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A Case Series of Olfactory Dysfunction in Imported covid-19 Patients:A 12-Month Follow-Up Study

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Biomedical and Environmental Sciences 2022年第5期35卷 402-411页

作者： WANG Ni YANG Ming Bo YANG Pu Ye CHEN Ren Bo HUANG Fei SHI Nan Nan MA Yan ZHANG Yan XU You LIU Si Hong LU Heng Yi FU Qing Qing FAN Yi Pin KAN Hong Min WANG Xiao Hong GUO Ya Ling national Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Hepatology Department of TCM Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Department of Integrated chinese and Western medicine Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Basic Research in Clinical medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Infection Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Information on traditional chinese medicine China Academy of Chinese Medical SciencesBeijing 100700China

Objective The scientific community knows little about the long-term influence of coronavirus disease2019(covid-19) on olfactory dysfunction(OD). With the covid-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported cases.Methods A prospective follow-up design was adopted. A total of 11 self-reported patients with covid-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, 2021.Demographics, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month follow-up.Results Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent cases.Conclusions Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with covid-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.

关键词： covid-19 Olfactory Imported cases Hyposmia Anosmia Follow-up

Diagnostic Value of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Patients with Severe covid-19—7 PLADs,China,January 21–February 10,2020

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China CDC weekly 2022年第10期4卷 195-198,I0001页

作者： Yan Ma Dongshan Zhu Nannan Shi Lei Zhang Guangkun Chen Youwen Ge Zelei Zhang Renbo Chen Sihong Liu Yipin Fan Huamin Zhang Yanping Wang Department of Infectious Disease Prevention Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijingChina Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Jinan250012China chinese medicine Standardization Research Center Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijingChina Institute of Information on traditional chinese medicine China Academy of Chinese Medical SciencesBeijingChina Institute of chinese Materia Medica China Academy of Chinese Medical SciencesBeijingChina.

Summary What is already known about this topic?Coronavirus disease 2019(covid-19)causes symptoms ranging from mild to severe.Indicators for identifying severe covid-19 infection have not been well identified,especially for young patients.What is added by this report?Both neutrophil-lymphocyte ratio(NLR)[area under curve(AUC):0.80;the odds ratios(OR)and 95%confidence intervals(95%CI):1.30(1.13–1.50)]and platelet-lymphocyte ratio(PLR)[AUC:0.87;OR(95%CI):1.05(1.01–1.09)]were determined to be indicators for recognition of patients with severe covid-19 in young patients less than age 40.What are the implications for public health practice?NLR and PLR are useful indicators for identifying patients with severe covid-19,especially in young patients less than age 40.

关键词： Lymphocyte Patients Platelet

Mining intrinsic information of convalescent patients after suffering coronavirus disease 2019 in Wuhan

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Journal of traditional chinese medicine 2022年第2期42卷 279-288页

