Persistent occult hepatitis B virus infection:Experimental findings and clinical implications
Persistent occult hepatitis B virus infection: Experimental findings and clinical implications作者机构：Molecular Virology and Hepatology Research Division of BioMedical Science Faculty of Medicine Health Sciences Centre Memorial University St. John's NL A1B 3V6 Canada
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2007年第13卷第43期
页 面：5682-5686页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：operating research grants from the Canadian Institutes of Health Research Canada and the Canada Research Chair Program and the Canada Foundation for Innovation
主 题：Hepatitis B viWoodchuck hepatitis virus Hepadnaviruses Hepadnaviral hepatitis Occult viral persistence Hepadnavirus lymphotropism Primary occult infection Secondary occult infection Virus reactivation
摘 要：Hepatitis B virus (HBV) is a highly pathogenic virus that causes chronic liver diseases in millions of people globally. In addition to a symptomatic, serologically evident infection, occult persistent HBV carriage has been identified since nucleic acid amplification assays of enhanced sensitivity became introduced for detection of hepadnaviral genomes and their replicative intermediates. Current evidence indicates that occult HBV infection is a common and long-term consequence of resolution of acute hepatitis B. This form of residual infection is termed as secondary occult infection (SOI). The data from the woodchuck model of HBV infection indicate that exposure to small amounts of hepadnavirus can also cause primary occult infection (POI) where virus genome, but no serological makers of exposure to virus, are detectable, and the liver may not be involved. However, virus replicates at low levels in the lymphatic system in both these forms. We briefly summarize the current understanding of the nature and characteristics of occult hepadnaviral persistence as well as of its documented and expected pathological consequences.
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