A Case Series of Olfactory Dysfunction in Imported COVID-19 Patients:A 12-Month Follow-Up Study

作     者：WANG Ni YANG Ming Bo YANG Pu Ye CHEN Ren Bo HUANG Fei SHI Nan Nan MA Yan ZHANG Yan XU You LIU Si Hong LU Heng Yi FU Qing Qing FAN Yi Pin KAN Hong Min WANG Xiao Hong GUO Ya Ling WANG Ni;YANG Ming Bo;YANG Pu Ye;CHEN Ren Bo;HUANG Fei;SHI Nan Nan;MA Yan;ZHANG Yan;XU You;LIU Si Hong;LU Heng Yi;FU Qing Qing;FAN Yi Pin;KAN Hong Min;WANG Xiao Hong;GUO Ya Ling

作者机构：National Center for Tuberculosis Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Hepatology Department of TCMXi’an NO.8 HospitalXi’an 710061ShaanxiChina Department of Integrated Chinese and Western MedicineXi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Department of InfectionXi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Information on Traditional Chinese MedicineChina Academy of Chinese Medical SciencesBeijing 100700China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2022年第35卷第5期

页      面：402-411页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：funded by the COVID-19 Project of Shaanxi Administration of Traditional Chinese Medicine[SZY-KJCYC-2020-YJ002] the COVID-19 Project of National Administration of Traditional Chinese Medicine[2020ZYLCYJ06-4] and the CACMS Innovation Fund[CI2021A00704] 

主　　题：COVID-19 Olfactory Imported cases Hyposmia Anosmia Follow-up 

摘      要：Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported *** A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, ***, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month *** Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional Chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent *** Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with COVID-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.