作者： YAN Shixing LüYi LIU Ziqing REN Meng HE Haiyang XIAO Li GUO Feng PENG Miao LI Xiaoxia WANG Yong XU Xi YANG Tao SHAO Zuoyu HUANG Jingjing XIAO Mingzhong Department of TCM Data Intelligence Shanghai Daosh Medical Technology Co.Ltd.Shanghai 201200China Hepatic Disease Institute Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Affiliated Hospital of Hubei University of chinese medicine Wuhan 430061China Hubei Academy of traditional chinese medicine Wuhan 430074China Electronical Medical Records and Information Management Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai 200437China chinese medicine Development research Center Shanghai Literature Institute of TCMShanghai 200025China College of Acupuncture and Massage Shanghai University of Traditional Chinese MedicineShanghai 201203China College of Artificial Intelligence and Information Technology Institute of Information and Technology Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To summarize the potential characteristics of convalescent patients with coronavirus disease 2019(covid-19)in China based on emerging clinical tongue data and guide the treatment and recovery of covid-19 patients from the perspective of traditional chinese medicine tongue diagnosis.METHODS:In this study,we developed and validated radiomics-based and lab-based methods as a novel approach to provide individualized pretreatment evaluation by analyzing different features to mine the orderliness behind tongue data of convalescent patients.In addition,this study analyzed the tongue features of convalescent patients from clinical tongue qualitative values,including thick and thin,fur,peeling,fat and lean,tooth marks and cracked,and greasy and putrid fur.RESULTS:We included 2164 tongue images in total(34%from day 0,35.4%from day 14 and 30.6%from day 28)from convalescent patients.The significance results are shown as follows.Firstly,as the recovery time prolongs,the L average values of tongue and coat decrease from 60.21 to 57.18 and from 60.06 to 57.03 respectively.Secondly,the decrease of abnormality rate of tongue coat,included greasy tongue fur,putrid fur,teeth-mark,thick-thin fur,are of significant statistical difference(P194,the average value of entropy increases from 0.606 to 0.665,the average value of inverse difference normalized decrease from 0.981 to 0.979,and the average value of dissimilarity decrease from 0.1576 to 0.1828.The details of other radiomics features are describe in results section.CONCLUSIONS:Our experiment shows that patients in different recovery periods have a relationship with quantitative values of tongue images,including L color space of the tongue and coat radiomics features analysis.This relationship can help clinical doctors master the recovery and health of patients as soon as possible and improve their understanding of the potential mechanisms underlying the dynamic changes and mech

关键词： covid-19 tongue inspection quantitative values dynamic change mechanisms radiomics features analysis

Reyanning Mixture on Asymptomatic or Mild SARS-CoV-2 Infection in Children and Adolescents:A Randomized Controlled Trial

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中国结合医学杂志:英文版 2023年第10期29卷 867-874页

作者： XU Xiang-ru ZHOU Shuang JIN Guo-qiang WU Hong-ze LI Jin-hua ZHOU Jing PENG Wei ZHANG Wen SUN Ding FANG Bang-jiang Department of Emergency Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200032China Acupuncture and Massage College Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Health Management The First Affiliated Hospital of Nanchang UniversityNanchang330006China Jiangxi Provincial traditional chinese medicine Nephropathy Clinical Research Center Jiujiang Hospital of Traditional Chinese MedicineJiujiangJiangxi Province332099China Department of Respiratory and Critical Care medicine The First Affiliated Hospital of Nanchang UniversityNanchang330006China Institute of Critical Care Shanghai University of Traditional Chinese MedicineShanghai200032China

Objective: To assess the effect and safety of Reyanning Mixture(RYN) in treating asymptomatic or mild severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) infection in children and adolescents. Methods: This is a prospective, open-label, randomized control ed trial. Patients aged 1–17 years and diagnosed with asymptomatic or mild coronavirus disease-2019(covid-19) were assigned to an intervention group(RYN plus standard care) and a control group(standard care) according to a randomization list. The primary outcomes were SARS-Co V-2 negative conversion time. Secondary outcomes included negative conversion rate on days 3 and 7, hospital length of stay, symptom relief rate, new-onset symptoms of asymptomatic infected patients, and progressive disease rate. The cycle threshold(Ct) values of ORF1ab or N genes were also tested. Results: A total of 214 patients in the intervention group and 217 in the control group were analyzed. The SARS-CoV-2 negative conversion time was significantly shortened in the intervention group [5 days(interquartile range(IQR): 5–6) vs. 7 days(IQR: 6–7), P0.05). Symptoms of cough were significantly improved(82.2% vs. 70.0%, P=0.02) and wheezing was significantly reduced(0.7% vs. 12.9%, P<0.01) in the intervention group compared with the control group. During the trial, no disease progression or serious adverse events were reported. Conclusion: Adding RYN to standard care may be a safe and effec

关键词： coronavirus diseases-2019 severe acute respiratory syndrome coronavirus 2 Omicron children Reyanning Mixture randomized controlled trial chinese medicine

Effectiveness of traditional chinese medicine on coronavirus disease 2019 in 92 patients:a retrospective study

