at sites of vascular injury, forming the platelet plug （i.e. the first wave of hemostasis）. Activated platelets can also provide negatively charged phosphatidylserine- rich membrane surface that enhances cell-based thrombin generation, which facilitates blood coagulation （i.e. the second wave of hemostasis）. Platelets therefore play central roles in hemostasis. However, the same process of hemostasis may also cause thrombosis and vessel occlusion, which are the most common mechanisms leading to heart attack and stroke following ruptured atherosclerotic lesions. In this review, we will introduce the classical mechanisms and newly discovered pathways of platelets in hemostasis and thrombosis, including fibrinogen-inde- pendent platelet aggregation and thrombosis, and the plasma fibronectin-mediated ＂protein wave＂ of hemostasis that precedes the classical first wave of hemostasis. Furthermore, we briefly discuss the roles of platelets in inflam- marion and atherosclerosis and the potential strategies to control atherothrombosis.

关键词： platelets thrombosis and hemostasis integrin αIIbβ3 fibrinogen fibronectin

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A spiral microfluidic device for rapid sorting,trapping,and long-term live imaging of Caenorhabditis elegans embryos

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Microsystems & Nanoengineering 2023年第1期9卷 203-213页

作者： Peng Pan Zhen Qin William Sun Yuxiao Zhou Shaojia Wang Pengfei Song Yong Wang Changhai Ru Xin Wang John Calarco Xinyu Liu Department of Mechanical and Industrial Engineering University of Toronto5 King’s College RoadTorontoOntarioM5S 3G8Canada Upper Canada College 200 Lonsdale RoadTorontoOntarioM4V 1W6Canada School of Advanced Technology Xi’an Jiaotong-Liverpool University111 Ren’ai RoadSuzhou215000China School of Electronic and Information Engineering Suzhou University of Science and TechnologySuzhou215009China Department of Mechanical and Aerospace Engineering Jilin UniversityChangchun130012China Department of Cell&Systems Biology University of Toronto25 Harbord StTorontoOntarioM5S 3G5Canada Institute of Biomedical Engineering University of Toronto164 College StreetTorontoOntarioM5S 3G9Canada

Caenorhabditis elegans embryos have been widely used to study cellular processes and developmental regulation at early ***,most existing microfluidic devices focus on the studies of larval or adult worms rather than *** accurately study the real-time dynamics of embryonic development under different conditions,many technical barriers must be overcome;these can include single-embryo sorting and immobilization,precise control of the experimental environment,and long-term live imaging of *** paper reports a spiral microfluidic device for effective sorting,trapping,and long-term live imaging of single *** embryos under precisely controlled experimental *** device successfully sorts embryos from a mixed population of *** at different developmental stages via Dean vortices generated inside a spiral microchannel and traps the sorted embryos at single-cell resolution through hydrodynamic traps on the sidewall of the spiral channel for long-term *** the well-controlled microenvironment inside the microfluidic device,the response of the trapped *** embryos to mechanical and chemical stimulation can be quantitatively *** experimental results show that a gentle hydrodynamic force would induce faster growth of embryos,and embryos developmentally arrested in the high-salinity solution could be rescued by the M9 *** microfluidic device provides new avenues for easy,rapid,high-content screening of *** embryos.

关键词： larval spiral trapping

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