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microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease

Animal models and Experimental medicine 2021年第3期4卷 233-242页

作者： Zhiqi Song Yajin Qu Yanfeng Xu Ling Zhang Li Zhou Yunlin Han Wenjie Zhao Pin Yu Yu Zhang Xianglei Li Chuan Qin Key Laboratory of Human Disease Comparative medicine Chinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina

Background:Alzheimer's disease(AD)is an incurable and irreversible neurodegen-erative disease,without a clear pathogenesis.Therefore,identification of candidates before amyloid-βplaque(Aβ)deposition proceeds is of major significance for earlier intervention in AD.methods:To explore the potential noninvasive earlier biomarkers of AD in a 5XFAD mouse model,microRNAs(miRNAs)from urinary exosomes in 1-month-old pre-Aβaccumulation 5XFAD mice models and their littermate controls were profiled by mi-croarray analysis.The differentially expressed miRNAs were further analyzed via droplet digital PCR(ddPCR).Results:microarray analysis demonstrated that 48 differentially expressed miRNAs(18 upregulated and 30 downregulated),of which six miRNAs-miR-196b-5p,miR-339-3p,miR-34a-5p,miR-376b-3p,miR-677-5p,and miR-721-were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.Conclusions:Urinary exosomal miRNAs showing differences in expression prior to Aβ-plaque deposition were identified.These exosomal miRNAs represent potential noninvasive biomarkers that may be used to prevent AD in clinical applications.

关键词： 5XFAD mouse model Alzheimer's disease biomarkers microarray miRNA urinary exosome

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维普期刊数据库

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The battle against SARS and mERS coronaviruses: Reservoirs and Animal models

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Animal models and Experimental medicine 2018年第2期1卷 125-133页

作者： Shu-ran Gong Lin-lin Bao institute of Laboratory Animal sciences Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine CenterPeking Union Medical College (PUMC) Key Laboratory of Human Disease Comparative Medicine Ministry of Health Key Laboratory for Animal Models of Emerging and Reemerging Infectious

in humans, infection with the coronavirus, especially the severe acute respiratory syndrome coronavirus(SARS-CoV) and the emerging middle East respiratory syndrome coronavirus(mERS-CoV), induces acute respiratory failure, resulting in high mortality. irregular coronavirus related epidemics indicate that the evolutionary origins of these two pathogens need to be identified urgently and there are still questions related to suitable laboratory animal models. Thus, in this review we aim to highlight key discoveries concerning the animal origin of the virus and summarize and compare current animal models.

关键词： animal models coronaviruses reservoirs the middle East respiratory syndrome(canonical form) the severe acute respiratory syndrome

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维普期刊数据库

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