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Journal of traditional chinese medicine 2023年第3期43卷 582-587页

作者： XU Guihua CHEN Feifei ZHANG Wei WU Yingen CHEN Xiaorong SHI Kehua WANG Zhenwei SHI Miaoyan ZHANG Xing LU Yunfei YUAN Weian LYU Hua CHEN Xuan Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China Shanghai Hospital of traditional chinese medicine Shanghai 200071China Yueyang Hospital of Integrated traditional chinese and Western medicine Shanghai 200437China

OBJECTIVE:To investigate the antipyretic effect of early treatment with traditional chinese medicine(TCM) on coronavirus disease 2019(covid-19) patients.METHODS:We retrospectively analyzed 369 patients from January 26th,2020 to April 15th,2020,who had been diagnosed with covid-19.Among 92 eligible cases,45 cases were identified as treatment group Ⅰ(n = 45) and 47 cases were identified as treatment group Ⅱ.Patients in the treatment group Ⅰ were treated with TCM herbal decoction within 5 d after admission.Patients in the treatment group Ⅱ were treated with TCM herbal decoction after the 6th admission day.The onset time of antipyretic effect,the antipyretic time,the time of negative oropharyngeal swab nucleic acid conversion,and the changes of cell count in blood routine test were compared.RESULTS:The treatment group Ⅰ showed shorter average antipyretic duration(4 vs 7 d;P 38 ℃,patients in the treatment group I had shorter median onset time of antipyretic effect than those in the treatment group Ⅱ(3 vs 4 d;P covid-19 patients,reduced the time required for PCR test results to turn negative.Moreover,early TCM intervention also impr

关键词： covid-19 medicine chinese traditional antipyretics immune-inflammatory parameters retrospective studies

SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor

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药学学报:英文版 2023年第7期13卷 3043-3053页

作者： Yiqun Li Mingrui Yang Yanan Nan Jiaming Wang Sanjiao Wang Dongxiao Cui Jiajian Guo Pengfei He Wenxin Dai Shuqi Zhou Yue Zhang Wenfu Ma School of Life Science Beijing University of Chinese MedicineBeijing 102488China

Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.Only surface-exposed S can be recognized by B cell receptor(BCR)or anti-S therapeutic monoclonal antibodies(m Abs)that is the trigger step for B cell activation after S m RNA vaccination or infected cell clearance by S m Abs.Now,a drug strategy to promote S host surface exposure is absent.Here,we first combined structural and biochemical analysis to characterize S COPI sorting signals.A potent S COPI sorting inhibitor was then invented,evidently capable of promoting S surface exposure and facilitating infected cell clearance by S antibody-dependent cellular cytotoxicity(ADCC).Importantly,with the inhibitor as a probe,we revealed Omicron BA.1 S is less cell surface exposed than prototypes because of a constellation of S folding mutations,possibly corresponding to its ER chaperone association.Our findings not only suggest COPI is a druggable target against covid-19,but also highlight SARS-Co V-2 evolution mechanism driven by S folding and trafficking mutations.

关键词： COPI inhibitor SARS-CoV-2 spike Spike sorting motifs Protein folding Protein trafficking Anti-covid-19 Omicron variants and drug discovery

3-to 24-month Follow-up on covid-19 with Pulmonary Tuberculosis Survivors after Discharge:Results from a Prospective,Multicenter Study

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Biomedical and Environmental Sciences 2022年第12期35卷 1091-1099页

作者： WANG Jing Ya ZONG Xing Yu WU Gui Hui QI Yuan Lin LI Hui Zhen JI Xin Yu TONG Lin ZHANG Lei YANG Ming Bo YANG Pu Ye LI Ji Ke XIAO Fu Rong ZHANG Lin Song HU Yun Hong LIU Hong De XU Shou Fang SUN Sheng WU Wei MAO Ya LI Min Qing HOU Hao Hua GONG Zhao Yuan GUO Yang JIAO Li Wen QIN Jin WANG Ding Yi WANG Fang GUAN Li LIN Gang MA Yan WANG Yan Ping SHI Nan Nan Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical medicine China Academy of Chinese Medical SciencesBeijing 100700China Public Health Clinical Center of Chengdu Chengdu 610066SichuanChina Yiyuan TCM Hospital Zibo 256199ShandongChina Institute of Information on traditional chinese medicine China Academy of Chinese Medical SciencesBeijing 100700China Xi’an Eighth Hospital Xi’an 710000ShaanxiChina Harbin Infectious Disease Hospital Harbin 150000HeilongjiangChina Hospital(T.C.M)Affiliated to Southwest Medical University Luzhou 646000SichuanChina Xingtai Hospital of chinese medicine Xingtai 054000HebeiChina Shijiazhuang Fifth Hospital Shijiazhuang 050000HebeiChina Jiamusi Infectious Disease Hospital Jiamusi 154000HeilongjiangChina Chengde Hospital of traditional chinese medicine Chengde 067040HebeiChina Hanzhong Central Hospital Hanzhong 723000ShaanxiChina Ankang Hospital of traditional chinese medicine Ankang 725000ShaanxiChina Department of traditional chinese medicine Dazhou Central HospitalDazhou 635000SichuanChina China national medicines Corporation Ltd Beijing 100077China Beijing University of chinese medicine Beijing 101121China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChin

Objective Coronavirus disease 2019(covid-19)and tuberculosis(TB)are major public health and social issues worldwide.The long-term follow-up of covid-19 with pulmonary TB(PTB)survivors after discharge is unclear.This study aimed to comprehensively describe clinical outcomes,including sequela and recurrence at 3,12,and 24 months after discharge,among covid-19 with PTB survivors.Methods From January 22,2020 to May 6,2022,with a follow-up by August 26,2022,a prospective,multicenter follow-up study was conducted on covid-19 with PTB survivors after discharge in 13 hospitals from four provinces in China.Clinical outcomes,including sequela,recurrence of covid-19,and PTB survivors,were collected via telephone and face-to-face interviews at 3,12,and 24 months after discharge.Results Thirty-two covid-19 with PTB survivors were included.The median age was 52(45,59)years,and 23(71.9%)were men.Among them,nearly two-thirds(62.5%)of the survivors were moderate,three(9.4%)were severe,and more than half(59.4%)had at least one comorbidity(PTB excluded).The proportion of covid-19 survivors with at least one sequela symptom decreased from 40.6%at 3 months to 15.8%at 24 months,with anxiety having a higher proportion over a follow-up.Cough and amnesia recovered at the 12-month follow-up,while anxiety,fatigue,and trouble sleeping remained after 24months.Additionally,one(3.1%)case presented two recurrences of PTB and no re-positive covid-19during the follow-up period.Conclusion The proportion of long symptoms in covid-19 with PTB survivors decreased over time,while nearly one in six still experience persistent symptoms with a higher proportion of anxiety.The recurrence of PTB and the psychological support of covid-19 with PTB after discharge require more attention.

关键词： covid-19 Pulmonary tuberculosis Long-term Sequela Recurrence Re-positive

Treatment Outcomes in covid-19 Patients with Brucellosis:Case Series in Heilongjiang and Systematic Review of Literature

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Biomedical and Environmental Sciences 2023年第10期36卷 930-939页

作者： YANG Man Li WANG Jing Ya ZONG Xing Yu GUAN Li LI Hui Zhen XIONG Yi Bai LIU Yu Qin LI Ting JI Xin Yu SHANG Xi Yu ZHANG Hui Fang GUO Yang GONG Zhao Yuan ZHANG Lei TONG Lin CHEN Ren Bo FAN Yi Pin QIN Jin WANG Fang LIN Gang SHI Nan Nan WANG Yan Ping MA Yan Nanjing University of chinese medicine Nanjing 210023JiangsuChina Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical medicine China Academy of Chinese Medical SciencesBeijing 100700China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChina Institute of Information on traditional chinese medicine China Academy of Chinese Medical SciencesBeijing 100700China Beijing University of chinese medicine Beijing 101121China

Objective Clinical characteristics and outcome in covid-19 with brucellosis patients has not been well demonstrated,we tried to analyze clinical outcome in local and literature covid-19 cases with brucellosis before and after recovery.Methods We retrospectively collected hospitalization data of comorbid patients and prospectively followed up after discharge in Heilongjiang Infectious Disease Hospital from January 15,2020 to April29,2022.Demographics,epidemiological,clinical symptoms,radiological and laboratory data,treatment medicines and outcomes,and follow up were analyzed,and findings of a systematic review were demonstrated.Results A total of four covid-19 with brucellosis patients were included.One patient had active brucellosis before covid and 3 patients had nonactive brucellosis before brucellosis.The median age was54.5 years,and all were males(100.0%).Two cases(50.0%)were moderate,and one was mild and asymptomatic,respectively.Three cases(75.0%)had at least one comorbidity(brucellosis excluded).All4 patients were found in covid-19 nucleic acid screening.Case C and D had only headache and fever on admission,respectively.Four cases were treated with traditional chinese medicine,western medicines for three cases,no adverse reaction occurred during hospitalization.All patients were cured and discharged.Moreover,one case(25.0%)had still active brucellosis without re-positive covid-19,and other three cases(75.0%)have no symptoms of discomfort except one case fell fatigue and anxious during the follow-up period after recovery.Conducting the literature review,two similar cases have been reported in two case reports,and were both recovered,whereas,no data of follow up after recovery.Conclusion These cases indicate that covid-19 patients with brucellosis had favorable outcome before and after recovery.More clinical studies should be conducted to confirm our findings.

关键词： covid-19 Brucellosis Treatment outcomes Sequelae Relapse

Effectiveness and safety of Jinshuibao capsules(金水宝胶囊)in treatment of residual cardiopulmonary symptoms in convalescent patients of coronavirus disease 2019:a pilot randomized,double-blind,placebo-controlled clinical trial

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Journal of traditional chinese medicine 2023年第1期43卷 134-139页

作者： ZHANG Yuehong DONG Dandan YAN Youqin ZHANG Hao WANG Guangli ZHOU Wei LI Wei QIU Li LI Tingming LIU Quan XIA Ping MAO Lina YANG Danlin YANG Lu LIAN Fengmei TONG Xiaolin BA Yuanming Department of Endocrinology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Infectious Diseases Wuhan No.7 HospitalWuhan 430071China Department of Electrocardiograms Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Department of Respiratory Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Department of Nephrology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Department of Orthopaedics Wuhan No.1 HospitalWuhan 430061China Department of Respiratory Wuhan No.1 HospitalWuhan 430061China

OBJECTIVE:To evaluate the effectiveness and safety of Jinshuibao capsules(金水宝胶囊),a traditional chinese medicine(TCM),in the treatment of residual cardiopulmonary symptoms in convalescent corona virus disease 2019(covid-19)patients.METHODS:A total of 200 participants with covid-19 in convalescence phase were randomly assigned into two groups at a 1:1 ratio in this multicenter randomized,double-blind,placebo-controlled trial.One group received Jinshuibao capsules,and the other received placebo.The patients were followed up at one and two weeks of treatment.Five symptoms(dry cough,shortness of breath,sweating,chest tightness and palpitation)improvement rates and full recovery rates were compared.RESULTS:All baseline characteristics were comparable between the two groups.After two weeks of treatment,symptom improvement rates for dry cough(74.00%vs 50.00%,P=0.015),shortness of breath(78.95%vs 46.15%,P19.57%,shortness of breath 18.95%vs 7.69%,sweating 36.00%vs 19.72%,chest tightness 32.94%vs 13.95%,and palpitation 48.75%vs 29.11%)in participants with covid-19 in convalescence phase compared with the control group(Pcovid-19 patients,with few adverse events.

关键词： covid-19 convalescence signs and symptoms randomized controlled trial Jinshuibao capsules